huntington s disease in late teens
Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
Ngày tải lên :
16/03/2014, 18:20
... (1993) Loss of cannabinoid receptors in the substantia nigra in Huntington s disease Neuroscience 56, 523–527 Richfield, E.K & Herkenham, M (1994) Selective vulnerability in Huntington s disease: preferential ... ubiquitously expressed transcription factors Another possibility is that mutant huntingtin itself has a characteristic that is unique when this protein is expressed in the striatum It appears that ... technical assistance References Martin, J.B & Gusella, J.F (1986) Huntington s disease: pathogenesis and management N Engl J Med 315, 1267–1276 The Huntington s Disease Collaborative Research Group...
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Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx
Ngày tải lên :
23/03/2014, 07:20
... Alzheimer s and Parkinson s diseases is starting to cast doubt on the universality of the amyloid hypothesis in those diseases as well In Alzheimer s disease, genetic mutations in familial Alzheimer s ... hypothesis disease, and Alzheimer s disease [15] Polyglutamine diseases have often been historically considered as amyloid diseases New models, new insights One problem with huntingtin exon mouse ... from huntingtin small-fragment models and studies focusing on the toxic species of polyglutamine in different disease contexts Proof-ofconcept successes with SCA1 pointing to serine kinase inhibition...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... Coexpression of HIPPI and BLOC 1S2 does not increase apoptosis but sensitizes apoptosis induction by staurosporin or death ligand In addition, the expression of BLOC 1S2 is increased in some tumors ... & Sipione S (2001) Loss of normal huntingtin function: new developments in Huntington s disease research Trends Neurosci 24, 182–188 Hickey MA & Chesselet MF (2003) Apoptosis in Huntington s disease ... promoters of caspase-1, caspase-8 and caspase-10, and increase their expressions In turn, increased pro-caspase-8 is recruited to HIPPI–HIP-1 heterodimer and increases apoptosis The role of caspase-1...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
Ngày tải lên :
23/03/2014, 10:20
... RJ, Rosen BR & Beal MF (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington s disease ... Vecsei L (2006) Behaviour changes in a transgenic model of Huntington s disease Behav Brain Res 169, 137–141 26 Hedreen JC & Folstein SE (1995) Early loss of neostriatal striosome neurons in Huntington s ... Huntington s and Parkinson s diseases Neurology 50, 1033–1040 Ma Y & Eidelberg D (2007) Functional imaging of cerebral blood flow and glucose metabolism in Parkinson s disease and Huntington s...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson 's disease, Huntington' s disease, and amyotrophic lateral sclerosis Gait reflects several ... cycle timing in Parkinson 's disease and Huntington' s disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability ... and processing 20 21 22 References Salarian A, Russmann H, Vingerhoets FJ, Dehollain C, Blanc Y, Burkhard PR, Aminian K: Gait assessment in Parkinson 's disease: toward an ambulatory system for...
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Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
Ngày tải lên :
10/08/2014, 05:21
... Huntington s Disease W.B Saunders London, 1996 Ross CA: Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington s disease and related disorders Neuron 2002, 35(5):819-822 Behrens PF, ... Fritsch JN, Barton SJ, Rebec GV: Altered information processing in the prefrontal cortex of Huntington s disease mouse models J Neurosci 2008, 28(36):8973-8982 15 Mangiarini L, Sathasivam K, Seller ... toxicity in the striatum of the R6/2 Huntington s disease transgenic mice is agedependent and correlates with decreased levels of glutamate transporters Neurobiol Dis 2009, 34(1):78-86 12 Rothstein...
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Báo cáo khoa hoc:" Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson''''s disease in two European populations" pps
Ngày tải lên :
11/08/2014, 08:20
... a serine-threonine kinase domain with homology to kinases of the Ca2+/calmodulin family[3] It appears to exert protective effects against cellular stress within mitochondria[3] These findings ... This screening did not reveal any disease- relevant mutation in our cohorts Discussion As recently shown, mutations in the PINK1 gene rarely cause autosomal-recessively transmitted PD [3] Besides ... of onset, the observed clinical symptoms in PD caused by PINK1 are similar to symptoms in idiopathic PD In this population-based study, we investigated whether sequence variations in the PINK1...
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Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx
Ngày tải lên :
14/08/2014, 14:21
... large size of Htt and its apparent role in several cellular processes has raised the possibility that Htt serves as a scaffold that arranges protein complexes by modulating the binding of accessory ... new interacting proteins using a total of 52 baits These baits included proteins involved in cellular processes associated with Htt, proteins known to interact with Htt, and five different amino-terminal ... domains of transcription factors and independently fusing these domains with candidate interacting proteins [21,22] Constructs encoding these fusion proteins are transformed into yeast cells; if the...
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Cushing’s Disease in Children: Report of Three Cases potx
Ngày tải lên :
22/03/2014, 10:20
... Cushing s disease Two of our patients presented with such problems as initial symptoms Thus a high index of suspicion of Cushing s syndrome is essential for its diagnosis in children with obesity, ... two and a half years’ follow-up Discussion Cushing s disease is rare in children, and its clinical presentations differ from those in adults In children with Cushing s disease, growth retardation ... Cushing s disease The diagnosis of Cushing s disease is based on the clinical suspicion and biochemical confirmation of hypercortisolism Lack of a diurnal rhythm in serum cortisol levels is the...
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NERVOUS DISEASE IN LATE EIGHTEENTH-CENTURY BRITAIN: THE REALITY OF A FASHIONABLE DISORDER pptx
Ngày tải lên :
22/03/2014, 16:20
... rival system of disease classification According to Brown, all diseases were of two types: sthenic diseases, defined as diseases induced by excess nervous excitability, and asthenic diseases, or diseases ... of its sufferers, ‘the signs of such uncommonness were surprisingly common’.112 Such instances only encouraged sceptics to insist that nervous disease was imaginary, 26 Nervous Disease in Late ... predecessors, Cheyne stressed the somatic nature of nervous disease, arguing that physically weak nerves were the cause of the depressed spirits so common among hypo- Defining Nervous Disease in...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
Ngày tải lên :
23/03/2014, 04:20
... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with ... RB, WilsonDelfosse AL & Chen SG (2007) The Parkinson s disease- associated protein, leucine-rich repeat kinase (LRRK2), is an authentic GTPase that stimulates kinase activity Exp Cell Res 313,...
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Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc
Ngày tải lên :
23/03/2014, 07:20
... disease- causing proteins associated with various neurodegenerative disorders, such as mutant huntingtin [causing Huntington s disease (HD)], ataxin-3 (causing spinocerebellar ataxia 3), forms ... carbamazepine (CBZ) and valproic acid (VPA), which inhibit inositol (Ins) synthesis Although lithium also inhibits glycogen synthase kinase-3b (GSK-3b) in the wingless (Wnt) signaling pathway ... be induced with drugs that decrease IP3 levels in the phosphoinositol signaling pathway in an mTOR-independent fashion, such as lithium (LiCl), which inhibits inositol monophosphatase (IMPase),...
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Huntington’s Disease – Core Concepts and Current Advances Edited by Nagehan Ersoy Tunali potx
Ngày tải lên :
30/03/2014, 23:20
... (1995) Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer 's disease, Lewy body dementia, Parkinson 's disease and Huntington' s disease Journal ... Buckley, 2009) These findings strongly support a model of strengthened REST/NRSF repression of target genes in HD brains Besides REST/NRSF, mutation in huntingtin proteins impairs its interaction with ... researchers working on Huntington s Disease The invaluable efforts of the 58 international scientists and clinicians were eventuated in successful mapping of the disease gene to chromosome in...
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báo cáo khoa học: "Fulminant Leptospirosis (Weil’s disease) in an urban setting as an overlooked cause of multiorgan failure: a case report" pptx
Ngày tải lên :
11/08/2014, 02:22
... as noninfectious diseases such as small vessel vasculitides, systemic lupus erythematosus or even malignancies The initial diagnosis of leptospirosis remains a clinical one, a presumed analysis ... diagnosis of leptospirosis requires a high degree of clinical suspicion because the disease s numerous manifestations can mimic other tropical infections or other nonspecific febrile illnesses, as ... and did manuscript revisions EE was involved in direct patient care as the hospitalist NM was involved in direct patient care as the infectious disease specialist SE was involved in Page of direct...
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Báo cáo khoa hoc:" Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison''''s disease in girls and women with Turner syndrome" docx
Ngày tải lên :
11/08/2014, 08:21
... biosynthesis Rate limiting enzyme in the synthesis of serotonin APS II 21-Hydroxylase (21-OH) Steroid hormone synthesis Description of important autoantigens in Addison 's disease, Addison 's disease ... melanin catalyser in the inner ear [22] Some inner ear diseases are known to be caused by water and ion regulating problems, which is the case with Addison 's disease The aim of this study was to investigate ... history was attained, focusing on autoimmune diseases, previous and current ear diseases, ear operations and hearing problems A clinical investigation of the EarNose and Throat area was also...
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Báo cáo y học: "Manifestations of Ollier’s disease in a 21-year-old man: a case report" pdf
Ngày tải lên :
11/08/2014, 14:20
... problems caused by limb-length discrepancy, as lesions frequently involve the femur or tibia [2] Malignant changes in Ollier s disease may occur in adult patients [2] As dysplasia progresses, there ... calcifies, it is detected as irregular opacities It has been emphasized that Ollier s disease usually stops spontaneously with skeletal maturity; therefore, any lesion showing activity or increased ... diagnosis of benign lesions was reliable Retrospective assessment of our patient revealed that the etiology of increased uptake in the lower limb lesions was due to previous insufficiency fractures...
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Báo cáo y học: " Synchronously diagnosed eosinophilic granuloma and Hodgkin''''s disease in a 12-year-old boy: a case report" pptx
Ngày tải lên :
11/08/2014, 19:21
... Hematoxylin and Eosin Competing interests The authors declare that they have no competing interests simultaneous occurrence of Hodgkin 's disease, Langerhans cell histiocytosis and multiple myeloma in ... frequent initial symptom In 5– 10% of patients, general symptoms such as fever, malaise and peripheral eosinophilia may be present Microscopic findings of Langerhans cell histiocytosis include eosinophils ... Giardini R: Langerhans cell histiocytosis arising after Hodgkin 's disease Pediatr Hematol Oncol 1997, 14:585-8 Shin MS, Buchalter SE, Ho KJ: Langerhans' cell histiocytosis associated with Hodgkin's...
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Báo cáo y học: " Accidental Jorge Lobo''''s disease in a worker dealing with Lacazia loboi infected mice: a case report" doc
Ngày tải lên :
11/08/2014, 20:20
... reach the subcutaneous tissues through imperceptible abrasions on the upper layers of the skin Since this pathogen is a slow growing fungus in its parasitic stage, L loboi should possess a yet ... staining showed spherical to oval yeast-like cells mostly uniform in size and arranged singly or in small chains of cells linked by small tube-like structures (Figures Figure Hematoxylin-eosin stained ... Lobo 's disease proven cases in humans or dolphins, or researchers working with purified yeast-like cells of L loboi, should be carefully considered during clinical investigation of nodular skin disease...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
Ngày tải lên :
15/02/2014, 01:20
... displayed quantitative differences, regardless of whether or not a-synuclein was overexpressed (Fig 2, insets; black versus white bars) Dopamine-responsive proteins were involved in protein synthesis, ... Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase in lamin A ⁄ C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced ... containing human a-synuclein cDNA (a-syn) As a control, we used 4910 β-Actin α-Synuclein Fig Relative expression of a-synuclein in b-gal and a-syn cells in response to dopamine (DA) treatment Results...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only wild-type human a-synuclein Similar ... ApoE-containing lipoparticles via the ATP-binding cassette family of active transporters regulates Ab deposition PDAPP mice overexpressing murine ATP-binding cassette family of active transporters are...
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