implications for™the design of novel therapeutic agents for™psychiatric disorders

Báo cáo y học: "Safety concerns on the development of novel therapeutic drugs" docx

Ngày tải lên : 09/08/2014, 08:22

... the mechanisms of action and off-target effects of a drug can be gained An understanding of the molecular mechanisms that are triggered by a substance possibly may widen its field of indication ... gained and differences in the activation of human and animal cells detected This is of special interest for novel therapeutic strategies that are specifically designed for the human environment, such ... applied to learn more about the effect of a therapeutic substance at the cellular level and about pathological mechanisms of the treated disease Although most of these new methods are not yet ready...

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Báo cáo y học: "Estimating the number of children exposed to parental psychiatric disorders through a national health survey" doc

Ngày tải lên : 13/08/2014, 18:21

... underestimation of the burden of mental disorders in Canada's adult population [43] and as a consequence, to an underestimate of the number of children exposed to parental psychiatric disorders The ... analysis, as was the information about the presence of single parenthood The percent of respondents reporting symptoms of anxiety disorders, mood disorders, substance problems or dependence issues, ... 'acting-out' disorders, represented mainly by harmful substance use [51] Although initial findings suggested that children of parents with disorders from one of these groups were only at higher risk of...

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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx

Ngày tải lên : 12/08/2014, 23:22

... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... parts of this review, we draw the current portrait of the epigenetic control of HIV-1 transcription and we underline the potential of some new pharmacological agents to address the purge of the ... general) in the maintenance of a reservoir of latently-infected CD4+ T cells [163], thereby questioning the relevance of immune activation therapy in the context of a purge of latentlyinfected reservoirs...

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**Báo cáo khoa học: "THE DESIGN OF THE KERNEL ARCHITECTURE FOR THE EUROTRA* SOFTWARE" pptx**

Ngày tải lên : 08/03/2014, 18:20

... language (Georgeff 1982) The elements of the vocabulary of a control language are names of PSs, and the well-formed strings of the language define just those sequences of PS applications which are allowed ... many software engineering projects this might be an entirely adequate architecture to support the design of problem oriented systems In OUr case, however, an architecture of this kind only offers ... manipulation of the syntax of a language from computation of its meaning Since the syntactic manipulation of programming languages is by now well understood, we can take advantage of this separation...

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solvothermal reactions- an original route for the synthesis of novel materials

Ngày tải lên : 20/03/2014, 13:08

... the nature of the reagents and the nature of the solvent The chemical composition of the precursors must be appropriated to that of the target-materials In addition, the concentration of the precursors ... illustration of the use of reducing agent in addition of the reagents involves the preparation of the mixed-valent spinel CuCr2Se4, which is metallic and ferromagnet with a Curie temperature of 450 ... development of solvothermal reactions in Materials Chemistry a speciﬁc attention will be given to the synthesis of novel materials and the development of new processes Solvothermal synthesis of novel...

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Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot

Ngày tải lên : 23/03/2014, 13:20

... (2005) 2050–2059 ª 2005 FEBS Sites for the design of inhibitors of PepX activity A B C D Fig Structures of enzymes of the clan SC The N-terminal domain of each enzyme is colored red, the catalytic ... active site of: (A) the crystalline structure of PepX from L lactis; (B) the modeled structure of PepX from S gordonii (C) Structure of PepX from S gordonii (orange) computed by MODELLER software, ... the active site of the human DPP-IV; 3, docked into the active site of the crystalline structure of PepX from L lactis; and 4, docked into the active site of the modeled structure of PepX from S...

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Báo cáo khoa học: "The Design of a Computer Language for Linguistic Information" ppt

Ngày tải lên : 24/03/2014, 01:21

... By way of example, we present a trivial grammar for a fragment of English with a lexicon associating words with DAGs properties of PATR-II to give a flavor for our approach to the design of the ... such power is clearly desirable -.ince the intent of the language is to enable the modeling of m~my kinds of linguistic analyses from a range of theories As s*l,'h, PATR-II is a tool, not a result ... originally in the definition of LFG to maintain the decidability of that f{,rmalism [Kaplan and Bresnan, 83] Off-line parsability req.ires that the context-free "skeleton" of the grammar allows no...

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Báo cáo khoa học: "TENSE GENERATION IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING: SOME ISSUES IN THE DESIGN OF THE VERB EXPERT" pot

Ngày tải lên : 01/04/2014, 00:20

... fundamental step in the design of the verb generation module This problem has no agreed upon solution, and it constitutes one of the most critical parts of any theory of tense generation (Ehrich, ... follows, in order to better understand the discussion of the Domain Expert, a sketchy account of the system mode of operation is given The problem of choosing the right verb tense in order to convey ... in order to compute some of the tense features not explicitly present in the schematic description of the exercise The first task of the expert module is therefore that of deriving possible new...

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Báo cáo hóa học: "A framework for ABFT techniques in the design of fault-tolerant computing systems" pot

Ngày tải lên : 20/06/2014, 22:20

... error-detecting Their design properties guarantee for detecting the onset of errors because of failures, regardless of any error-free region following the beginning of a burst of errors Consider designing ... contain no subsequence of b zero For any convolution code of rate R that corrects all bursts of length a or less relative to a guard space of length b, b 1+R ≥ a 1−R (1) The bound of (1) is known as ... syndrome vector with (l+1) values, in this class of codes (n - k) equal The design properties of this class of codes assure any contribution of errors in one observed vector, [E]m, appearing...

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Báo cáo hóa học: " Optimizing the design of nanostructures for improved thermal conduction within confined spaces" docx

Ngày tải lên : 21/06/2014, 03:20

... optimum design based on the use of carbon nanocones and carbon nanotubes in the form of a conical and branched structure In the Description of structure section, we give the detailed description of ... interior of an electronic device to micro space, and in the Optimum design Page of section, we present optimum design for heat conduction from the interior to the exterior and nano- to microspaces of ... backgrounds of Figure 4a, b show two optimum designs of the branched single-wall carbon nanotubes with b = 0.3, m = 2, N = and different length ratio g The design in the background of Figure 4a...

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Báo cáo hóa học: "Research Article A Novel Approach to the Design of Oversampling Low-Delay Complex-Modulated Filter Bank Pairs" doc

Ngày tải lên : 21/06/2014, 19:20

... that the mean value of the group delay is restricted to integer multiples of the number of channels For the ﬁrst design step we have introduced a novel procedure for the design of low-delay AFB ... on the region of support Bs , the conjunction of all stopbands, which is a subset of the bounded interval [0, π] This makes allowances for the symmetry of the frequency response of real-valued ... values of p Design of Low-Delay FIR Filter Bank Pair In this section a method to design a prototype ﬁlter for the SFB is introduced The main objective lies in obtaining a distortion function of an...

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Báo cáo khoa học: "Doses to internal organs for various breast radiation techniques - implications on the risk of secondary cancers and cardiomyopathy" ppt

Ngày tải lên : 09/08/2014, 09:20

... target volume of 113 cc requires a hundred 103Pd seeds of 2.7 U, corresponding to a total activity of 0.2088 Ci to deliver a dose of 90 Gy on the minimal peripheral dose [14] Risk of secondary ... middle of the left breast The number of photons that were generated was calculated based on the dwell time needed to treat a target volume of cm radius (113 cc), corresponding to a volume of 113 ... [12-17] All of these techniques deliver different levels of scatter doses to internal organs and hence may induce different risks of secondary cancers or cardiomyopathy The purpose of this paper...

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Báo cáo y học: "A systematic approach for the identification of novel, serologically reactive recombinant Varicella-Zoster Virus (VZV) antigens" ppsx

Ngày tải lên : 12/08/2014, 04:20

... observation of waning immunity to VZV primary disease after varicella vaccination Hence, the identification of novel varicella immune correlates of protection and the consequently development of novel ... for the screening of novel serological markers of (in this case: VZV) infection By using this systematic approach we could identify five Figure Time course of seroconversion of an adult suffering ... analysis of the IgM-portfolio against individual viral antigens The VZV-IgG detection limit of our novel recomLine VZV has been determined as 250 mIU/ml by using two-fold serial dilutions of a WHO...

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guide for the design of durable parking structures

Ngày tải lên : 24/10/2014, 21:59

... requirements-Complete functional design of a parking facility is not within the scope of this guide, but a limited review is necessary to discuss the DESIGN OF PARKING STRUCTURES selection of a structural system ... exclusive of pore space in aggregate particles, usually expressed as a percentage of total volume of the paste, mortar, or concrete Air entrainment-The incorporation of air in the form of minute ... varieties, and in a variety of colors; it is composed of silica in the form of chalcedony, cryptocrystalline or microcrystalline quartz, or opal, or combinations of any of these Cold joint-A joint...

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THE STUDY OF NOVEL LIGHT DELIVERY SYSTEMS FOR HEAT ASSISTED MAGNETIC RECORDING

Ngày tải lên : 09/09/2015, 08:17

... demonstrate the potential of tape as a reusable medium Hermann Bucher, Chairman of the Board of Directors of AEG, signed a contract with Pfleumer to develop a recorder which became one of the greatest ... xi List of Tables xviii List of Symbols and Abbreviations xix List of Publications, Patents and Conferences xxiv Chapter Introduction 1.1 Fundamentals of Magnetism ... Characteristics of FePt 63 4.2 Effect of FePt on The Transmission Characteristic of The NFT 66 4.3 Fly Height Effect 67 4.4 Effect on Resonant Transmission of The NFT ...

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Development and implementation of efficient segmentation algorithm for the design of antennas and arrays

Ngày tải lên : 11/09/2015, 09:02

... completion of this course ii Table of Contents ACKNOWLEDGEMENTS I TABLE OF CONTENTS .III SUMMARY VI LIST OF FIGURES IX LIST OF TABLES XV LIST OF ... VARIATION OF LENGTH, S2 OF THE PENTAGON-SLOT PATCH (SIMULATED) 149 FIG.4.40: VARIATION OF LENGTH, S1 OF THE PENTAGON-SLOT PATCH (SIMULATED) 149 FIG.4.41: COMPARISON OF BROADSIDE GAIN OF THE SEMI-CIRCLE ... reduction of computer time by a factor of approximately 60 as compared to the commercial software, IE3D After developing the segmentation technique, MBF-PM-AIM is applied to the design of broadband...

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Approaches to the design of model predictive controller for constrained linear systems with bounded disturbances

Ngày tải lên : 11/09/2015, 14:29

... 125 5.A.5 Proof of Theorem 5.3.3 126 NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE TABLE OF CONTENTS 5.A.6 Proof of Theorem 5.4.1 ix 128 Design of Feedback ... 123 5.A.1 Choice of Λ 123 5.A.2 Proof of Theorem 5.3.1 123 5.A.3 Proof of Lemma 5.3.1 124 5.A.4 Proof of Theorem 5.3.2 ... 92 4.A.1 Proof of Theorem 4.4.1 92 4.A.2 Proof of Theorem 4.4.2 93 96 4.A.3 Computation of β 4.A.4 Proof of Theorem 4.5.1...

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Approaches to the design of model predictive controllers for linear, piecewise linear and nonlinear systems

Ngày tải lên : 11/09/2015, 14:29

... interior of Ω cl(Ω) closure of Ω |Ω| cardinality of Ω NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE LIST OF SYMBOLS xiii Area(Ω) size of Ω Vol(Ω) hypervolume of Ω In1 (Ω) inner polytopal approximation of ... handling of the piecewise nature of PWL systems and the effect of disturbances under such a structure One key problem in the controller design for PWLBD systems is the lack of convexity of the ... d-invariant set of system (2.31) Remark 3.1.1 It is well known that the size of the domain of attraction XN (3.14) depends on the size of X f and the length of the horizon N Increasing both of them yields...

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Development and applications of novel solvent minimized techniques in the determination of chemical warfare agents and their degradation products

Ngày tải lên : 14/09/2015, 14:08

... HF-LPME of chemical agents 91 4.3.2 Method validation for HF-LPME of chemical agents 96 4.3.3 Comparison of HF-LPME of chemical agents with SPME 97 4.3.4 Optimization of parameters for HF-LPME of ... in any proficiency test Since 1996 to 2007, a total of twenty two official OPCW proficiency tests have been conducted As of the 23rd Official OPCW Proficiency Test, there are twenty designated ... presence of nerve agents in various types of water such as tap, reverse osmosis, and deionized water [215] In a study of MIP-SPE for the determination of degradation products of nerve agents (Figure...

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Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy

Ngày tải lên : 26/11/2015, 22:41

... delivery of therapeutic agents into the brain Paclitaxel, one of the most widely used anti-cancer drugs, has limited application in treating brain tumor because of the existence of BBB Of various ... xi List of Tables Table 2.1 Summary of BBB History Table 2.2 Summary of in vivo techniques to study BBB Table 2.3 Summary of biodegradable polymers for drug delivery Table 2.4 Summary of drug ... responsible for ATP-dependent outward transport of a wide range of substances, including many therapeutic agents (Crone, 1971) The major function of the blood brain barrier is to protect the brain...

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