homeostatic mechanisms of the major functional systems

... evaluating the effect of failures in auxiliary electrical spstem on the reliability of a generating unit We would like t o note that the performance of auxiliary electrical system (and of other systems) ... t o the other material presentedin the paper, we offer the following comments and questions The cost of unreliability is mentioned in the paper but no cost estimateshavebeenassociatedwiththecalculatedreliabilityindices ... units in the station Some of the buses can be supplied from the station common bus or thebuses of other units For this reason, the whole auxiliary electrical system of the stationwill have to be...

Ngày tải lên: 03/01/2014, 19:39

... dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of CKS with CDK2 ⁄ cyclin ... for destabilizing the double bond character of the pThr-Pro bond [26] Further evidence is available for the catalytic mechanism of Pin1 resembling more closely that of the other prolyl cis ⁄ ... whereas in the study on cyclin E degradation, Pin1 was brought in by the phospho-cyclin E and not by the CDC4a component of the final complex (Fig 2) [35] Therefore, the outcome of the molecular...

Ngày tải lên: 07/03/2014, 05:20

... from the administered [75Se]Der p2, indicate together with its own remaining intact levels (the 16 kDa band) that the clearance and further metabolism of the allergen was altered as a result of the ... conclude that the inflammatory state of the lung influence on the rate of metabolism and clearance of Der p Thus, an allergic response may lead to prolonged retention of the allergen in the airways ... airways of Der p 2-sensitized and nonsensitized mice The fate of the allergen could be followed in vivo both at the whole-body level and at the molecular level, through the application of a newly...

Ngày tải lên: 07/03/2014, 21:20

... regarding the biochemical properties of the major ubiquitin receptors from different species, in terms of their selectivity for linkage types and the lengths of the ubiquitin chains and their associated ... RPN13 The potential involvement of the hydrophobic patch in the UBL of hHR23b was also examined The UBL variants constructed for analysis of the association of RPN10 with human hHR23b and the DSK2 ... which each of the UBAs of Arabdopsis RAD23 contributes additively to the binding of K48-linked ubiquitin chains (Table and data not shown) The roles of the UBAs in ubiquitin chain binding of human...

Ngày tải lên: 15/03/2014, 09:20

... zinc Indeed, 33% of the total zinc in the ovary at stage and 13% of the total zinc in the testis at stage is still bound to MYP On the basis of the results of the present study and others, we propose ... measured the protein content of the CFMYP and EGMYP bands by densitometry of the SDS ⁄ PAGE gel of the purified MYP, and the ratio of CFMYP to total MYP (CFMYP + EGMYP) was calculated (Fig 3B) In the ... 1.7% of the MYP was CFMYP at stage and 18.3 ± 2.6% at stage In the testes, the proportions of CFMYP were 17.7 ± 5.3% at stage and 6.9 ± 3.5% at stage The higher the proportion of CFMYP, the more...

Ngày tải lên: 16/03/2014, 05:20

... contents of the individual glycoforms (MALDI-TOF-MS), the proportions of glycoforms I and II can be calculated to be 35 and 65%, respectively HPAEC analysis showed that the main sugar constituents of ... is needed to establish the proximal calcium binding site The binding of Ca2+ has been proposed to change the electronic properties of the heme iron or the topology of the heme vicinity and might ... temperature of SPC4 was between that of HRP C (Tm ẳ 60 C) and the African palm tree peroxidase (Tm ẳ 74 C) [37] In the presence of Ca2+, the Tm of SPC4 is near that of soybean peroxidase, which is one of...

Ngày tải lên: 16/03/2014, 13:20

... the presence of antimycin A, suggesting that the functional state of the mitochondria is somehow sensed by regulatory mechanisms Perhaps the decreased levels of these enzymes, and other yet not ... regulation of gene expression [27–30] Therefore, we have evaluated possible influences of cTPxI and of the functional state of the mitochondria in the expression of selected yeast antioxidant genes ... in all of the conditions tested (Fig 6) In spite of the increased basal expression levels of a variety of genes in tsa1 cells, we did not observe GFP-Yap1 accumulation in the nucleus of these...

Ngày tải lên: 16/03/2014, 14:20

... for the development of allergy vaccines which are based on the reduction of allergen fold Results Comparison of natural and recombinant group grass pollen allergens Although the majority of rPhl ... for the design of safe allergy vaccines with reduced allergenic activity Disruption of the native structure of respiratory allergens allows for the maintenance of important T cell epitopes of ... expression of Phl p They are exclusively expressed in mature pollen grains where they are localized mainly in the cytoplasm [8] Using immuoelectronmicroscopy two mechanisms for the release of group...

Ngày tải lên: 16/03/2014, 18:20

... majority of the sulfated sugar In conclusion, the results obtained provide evidence of the nature of the glycans present in the unique N-glycosylation site present in the C-terminal domain of cruzipain ... in Fig 6B) Altogether, these data confirm the presence of sulfated high-mannose type oligosaccharides in cruzipain and in its C-terminal domain This is the first report of the use of nor-harmane ... confirm the nature of the substitution present in glycans obtained from cruzipain, desulfation was carried out using sulfatase The UV-MALDI-TOF spectra of the treated sample, obtained in the negative...

Ngày tải lên: 23/03/2014, 15:20

... using synthetic peptides, determined the location of four immunodominant CD4+ T-cell epitopes in the unprocessed precursor of the Brazil nut 2S albumin One of these epitopes matched with the signal ... as the starting material Although it has been described that the pH of the duodenum may vary within the range 5–7 [27–29], the most accurate range seems to be 6–6.5 [30–34] Therefore, the pH of ... (peak 3), a major component of the ‘large 346 Resistance to digestion in the gastrointestinal tract is thought to be one of the factors that may contribute to the allergenic potential of food proteins...

Ngày tải lên: 30/03/2014, 15:20

... requirement of an acceptable mechanism is that it must predict a rate law consistent with the experimental rate law Order of the Rate Law The order of the rate law is the sum of the exponents in the ... depend on the rate law and must give the right-hand side of Eq (1.3) the same units as the left-hand side A simple example of the need to define the rate in order to give the meaning of the rate ... expression for the concentration of one of the partners in the equilibrium, [B], in terms of the total concentration of the species involved in the equilibrium, [R] Since Kn = [B]/[A], then Rearrangement...

Ngày tải lên: 01/04/2014, 10:37

... counting the number of foot faults in the left and right forelimbs The sum of foot faults (SOFFF) in the forelimbs is defined as the number of faults of right and left forelimbs, whereas the differentiation ... stimulation of 200 pulses at Hz and 0.8 mA The measured latency was the time span from the stimulation to the beginning of the first wave, whereas the amplitude was the voltage difference between the ... differentiation of forelimb foot faults (DOFFF) is the difference between the number of faults for the right and left forelimbs SOFFF and DOFFF were used as an index of motor deficit CSF aspiration 80 μL of...

Ngày tải lên: 18/06/2014, 16:20

... volume” of the solute, solubility is predicted This is satisfied if the distance from the center of the solvent sphere to the center of the solute sphere (Rij) is smaller than the radius of the solute ... fines • The water content of the bio-oil • The extent of contamination of the bio-oil during storage by corrosion or leaching of the containers • Exposure to air during storage • The length of storage ... during pyrolysis • The extent of vapor dilution in the reactor • The time and temperature history of the vapors in the reactor • The time and temperature history of the vapors in the heated transfer...

Ngày tải lên: 19/06/2014, 14:02

... Figure 4: The example of the position of the referent and assigned element of the nested HS function in the block-matrix in the space of the selected hyperspheric block-matrix According to the translator ... separately, and therefore we develop specific translators of the ϑ Δk, Δn, type On the basis of the established graph, all option relations are shaped There are in total thirty of them 10 × , and they are ... the vector of real surfaces left column , deducting one degree of freedom k of the surface sphere we obtain the circumference, and for two degrees we get the point Moving through the vector of...

Ngày tải lên: 21/06/2014, 11:20

... automorphism group of order 432, and the other two STS(19) with 12 subsystems of order are the systems having automorphism groups of orders 108 and 144 The rank of an STS is the linear rank of its point–block ... classes) The rank over GF(2) gives the dimension of the binary code generated by the (rows or columns of) the incidence matrix The code generated by the rows of a point–block incidence matrix is the ... every 2-subset of points occurs in exactly one block The size of the point set, v := |X|, is the order of the design, and an STS of order v is commonly denoted by STS(v) Steiner triple systems form...

Ngày tải lên: 08/08/2014, 12:22

... investigate the influence of gender, female mice on the B10.Q background were immunized at the same time as their male littermates These females developed disease symptoms less severe than those of the ... mice Approval for the animal experiments was obtained from the ethical committee at Lund University Induction of disease Mice were immunized at the base of the tail with 100 µg of matrilin-1, purified ... in the acute phase at score or at the end of the experiment at day 130 The tissue was immediately either snap-frozen at -70°C or fixed in 4% paraformaldehyde solution for 24 hours and further...

Ngày tải lên: 09/08/2014, 01:24

... for 30 minutes and then incubated with trypsin at 30 nM for hours The addition of trypsin to the cells, pretreated with the PAR2-AP, further enhanced the COX-2 level (Figure 3B) These results indicate ... and then trypsin for another 30 minutes The relative levels of p-p65 were calculated by normalizing the band densities to that of GAPDH and setting the controls as 100% Chen et al Journal of ... synergistically induce COX-2 [18] Recently, the expression of COX-2 was shown to be induced by the activation of PAR-2 through bacterial infection, or the treatment of either trypsin or PAR2-AP, and mediated...

Ngày tải lên: 10/08/2014, 05:21

... reduction of the virus titer by more than orders of magnitude in Madin-Darby canine http://www.virologyj.com/content/6/1/124 kidney (MDCK) cells [28] However, the target sites and mechanisms of PVP-I ... influenza A and the other virus infections have hitherto remained unknown In this study, we investigated mechanisms underlying PVP-I antiinfluenza activity The apparent reduction of influenza A ... (Figure 3B) Effect of PVP-I on influenza A virus sialidase activity In order to examine the effect of PVP-I on sialidase activity of different subtypes of influenza virus strains, the enzyme activity...

Ngày tải lên: 12/08/2014, 04:22

... are the swine leukocyte antigen (SLA) complex, where the centromere of chromosome separates the class II region from the other parts of the MHC [34] and the recently described class I genes of the ... two of these small PARs in platypus BAC2 was mapped to the PARs of Y4 and the short arm of X5 This fits with the orientation of X5 in the chain where the short arm lies towards Y4 [21] Together ... genes They found eight 200-900 kbp scaffolds that contained orthologs to many of the genes in the eutherian MHC The interpretation is that the syntenies of the MHC region are ancient and predate the...

Ngày tải lên: 14/08/2014, 08:20

... here ofalignment mouse Individualthe theERV ESI-MS B6thevolume of MUPs Details ofselfgenome the genomic spectra of from the comparison visible tion pseudogeneof of urine is seen once The change thefileB ... again there is no evidence for secretion of the protein Discussion This is the first in depth analysis of the Mup gene clusters of two distinct strains of mice, strengthened by resolution of the ... pseudogenization By this model, the differences between the CDS of these loci may indicate the acquisition of individualized functions in the absence of homogenization by NAHR Of the six peripheral MUP...

Ngày tải lên: 14/08/2014, 08:21