hepatitis b virus genetic diversity disease pathogenesis

... et al Hepatitis < /b> C virus antibody and hepatitis < /b> C virus replication in chronic hepatitis < /b> B patients J Hepatol 1994;21:509-514 Liaw YF Role of hepatitis < /b> C virus in dual and triple hepatitis < /b> virus ... Xing Bing Xue Za Zhi 1999 ;20:141-143 Zarski JP, Bohn B, Bastie A, Pawlotsky JM, Baud M, Bost-Bezeaux F, Tran van Nhieu J, et al Characteristics of patients with dual infection by hepatitis < /b> B and ... 1983;11:191-205 Bradley DW, Maynard JE, McCaustland KA, Murphy BL, Cook EH, Ebert JW Non-A, non -B hepatitis < /b> in chimpanzees: interference with acute hepatitis < /b> A virus and chronic hepatitis < /b> B virus infections...

Ngày tải lên: 02/11/2012, 09:51

... 2005 of HBV infection was based on positive HBsAg The case definition for confirmed acute HBV infection includes the presence of HBsAg combined with IgM antibody to the HBV core (anti-HBc) A child ... transmission of hepatitis < /b> B virus in Okinawa, Japan Am J Epidemiol 1988; 127: 783-787 Tables Table Rate ratio of newly identified HBV infection in children, EHSSS, 1999-2003 Variable Conflict of ... rates of residual risk for HIV, hepatitis < /b> C, hepatitis < /b> B and human Tcell lymphotropic viruses in blood donors in Canada, 1990-2000 CMAJ 2003; 169: 767-773 Duval B, Boulianne N, De Serres G, et al...

Ngày tải lên: 02/11/2012, 11:08

... progress HBeAg-negative CHB HBeAg-negative chronic hepatitis < /b> B (e-CHB), characterized by HBV DNA levels detectable by nonamplified assays and continued necroinflammation in the liver, has been reported ... Asian hepatitis < /b> B virus carriers J Infect Dis 1999; 179:775-782 Ding X, Mizokami M, Yao G, Xu B, Orito E, Ueda R, et al Hepatitis < /b> B virus genotype distribution among chronic hepatitis < /b> B virus ... characteristics, such as HBV DNA or ALT levels [41] Occult Hepatitis < /b> B Occult hepatitis < /b> B is defined by the presence of HBV DNA in serum or liver in the absence of HBsAg [42,43] Serum HBV level is usually...

Ngày tải lên: 02/11/2012, 11:12

... infection establishes, the serology markers like HBeAg, HBeAb and HBsAb can be positive or negative except HBsAg and HBcAb (IgG form) remain positive HBeAg positive chronic hepatitis < /b> B Age at the ... hepatitis < /b> B virus infection Gastroenterology 1987;92:1839-43 15 Bortolotti F, Cadrobbi P, Crivellaro C, et al Long-term outcome of chronic type B hepatitis < /b> in patients who acquire hepatitis < /b> B ... Genotypes and clinical phenotypes of hepatitis < /b> B virus in patients with chronic hepatitis < /b> B virus infection J Clin Microbiol 2002;40:1207-1209 McMahon BJ, Holck P, Bulkow L, et al Serologic and clinical...

Ngày tải lên: 02/11/2012, 11:17

... disease [20] Hepatitis < /b> B patients also contain circulating antibodies against HBcAg (hepatitis < /b> B core antigen), and will develop antibodies against HBeAg and HBsAg (anti-HBe and anti-HBs) at later ... a unique feature of hepatitis < /b> B virus family, delays the development of anti-HBs antibody, has not been experimentally tested Anti-HBc antibody rises soon after infection but is not associated ... characterized by the presence of HBsAg, HBeAg, and IgM class of anti-HBc antibodies, and may last for decades In the intermediate stage, patients lose HBeAg, develop anti-HBe antibodies, and often...

Ngày tải lên: 03/11/2012, 09:46

... SHBs was able to bind specifically to human hepatocytes, human fibroblasts and human blood mononuclear cells but not the rat hepatocytes This binding could be inhibited by recombinant HBs but ... misfolded MHBs seems to be able to interfere with the assembly of HBV virions in the persistently producing virus cell line HepG2.215 [29, 30] Anti-preS2 antibody (that recognizes MHBs) can block HBV ... not by the recombinant LHBs The binding of SHBs with human hepatocytes was further supported by the observation from Bruin et al [39] They have found that the particles only composed by SHBs can...

Ngày tải lên: 03/11/2012, 10:09

... trạng b nh lý phổ biến thương tổn tế b o gan Có nhiều nguyên nhân gây VG như: vi khuẩn, rượu, hóa chất vài loại thuốc vô số loại virus, có virus viêm gan B (VRVGB) [20] VRVGB hay Hepatitis < /b> B virus ... kết virus vào tế b o ký chủ; Xâm nhập virus vào tế b o (sự nhập b o); Phóng thích gen virus; Biểu sản phẩm gen virus; Sao chép gen virus; Lắp ráp hạt virion (virus hoàn chỉnh); Phóng thích virus ... biến đổi Vì thế, HBV dùng protein huyết biến đổi phương tiện chuyên chở để vào tế b o gan [6]  Xâm nhập virus vào tế b o (sự nhập b o) Cơ chế HBV vào tế b o chủ chưa hiểu biết rõ ràng: vỏ HBV...

Ngày tải lên: 16/03/2013, 09:26

... FEBS 2603 Betulinic acid inhibits hepatitis < /b> B virus D Yao et al D 200 100 * 50 100 BetA/CREB CTL E 300 (Arbitrary units) siCREB 200 * 100 * CTL BetA BetA/CREB siCREB 100 * * CTL BetA BetA/CREB ... siCREB F 200 * * (Arbitrary units) 100 pCREB level by Western blot (Arbitrary units) 200 pCREB (Ser133) level by Western blot BetA/CREB 200 siCREB C BetA 300 SOD2 protein level by Western blot ... 2009 FEBS 2607 Betulinic acid inhibits hepatitis < /b> B virus B 150 CTL BetA Enzyme activity (Arbitrary units) HBV expression (Arbitrary units) A D Yao et al PC 100 * 50 * * * * * HBsAg HBeAg HBV-DNA...

Ngày tải lên: 16/03/2014, 01:20

... (1987) The molecular biology of the hepatitis < /b> B viruses Annu Rev Biochem 56, 651–693 Antonucci TK & Rutter WJ (1989) Hepatitis < /b> B virus (HBV) promoters are regulated by the HBV FEBS Journal 277 (2010) ... might HBV gene expression consequently be increased, but also the anti-HBV effects of IFNs might be reduced These observations indicate that the physiological regulation of HBV biosynthesis by bile ... the hepatitis < /b> B virus enhancer Mol Cell Biol 9, 1804–1809 Honigwachs J, Faktor O, Dikstein R, Shaul Y & Laub O (1989) Liver-specific expression of hepatitis < /b> B virus is determined by the combined...

Ngày tải lên: 22/03/2014, 21:21

... was obtained using R (http://www.r-project.org) The broken line and box (black) represent the distribution of MFE values of the HBV genome background against each ISS The bold line in the box ... A, Pol S, Brechot C & Kremsdorf D (2003) The expression of hepatitis < /b> B spliced protein (HBSP) encoded by a spliced hepatitis < /b> B virus RNA is associated with viral replication and liver fibrosis J ... [14] Hepatitis < /b> B virus (HBV) infects more than billion people worldwide, causing acute and chronic hepatitis,< /b> hepatocirrhosis and hepatocellular carcinoma The pre-genomic RNA (pgRNA) of HBV can be...

Ngày tải lên: 28/03/2014, 23:20

... Seeger, C & Mason, W.S (2000) Hepatitis < /b> B virus biology Microbiol Mol Biol Rev 64, 51–68 Robinson, W.S., Clayton, D.A & Greenman, R.L (1974) DNA of a human hepatitis < /b> B virus candidate J Virol 14, ... exact contribution of the mutations to the natural course of HBV infection remains to be elucidated, but the genetic variations of HBV are possibly related to the infidelity of the HBV polymerase ... mechanism of hepatitis < /b> B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC) J Virol 75, 4771–4779 Zoulim, F (1999) Therapy of chronic hepatitis < /b> B virus infection: inhibition of...

Ngày tải lên: 31/03/2014, 01:20

... transmission of major communicable diseases like Hepatitis < /b> B virus, Hepatitis < /b> C virus and Human Immunodeficiency Virus The seropositivity rate of Hepatitis < /b> B surface antigen (HBsAg) varies in the different ... specific bands in patients infected 2.5% agarose hepatitis < /b> B virus 2.5% agarose gel showing genotype specific bands in patients infected with hepatitis < /b> B virus M: 50 bp marker; Lane 2–3: HBV genotype ... of blood borne viruses such as hepatitis < /b> B and C, Ebola, Lassa virus infections and malaria [34] A simple mass-action model was applied to world census which showed that about 8– 16 million HBV,...

Ngày tải lên: 18/06/2014, 18:20

... number not for citation purposes) Virology Journal 2007, 4:74 http://www.virologyj.com/content/4/1/74 Table 1: Primer First PCR P1 S1-2 Second PCR Mix A B2 BA1R BB1R BC1R Mix B BD1 BE1 BF1 B2 R ... Serological markers Serologic markers for HBV (hepatitis < /b> B surface antigen [HBsAg], hepatitis < /b> Be antigen [HBeAg] and antibodies to hepatitis < /b> B core antigen [anti-HBc]) (enzyme immunoassay [EIA]; Adaltis, ... Leef SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO: Genetic Diversity of Hepatitis < /b> B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HBsAg Subtypes Intervirology 2004,...

Ngày tải lên: 18/06/2014, 18:20

... given by the manufacture 10 11 Abbreviations HBV, hepatitis < /b> B virus; HBsAg, hepatitis < /b> B surface antigen; HBpreSAg, hepatitis < /b> B pre-surface antigen; HBeAg, hepatitis < /b> B e antigen, anti-HBs, antibody ... Table 2: Comparisons of serological markers for HBV replication versus HBVDNA copies in serum specimens HBV DNA+ HBpreSAg+ HBpreSAgn = 149 HBeAg+ HBeAg- 48 23 HBV DNA+ 43 28 n=149 HBpreSAg+ HBpreSAgn=154 ... increase of HBpreSAg binding to polyclonal anti-preS (black circle) before HBsAg could bring any interference based on the absorbance measurements using recombinant S protein Thus when it is below 20...

Ngày tải lên: 18/06/2014, 18:20

... de Perre P, Cartoux M, Mandelbrot L, Dabis F: HBs antigen carrier state in pregnant women in Bobo Dioulasso (Burkina Faso)] Dakar Med 2000, 45:188-190 Simpore J, Ilboudo D, Samandoulougou A, Guardo ... Leone West Afr J Med 2005, 24:18-20 Ahmed SD, Cuevas LE, Brabin BJ, Kazembe P, Broadhead R, Verhoeff FH, Hart CA: Seroprevalence of hepatitis < /b> B and C and HIV in Malawian pregnant women J Infect 1998, ... and control of hepatitis < /b> C Report of a WHO Consultation organized in collaboration with the Viral Hepatitis < /b> Prevention Board, Antwerp, Belgium J Viral Hepat 1999, 6:35-47 Madhava V, Burgess C, Drucker...

Ngày tải lên: 18/06/2014, 18:20

... References HBSP A BH3 HBSP B BH3 HBSP C BH3 21 31 32 35 LEEELPRLADADLHR LEEELPRLADEDLNH LEEELPRLADEGLNR Figure Alignment of BH3 domains of HBSPs Alignment of BH3 domains of HBSPs Alignment of the BH3 ... characterization of hepatitis < /b> B virus surface antigen mutants in Singapore patients with hepatocellular carcinoma and hepatitis < /b> B virus carriers negative for HBsAg but positive for anti-HBs and anti-HBc J Gastroenterol ... 30 incubation http://www.virologyj.com/content/4/1/117 Western blot analysis HBSP polyclonal anti-serum was acquired by boosting rabbit using an internal HBSP peptide: CDLNLGQDQQQPVRD (Biogenes,...

Ngày tải lên: 18/06/2014, 18:20

... a novel hepatitis < /b> B virus x binding protein that inhibits viral replication J Virol 1998, 72:1737-1743 Lee TH, Elledge SJ, Butel JS: Hepatitis < /b> B virus X protein interacts with a probable cellular ... proteasome alpha-subunit Virus Genes 1995, 10:99-102 Hu Z, Zhang Z, Doo E, Coux O, Goldberg AL, Liang TJ: Hepatitis < /b> B virus X protein is both a substrate and potential inhibitor of the proteasome ... indicate negative interaction between bait and library Colonies remained white HBV infection to be traced via interactions with the HBX protein which had been implicated in HBV-related hepatocellular...

Ngày tải lên: 19/06/2014, 08:20

... HBsAg-negative chronic hepatitis < /b> The diagnosis of HBeAg-negative chronic hepatitis < /b> B is based on the presence of HBsAg for more than months, undetectable HBeAg, presence of anti-HBe, detectable ... develop antibody to HBsAg (anti-HBs) are diagnosed as having resolved hepatitis < /b> B [3,4] This is an uncommon phenomenon in chronic HBV infection During stage HBV DNA may still be detectable by PCR ... transplantation, HBV can be reactivated in patients with resolved hepatitis < /b> B [13] Clinical spectrum HBeAg positive Chronic Hepatitis < /b> Patients with HBeAg-positive chronic hepatitis < /b> B usually present...

Ngày tải lên: 19/06/2014, 08:20

... C b nh nhân nhi m HBV có ki u gen B+ C (p>0,05) 3.2.2.2 N ng N ng virus HBV virus c a b nh nhân khám i u tr t i s y t t nh k L k trình b y b ng 3.12 B ng 3.12 N ng virus c a b nh nhân nhi m HBV ... HBeAg c a b nh nhân khám i u tr t i s y t t nh k L k trình b y b ng 3.14 B ng 3.14 Kháng th anti HBeAg c a b nh nhân nhi m HBV t i KI U GEN Kháng th Anti HBeAg(+) Anti HBeAg (-) kL k P S BN B ... nhi m HBV ki u gen C b nh nhân nhi m HBV ki u gen B+ C (p>0,05) Trong ó s lư ng h ng c u c a b nh nhân nhi m HBV ki u gen B b nh nhân nhi m HBV ki u gen B+ C có s khác bi t (p

Ngày tải lên: 19/06/2014, 11:36

... transmission of major communicable diseases like Hepatitis < /b> B virus, Hepatitis < /b> C virus and Human Immunodeficiency Virus The seropositivity rate of Hepatitis < /b> B surface antigen (HBsAg) varies in the different ... specific bands in patients infected 2.5% agarose hepatitis < /b> B virus 2.5% agarose gel showing genotype specific bands in patients infected with hepatitis < /b> B virus M: 50 bp marker; Lane 2–3: HBV genotype ... of blood borne viruses such as hepatitis < /b> B and C, Ebola, Lassa virus infections and malaria [34] A simple mass-action model was applied to world census which showed that about 8– 16 million HBV,...

Ngày tải lên: 20/06/2014, 01:20