identification of heat shock factor regulated genes and pathways
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... R Abane and V Mezger 113 Trinklein ND, Chen WC, Kingston RE & Myers RM (2004) Transcriptional regulation and binding of heat shock factor and heat shock factor to 32 human heat shock genes during ... Role of Heat Shock Factor in cerebral cortex formation and as a regulator of p35 expression Genes Dev 20, 836–847 124 Morrison AJ, Rush SJ & Brown IR (2000) Heat shock transcription factors and ... of modifier genes that would enhance or diminish the impact of HSF2 deficiency Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryos The role of HSF2 in oogenesis and...
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Báo cáo y học: " Early Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophage" ppt
... in vaccinia virus infected human and heat shock RT-PCR1analysis of the heat shock factor blood macrophages RT-PCR analysis of the heat shock factor and heat shock proteins in vaccinia virus infected ... after h of virus adsorption and fresh medium added Induction of the heat shock protein synthesis requires earlier activation of heat shock factors HSF1 is assumed to be the main mediator of the ... Differential expression and regulation of hsp70 and hsp90 by phorbol esters and heat shock J Biol Chem 1995, 270:14094-14099 Victor M, Benecke BJ: Expression levels of heat shock factors are not functionally...
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Báo cáo y học: "Genomic analysis of heat-shock factor targets in Drosophila" doc
... -test and statistical inferences of gene changes Bioinformatics 2001, 17:509-519 Fernandes M, Xiao H, Lis JT: Binding of heat shock factor to and transcriptional activation of heat shock genes ... 40 cycles of 94°C, 60 sec; 60°C, 30 sec and 72°C, 60 sec The primer pairs to amplify heat- shock element and 3' ends of the genes for heat- shock proteins 26 (3' UTR) and 70 (5' HSE and 3' UTR) ... derived from heat- shocked and non -heat- shocked embryos [37] Of the genes represented on the custom array, 21 are found in our top 188 Hsf-binding genes; of these, seven genes (Hsp26, 27 and 23, DnaJ-1,...
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Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
... expression of more than 50 genes, out of 7,075 genes that were examined [11] Exposure of the human T-cell line CCRF-CEM to cadmium altered the mRNA levels of more than 100 genes in a dose- and time-dependent ... understanding of the global transcription profile, current C elegans GO data are not sufficient to predict the functions of all of the cadmium-responsive genes Several C elegans cadmium -regulated genes ... of other interactions Late response Down -regulated Figure Heat map of cadmium-responsive genes Heat map of cadmium-responsive genes Cadmium responsive genes (≥2fold) based on decreased expression...
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Tài liệu Báo cáo khóa học: Cloning and characterization of two distinct isoforms of rainbow trout heat shock factor 1 ppt
... cycle of 15 at 95 °C, amplification cycles of 0.5 at 94 °C, 0.5 at 50 °C and 0.5 at 72 °C, and one termination cycle of at 72 °C, with 35 cycles in total for HSF1a and HSF1b and 30 for heat shock ... Morimoto, R.I (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators Genes Dev 12, 3788–3796 Pirkkala, ... Regulation of heat shock factor trimer formation: role of a conserved leucine zipper Science 259, 230–234 19 Zuo, J., Rungger, D & Voellmy, R (1995) Multiple layers of regulation of human heat shock...
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Báo cáo khoa học: Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster pdf
... Differences between heat and cold responses could arise from differential activation of the various Drosophila heat shock factor (HSF) isoforms [54] or from incomplete activation of HSFs under cold ... expression of Hsp67 is upregulated by heat stress [32,33] Therefore, it seems that, unlike the other Hsp genes tested here, Hsp67 does not respond similarly to heat and cold stress The absence of transcriptional ... expression changes in the same set of heat shock genes However, differences exist between the two responses: the level of expression is much higher for heat stress, and the response is also direct,...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
... regulating the expression of heatinducible genes other than classical heat shock genes Expression of nonclassical heat shock genes induced by HSFs Although the heat shock response was originally ... half of the target genes are expressed during heat shock [59] We now refer to these heat- inducible genes that are different from the classical heat shock genes as ‘nonclassical heat shock genes ... expression of nonclassical heat shock genes was induced by mouse HSF3 or chicken HSF1, nonclassical heat shock genes were identified in MEF cells [31] Induction of one of the nonclassical heat shock genes, ...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... regulation and binding of heat shock factor and heat shock factor to 32 human heat shock genes during thermal stress and differentiation Cell Stress Chaperones 9, 21–28 Alastalo TP, Hellesuo M, Sandqvist ... (1998) Direct sensing of heat and oxidation by Drosophila heat shock transcription factor Mol Cell 2, 101–108 Ahn SG & Thiele DJ (2003) Redox regulation of mammalian heat shock factor is essential ... an activator and a repressor of heat shock genes by alternative splicing J Biol Chem 274, 27845–27856 Hu Y & Mivechi NF (2006) Association and regulation of heat shock transcription factor 4b with...
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Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt
... Roles of heat shock factors in gametogenesis and development FEBS J 277, 4150–4172 Pirkkala L, Nykanen P & Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the ... (1998) Direct sensing of heat and oxidation by Drosophila heat shock transcription factor Mol Cell 2, 101–108 Ahn SG & Thiele DJ (2003) Redox regulation of mammalian heat shock factor is essential ... SWI ⁄ SNF complex for robust nucleosome displacement at promoters of heat shock factor and Msn2- and Msn4 -regulated heat shock genes Mol Cell Biol 28, 1207–1217 57 Erkina TY, Zou Y, Freeling S,...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
... protein) of YYY49 and YYT42 contained approximately and ng of hHSF2, and those of YYT50 and YYT17 contained approximately 0.01 and 0.1 ng of hHSF4, as judged by the intensity of each band (C) ... of heat shock transcription factor dictates DNA-binding specificity and responses to heat stress Genes Dev 15, 2134–2145 42 Ahn SG & Thiele DJ (2003) Redox regulation of mammalian heat shock factor ... activation and protection from stress Genes Dev 17, 516–528 43 Trinklein ND, Chen WC, Kingston RE & Myers RM (2004) Transcriptional regulation and binding of heat shock factor and heat shock factor...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... role of HSP70 in the inhibition of the release of Smac and apoptosis GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role of the ATP-binding domain of HSP70 in the prevention of the release of ... that of the endogenous proteins induced by heat shock This system mimics the antiapoptotic effects of heat shock and is very instrumen2618 tal with respect to our investigation of the role of HSP70 ... stress-inducible heat shock protein, heat shock protein (HSP) 70 has been shown to protect cells from a number of apoptotic stimuli, including heat shock, tumor necrosis factor, growth factor withdrawal,...
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Báo cáo Y học: Determination of the consensus binding sequence for the purified embryonic heat shock factor 2 potx
... heat shock factor genes in humans Proc Natl Acad Sci USA 88, 6911–6915 Sarge, K.D., Zimarino, V., Holm, K., Wu, C & Morimoto, R.I (1991) Cloning and characterization of two mouse heat shock factors ... inducible and constitutive DNA-binding ability Genes Dev 5, 1902–1911 Nakai, A & Morimoto, R.I (1993) Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, ... new member of the human heat shock factor family which lacks properties of a transcriptional activator Mol Cell Biol 17, 469–481 Wu, C (1995) Heat shock transcription factors: structure and regulation...
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Báo cáo khoa học: "Effect of neoadjuvant chemoradiation and postoperative radiotherapy on expression of heat shock protein 70 (HSP70) in head and neck vessels" potx
... might be some coherence between high levels of HSP70 expression and the prevention of thickening of the intima layer of arteries and the media layer of vein from Funding The article processing ... activation of heat shock genes Science 1993, 259:1409-10 Tavassol F, Starke OF, Kokemüller H, Wegener G, Müller-Tavassol CC, Gellrich NC, Eckardt A: Prognostic significance of heat shock protein ... carboplatin and paclitaxel, group3) Intima of the veins (A, * p < 0.05 vs group1 and group 2), media of the veins (B, * p < 0.05 vs group 2, + p < 0.05 vs group and #p < 0.05 vs group1 and group2.),...
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báo cáo khoa học: " Antitumor activity of mixed heat shock protein/ peptide vaccine and cyclophosphamide plus interleukin-12 in mice sarcoma" pot
... percentage of mHSP/P+Cy +IL12 vaccine was significantly higher than that of mHSP/ Ps vaccine and naïve mice, P < 0.05, and that of tumor bearing mice, P < 0.01 In addition, the proportion of lysis of ... combination of IL-12 and Cy eradicated tumors in 30% of mice, and in IL-12-treated mice, all tumor mass necrosis and an ulcer formed before tumor eradication, suggesting the anti-angiogenesis activity of ... mixture of HSP/Ps which, in addition to HSP70 or Gp96, also included HSp60 and HSP110 The antitumor effects of this mHSP/Ps vaccine were more potent than those of HSP70 or HSP60 alone and of tumor...
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Báo cáo y học: "A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens" pptx
... presentation and T cell stimulation by dendritic cells Annu Rev Immunol 2002, 20:621-667 Anderson KM, Srivastava PK: Heat, heat shock, heat shock proteins and death: a central link in innate and adaptive ... Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses Annu Rev Immunol 2002, 20:395-425 Srivastava PK, Amato RJ: Heat shock ... to the design and supervision of the immuno-stimulatory assays TCJ and UB conceived and designed the methods for the isolation of the peptide mimics of Hsp-PCs and identified all of the peptides...
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Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx
... assembly and nucleocytoplasmic transport of newly synthesized pre-rRNAs [11] Because of its widespread distribution and broad range of involvement, as well as the cross-talking among molecules of different ... effect of Hsp70 B Jiang et al After 24 h of H2O2 exposure, 44% of untransfected control cells and 45% of cells transfected with the empty vector (pcDNA3.1) exhibited similar features of apoptotic ... activator of caspases), activation of caspase-3 and caspase-9, and apoptosis in C2C12 myogenic cells [24] Stankiewicz et al [25] found that Hsp70 overexpression stabilizes Mcl-1 protein in heat- shocked...
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Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt
... Firdaus et al downstream of the initiator ATG in exon (Ex1) of the 67 exon-containing htt gene [5] Pathogenesis in HD correlates with the cleavage of mutated htt and the release of an N-terminal fragment ... [39] and are associated with aggregates in the brains of HD transgenic mice [40] Hsp70 and Hdj-1 can inhibit polyQ aggregation and reduce the size of htt-polyQ inclusion bodies [15,36,37] and ... Quantitative analysis of the protective effect of heat shock proteins (Hsps) and NAC against httEx1-polyQ-mediated DYm disruption Transfections were performed with a combination of either httEx1-72Q-EGFP...
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Báo cáo khoa học: The influence of cold shock proteins on transcription and translation studied in cell-free model systems pdf
... efciency of various genes under the control of a strong promotor is inuenced by many 4695 Inuence of CSPs on transcription and translation different factors One of the most crucial factors next ... with the results of [3] They found an increase in the translation of cold shock mRNAs and of cold tolerant mRNAs with the addition of CspA to a translation assay Thus translation of non-CSPs would ... translation of cold shock mRNAs resulting out of an increase of the three translation initiation factors [3,11] Furthermore it is known for E coli, that the 159 nucleotides of the 5Â-UTR of the cspA...
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Báo cáo khoa học: "Automatic Identification of Word Translations from Unrelated English and German Corpora" pot
... terms of corpus frequencies: kl~ = frequency of common occurrence of word A and word B kl2 = corpus frequency of word A - kll k21 = corpus frequency of word B - kll k22 = size of corpus (no of tokens) ... teacher and school cooccur more often than expected by chance in a corpus of English, then the German translations of teacher and school, Lehrer and Schule, should also co-occur more often than ... cooccurrences of words that are translations of each other If - for example - in a text of one language two words A and B co-occur more often than expected by chance, then in a text of another language...
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Support to the identification of potential risks for the environment and human health arising from hydrocarbons operations involving hydraulic fracturing in Europe doc
... operational and post-abandonment lifetime of the plant (well pad) so as to avoid the risk of surface and/ or groundwater contamination The challenge of ensuring that spillages of chemicals and waste ... impacts of HVHF processes can be greater than the impacts of conventional gas exploration and production processes per unit of gas extracted The challenge of ensuring the integrity of wells and other ... the development and operational lifetime of the plant (well pad) The challenge of ensuring a correct identification and selection of geological sites, based on a risk assessment of specific geological...
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