genetics and biochemistry of mycotoxin synthesis
Báo cáo Y học: The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus pot
Ngày tải lên :
31/03/2014, 21:21
... inhibitors of other RTs such as that of HIV [12] In the present study we have extended the investigation of BLV RT by an in vitro analysis of the processivity and the fidelity of DNA synthesis ... the ability of BLV RT to misincorporate nucleotides at the 3¢ end of the growing DNA strand and the further extending of the preformed mismatches) MATERIALS AND METHODS Recombinant RTs and DNA polymerase ... (depending on activity) and Ó FEBS 2002 Processivity and fidelity of BLV RT (Eur J Biochem 269) 861 Table Quantitative analysis of DNA primer-extension and relative processivity of DNA synthesis The radioactivity...
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kumar - molecular genetics and breeding of forest trees (haworth, 2004)
Ngày tải lên :
03/04/2014, 12:10
... molecular genetics such as functional genomics, ESTs, and SSRs, and the profound case studies addressing temperate and tropical trees.” Prof Dr Reiner Finkeldey Chair of Forest Genetics and Forest ... Highlights of the book include a description of the EST databases of Genesis Research and Development Corporation, Ltd., in New Zealand; an excellent review of the state of knowledge of lignin ... quality and productivity of forests, which has been spread through a diverse array of journals and periodicals in need of consolidation for educational and reference material Molecular Genetics and...
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the genetics and biology of sex determination - novartis foundation
Ngày tải lên :
08/04/2014, 13:09
... Zarkower Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street, SE, Minneapolis, MN 55455, USA The Genetics and Biology of Sex Determination: ... Chadwick and Jamie Goode Copyright Novartis Foundation 2002 ISBN: 0-470-84346-2 An introduction to the genetics and biology of sex determination Roger V Short Department of Obstetrics and Gynaecology, ... expression of other genes, such as Amh, and led to the repression of Sry and Dax1 The di¡erentiating Sertoli cells also produce signals responsible for the migration of peritubular myoid and endothelial...
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GENETICS AND ETIOLOGY OF DOWN SYNDROME pdf
Ngày tải lên :
28/06/2014, 05:20
... after QFQ-staining are diagnosed in 2.0 % of band p11.2 and 10.0 % of band p13 Duplications in p12 show a frequency of 0.7-1.3 % and 0.1 % in the satellites of p13 Deletions in all three regions ... order of size and of the position of the centromere According to the type of induced banding pattern, two subtypes can be defined: a) those resulting in bands distributed along the length of the ... heterochromatic but consists of different types of repetitive DNA (Figure 1)(Wyandt and Tonk, 2004) The relative length of the short arm of chromosome 21 comprises 30 % of its total length (Figure...
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GENETICS AND PATHOPHYSIOLOGY OF ESSENTIAL HYPERTENSION doc
Ngày tải lên :
28/06/2014, 15:20
... pathophysiology, genetics and genomics of hypertension This book is divided into two main sections: Pathophysiology, and Genetics and Genomics In pathophysiology, topics such as pathophysiology of resistant ... mitochondrial mutations and pharmacogenetics of hypertension A chapter on microarray technology details the technique and identifies expression of altered genes Role of TGF-β and other inflammatory ... the incidence of ischemic disease of the heart, heart failure, brain attack, and the incidence of lethal attacks It is necessary to understand the regulation of blood pressure and especially...
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Báo cáo y học: " Advances in the genetics and epigenetics of gene regulation and human disease" pps
Ngày tải lên :
14/08/2014, 17:22
... generations of offspring He and his colleagues postulate that maternal nutrition before and during pregnancy may affect the establishment of CpG methylation and the life-long expression of metastable ... analysis of genes that are involved in cell-cycle control and cell-size regulation in Drosophila Using flow cytometry, Björklund and colleagues analyzed the RNAi-induced loss -of- function of 70% of ... specificities and the assembly of their binding sites to form tissuespecific enhancer elements is critical for understanding key regulatory mechanisms of human gene expression Outi Hallikas (University of...
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The Art and Science of Total Synthesis
Ngày tải lên :
26/08/2016, 11:15
... point of view, but also in that the total synthesis of each molecule reflects the limits of the power of the art and science of organic synthesis at the time of the accomplishment One of the ... careers of not only his students, but also of his peers and colleagues, for example, J Wilkinson (sandwich structure of ferrocene), K Block (steroid biosynthesis), R Hoffmann (Woodward and Hoffmann ... outstanding contributions to organic synthesis At the dawn of the twenty-first century, the state of the art and science of total synthesis is as healthy and vigorous as ever The birth of this...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
Ngày tải lên :
20/02/2014, 01:20
... 341 nt of the 3¢-end of the HCV minus-strand RNA in vitro and that deletion of the 3¢ 45 nt greatly impaired RNA synthesis [17] Oh et al [18] showed that RNA synthesis from the HCV minus-strand ... basis of the structure of the 5¢UTR of the plus-RNA, the structure of the 3¢-end of the minusstrand RNA being at that time unavailable In the present study we investigated the involvement of sequences ... sequences and ⁄ or structures in RNA synthesis directed in vitro by HCV NS5B by using new mutants of the 3¢-end of minus-strand RNA Results Effect of mutations in the 3¢- or the 5¢-end of the (–)IRES...
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![Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc](https://media.store123doc.com/images/document/14/br/vp/medium_vpv1392870032.jpg)
Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc
Ngày tải lên :
20/02/2014, 11:20
... potential, and addition of a TPP-moiety has been used to drive the selective uptake of a wide variety of Ó FEBS 2003 Fig Selective uptake of mitoDC-81 by mitochondria and subsequent alkylation of mtDNA ... mitochondria and cells In addition to facilitating the development of antigenomic therapies, such a reagent might also be useful in investigating the rate of turnover of mtDNA and in the derivation of ... the vicinity of mtDNA with the resultant binding and selective alkylation leading to a depletion of mtDNA in intact cells (Fig 1) Here we report the synthesis and characterization of a novel mitochondria-targeted...
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Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx
Ngày tải lên :
22/02/2014, 04:20
... chloroform and upper aqueous phases In the absence of CMP and in both +PIS and –PIS strains, a release of label in the aqueous phase was observed after incubation To calculate the liberation of ... concentrations of manganese chloride and varying amounts of EDTA appear on the y axis just above a maximum activity of 2.0 nmol PtdInsÆmg)1Æmin)1 between 2.5 and mM EDTA At 10 mM, synthesis decreased ... the same plot of the values found for de novo synthesis in the presence of 7.5 or 2.5 mM MnCl2 with various amounts of EDTA, or in the presence of MnCl2 only [11], as a function of the concentration...
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Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx
Ngày tải lên :
07/03/2014, 01:20
... activity of RP mRNA for adjustment of the biosynthesis of ribosomes to the requirements of cell growth and differentiation In addition, a relevant contribution of protein turnover to the regulation of ... ribosome pathologies have had in our understanding of regulatory mechanisms of RP synthesis Translational regulation of RP synthesis Sequence comparison of some vertebrate RP genes cloned in the ... mechanism of DBA in cultured cells showed that alteration of any of the involved RPs can affect the maturation of rRNA [72] Moreover, investigations on the effect of mutations on the synthesis of RPS19...
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Báo cáo khoa học: Synthesis and characterization of a new and radiolabeled high-affinity substrate for H+/peptide cotransporters pdf
Ngày tải lên :
07/03/2014, 05:20
... parameters and transport characteristics of Bip-[3H]Pro Results and Discussion Synthesis, chemical characterization and stability of Bip-Pro Figure shows the structure (Fig 1A) and the synthesis ... cells and 10 and 100 lm in SKPT cells) in the presence of increasing concentrations of Bip-Pro (0– 100 lm and 0–50 lm, respectively) The results are Fig Interaction of Bip-Pro with PEPT1 and PEPT2 ... concentrations and at increasing Bip-Pro concentrations The diffusional component of [14C]Gly-Sar uptake, of 8% in Caco-2 cells and of 4% in SKPT cells, measured in the presence of excess of Gly-Sar...
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Báo cáo khoa học: Characterization of the tRNA and ribosome-dependent pppGpp-synthesis by recombinant stringent factor from Escherichia coli pot
Ngày tải lên :
07/03/2014, 16:20
... concomitant release of tRNA [5] The activity of SF was found to increase threefold in the presence of TC ribosomes (Fig 4, lane 2; 450 pmol pppGppÆpmol SF)1Æmin)1) and twofold in the presence of reassociated ... appears that extensive purification of ribosomes impairs the tRNA-binding and pppGpp synthesis stimulating activity of ribosomes Template-dependence of pppGpp -synthesis Table shows that if SF is ... formed with twofold excess (A, C, D, E) or equimolar amounts of tRNAMet (B) before addition of threefold excess f of tRNAPhe (D, E) DMS (A, B, E) and kethoxal (C, D) modifications and primer extensions...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
Ngày tải lên :
08/03/2014, 09:20
... [1-14C]AA-CoA in the presence of the purified enzyme resulted in the release of AA Km and Vmax values obtained for the reactions were 4.1 and lM and 948 and 193 nmolÆmin)1Æmg)1 for CTE-I and a MTE-I, respectively ... Combined effect of triacsin C and NDGA on steroid hormone synthesis Y1 cells were preincubated in the presence or the absence of increasing concentrations of triacsin C (4 h, 37 °C) and of NDGA (15 ... effect of NDGA and triacsin C, an inhibitor of the AA-CoA synthetase Our results are consistent with the involvement of an acyl-CoA synthetase and an acyl-CoA thioesterase as important regulators of...
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Synthesis and Application of Nanosize Semiconductors for Photoxidation of Toxic Organic Chemicals pptx
Ngày tải lên :
14/03/2014, 20:20
... in both dispersed and heterogeneous forms (supported) tsnl Advantanges of this Approach•The light absorption and energy levels of the semiconductor valence and conduction bands can be adjusted ... photostability and low toxicity can be selected (e.g MoS2) •Our synthesis allows easy chemical modification of the nanocluster surface properties (e.g deposition of a metal) •Small size of nanocluster ... Treatment of large volumes of highly diluted toxins 3) Cost of treatment tsnl Possible Treatment ApproachesStep 1: Excavation, Soil Washing Conventional Treatment Options: 1)Filtration and/ or Adsorption...
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Báo cáo khoa học: The occurrence of riboflavin kinase and FAD synthetase ensures FAD synthesis in tobacco mitochondria and maintenance of cellular redox status docx
Ngày tải lên :
16/03/2014, 04:20
... (B) Dependence of the rate of FMN synthesis on Rf concentrations (C,D) Time courses of FAD synthesis and Rf appearance after addition of either lM or 50 lM FMN Values are the mean of three replicates ... mitochondrial and the extramitochondrial amounts of Rf, FMN and FAD in the acid-extractable fractions were measured via HPLC and compared to the amounts of avin cofactors in whole protoplasts and plastids ... proteinligand, proteinprotein and proteinsurface interaction: development of integrated experimental and computational approaches to the study of systems of pharmaceutical interest and from `...
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Synthesis and characterization of silicon nanowires using tin catalyst for solar cells application
Ngày tải lên :
16/03/2014, 15:12
... morphological property of SiNWs, a FE-SEM observation was carried out after synthesis of SiNWs Fig 1(b) shows the topview (15° tilted) and cross-section (see inset of Fig 1(b)) FE-SEM images of the SiNWs ... at λ b 700 nm [20] The difference of the reflectance might be the effect of synthesis conditions, such as thickness of metal film and SiH4 gas flow The reduction of reflectance is very helpful to ... Therefore, further reduction of the reflectance will be expected from the optimization of the synthesis conditions of SiNWs For analysis of the electrical properties, the I–V curve of the fabricated SiNWs...
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Synthesis and characterization of semiconducting nanowires for gas sensing
Ngày tải lên :
16/03/2014, 15:25
... investigation of the termination of the nanowire lateral sides and apex Electron diffraction (ED) and analysis of zero-order and higher-order Laue-zones allows precise determination of unit cell and space ... nanowire, (d) STEM-HAADF image of a nanowire, and (e) linescan of the HAADF signal (solid line) and numerical fit of the shape of the nanowire (dashed line) As both composition and phase can be considered ... effect is fast (time scale order of seconds) and fully reversible The amplitude of quenching achieves its maximum at room temperature and the influence of humidity and other reducing gases is negligible...
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Báo cáo khoa học: Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels doc
Ngày tải lên :
17/03/2014, 10:20
... sidechains of Glu332 of each rat Kv1.2 a-subunit (Kv1.2 channel is composed of four a-subunits) and Arg10, Arg19, Lys30 and Lys33 of Pi4 The Lys26 sidechain of Pi4 enters into the ion channel pore and ... binding of [125I]apamin without any other ligand, and B is the binding in the presence of the indicated concentrations of competitor Abscissa axis is the logarithm of the molar concentration of competitor ... atoms of the P-domain selectivity filter Residue Tyr35 of Pi4 is involved in a hydrophobic cluster of aromatic residues consisting of Trp344, from one of the four Kv1.2 a-subunits, and Trp345 and...
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