... monitored by comparing the UV and MS peak areas of IS to the LC-MS/MS analyses. Calibration curves of each standard were created from seven concentrations using Microsoft Excel software. The concentrations ... without intact germ; ESI-MS, electrospray ionization mass spectrom- etry; API-ES, atmospheric pressure interface-electrospray; ICC, ion-charge control; CID, collision-induced dissociation; frag, ... direct on-line identification and quantification of the vitamin E and γ-oryzanol components in rice bran and germ. KEYWORDS: Rice bran; rice germ; γ-oryzanol; vitamin E; LC-MS/MS INTRODUCTION Free...
Ngày tải lên: 15/03/2014, 15:33
Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway pdf
... no effect on the cytosolic accumulation of cytochrome c, suggesting that active caspases are not required for cytochrome c release in morphine-induced cell death, and that cytochrome c release ... detection of cleaved caspase-3 and cytochrome c. (a) A representative image of immunoblots for cleaved caspase-3 and cytochrome c. (b) Densitometric analysis of changes in levels of cleaved caspase-3 ... the effect of morphine treatment on cytochrome c release. The cytosolic fractions from cells were isolated, and the presence of cytochrome c was detected by antibody against cytochrome c. Treatment...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: Vitamin C Biosynthesis, recycling and degradation in mammals doc
... typhimurium, and Klebsiella pneumoniae), but also in Lactobacillales (Enterococcus faecium, Streptococcus agalactiae, Streptococcus pneu- moniae, Streptococcus pyogenes, and Streptococcus uberis) and ... Crane FL (1988) Cell surface glycoconjugates control the activity of the NADH-ascorbate free radical reductase Vitamin C metabolism and recycling in mammals C. L. Linster and E. Van Schaftingen 20 ... in the presence of H 2 O 2 [140], indicating that the reaction proceeds by successive cleavage of the bonds between C1 and C2 , and C2 and C3 . It was speculated that the highly reactive ketose, l-erythrulose,...
Ngày tải lên: 16/03/2014, 12:20
báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... 4). The CEF-specific precursor frequencies were highly consistent throughout the study period. The mean frequency of MVA-specific T cells was decreased slightly from 1:615 PBMCs pre-vaccination ... vaccine and high- dose IL-2 elicited 5T4-specific humoral and cell-mediated immunity. All patients devel- oped an increase in 5T4 antibody titers after vaccination, consistent with previous clinical ... disease, which was associated with increased effector T cells, reduced Tregs and increased effector to regulatory T cell Representative effector CD8+ T cell and Treg responses in 3 patients (A -C) Figure...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis" potx
... high dose concentration ascorbic acid given twice. Group G: high dose concentration ascorbic acid twice for 4 days, S-180 cells same as Group D, and then high dose concentration ascorbic acid ... injected with high dose concentration ascorbic acid for four days before injecting cancer cells, and was then treated with high dose concentration ascor- bic acid for 24 days after cancer challenging ... injected with low dose ascorbic acid before injecting cancer cells, and was then treated with high dose concen- tration ascorbic acid after cancer challenging for 24 days. Group G group was injected...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... following antibodies: anti-CD25-phycoerythrin (PE)–cyanin (Cy) 5.5, anti-CD4-peridinin chlorophyll protein, anti-CD8- allophycocyanin (APC), anti-CD3-APC-Cy7, and isotype controls(BDBiosciences;SanJose,CA,USA).Thetest tubes ... side scatter prop- erties, and T cells were identified based on their expression of CD4 and CD3. To discriminate bet ween CD25 high Treg and CD25 low activated effector-memory T cells, we used CD25 expression ... CD25 expression on CD8 + cellsasaninternalcontrol.Only CD4 + cells expressing CD25 with higher intensities than the CD8 + cells were included in the gate for CD25 high cell s. The gate for CD25 low cell s...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo y học: "Qualitative Dosimetric and Radiobiological Evaluation of High – Dose – Rate Interstitial brachytherapy Implant" doc
... uniform dose distribution is rarely achieved. Hence the biologically effective dose (BED) or TCP calculated on the basis of the dose that corresponds to the isodose surface which encompasses ... Aardweg GJMJ, Levendag PC. Pulse dose rate and fractionated high dose rate brachytherapy: Choice of brachytherapy schedules to replace low dose rate treatments. Int J Radtiat Oncol Biol Phys 1996; ... radiobiological parameters, considered in the TCP formulation, such as clonogenic cell density (ρ), radio-sensitivity (α), and cell proliferation rate (T p ) influence the TCP phenomenological and...
Ngày tải lên: 08/08/2014, 17:20
Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
... lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma treated with high- dose hyperfractioned radical radiotherapy. Acute and late cutaneous and subcutaneous ... Budach V, Belka C, Dietz K: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma ... Clin Cancer Res 2005, 11:7426-7433. 21. Bordon E, Henriquez Hernandez LA, Lara PC, Pinar B, Fontes F, Rodriguez Gallego C, Lloret M: Prediction of clinical toxicity in localized cervical carcinoma...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo khoa học: " In vivo assessment of catheter positioning accuracy and prolonged irradiation time on liver tolerance dose after single-fraction 192 Ir high-dose-rate brachytherapy" pot
... registration inaccuracy. An asymmetry coefficient of the scalar and vector pro- duct was calculated to differentiate between a systematic shift and registration inaccuracy: AC S = | S axial |− S ortho 0.5 ( |S axial | ... 0.005). Conclusions: Positioning accuracy of brachytherapy catheters is sufficient for clinical practice. Reduced tolerance dose in areas exposed to prolonged irradiation is contradictory to ... HDR-BT in vivo. 5 Conclusions In conclusion, positioning accuracy of brachytherapy catheters is sufficiently precise with approx. 5-6 mm. Accuracy was within the 5-mm slice thickness of the treatment...
Ngày tải lên: 09/08/2014, 09:21
Báo cáo khoa học: "High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients" potx
... Pre-treatment complaints and acute toxicity according to the Common Toxicity Criteria (CTC) and late toxicity according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment ... Common Toxicity Criteria (CTC). The goal was to score late toxicity according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) scale with ... Radiation Oncology, University Medical Center Utrecht, The Netherlands, 2 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands and 3 Department...
Ngày tải lên: 09/08/2014, 09:22
Báo cáo khoa học: "Analysis of health related quality of life (HRQoL) of patients with clinically localized prostate cancer, one year after treatment with external beam radiotherapy (EBRT) alone versus EBRT and high dose rate brachytherapy (HDRBT)" docx
... jon.tonita@saskcancer.ca; Nadeem Pervez - nadeempe@cancerboard.ab.ca; Cormac Small - cormacsm@cancerboard.ab.ca; Patricia Tai - patricia.tai@scf.sk.ca * Corresponding author Abstract Purpose: Prostate cancer ... Canadian Cancer Society/National Cancer Institute of Canada: Cana- dian Cancer Statistics 2008. Toronto, Canada 2008. 2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun MJ: Cancer statistics ... Radiation Oncology Tom Baker Cancer Center & University of Calgary, Calgary, Alberta, Canada and 4 Department of Radiation Oncology, Allan Blair Cancer Centre and University of Saskatchewan,...
Ngày tải lên: 09/08/2014, 09:22
Báo cáo y học: " Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy" potx
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Overcoming beta-agonist tolerance: high dose salbutamol and ipratropium bromide. Two randomised controlled trials" pps
Ngày tải lên: 12/08/2014, 15:20
Báo cáo y học: " Bench-to-bedside review: Diaphragm muscle function in disuse and acute high-dose corticosteroid treatment" ppsx
Ngày tải lên: 13/08/2014, 18:22