... Policy Center ofthe RAND National Defense Research Institute, a federally funded research and development center sponsored by the Office ofthe Secretary of Defense, the Joint Staff, the Unified ... may wish to address the implications of any capacity changes in its CCSS implementation plan.6. Marketinge sixth ofthe eight core tasks is to promote the principles ofthe CCSS reform to school ... administered the TerraNova third edition in the spring of 2009.Shifting the instructional focus away from the development of students’ lower-level skills and toward the development of higher-level...
... possible role of this chaperone in the stabilization ofthecore struc-ture ofthe bc1complex can be excluded on the basis of the existence ofthe 500 kDa bc1sub-complex alsoin the DBCS1 deletion ... subunitwith the bc1complex precedes the binding of ISP. Infact, the direct absence of ISP (DISP), or the block of its insertion into the bc1complex due to the deletion of the chaperone ... incorporation ofthe two core proteins. The minimal, yet stable, composition ofthe core structure ofthe yeast bc1complex includes the two cat-alytic subunits, cytochrome b and cytochrome c1, the two...
... found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured coat proteins to the gel [34,35]. The elution of some D11N ... Figure 5C shows that the spectra of the sample subjected to compression and decompression aresimilar to the non-treated sample, even in the case of the M88V mutant. The elution ofthe samples after ... promote significant binding of bis-ANS to any of the particles, with the exception of T45S, which bound asmall amount of bis-ANS, increasing, by twofold, the emission ofthe probe (Fig. 7B). M88V...
... Elucidation ofthe structure of the lipopolysaccharide core and the linkage between thecore and the O-antigen in Pseudomonas aeruginosa immunotype 5 using strongalkaline degradation ofthe lipopolysaccharide. ... werealso found. The 1H-NMR spectrum revealed the absence of anomericsignals from GlcN I and GlcN II of Lipid A, the lack of pyruvate methyl groups, as a consequence ofthe cleavage of the ketal group ... found either inwild-type strains and in mutant strains harboring mutationsin the genes encoding enzymes ofthe biosynthesis and/or the transfer ofthe O-specific polysaccharide [12,13]. The core...
... found that the metal-binding site of deoxyribo-zyme 10–23 involves both nonbridging oxygens of the P5 phosphate of adenosine at position 5, and the oxy-gen atom ofthe 6-carbonyl group ofthe subsequentnucleoside ... ofthe metal-binding sitein the catalytic coreof deoxyribozyme 10–23 includes the interactions of divalent cations with both the pro-RPand proSPoxygens of P5, and an interaction with the ... depending on the metal ion present.There was no increase ofthe enzyme efficiency in the presence of Mg2+, compared to P1 substitution itself,but in the presence of Mn2+ the krelfor the P1 ⁄...
... core subunit of Pph3p required for the binding of Psy2p, we examined the sensitivity ofthe YBL046w ⁄ Psy4p deletion strainto cisplatin. The comparable increased sensitivities tocisplatin of ... was the same as that ofthe controlstrain transformed with the vector YCplac111 (datanot shown). The YBL046w gene was therefore termedPSY4 (for platinum sensitivity 4). The primary target of ... removed. The glass beads were washed with one pelletvolume of lysis buffer and the supernatants were pooled.ABFig. 5. (A) Investigation ofthe effects of the cisplatin sensitivity of Saccharomyces...
... 1209.Structure ofthecore region ofthe Hep4-glycoforms. In the 1H NMR spectrum of OS-1¢-B (Fig. 5C), anomericresonances ofthe three heptose residues (HepI–HepIII) in the inner -core region were ... to the partial occurrence of PEtn attached to the phosphate groupat O-4 of Kdo [11,12,15].Structure ofthecore region ofthe Hep3-glycoforms. In the 1H NMR spectra of OS-1¢-A (Fig. 5A) and ... component ofthe inner- core region of bacterial LPS, but has also in a few rareoccasions been found in the outer -core region [30,31]. The L,D–Hep residue was found to be located at O-6 of the...
... between the alignedpolypeptide chains of only 0.26 A˚over all backbone atoms.Even in the region ofthe mutation, the basic fold ofthe WTprotein is preserved, but the deletion ofthe hydroxyl ... in Fig. 3. The model of Y42F LPC has 91.8% ofthe residues in the most favored regions ofthe Ramachandran plot and 8.2%in the additionally allowed regions. Some characteristics of the refined ... in the extracts of cells not expressing Y42F LPC. The pHsensitivity ofthe catalase activity of Y42F LPC contrastswith the behavior ofthe WT enzyme whose activity variesonly slightly over the...
... rely on the SecB pathway,because of overloading ofthe SRP pathway. The re-routing of (G-10L)prePhoE to the Sec translocon via the SRPinstead ofthe SecB pathway could be explained by the increased ... thatsubstitution of Gly)10by a-helix-promoting residues (Ala,Cys or Leu) reduced the proton-motive force dependency of the translocation ofthe precursor, but the actual role of the helix breaker ... considered the possibility that extension ofthe a-helical structure in the signal sequence resulting from the Gly)10substitutionsaffects the targeting pathway ofthe precursor. Indeed, the mutations...
... gaps of Ge- core/ Si-shell and Si -core/ Ge-shell nanowires at the level of density functional theory, where the composition is definedas the ratio ofthe number of atoms ofthecore to the number of ... the existence ofthe region around the interface between the core and the shell of a core shell nanowire.Basically, it is unreasonable for thecore or the shell toinclude the volume ofthe whole ... affect the values of Young’s modulus ofthecore shell nanowire; (2) although the trends ofthe fractionalvolumes varying with the composi tion are quite similar tothose ofthe ðV core =VÞY core and...
... and “ there’s a” in “ When there’s a will, there’s a way”). Those two kinds of recurrence are characteristic of nursery rhymes ofthe alliterative and rhyming babble of infants and ofthe repetitive ... warning, and rules and wisdoms the elders want to express on the minds of their young. The punch line character of proverbs - the shorter the better- make it easy to commit them to memory for ready ... Table Of Contents Table of contents 1 Acknowledgement 3 Part I: introduction 4 1. Rationale 4 2. Purpose of study 4 3. Scope ofthe study 5 4. Method ofthe study 5 5. Design ofthe study...
... personification ofthe History of Art, the ‘‘holy assembly’’ of pious men as the ‘‘scientific community’’ of iconologists . . . and Erwin Panofsky in the role of Azriel, the miraculous rabbi, the sage, the ... connections, of memories, of prophecies touching upon everything, from the creation of Adamto the end of time, from the simple form ofthe letter M (the initial of Mary) to the prodigious construction of ... together the modesty of the humanist scholar and the conquest of knowledge, Warburg made the effacement ofthe philologist rhyme with a true tragedy of knowl-edge: a Kantian victory ofthe (axiomatic)...
... Our resultsprovide the basis for a further investigation of the regulation ofthe cdc2 promoter by LINC in differentphases ofthe cell cycle.Discussion The primary goal of this study was to ... pro-moters in the S phase and mediates their activation [4,5]. The composition ofthe S-phase complex differs fromthat ofthe G0 complex. Specifically, in the S phase, the interaction of LINC with ... fragment of the cdc2 promoter. Competition was performed with 100 ng ofthe unlabeled wild-type cdc2 promoter or the indicated promotermutants.LIN54 is an essential core subunit ofthe DREAM...
... encoding the residues L and Nat the N-terminal end ofthe truncated bB2, and the residuesQ and W at the C-terminal end of truncated bB2, becausethese four residues are present in the structure of ... residues occur upon the surfaces of bB2 and cB. Furthermore, the bottom part of Fig. 1shows a schematic representation ofthe transplanta-tion. This part ofthe figure emphasizes the conceptualpoint ... MALDI-TOF mass spectrometry in the linear mode. The identity ofthe protein was furtherconfirmed by MALDI-TOF-based peptide mass finger-printing, with 1–2 Da accuracy, involving detection of the...