genetic predisposition to coronary heart disease

... Packard CJ, Ehrenborg E. Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Int ... Conclusions To address the question whether the +T294C polymorphism in PPARδ is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we investigated this genetic ... CM, Gotto AM, Marian AJ. Effects of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary...

Ngày tải lên: 31/10/2012, 17:03

... Garry Editors Coronary Heart Disease Clinical, Pathological, Imaging, and Molecular Profiles 151 Anatomy of Coronary Vessels septum is supplied by branches arising from both the right coronary ... the heart tube to contribute to the connective tissue of the myocardium and epicardium and give rise to the coronary arteries [ 6, 7 ] . Chapter 2 Cardiac Development and Congenital Heart Disease ... second heart field onto the outflow tract. This process is regulated by global cardiac transcription factors including Nkx2-5 , Gata4 , and transcription factors specific to the second heart...

Ngày tải lên: 12/05/2014, 17:13

... exploratory factor analysis should be used to determine the original factor structure of an instrument, and confirmatory factor analysis used to determine how well an a priori-defined factor structure fits ... literature to see exploratory factor analysis used to investigate the factor structure of an instrument that has previously been investigated using exploratory factor analysis. Consequently, exploratory ... (HADS) is a widely used screening tool designed as a case detector for clinically relevant anxiety and depression. Recent studies of the HADS in coronary heart disease (CHD) patients in European...

Ngày tải lên: 20/06/2014, 15:20

... completed prior to intervention and 1, 3, 6 and 12 months post-intervention in a study enrolling 561 patients with symptomatic coronary stenosis. Patients were randomized to off-pump coronary artery ... the OctoStent off-pump CABG group; changes in the Octopump groups are comparable to this group and therefore omitted from the table Histogram of baseline EQ-5D and SF-6D scoresFigure 2 Histogram ... symptomatic coronary sten- osis. Methods We included patients with symptomatic coronary stenosis enrolled in two multicenter randomized controlled trials assessing the efficacy of the Octopus...

Ngày tải lên: 20/06/2014, 15:20

... patients have roughly correspond to their dis- ease severity, so it was important to take the disease stage into account when trying to map from disease specific variables to the EQ-5D index. Several ... Mapping models may need to be derived sepa- rately for different disease groups, since the most effec- tive predictors may vary between diseases. Also, mapping models need to incorporate variables ... groups, including those with coronary heart disease. Studies often require patients to complete many questionnaires and the EQ-5D may not be gathered. This study aimed to assess whether demographic...

Ngày tải lên: 20/06/2014, 16:20

... associated with coronary heart disease. 9,10 However, unlike previous investigators, we used an- giographically diagnosed coronary artery disease to define existing coronary heart disease. Patients ... mortality in stable coronary disease 671 end-diastolic pressure, and were more likely to have a history of myocardial infarction, clinically signifi- cant coronary artery disease, and diabetes; ... findings (%) <0.001 No coronary artery disease 31 19 14 16 1-Vessel disease 28 21 13 18 2-Vessel disease 19 24 23 19 3-Vessel disease 15 26 40 36 Left main coronary artery disease 7 10 10 11 LVEF...

Ngày tải lên: 27/06/2014, 00:20

... (<22.0, 22.0 to 22.9, 23.0 to 23.9, 24.0 to 24.9, 25.0 to 27.9, 28.0 to 29.9, 30.0 to 31.9, 32.0 to 33.9, 34.0 to 39.9, or ≥40.0), smoking status (never, past, or current [1 to 14, 15 to 24, or ... risk of coro- nary heart disease must take each macronutrient into consideration. Different types of fat appear to have different effects on the risk of coronary heart disease. In epidemiologic ... the U.S. Postal Service. 21 Fatal coronary heart disease was con- firmed by an examination of autopsy or hospital records, by a listing of coronary heart disease as the cause of death on the...

Ngày tải lên: 27/06/2014, 00:20

... Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women n engl j med 351;25 www.nejm.org december 16, 2004 inflammatory markers and the risk of coronary heart disease ... the role of inflammatory markers in coronary heart disease, we used an etiologic approach in our main analyses, to take into account the pathophysiology of coro- nary heart disease and include ... www.nejm.org december 16, 2004 inflammatory markers and the risk of coronary heart disease in men and women 2607 the risk of coronary heart disease and that the risks were attenuated...

Ngày tải lên: 27/06/2014, 00:20

Ngày tải lên: 13/07/2014, 22:20

Ngày tải lên: 27/07/2014, 11:20

Ngày tải lên: 11/08/2014, 12:20

Ngày tải lên: 12/08/2014, 04:21

Ngày tải lên: 12/08/2014, 20:20

... Medical genetics—Methodology. 3. Genomics. I. Khoury, Muin J. [DNLM: 1. Genetics, Medical—methods. 2. Genetic Diseases, Inborn—epidemiology. 3. Genetic Predisposition to Disease epidemiology. 4. Genetic ... point that is central to the search for moderate- to high-frequency low- penetrance variants associated with human diseases and traits (12). Efforts to replicate are necessary to guard against the ... data to validate gene discoveries for clinical and population-level applications, especially given the modest associations between genetic factors and disease burden; (c) commitments to evidence-based...

Ngày tải lên: 11/06/2014, 10:43