... participate in the metabolism of nucleotides. In this context, the assertion that pyridoxine may be the precursor of the pyrimidine moiety of thiamin in yeast is intriguing [27]. In fungi, pyroA and ... Glutamine was effective in protecting the enzyme from inactivation and its effect was again dose-dependent, suggesting that inhibition by DON occurs at the active site or the glutamine-binding ... of the genes. In SNO1, the 199th G from the 5Â terminus of the open reading frame was deleted to result in a frame-shift and appearance of stop codons in the downstream. As a result, a protein...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... concerning the kinetics and properties of the enzyme. More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A. suum larvae in vitro. Materials and methods Parasites Adult ... determined by incubating the diluted recombin- ant proteins in the standard reaction mixture in the presence of increasing concentrations of PP i (0.05–0.5 m M )at55°C. Data were fit to the appropriate ... and minced with a surgical knife. The minced tissue was wrapped in cotton gauze and suspended in NaCl/P i containing 100 lgặmL )1 penicillin/ streptomycin at 37 °C for 3 h. After incubation the...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... protein containing a single ankyrin repeat that interacts with HIV-1 viral protein R (Vpr) and we designated this protein as Vpr-binding ankyrin repeat protein (VBARP). This interaction was further ... ankyrin repeats from over 4000 proteins, indicated that the ankyrin repeat domains in VBARP exhibit a high homology to those present in the consensus within the conserved, semiconserved and the ... that the interaction between VBARP and Vpr is specific. The input panel represents the amount of protein used in this assay indicating that an equal amount of protein was used in all our samples and...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: "Towards Finding and Fixing Fragments: Using ML to Identify Non-Sentential Utterances and their Antecedents in Multi-Party Dialogue" ppt
... described in (Kohavi and John, 1997; Strube and Măuller, 2003): we start with training a model using a base- line set of features, and then add each remaining feature individually, recording the gain ... (as in (1-b) and (1-c) above). Structural information (iqu) further im- proves the model; however, the remaining features only seem to add interfering information, for perfor- mance using the ... success in identifying fragments, but adding the remaining features still boosts the performance. Having available the string (condition s.s; slipper with set valued features) interestingly does...
Ngày tải lên: 08/03/2014, 04:22
Off the Rim Basketball and Other Religions in a Carolina Childhood docx
... respiration—were placed in the dreaded iron lung. Others had legs and other limbs paralyzed. And others, including me, endured the hot packs and the massages for a few weeks and then walked out of the hos- pital. When ... predecessor Trinity College. In the 1890s my Grandfather Tuttle had played three years for Trinity, and then in graduate school—another three years for Vanderbilt, there being no NCAA in those days to ... the man-child out of the Carolina hills, overachieved in October walk-on tryouts and thereby won the right to guard Billy Cunningham in practice and, in games, grace the bench of the Tar...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e. inhibiting ... region [15]. These are: the nucleotide binding domain, which binds ATP; the phosphorylation domain, which can be phos- phorylated on Asp351; and the actuator, which may be involved in anchoring the other ... curcumin inhibition. This scheme shows the potential effects of curcumin (I) on the interactions between the nucleotide binding domain (N) and the phosphorylation domain (P), to give competitive inhibition...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo khoa học: Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells ppt
... fresh media. The cells were incubated without or with curcumin for 4 and 8 h, and then stained with PI. The effect of curc- umin on the kinetics of the release of the mitotic block was examined in a ... protein Eg5 and induced monopolar spindle formation. Further, curcumin increased the accumulation of Mad2 and BubR1 at the kinetochores, indi- cating that it activated the mitotic checkpoint. In addition, ... calcu- lated using the Student’s t-test. CI determination MCF-7 cells were incubated either separately with curcu- min, paclitaxel and vinblastine or in combination with curc- umin and vinblastine or...
Ngày tải lên: 23/03/2014, 03:20
Báo cáo khoa học: "A Logical Basis for the D Combinator and Normal Form in CCG" pptx
... associativity and permutation of symbols within a sequent, in combination with the slash introduction and elimination rules of the base logic. To control application of these rules, Baldridge keys them ... ar- gument, and so is effectively an inert functor. In Baldridge’s (2002) system, only proofs involv- ing the ARP and ALP rules produce inert categories. In Eisner NF, all instances of B-rules result in ... the subject or agent of the subordinate verb (the causee). However, it has been argued that Spanish causative verbs do not in fact take objects (Ackerman and Moore, 1999, and refs therein). There...
Ngày tải lên: 31/03/2014, 00:20
solutions to the class 1 and 2 problems in transport phenomena (wiley_ 1960)(175s)
Ngày tải lên: 02/04/2014, 16:45
báo cáo hóa học: " Factor structure of the Hospital Anxiety and Depression Scale in Japanese psychiatric outpatient and student populations" pdf
... longitudinal research study would allow the temporal stability of the HADS to be examined. Finally, the construct overlap between the HADS and the other assessment instruments was not examined. The HADS ... shortages, the scoring system of the HADS should adhere to the original instructions by Zig- mond and Snaith [1]; the HADS-A and HADS-D subscales should each be comprised of the original seven items. The confirmatory ... factor. Using the data of Group 2, a confirmatory factor analysis examined the models refined in this study as well as in the previous studies. The current model defined in this study is derived from the...
Ngày tải lên: 18/06/2014, 18:20
báo cáo hóa học: " The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease" pot
... emotional function domain and HADS scores and lowest between the CRQ dyspnea and Feeling Thermometer and the HADS scores. We found strong correlations (≥ 0.5) between the HADS anxiety domain and the CRQ emo- tional ... the instru- ment of interest. In our analysis, we first assessed the correlation between the anchors (CRQ and Feeling Thermometer) and the HADS domain and total score. We decided to use linear ... linear regression analysis where the instrument of interest is the dependent and the anchors the independent variable. Using the equation one can estimate the minimal important difference of the...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Methods to recognize work-related cancer in workplaces, the general population, and by experts in the clinic, a Norwegian experience" pptx
... filling the form and filing the report. Informed consent should be obtained prior to filing report. Once the report form is filed, it must be up to the labor inspectorate, the insurance scheme and/ or ... welders in the neighborhood, if there was ongoing concomitant insulation (asbestos), the extent to which he use certain kinds of respirators, and finally - the extent to which there were other possible ... lung cancer in Finland - wheretheincidenceinwomeninthe1950wasabout2 cases per 100,000 per year [6]. The use of these two alternative entities as reference may result in differences in the attribution...
Ngày tải lên: 20/06/2014, 00:20
báo cáo hóa học:" Assessment of the structure of the Hospital Anxiety and Depression Scale in musculoskeletal patients" pdf
... populations. The HADS consists of an anxiety and depression subscale, each containing seven items, making it quick and easy to use in clinical settings. Since its publication in the early 1980's the ... = .005], the other fit indices indicated good fit. The GFI sta- tistic (.916) was reasonable, and the TLI (.953), CFI (.961), and RMSEA (.058) indicated good fit. Inspection of the residuals and modification ... original authors, and in the format used by the majority of previous researchers and clinicians. The 13-item two-factor CFA (excluding item 7) indicated that the revised model was a good fit to the...
Ngày tải lên: 20/06/2014, 15:20
báo cáo hóa học:" Structural ambiguity of the Chinese version of the hospital anxiety and depression scale in patients with coronary heart disease" doc
... participated in the design of the study and assisted in the drafting of the manuscript. VL participated in the design of the study and assisted in the drafting of the man- uscript. CM participated in the ... artifactual of the original translation process, which may also explain inconsistencies between the underlying factor structure of the instrument between Mandarin-speaking Chinese CHD patients in the current ... defining the underlying factor structure of the HADS. The HADS clearly cannot be both bi-dimensional and tri-dimensional within the same data set and further clarification of the structure of the...
Ngày tải lên: 20/06/2014, 15:20
Báo cáo hóa học: " Editorial Cross-Layer Design for the Physical, MAC, and Link Layer in Wireless Systems" doc
Ngày tải lên: 21/06/2014, 22:20
Báo cáo y học: "Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis" doc
Ngày tải lên: 09/08/2014, 08:23
Báo cáo khoa hoc:" Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis" pot
Ngày tải lên: 11/08/2014, 08:20