implications for clinical practice

... basis for this disparity is unclear, this information still has potential important clinical implications This biological phenomenon of discordant gene mutations could partially account for the ... primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice Journal of Experimental & Clinical Cancer Research 2011 30:30 Submit your next manuscript to ... therapeutic implications for EGFR-targeted therapy strategy For NSCLC patients with metastases, determining the KRAS and EGFR mutation status in both primary and metastatic tumors may be critical for...

Ngày tải lên: 10/08/2014, 10:21

... other appro priate clinical resources prior to applying information in this manual for direct patient care This is ix x Preface particularly important since patterns of practice and clinical evidence ... Tenectepalse IV bolus over 10 15 s, weight based: 30 mg for weight

Ngày tải lên: 06/03/2014, 11:20

... reasons for ART discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART ... findings have important implications for the use and interpretation of data derived from routine HIV observational databases for research and audit, and they highlight the need for ongoing regular ... data items and codes for abstraction onto the summary sheet The provision of a summary sheet of key clinically useful data, such as serial CD4 counts and clinical events for each patient to facilitate...

Ngày tải lên: 20/06/2014, 08:20

... encouraging new avenues for novel therapeutic strategies in RA Still, more work is required to establish whether harnessing CD4+CD25+ Treg will represent a viable therapy for RA and other autoimmune ... a benchmark therapy for RA, drastically influences the function of CD4+CD25+ Treg [18] The crucial point of that study was that Treg isolated from patients with active RA before treatment with ... inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis J Immunol 2004, 172:6435-6443 van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS: CD4+CD25+...

Ngày tải lên: 09/08/2014, 06:23

... severe groups The same was found when assessing the separate indicators for severity, except for the radiographic ones In clinical practice intra-articular corticosteroid injec­ tions are indicated ... Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT): EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the ... Committee for International Clinical Studies Including Therapeutics (ESCISIT) Ann Rheum Dis 2005, 64:669-681 National Collaborating Centre for Chronic Conditions: Osteoarthritis: national clinical...

Ngày tải lên: 12/08/2014, 15:22

... Imaging A handbook for clinical practice BCIPR 6/17/05 9:53 PM Page ii BCIPR 6/17/05 9:53 PM Page iii THE ESC EDUCATION SERIES Cardiovascular Imaging A handbook for clinical practice EDITED BY ... 2D Doppler echocardiography gives sufficient information for imaging of MS TEE has additional value for the evaluation of LA clot, and in some cases for assessment of mitral regurgitation and subvalvular ... single parameter exists that is both easy to obtain and reliable for grading MR Clinical assessment of MR therefore relies on gathering information on several characteristics and parameters, including...

Ngày tải lên: 13/08/2014, 12:20

... VTIAS-Jet = CSALVOT ¥ VTILVOT Solving for aortic valve area (Fig 3.7): AVA = (CSALVOT ¥ VTILVOT)/VTIAS-Jet In clinical practice, maximum velocities may be substituted for velocity time integrals as ... repair in some patients before symptoms even occur In AR, criteria for early detection of myocardial damage focus on ventricular size and function Current practice guidelines for the timing of surgery ... necessary for evaluation Mitral prosthetic regurgitation can have several etiologies: Bioprosthetic degeneration: the wear-and-tear lesions of bioprostheses may remain entirely clinically silent before...

Ngày tải lên: 13/08/2014, 12:20

... 86% for aortic disease Sensitivity was 67% for overt aortic dissection, 61% for non-dissecting aneurysm, and 63% for intramural hemorrhage or penetrating ulcer However, sensitivity was lower for ... for the initial diagnosis of aortic dissection Choice of imaging modality Barbant et al.12 used Bayes theorem to calculate predictive values and accuracies for angiography, CT, MRI, and TEE for ... Chapter MRI, and TEE, but were 65% for contrast aortography In low-risk populations (disease prevalence 1%), positive predictive values were 100% for MRI and £50% for contrast aortography, CT, and...

Ngày tải lên: 13/08/2014, 12:20

... poor clinical outcome, and frequent need for surgery.9 Early and accurate identification of periannular extension or prosthetic dehiscence in patients suspected of having IE are critical for appropriate ... regurgitation on left ventricular volumes and function, along with clinical evaluation, is needed for adequate timing of intervention Guidelines for the use of echocardiography in suspected or definite infective ... been used for the detection and quantification of coronary calcium By detecting calcium in the coronary arteries, the evidence for atherosclerosis is compelling An exceptional cause for vessel...

Ngày tải lên: 13/08/2014, 12:20

... guideline update for the clinical application of echocardiography: a report of the ACC/AHA task force on practice guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application ... Cardiology/American Heart Association (ACC/AHA) Task Force on Practice Guidelines 2002 guideline update for exercise testing: a report of the ACC/AHA Task Force on Practice Guidelines (Committee to Update ... Cardiology (ACC/AHA/ASNC) guidelines for the clinical use of cardiac radionuclide imaging: a report of the ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide...

Ngày tải lên: 13/08/2014, 12:20

... and DSE for risk stratification before vascular surgery, showed that the prognostic value of both non-invasive stress tests had similar predictive accuracy but the summed odds ratios for cardiac ... indicated that DSE had a positive trend towards a better diagnostic performance for the prediction of perioperative cardiac complications for vascular surgery compared with the other tests (ambulatory ... Guidelines on Perioperative Cardiovascular Evaluation for Non-cardiac Surgery ACC/AHA guideline update for perioperative cardiovascular evaluation for non-cardiac surgery: executive summary a report...

Ngày tải lên: 13/08/2014, 12:20

... valuable for the assessment of dyssynchrony before CRT implantation and for follow-up Parasternal M-mode Beyond the measurement of ventricular dimensions, the classic parasternal M-mode provides information ... echocardiographic evaluation is one of the most important steps to select good clinical responders before implantation Information on the presence and extent of mechanical cardiac dyssynchrony can ... involves the same variables that have been discussed for the assessment of dysynchrony and for verification of CRT efficacy during follow-up For practical purposes, a limited number of LV–RV offsets...

Ngày tải lên: 13/08/2014, 12:20

... with LV dysfunction and a high likelihood for CAD should be screened for the presence of hibernating myocardium Several non-invasive imaging modalities for the detection of hibernating myocardium ... ejection fraction, or flow velocity in adjacent vessels Therefore, the impact of a tumor on cardiovascular function can be evaluated In clinical practice, MRI is most often used to verify or exclude ... divided into two clinicopathologic forms Most frequently, angiosarcomas are found in the RA (Fig 18.7) In this form, no evidence of Kaposi sarcoma is found Another form is characterized by involvement...

Ngày tải lên: 13/08/2014, 12:20

... reducing the need for repeated EMBs, to optimize their timing, and to add information relevant for clinical management Echocardiography is the most extensively used diagnostic technique for noninvasive ... predictive for outcome, none of these parameters can consistently predict the clinical evolution Early follow-up (first month) is likely a better way of foreseeing the evolution,4 but the impact on clinical ... The main limitations of EMB are patient discomfort, risk of complications (less than 1% when performed by skilled personnel: right ventricle perforation, tricuspid leaflet disruption, bleeding,...

Ngày tải lên: 13/08/2014, 12:20

... papillary fibroelastoma, cardiac 225 patent foramen ovale (PFO) 170–1 percutaneous transmitral commissurotomy (PTMC) cardiac catheterization before 9, 10 TEE before 8, Wilkins scoring system 7, pericardial ... while chest deformations may also be present Catheter-driven angiography has clear advantages in imaging quality, but radiation burden and invasiveness are important drawbacks Therefore, magnetic ... MRA sequence is performed Then, 3D reconstructions can be acquired of the vessel, clearly depicting any region of interest Another rapidly advancing technique is coronary MRA for the depiction...

Ngày tải lên: 13/08/2014, 12:20

... well-known process of RBC formation and destruction In so doing it shows the cause for hitherto unexplained observations [13] and predicts other clinical applications for routine blood analysis ... continues to rise until all the normal cells formed before the iron-deficient haemopoiesis have been removed from the circulation After this, there is a uniform population of iron deficient RBC, the ... span of 120 days is assumed I also take the lower level for normal of Hb as 110 g/l (the World Health Organisation's lower limit for normal Hb for adult women) and the upper limit of normal RDWCV%...

Ngày tải lên: 13/08/2014, 23:20

... general use for predicting risk but with low sensitivity They are not specific for arrhythmic deaths Clinical predictors have variable power, some of which are useful as predictors for cardiac ... assessment of clinically useful measures of the consequences of treatment N Engl J Med 1988; 318: 1728–1733 Califf RM, DeMets DL Principles from clinical trials relevant to clinical practice: Part ... Donald For further information on Blackwell Publishing, visit our website: www.blackwellcardiology.com The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry...

Ngày tải lên: 14/08/2014, 07:20

... level [48], has contributed to the exploration of its clinical use In the only randomized clinical trial performed, post-MI patients at high risk for sudden death were allocated to either placebo, ... This trial provided the “proof of concept” for the antifibrillatory effect of LCSD in man In clinical practice, however, the main current use of LCSD is for patients affected by LQTS The most recent ... sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials Circulation 2001; 103: 2072–2077 La Rovere MT, Camm AJ,...

Ngày tải lên: 14/08/2014, 07:20

... al The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications Silvia: “chap06” — 2005/10/6 — 22:32 — page 86 — #13 Clinical characteristics ... Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) Available at www.acc.org /clinical/ guidelines/stemi/index.pdf ... underscores the rationale for the class I recommendation on both sides of the Atlantic for prescription of aspirin to patients with known ischemic heart disease or who are at risk for it [12–14] Alternative...

Ngày tải lên: 14/08/2014, 07:20