grb2 shc and gab1 adaptor proteins in colorectal cancer an open question
Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
Ngày tải lên :
03/10/2015, 20:57
... least seven proteins including, MLH1 and MSH2 The MLH1 and MSH2 protein are essential in the mismatch repair machinery and mutations in MLH1 and MSH2 have been implicated in HNPCC (Boland et al., ... our hypothesis in determining clinical significance of cancer stem-cell marks in colorectal cancer Our main objective is to understand the clinical value of cancer stem-cell markers and their relationship ... stemcell markers and its related proteins in colorectal cancers were investigated Tissue microarray analysis were combined with an automated image scanning v and analysis platform to examine the immunohistochemical...
- 116
- 277
- 0
Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding protein Targeting sequence Gelsolin Direct or indirect association ... protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ()) Cross-linking proteins Functions as scaffolds for signaling intermediates that stimulate actin elongation; ... members of the actin-binding LIM protein (ABLIM) family, ABLIM-2 and -3, as STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates...
- 17
- 573
- 0
Báo cáo khoa học: Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation pptx
Ngày tải lên :
23/03/2014, 06:20
... discuss the interplay between host and virus via their RS domain-containing proteins Virus-encoded SR proteins cutaneous and mucosal lesions, ranging from warts to neoplasia and even cancer [14] ... viral life cycle, including positive-strand and minus-strand DNA synthesis, pre-genomic RNA packaging, and virion formation and release [17,18] This core protein is a phosphoprotein, and its function ... phosphorylation can modulate protein–protein and protein–RNA interactions of SR proteins [1–5] Reversible phosphorylation of SR proteins is important for assembly and function of the spliceosome and for...
- 10
- 317
- 0
Báo cáo hóa học: " LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer" pptx
Ngày tải lên :
18/06/2014, 16:20
... statistical data analysis AJ and TK coordinated the study and were involved in drafting the manuscript and revised it critically All authors read and approved the final manuscript Competing interests ... surprising findings suggest that TCF4 might be the main binding partner for b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/bcatenin transcriptional ... exclusive in colorectal cancer In accordance with published literature we found nuclear b-catenin positivity in 75% of cases In contrast LEF-1 expression was found only in 26% and TCF4 in 46% of colorectal...
- 8
- 664
- 0
Báo cáo sinh học: "Protein kinase CK2a is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes" docx
Ngày tải lên :
18/06/2014, 19:20
... DW and LL helped in drafting the manuscript and contributed specific information and critical analysis throughout the manuscript All authors read and approved the final manuscript Competing interests ... activity can inhibit the expression of EMT-related genes, suggesting that an increase in CK2a protein or activity may facilitate EMT and thus plays an important role in colorectal cancer invasion ... The human colorectal cancer cell lines LoVo, SW480, HT29, HCT116 and LS174T were maintained in RPMI 1640 (Gibco, Grand Island, NY, USA) supplemented with 10% fetal bovine serum at 37°C in a 5%...
- 11
- 382
- 0
Báo cáo khoa học: "Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?" ppt
Ngày tải lên :
09/08/2014, 04:20
... apoptosis in colorectal cancer cell lines [13,14] In this study we investigated whether doxycycline works in synergy with cisplatin and oxaliplatin or not in HT 29 colorectal cancer cell line Methods ... with the findings obtained in caspase gene expressions Discussion Colorectal cancer constitutes the third most common cancer and the second leading cause of cancer deaths in UK About one in 20 men ... transcripts increased in the time dependent manner in the HT 29 colorectal cancer cells treated with cisplatin and oxaliplatin but caspase transcripts levels decreased in the time dependent manner...
- 8
- 252
- 0
báo cáo khoa học: " Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival" docx
Ngày tải lên :
11/08/2014, 12:21
... drafted the manuscript AN and TOR collected and contributed the clinical specimens and data RAL and RIS conceived and directed the project All authors participated in drafting the manuscript and have ... exon, and will be referred to as such herein The arrays were finally washed, stained and scanned according to the manufacturer’s protocol Data analysis Scanning of the microarrays and preprocessing ... and 4.3 years after surgical removal of their primary tumor Validation of TIN in an independent series of stage II and III colorectal cancers Transcriptome instability was tested also in an independent...
- 13
- 283
- 0
Báo cáo y học: "Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption" pptx
Ngày tải lên :
13/08/2014, 13:20
... as an interface between the egg and sperm, and secondly as an interface between the embryo and its environment [35] The egg envelope is a major structural determinant of the eggshell in fish, and ... Hepatocyte Hsp 90 ER Hsp 90 ER ER Vtg and Zr protein ERE Vtg and Zrp genes Secretion of Vtg and Zr protein Vtg and Zrp mRNA Transport to ovary and incorporation into oocytes Figure Simplified diagram ... Sullivan CV and Hara A Identification and characterization of proteases involved in specific proteolysis of vitellogenin and yolk proteins in salmonids J Exp Zool 2002, 292:11-25 Colborn T and...
- 21
- 370
- 0
Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
Ngày tải lên :
09/09/2015, 11:25
... 10% of all cancer incidence and mortality in 20132 Consistent with trends in developed countries, CRC is the most frequent cancer in Singapore, accounting for 14% to 18% of all cancer incidence ... soon detected in a range of cancerous and disease conditions as shown in Table 1-1 Table 1-1: STMN1 up-regulation in cancer and disease Representative publications between 1988 and 2013 First ... up-regulation in CRC is shaded grey Cancer/ Disease Publication Leukemia Adenoid cystic carcinoma (salivary glands) Breast cancer Ovarian cancer Oral squamous-cell carcinoma Prostate cancer Medulloblastoma...
- 175
- 634
- 0
The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
Ngày tải lên :
14/09/2015, 14:25
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain such ... experiments and detailed guidance in scientific writing Dr Ling Chin Hwang provided great support in alignment of the optical system and helped in mathematic analysis Dr Sudhaharan Thankiah and Miss ... structures on native cell membrane, and ligand binding induces conformational changes of the transmembrane and cytoplasmic domains of the receptor instead of inducing receptor dimerization, then...
- 173
- 360
- 0
Sterol rich membrane domains and membrane associated proteins in the fission yeast schizosaccharomyces pombe
Ngày tải lên :
15/09/2015, 17:09
... mutant cells form actomyosin rings during metaphase and anaphase 66 5.2 cdc15 mutant cells maintain stable actomyosin rings in metaphase 69 5.3 Mid1p is required for actomyosin ring maintenance ... formin Cdc12p in a medial spot and in the actomyosin ring, and these two proteins exhibit direct interaction (Carnahan and Gould, 2003) Cdc15p has also been shown to organise sterol-rich membrane ... protein linking the ring to the membrane (i.e transmembrane or lipid/GPI-anchored protein which interacts with components of the actomyosin ring; mutants exhibit phenotypes in ring assembly, maintenance...
- 186
- 262
- 0
Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
Ngày tải lên :
07/03/2014, 15:20
... sequence can interfere with CREB binding, and specifically inhibit PKA subunit expression, interfering with the CRE-PKA pathway [17] This causes specific inhibition of growth in cancer cells, and although ... Apoptosis, growth arrest and suppression of invasiveness by CRE-decoy oligonucleotide in ovarian cancer cells: protein kinase A downregulation and cytoplasmic export of CREbinding proteins Mol Cell Biochem ... bovine serum HCT116 and GEO cell lines were both wild-type p53, and SW620 lines were mutant p53 No antibiotics were used in our experiments, and all cell lines were incubated in a humidified atmosphere...
- 9
- 331
- 0
Báo cáo sinh học: "A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" ppt
Ngày tải lên :
18/06/2014, 19:20
... Lieberman D: Progress and challenges in colorectal cancer screening and surveillance Gastroenterology 2010, 138:2115-2126 Kim MS, Lee J, Sidransky D: DNA methylation markers in colorectal cancer Cancer ... participated in discussion, and CC Chien helped in the analyses of the experiments SHY, SMH and CJH worked on the manuscript, and SHY and CJH also provided grant support for this study All authors read and ... study and carried out the molecular analyses YCC and HHW performed the qRT-PCR, statistical analyses, and RNAi and overexpression of target gene, flow cytometry and immuno-analyses CML and CLL...
- 8
- 357
- 0
báo cáo hóa học:" A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" doc
Ngày tải lên :
20/06/2014, 03:20
... Lieberman D: Progress and challenges in colorectal cancer screening and surveillance Gastroenterology 2010, 138:2115-2126 Kim MS, Lee J, Sidransky D: DNA methylation markers in colorectal cancer Cancer ... participated in discussion, and CC Chien helped in the analyses of the experiments SHY, SMH and CJH worked on the manuscript, and SHY and CJH also provided grant support for this study All authors read and ... study and carried out the molecular analyses YCC and HHW performed the qRT-PCR, statistical analyses, and RNAi and overexpression of target gene, flow cytometry and immuno-analyses CML and CLL...
- 8
- 356
- 0
Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
Ngày tải lên :
08/08/2014, 16:23
... other diseases, and extending survival in cancer survivors Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer survivors and that this effect ... few in number, however, and of limited quality Further research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer ... Health-Related Quality of Life Atlanta, GA: USCenters for Disease Control and Prevention 2000:1–44 23 American Cancer Society Cancer Facts and Figures Atlanta, GA: American Cancer Society; 2001 24 Hortobagyi...
- 5
- 403
- 0
báo cáo khoa học: "Adenovirus-mediated siRNA targeting Bcl-xL inhibits proliferation, reduces invasion and enhances radiosensitivity of human colorectal cancer cells" ppt
Ngày tải lên :
09/08/2014, 02:21
... and protein were obviously higher in human CRC cell lines than in human intestinal epithelial cell line (Figure.1A and B) Among CRC cell lines, the expression levels of Bcl-xL mRNA and protein ... diagnosed cancer around the world and the incidence of CRC in China is lower than that in the west countries, but has increased in recent years and become a substantial cancer burden in China, particularly ... activity and this advantage could be created by inducing resistance to apoptosis against cytokines, increasing cell survival in 12 circulation, and enhancing anchorage-independent growth [22] Meanwhile,...
- 27
- 385
- 0
Báo cáo khoa học: "Postmastectomy locoregional recurrence and recurrence-free survival in breast cancer patients" pdf
Ngày tải lên :
09/08/2014, 03:21
... 2005 CA Cancer J Clin 2005, 55(1):10-30 American Cancer Society: Cancer Facts & Figures 2004 Atlanta, GA, American Cancer Society; 2004 Cady B, Stone MD, Schuler JG, Thakur R, Wanner MA, Lavin PT: ... within 2.5 years (P\0.001) [32] In the BIG 1-98 trial, significant predictors of early recurrence in multivariate analysis also included tumor size and grade and node positivity [33] and in the ... contraceptives and prognosis in breast cancer: effects of duration, latency, recency, age at first use and relation to parity and body mass Page of 39 40 41 42 index in young women with breast cancer...
- 7
- 401
- 0
Báo cáo khoa học: "Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report" pdf
Ngày tải lên :
09/08/2014, 04:21
... with liver dominant hepatic metastasis after ingDisease Free Survival failing standardSurvival ofIrinotecan drug elutingIrinotecan drug eluting beads with liver dominant faila) standard a) Disease ... data, or analysis and interpretation of data, involved in drafting the manuscript or revising it critically for important intellectual content RP have been involved in drafting the manuscript ... Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 2000, 92:205-216 Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni...
- 12
- 404
- 0
Báo cáo khoa học: "Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer" ppsx
Ngày tải lên :
09/08/2014, 07:21
... categories: pT < and pT > Presence of mucorrhea and anismus, hematocrit value ranging between 16,7% and 31%, WBC count between 4500 and 5800/mm3 and fibrinogen value > 400 mg/dl were significantly related ... carcinoma treated with resection only Cancer 1996, 78:403-8 National Cooperative Group on Pathology and Prognosis of colorectal cancer: Pathology and prognosis of colorectal cancer in Chinese ... 16,7 and 31% and WBC count ranging between 4500 and 5800/mm3 were significantly associated to pT > Further fibrinogen value > 400 mg/dl both on univariate and multivariate analysis was significantly...
- 7
- 452
- 0