imaging techniques in rheumatoid arthritis

... the MRI finding of erosions in the finger joints is that Table Signs of inflammation on ultrasonography versus clinical joint assessment in finger joints Signs of inflammation US + clinical assessment ... Ultrasonography in rheumatoid arthritis: a very promising method still needing more validation Curr Opin Rheumatol 2004, 16:223-230 25 Klarlund M: Magnetic Resonance Imaging of Wrist and Finger Joints in Rheumatoid ... plain film radiography in assessing bone destruction in the examined joints, and had equal specificity B-mode ultrasonography was more sensitive than clinical examination in assessing signs of inflammation,

Ngày tải lên: 09/08/2014, 07:20

... emotional health, social functioning, and vitality The SF36 scores decreased (indicating a linear decline in HRQL), especially in the physical dimension, with increasing age in all categories of IRD ... assessing erosions and joint space narrowing of joints of hands and feet in peripheral PsA The proposed adapted scoring method for PsA is a detailed scoring method evaluating erosions, joint space ... (including biological agents) with the goal of preventing or slowing permanent structural joint damage and longterm disability in IRD is the accurate monitoring of HRQL in daily practice and in

Ngày tải lên: 18/06/2014, 19:20

... of incorporating patients' preferences for domain functioning? Health Psychol 2001, 20:136-40. 44. Feeny D, Torrance GW: Incorporating utility-based quality-of- life assessments in clinical ... defined (e.g. dead), comparison of scores between individuals might be invalid. The anchors for the VAS used in this study (as included in the EQ5D questionnaire) were labeled "best imaginable ... in the elderly: the influence of response shift and other fac- tors. Soc Sci Med 1999, 48:1549-1561. 38. Howard GS, Schmeck RR, Bray JH: Internal invalidity in studies employing self-report instruments.

Ngày tải lên: 20/06/2014, 15:20

... HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the BX 7 B motif) binds ... domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used for palmitoylation. The cytoplasmic tail includes the binding sites for ezrin radixin moesin ... phosphorylation. Insets: CD44 functions. Inset a, the basic cluster and the amino acids critical to HA binding. Inset b, binding sites for ezrin radixin moesin (ERM) and for ankyrin as well as two phosphorylation

Ngày tải lên: 09/08/2014, 01:21

... occurring in 3,000 patients exposed to this agent in RCTs, an incidence of 0.1% However, the incidence increased when examining subjects who received this agent in longer-term treatment or in combination ... leflunomide [5] in 1998 and infliximab in 1999 [6] established a firm regulatory precedent in RA, resulting in the introduction of This progress in clinical development was driven, in part, by the ... interleukin-1beta converting enzyme (ICE) inhibitor, in a 285 patient PhII trial in rheumatoid arthritis (RA) [abstract] Arthritis Rheum 2002, 44:S241 Tugwell P, Pincus T, Yocum D, Stein M, Gluck

Ngày tải lên: 09/08/2014, 01:22

... present in the rheumatoid synovium [8], suggesting that innate immunity may be involved in initiating the inflammatory process or in inhibiting regulation mechanisms that normally prevent chronic inflammation. ... signal- ing in antigen-presenting cells [39]. Finally, studies on human rheumatoid tissue indicate that TLRs play a potential role in driving inflammation and/or destructive process in RA [40]. In ... MC: Rheumatoid arthritis: direct and indirect costs. Joint Bone Spine 2004, 71:518-524. 2. Falgarone G, Jaen O, Boissier MC: Role for innate immunity in rheumatoid arthritis. Joint Bone Spine

Ngày tải lên: 09/08/2014, 01:22

... osteoporosis, rheumatoid arthritis Introduction Rheumatoid arthritis is characterized by cartilage destruction, bone erosions, periarticular osteoporosis, and generalized bone loss resulting in increased ... 2-year clinical randomized, single blind, controlled study The women had to be postmenopausal, defined as not having menstruated in the previous year and having a serum follicle-stimulating hormone ... and intra-articular and intramuscular glucocorticosteroid injections were allowed during the study period The patients were not receiving and had not used in the preceding years drugs affecting

Ngày tải lên: 09/08/2014, 01:24

... enhanced arthritis susceptibility and severity in murine pristane-induced arthritis [3,4]. Activation of the NADPH complex by vitamin E ameliorated arthritis when given before arthritis induction, indicating ... explain these discrepant findings. The presence of regional HIF-1α expression in hyper- plastic areas of the RA lining layer would be consistent with a dynamic process in which the lining cells in ... SB: Outside -in signaling in the chondrocyte Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex J Clin Invest 1997,

Ngày tải lên: 09/08/2014, 01:24

... flare within preceding months; stable treatment within preceding months; nil or minimal clinical evidence of active inflammatory disease and CRP below 15 mg/l Available online http://arthritis-research.com/content/7/1/R80 ... suggesting that inflammation was driving naïve CD4+ T-cell proliferation and differentiation, leading to dilution of TREC-containing cells We could not, however, exclude an additional intrinsic ... Available online http://arthritis-research.com/content/7/1/R80 Research article Open Access Vol No Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia

Ngày tải lên: 09/08/2014, 06:22

... survivin in the pathogenesis of arthritis. Studying the variability of survivin levels in patients with RA, we observed that in most cases survivin levels were inclined to decrease in survivin-positive ... azathi- oprine. The inhibitors of TNF-α were used in 47 patients (42 patients in combination with MTX, three patients in combination with azathioprine, one patient in combination with cyklosporine, ... defined as the loss of cortical definition at the joint, was recorded in proximal interphalangeal joints, metacar- pophalangeal joints, carpus joints, wrist joints, and metatar- sophalangeal joints.

Ngày tải lên: 09/08/2014, 06:22

... (NKT) cells in rheumatoid arthritis (RA) patients and healthy control individualsFrequency of natural killer T (NKT) cells in rheumatoid arthritis (RA) patients and healthy control individuals. ... 1.90%). These findings indicate that the reactivity of peripheral blood NKT cells to α-GalCer is impaired in some RA patients, whereas it is intact and even increased in others. Cytokine profile ... intracellular staining. Error bars indicate standard error of the mean. *P < 0.05. Available online http://arthritis-research.com/content/7/3/R493 R501 individuals mainly consisted of IFN-γ producing

Ngày tải lên: 09/08/2014, 06:22

... suppressing both cytokine and rheumatoid factor produc- tion may also be most effective in protecting against cardio- vascular disease in RA. In addition, interventions aimed at preserving renal ... atherosclerosis in rheumatoid arthritis. J Rheumatol 2005, 32:435-442. 27. Dessein PH, Joffe BI, Stanwix AE: Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis. ... and the remaining 74 were included. Patients receiving lipid-lowering and antidia- betic medications were excluded. The baseline clinical and routine laboratory characteristics of the included RA

Ngày tải lên: 09/08/2014, 06:22

... and joint erosions in early rheumatoid arthritis. Arthritis Rheum 2001, 44:1744-1753. 3. Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, Lopez-Otin ... CD147), matrix metalloproteinase-1 (RA MMP-1), tissue inhibitor of metalloproteinases-1 (RA TIMP-1) and blank contrast (RA blank) in the lining and sublining layers in RA synovium (× 400). The ... ankylosing spondylitis; BSA = bovine serum albumin; CsA = cyclosporine A; CyPA = cyclophilin A; EMMPRIN = extracellular matrix metalloproteinase inducer; ERK = extracellular signal-regulated kinase;

Ngày tải lên: 09/08/2014, 06:23

... activation in infectious diseases, they are not considered to be relevant stimuli in autoimmune settings. So far, the most powerful known pathway inducing monocyte cytokine secre- tion in vivo in non-infectious ... Wilkinson PC, Liew FY: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996, 2:175-182. 21. McInnes IB, Leung BP, Liew FY: Cell–cell interactions in ... rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release Clin Exp Immunol 1996, 106:13-19 32 Shinohara... triglyceride levels in patients with rheumatoid

Ngày tải lên: 09/08/2014, 07:20

... cytokines, including TNF-α, may affect the myocardium in RA in either an endocrine (originating in the synovium) or paracrine (produced in the local environment of the progressively failing myocardium) ... Glembotski CC, Quintana PJ, Sabbadini RA: Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes Involvement of the sphingolipid signaling cascade in cardiac cell death J Clin Invest 1996, ... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines

Ngày tải lên: 09/08/2014, 07:20

... non-reducing conditions using 8% separat- ing gel containing 0.1% gelatin. The gels were then washed twice in 2.5% (w/v) Triton X-100 for 30 minutes at room tem- perature to remove SDS and were incubated ... processes in human hepatoma cells by disrupting the regulation of nitric oxide/ cGMP-sensitive intracellular Ca 2+ mobilization [19,20]. These findings also indicate that CD147 is involved in promoting ... hematoxylin and eosin; IL = interleukin; MFI = mean fluorescence intensity; MLS = macrophage-like synoviocytes; MMP = matrix metalloproteinase; OA = osteoarthritis; PBS = phosphate-buffered saline;

Ngày tải lên: 09/08/2014, 07:20

... involved in rheumatoid arthritis. The present study investigated variations in gene expression in synovial tissues within and between patients with rheumatoid arthritis. This was done by applying ... the synovial inflammation in RA, and during these studies it has become evident that there is a large variability in cell content and in pro- tein expression, both within single joints and between ... shown. Figure 3 Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original magnification × 250. Biopsy

Ngày tải lên: 09/08/2014, 07:20

... arrows). (C–E) Staining of sPLA 2 -V in three active RA tissues. In all cases, intense staining of the granulation tissue in the sublining interstitium was evident. Staining of the granulation tissue ... v) bovine serum albumin (for blocking) containing 0.1% (w ⁄ v) saponin (for permeabilization) in NaCl ⁄ P i for 1 h, with anti-sPLA 2 and anti-COX-2 1 h in NaCl ⁄ P i con- taining 1% albumin (1 ... sublining region showed intense staining (Cd, orange arrowheads). Although cartilage chondrocytes were negative, fibroblasts in ltrating into the cartilage were intensely stained (Eb). sPLA2s in...

Ngày tải lên: 19/02/2014, 16:20

... take part in existing educational activities, including self-management programmes. NICE clinical guideline 79 – Rheumatoid arthritis 4 Introduction Rheumatoid arthritis (RA) is an inflammatory ... characteristics to inform their decisions for individual patients. NICE clinical guideline 79 Rheumatoid arthritis: The management of rheumatoid arthritis in adults Ordering information You ... guideline 79 – Rheumatoid arthritis 15 or adding an NSAID or COX-2 inhibitor (with a PPI) if pain relief is ineffective or insufficient. 1.4.4.6 If NSAIDs or COX-2 inhibitors are not providing...

Ngày tải lên: 08/03/2014, 14:20

... resonance imaging machine [16]. Imaging and Radioanalytical Techniques in Interdisciplinary Research - Fundamentals and Cutting Edge Applications 42 Imaging and Radioanalytical Techniques in Interdisciplinary ... (P-32) in rats [7]. The major development of scintigraphic imaging started with the invention of the gamma camera by Anger in 1956 [1]. In parallel, positron imaging was developed. Both imaging ... system used. In two dimensional PET imaging, only lines of response lying within a specified imaging plane are considered (Figure 8, b). The lines of response are then organized into sets of...

Ngày tải lên: 16/03/2014, 22:20