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THE SHOES OF FORTUNE (I)
... twisting and writhing themselves in the dust of commonplace, which also expect to find a reading public.’ ‘Oh,’ exclaimed the clerical gentleman smiling, ‘there is much wit in them; besides ... roof. forced, in spite of his opposition, to drink with the rest. They took hold of the worthy man; who, hearing on every side that he was intoxicated, did not in the least doubt the truth of ... taken their ships while in the roadstead; and 34 of 260 the Councillor, before whose eyes the Herostratic* event of 1801 still floated vividly, agreed entirely with the others in abusing the...
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Tài liệu Đề tài " On the complexity of algebraic numbers I. Expansions in integer bases " ppt
... approachfor the notion of complexity of real numbers, by emphasizing the quantitativeaspect of the notion of calculability introduced by Turing [42]. According tothem, a real number is said to be ... set of states, Σkis the input alphabet, δ : Q × Σk→ Qis the transition function, q0is the initial state, ∆ is the output alphabet andτ : Q → ∆ is the output function.Annals of Mathematics ... quantita-tive version is established (in the sense that one bounds explicitly the number of exceptional subspaces).We now turn to the proof of Theorem 5. Keep the notation and the assumptions of...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... KLF4 is required for the expression of VSMC differentiation marker genesinduced by all-trans retinoic acid [4]; KLF4 couldinduce inhibition of proliferation of VSMC, which ismechanistically linked ... shown in Fig. 3C. Further-more, this transactivation was almost abolished uponfurther point mutations of the corresponding KLF4binding site. The specificity of transcriptional activity of KLF4 ... the proliferation, migration, differentiation and activation of cells are always highlights for researchers.Kru¨ppel-like factor 4 (KLF4) was first identified in the epithelial lining of the gut and skin,...
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Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... to the plasma membrane. The E3-ubiquitin ligase c-Cbl is directly involved in the ubiquitylation of several RTKs [24–26,32] and mayparticipate in the downregulation of FGFR1 via anindirect interaction ... ⁄ PmlI sites or PmlI ⁄ MluIsites. Wild-type and mutant FGFR3 cDNAs were thentransferred from pBSII to pcDNA3.1 at the HindIII ⁄ EcoRIrestriction sites.Single-point mutations in the intracellular ... mutations causing TDI induce variable constitutive phosphorylation of the receptor, which partially colocalizes with the ERmarker PDI. (A) Constitutive phosphorylation in the absence of ligand of...
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Tài liệu The History Of England, Volume I, Part Viby From Charles Ii To James Ii (illustrated Edition) (dodo Press) By David Hume ppt
... make him relinquish. All the defence which Vane could make was fruitless. The court, considering more the general opinion of his active guilt in the beginning and prosecution of the civil wars, ... obliged, by the late law, either to relinquish their livings, or to sign the articles required of them. A combination had been entered into by the more zealous of the Presbyterian ecclesiastics ... prevailed so far with the convention parliament as to make them restore the king with strict limitations, there is no question but the establishment of Presbyterian discipline had been one of the...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... role in promoter activity in the 5¢-upstreamregion of DNASE1 exon 1a.ResultsMapping of transcription initiation sites in the human DNASE1 geneTo identify the transcription initiation sites of DNASE1 ... Division of Legal Medicine, University of Fukui, Japan4 Third Division of Internal Medicine, University of Fukui, JapanDeoxyribonuclease I (DNase I, EC 3.1.21.1) is anenzyme that preferentially ... delineation of the transcriptionalregulation of human DNASE1 may provide clues to the mechanisms underlying ischemia-induced elevation of DNase I activity in vivo.Here, we describe the identification...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... that the N-terminal domain is involved inprotein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... from the dissociation of the intactcomplex I with mutated s ubunits during the solubilizationfor blue native gel electrophoresis. It remains to be seenwhether the 20 subunits of the integral ... Molecular Biology Section, University of California, San Diego, California, USA The ESSS protein is a recently identified subunit of mam-malian mitochondrial complex I. It is a relatively smallintegral...
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Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx
... phase of evolution, in which the indi-vidual specificities of the peroxidase families distinguishedwere already formed. Evidence is presented that class I of the heme peroxidase superfamily is ... oxidative activation of isoniazid (isonicotinicacid hydrazide) [3], still the most widely used antitubercu-losis drug. All heme peroxidases have important features of their catalytic mechanism ... feature in this region. The iron of the prosthetic heme group is invariantlyco-ordinated by the a bove essential proximal h istidine(Fig. 4A,C,D). However, in all C-domains of catalase–peroxidases,...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... of the South-ern hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns areshown as in Fig. 2A. Positions of the ... activity of region IV did not correlatewith the activity observed in transient transfectionassays. These observations demonstrate that regions II,III, and IV are involved in the transcription of the Ig-b ... without Bsr gene. Position of the probe(0.9 kb; )10.1 kb HindIII to )9.2 kb AccI fragment) for hybridizationis indicated by a black rectangle. Size and position of the HindIIIfragment hybridizable...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... amino acid substitution, Leu130Ile,might be involved in an evolutionally critical change in the thermal stabilities of vertebrate DNases I. AmphibianDNasesIhaveaSer205insertioninaCa2+-binding ... [13]. Thesefindings indicate that the thermal stabilities of DNase I in vitro might reflect the enzyme activities in vivo.Wefound that amphibian DNases I are characterized by a C-terminal end with ... considerably from those of other vertebrate DNases I, comprehensive characterization,including determination of thermal stabilities, of reptilianDNases I is required, not only to elucidate the...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... pragmatic interpretation. Each piece of information is a thresholding device with memory. It has an activity value, initially at a resting state, that is modified over time depending on the input, ... strictly linguistic analysis. The remainder of the paper focuses on our initial work in the adaptation (Gigley, 1984). As the research is currently underway, the discussion will raise several ... activation of all meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon 9 meanings...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... perfectlymatch the in vivo conditions. Because GBSSI is known to be the major determinant of amylose synthesis we are confidentthat the semi in vitro system is a good reflection of the in vivosituation.Fig. ... smithii.Both C. smithii and C. reinhardtii are interfertile ecotypesthat give rise to a fertile progeny. The GBSSI-defective strainBAFR1 (mt+ nit1 nit2 sta2–29::ARG7) contains a disrup-tion ... detailedcharacterization of amylose synthesis both in vivo andin vitro. We show that GBSSI is capable of synthesizing asignificant number of crystalline structures within starch.Quantifications of amount and type of...
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Báo cáo khoa học: Coordination of three and four Cu(I) to the a- and b-domain of vertebrate Zn-metallothionein-1, respectively, induces significant structural changes doc
... also linear increase of intensity. As luminescence intensity is a measure of how the Cu-thiolate luminophore is shielded fromsolvent quenching, the titrations indicate that the shielding of the ... sequence-specific assignments, the identification of the spin systems and the assignment of 398 and 252 of the NOESY cross-peaks of the a- and b-domain,respectively. The comparison of the chemical shiftswith ... spectraacquired from the synthetic a-domain of murineMT-1.Fig. S2. Averaged positive-ion mode ESI mass spectraacquired from the synthetic b-domain of murineMT-1.This material is available as part of...
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Báo cáo khoa học: Characterization of the NADH:ubiquinone oxidoreductase (complex I) in the trypanosomatid Phytomonas serpens (Kinetoplastida) ppt
... dehydrogenase activities revealed their different sensi-tivities to rotenone, piericidin, and diphenyl iodonium.AbbreviationsBN, blue native; CBB, Coomassie Brilliant Blue; DPI, diphenyl iodonium.3150 ... gel of the 39 kDasubunit of eukaryotic complex I in the mitochondrial lysate of P. serpens (A). The position of molecular mass markers is indicatedon the left. The immunopositive signal in a ... for which the presence of the LYR tripeptide in the N-terminal part is character-istic. Interestingly, the size of the B14 subunit in mosteukaryotes is 15 kDa, whereas its predicted size intrypanosomatids...
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The Government of England (Vol. I) doc
... XXXVPOLITICAL OSCILLATIONS 101CHAPTER XXXV 39CHAPTER I THE CROWN 16CHAPTER I 4CHAPTER XLIII THE LONDON COUNTY COUNCIL 215CHAPTER XLIII 46CHAPTER III THE CABINET AND THE MINISTERS 53CHAPTER III ... 535VOLUME IICHAPTER XXX 33CHAPTER XLBOROUGHS THE PERMANENT OFFICIALS 171CHAPTER XL 43CHAPTER VIMISCELLANEOUS OFFICES 131CHAPTER VI 9CHAPTER VIII THE MINISTERS AND THE CIVIL SERVICE 173CHAPTER ... http://www.pgdp.netTranscriber's Notes: Words in italics in the original are surrounded by underscores. Words in bold aresurrounded by =equal signs=. Variations in spelling and hyphenation remain as in the original....
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- the adventure of physics
- the nature of language
- are stimulated by extracellular matrix proteins such as type i collagen previous studies have demonstrated the involvement of a dggryy sequence located within the a1 chain cterminal telopeptide in type i collageninduced pmn activation
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- i want to know the history of english language
- the government of england under henry i
- walk in the light beautiful light jesus the light of the world
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