huperzine a as a pretreatment drug

... urine analysis and urine cytology were negative and a urine culture was sterile An ultrasound examination revealed a thickened bladder wall and a small bladder capacity but normal kidneys Cystoscopy ... ketamine is being used increasingly as a recreational drug we expect ketamine-associated cystitis to become more prevalent in young adults Health care workers should be aware of the problem and ... hydroxynorketamine can be measured in high quantities in the urine of patients using ketamine [6] It is possible that ketamine and its active metabolites cause significant bladder irritation Conclusion As...

Ngày tải lên: 11/08/2014, 21:22

... joints as well as inflammation, pannus formation, and bone damage, as indicated by histologic analysis [see Figure S2 in Additional data file 1] In vivo safety assays The observed amplification ... kinase via increased expression and decreased degradation of MKP-1 EMBO J 2001, 20:7108-7116 Abraham SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, Saklatvala J, Clark AR: Antiinflammatory ... Vehicle and test agents were administered via oral gavage Dosing volume was ml/kg and was adjusted weekly based on body weight measurements Treatment period was from day 10 through day 27 Tibiotarsal...

Ngày tải lên: 09/08/2014, 01:22

... Matsuda T, Yamashita M, Ito Y, Kawakami H, Matsuzaki Y, Watanabe W, Yamataka K, Ikeda S, Kodama E, Matsuoka M, Shinkai H: Novel HIV-1 integrase inhibitors derived from quinolone antibiotics J ... di Sanità, Rome, Italy (intramural grant: BASTET: Bases for Assessment and Evaluation of Eradication Strategies), and by the Italian Ministry of Research and University, Rome, Italy (FIRB grant: ... 31:11233-11238 Bujacz G, Alexandratos J, Wlodawer A, Merkel G, Andrake M, Katz RA, Skalka AM: Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects...

Ngày tải lên: 13/08/2014, 09:20

... IIIa Multimode AFM (Digital Instruments, Santa Barbara, CA, USA) operating in air at room temperature MTT Assay Experimental Section Reagents Daunorubicin was purchased from Nanjing Pharmacy Factory ... change Ultrapure water was added in which the final volume was 100 mL and the diameter of Au nanoparticle was about 15 nm The other reagents were analytical grade For the following studies, all ... Typical AFM images of a Au nanoparticles, and b PLA nanofiber Li et al Nanoscale Res Lett 2011, 6:29 http://www.nanoscalereslett.com/content/6/1/29 Page of Figure Typical AFM images of nano PLA/Au...

Ngày tải lên: 21/06/2014, 08:20

... ((AUC ) × Dose ) A BA R = B B A where AUC is the area under the curve Statistical analysis All data are presented as a mean value with its standard deviation indicated (mean ± SD) Statistical analysis ... with a UV detector at 232 nm The main pharmacokinetic parameters were calculated by DAS 1.0 (Anhui, China) program Bioavailability (BA) is a measurement of the rate and extent of a therapeutically ... PANs was studied in the aqueous medium, and the acute toxicity of PANs was evaluated in mice Morever, EPI was loaded into PANs and its pharmacokinetics was also assessed in rats to compare to...

Ngày tải lên: 23/04/2013, 21:38

... AGCTGGTGCAGGAGGAAGTA CCGAGAACCGAACTTACCAA AGGAAGCACCCAGCAATACCA CACCTTGGATGGGTATTCCA CACAGCTCCCATTCATTCCA TCCTCCCTGGAGAAGAGCTA CTCCTGGGACACGATGC CTGCGGTGCTGTTGTGG CACCATCATAAGGGTAAACAT ACAGCAAAAAGGAGGCCAAA ... ACAGCAAAAAGGAGGCCAAA GCCACAATCCAGTCATTCCA GATAAGCTTGTGGAAGTCGCGT TCTCACTGGCCCTAAACTGG CTGATAGGGGTTGGGTGATG GCATTTCCATTTCCCTAAGCAC CAACACAATCCTGAGGCACA TCCCTTTGCCTCCTGTTGTT GTACTTGCGCTCAGGAGGAG 178 246 ... BCRP CA9 BMP2 MT 2A CD237904 AL707095 AK095731 DKK1 BC037851 b-Actin GAAGAAGGGCCAGACGC CCTTCGCTGAGTTCCTGC ACATCAGCGGATACTACAGAG TTTGAATGGGCGAGTGATTG CGGAAACGCCTTAAGTCCAG AATAAGCTTCCGACTCTAGCCGC AGCTGGTGCAGGAGGAAGTA...

Ngày tải lên: 06/03/2014, 22:21

... Nanoparticles Based on Dissolution and Oxidative Stress Properties ACS Nano 2008, 2:2121-2134 Ahamed M, Akhtar MJ, Siddiqui MA, Ahmad J, Musarrat J, Al-Khedhairy AA, AlSalhi MS, Alrokayan SA: ... citrate buffer at pH 4, 5, and revealed faster metal release at pH than at pH (see Additional file 3), which was surprising and further illustrated that metal release is affected by more than ... competing ligand concentration on the rate of Cu release, which was actually faster at pH compared to pH This can be explained by looking at the various protonation states of citrate as a function...

Ngày tải lên: 21/06/2014, 02:20

... (MT H37Ra; DIFCO Laboratories, Detroit, MI, USA) was used as an adjuvant to induce arthritis Fresh adjuvant was prepared on the same day as arthritis was induced A volume of 0.1 ml of a mg suspension ... the same pattern: tarsal, metatarsophalangeal and then interphalangeal In the vehicle and nontreated arthritic group, the incidence of disease was 100% (that is, all animals in the group were affected) ... M, Aota S, Omata T, Tuzuike N, Itokazu Y, Oka H, Tamaki H, Nakamura T: Methotrexate maintains bone mass by preventing both a decrease in bone formation and an increase in bone resorption in adjuvant-induced...

Ngày tải lên: 09/08/2014, 10:21

... underlying causes of death, and the final coding was based on a mutual agreement Drug related death Death was drug related in 120 of 204 deaths (59%) Toxicological analyses were available for all of ... was about 1.55 times higher if opiates was abused at first admission and about 1.39 times higher risk if barbiturates were abused The risk was 0.87 if cannabis was the main drug abused As regards ... termination of treatment Page of and no association was found between dropout and dominant substance of abuse Based on the available data, we cannot determine if discharge status at first admission...

Ngày tải lên: 11/08/2014, 15:22

... individual variables and Cronbach's alpha for each proposed factor Overall Security Worries1 Variable Mean Having a Place to Stay Able to Get Food Being Robbed Being Assaulted Being Farmed Being Arrested ... collected the data upon which this analysis is based, and interpreted analysis results LC, RS and EAR completed the statistical analysis, and wrote the manuscript draft All authors read and approved ... stigma, and lack of resources associated with high-risk behaviours ranging from sharing injection drug paraphernalia to survival sex, while simultaneously acting as barriers to HIV/ AIDS treatment...

Ngày tải lên: 11/08/2014, 18:20

... it as a substitute because its easier to obtain cannabis than alcohol, illicit or prescription drugs, 11.9% use it as a substitute because cannabis has greater social acceptance, 57.4% use it as ... [12] Cannabis substitution has also been discussed as part of a harm reduction framework A record review of 92 medical cannabis patients who used marijuana as a substitute for alcohol was conducted ... Ogborne A, Smart R, Adlaf E: Self-reported medical use of marijuana: A survey of the general population Canadian Medical Association Journal 2000, 162:1685-1686 Mikuriya T: Medical Marijuana in California,...

Ngày tải lên: 11/08/2014, 18:20

... Holland GN: Ocular toxoplasmosis: a global reassessment Part II: disease manifestations and management Am J Ophthalmol 2004, 137:1-17 Oner A, Ozkiris A, Dogan H, Erkilic K, Karakukcu M: Bilateral ... ruptured macro-aneurism of the retina and shaken baby syndrome Other rare causes include thrombocytopenia secondary to bone marrow aplasia, leukemia, autoimmune hemolytic anemia, aplastic anemia secondary ... surgery (LASIK) Bilateral macular hemorrhages are even more uncommon, with a few reports associated with cases of head trauma, hemolytic anemia and thrombocytopenia [3] In our report, the patient...

Ngày tải lên: 11/08/2014, 19:21

... to January 2006), Cochrane Database of Systematic Reviews, Cochrane Clinical Trials Register, Database of Abstracts on Reviews and Effectiveness, and EMBASE (January 1950 to January 2006) Search ... Policastro A, Cerabona T, Austria L: Routine prophylactic antifungal agents (clotrimazole, ketoconazole, and nystatin) in nontransplant nonburned critically ill surgical and trauma patients J Trauma 1994, ... Altuna-Cuesta A, López A, Carrillo A, Garcia J, León J, Martínez-Pellús AJ: Prevention of nosocomial lung infection in ventilated patients: use of an antimicrobial pharyngeal nonabsorbable paste...

Ngày tải lên: 13/08/2014, 10:20

... increasing total peripheral vascular resistance secondary to systemic peripheral vasoconstriction [7] This transient change is rapidly counterbalanced by a decrease in heart rate and cardiac output ... extrapolations from healthy humans and animals and warrants careful evaluation in selected clinical states and their animal models Effects on inflammation Tissue hypoxia activates a large variety ... drowning, asphyxia, and cardiac arrest [10] In the specific case of traumatic brain injury, it has repeatedly been shown that, although HBO causes cerebral vasoconstriction, it increases brain tissue...

Ngày tải lên: 13/08/2014, 11:23

... participation We also thank the administrative staff at the B.C Centre for Excellence in HIV/AIDS, as well as the VIDUS and SEOSI study staff for their research assistance Page of (page number ... of this case support the conclusion that an assault was very likely the source of infection Additionally, comparison of data from study records and the qualitative interview revealed a high level ... Studentship and a CIHR Doctoral Research Award Dr Kerr is supported by a MSFHR Scholar Award and a CIHR New Investigator Award References 10 11 12 13 14 Joint United Nations Programme on HIV/AIDS (UNAIDS):...

Ngày tải lên: 13/08/2014, 13:21

... investigator All NSAIDs and aspirin were considered However, when aspirin was taken as an antiplatelet aggregant for the prevention of cardiovascular diseases (

Ngày tải lên: 13/08/2014, 16:20

... 2003; Taguchi et al., 1992; Wanasundara and Shahidi, 1995), increase flowability (Lee, 1981), mask taste (Deasy, 1984; Yajima et al., 2002; Yajima et al., 2003; Yajima et al., 1996; Yajima et al., ... material Taste masking is often required for pharmaceutical oral dosage forms because a large number of drugs have bitter or unpleasant taste Spray congealing is a useful technique for taste masking ... to have higher rates of release from the same type of matrix material Amorphous drug was released at a higher rate than crystalline drug (Savolainen et al., 2002) Encapsulation of praziquantel...

Ngày tải lên: 09/09/2015, 11:06

... interaction for intracellular uptake after the nanocarriers reach the target site from blood circulation and extravasation There are advantages and drawbacks for each of this strategy that will ... of nanosized asymmetrical poly(ester) dendrimers with one hemisphere attached to DOX and another functionalized with PEG as an anticancer nanomedicine that had comparable antitumour efficacy as ... Poly(carbonate)s are an emerging class of biomaterials in comparison to the widely used poly(amino acids) and poly(esters) Aliphatic poly(carbonate)s appears to 12 be suitable for use as a drug...

Ngày tải lên: 30/09/2015, 06:07

... OCT4 F: CGRGAAGCTGGAGGAGAAGGAGAAGCTG 55 oC R: AAGGGCCGCAGCTTACACATGTTC NANOG F: GGCAAACAACCCACTTCTGC 55 oC R: TGTTCCAGGCCTGATTGTTC β-ACTIN F: ACAGAGCCTCGCCTTTGCC 58 oC R: ACATGCCGGAGCCGTTGTC 2.1.5 ... ISO 10993 standards DMSO was used as control MTS assay is a standard laboratory colorimetric assay that measures the activity of mitochondrial activity Enzyme reductase from mitochondria converts ... using hESCs as a model In this study, taking hESCs differentiation towards osteogenic lineage as an example, we proposed a set of functional assays as a standard of hESCs as a model for drug discovery...

Ngày tải lên: 16/10/2015, 15:38

Ngày tải lên: 08/08/2012, 17:20