genetic insight into impaired immunity and disease
Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
Ngày tải lên :
21/02/2014, 15:20
... and jcasein ROA bands are therefore assigned to PPII structure The positive ROA bands in b- and j-casein at » 1290± 1295 cm)1 may originate in other types of loops and turns A negative ROA band ... Parkinson's disease and several other neurodegenerative diseases [25,26] This is similar to the case for tau protein, which forms the ®laments found in neuronal inclusions in Alzheimer's and other ... backscattered Raman and ROA spectra of disordered poly(L-glutamic acid) (top pair) and poly(L-lysine) (middle pair) in aqueous solution at pH 3.0 and 12.6, respectively, and of native human lysozyme...
- 9
- 667
- 0
Báo cáo khoa học: Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III ppt
Ngày tải lên :
23/03/2014, 05:22
... vitro, and we provided a direct comparison of the biochemical and pharmacological profiles of GCPII and GCPIII Although we observed differences in pH and salt concentration dependence and noted ... hinged by Asn540 ⁄ Trp541 and Gly548 at its N- and C-terminus, respectively, and the transition between open and closed conformations appears to depend on the presence of a ligand molecule in the substrate-binding ... consisting of seven b-strands flanked by eleven a-helices The apical domain (or the protease associated domain) is inserted into the protease domain and features a (3 + 4)stranded b-sandwich flanked by...
- 15
- 355
- 0
báo cáo khoa học: " Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility" pdf
Ngày tải lên :
11/08/2014, 12:20
... ribosomes and translation Figure Schematic representation of the detection of cis- and transregulatory variants and the type of polymorphisms involved in gene expression eQTL mapping and expression ... rSNPs affect transcription, and srSNP (structural RNA SNPs) affect RNA processing and translation genetic risk of complex disorders To evaluate the potential of ‘expression genetics’, we must account ... transcription, mRNA processing, and trans lation; and we must ask what we can learn from AE assays at individual SNPs and what the limitations of this approach are Regulatory variants and the complexity...
- 4
- 133
- 0
báo cáo khoa học: " New insight into the structures and formation of anthocyanic vacuolar inclusions in flower petals" potx
Ngày tải lên :
12/08/2014, 05:20
... in lisianthus petals Both SEM and light microscopy observations of isolated and in planta AVIs showed a rough and grainy surface comprised of strand-, granule- and sheet-like structures, suggestive ... experiments and therefore was used to briefly remove water from the AVI preparations prior to SEM The physical nature of the AVIs was a loose and porous body consisting of irregular granules, strands and ... resembling a coral reef (Fig 3F and 3G), with rough granular or sandy surfaces Internal structures and formation of AVIs To elucidate the internal structures of AVIs, light and TEM examinations were...
- 14
- 260
- 0
Báo cáo y học: "Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae" ppt
Ngày tải lên :
14/08/2014, 08:21
... YYO, TM and RAD designed the study; YYO, ND and SC carried out the experiments; YYO and HP performed data processing and statistical analysis; DB and SM created the GO database; YYO, TM and RAD ... MGG_06794.5, MGG_03640.5 and MGG_03843.5, which share close homology with toxin efflux pumps and multidrug transporters as well as MGG_07062.5 and MGG_09827.5, and MGG_04511.5 and MGG_00275.5, which ... (hydrophobic) and non-inducing (hydrophilic) surface of GelBond (Cambrex Bio Science Inc., Rockland, ME, USA) at 6.25 × 104 spores/cm2 and incubated at 25°C in the dark and for and 12 h By h,...
- 24
- 255
- 0
An insight into chemical kinetics and turbulence chemistry interaction modeling in flameless combustion
Ngày tải lên :
09/09/2015, 10:06
... volume and τ ∗ is the time scale for mass transfer between fine structure and ∗ surrounding fluid C D1 and C D2 are the model constants set equal to 0.134 and 0.5 leading to fine structure volume and ... temperature and major species, and those of predicted with KEE, DRM-22 and JL kinetic mechanisms for HM1 and HM3 flames Figure Comparison between profiles of experimental minor specie CO and predicted ... International Journal of Energy and Environment (IJEE), Volume 6, Issue 4, 2015, pp.383-390 Figure Comparison between profiles of experimental temperature and major and minor species, and those predicted...
- 8
- 314
- 0
PURIFICATION AND CATALYTIC REFORMING OF METHANE a NEW INSIGHT INTO CARBON ADSORBENT AND MEIC MEMBRANE REACTOR
Ngày tải lên :
09/09/2015, 10:13
... CGO and CGO60-LBFZ40 95 Figure 5.3 XRD patterns of LBFZ, YSZ and YSZ60-LBFZ40 96 Figure 5.4 TPR profiles of LBFZ, CGO60-LBFZ40 and YSZ60-LBFZ40 98 Figure 5.5 XRD patterns of LBFZ, CGO60-LBFZ40 and ... functional groups on final porous structure and surface properties during carbonization process, by which getting insight into the carbonization chemistry and mechanism of mesopore formation (2) ... porous AC and preparation methods of mesoporous AC, and mixed conductive ceramic membrane including the background of mixed conduction, mechanism of oxygen separation, POM into syngas and recent...
- 188
- 374
- 0
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
Ngày tải lên :
11/09/2015, 09:06
... total FLT3 receptor and multi-drug resistant related proteins (LRP, MRP1 and MDR) among the parental MV-11 and resistant lines R1, R2 and R3 induicate MV4-11-R1, MV4-11-R2 and MV4-11-R3 respectively ... cell cycle arrest and apoptosis caused by ABT-869 as a single agent and the potential mechanism of synergism with the cytotoxic agents Ara-C and Dox in vitro and in vivo Materials and methods 1.2.1 ... ABT-869 treatment in MV4-11 and MOLM-14 cells MV4-11 and MOLM-14 cells were exposed with ABT-869 nM and nM respectively for 0, 1, 4, and 16 hours, then washed, lysed and subjected to 12% SDS-PAGE...
- 121
- 368
- 0
Báo cáo khoa học: Degradation of chitosans with chitinase B from Serratia marcescens Production of chito-oligosaccharides and insight into enzyme processivity docx
Ngày tải lên :
07/03/2014, 16:20
... a DP of 3.04 and a FA of 0.44, and was concluded to consist mainly of DDA and DAA, in addition to minor amounts of ADA The tetramer fraction showed a DP of 4.1 and a FA of 0.33 and the dominant ... found that chitosans with full water-solubility and known random distribution of A- and D-units are useful substrates for obtaining deeper insight into the mode of action of ChiB, including its ... further insight into the chemical composition of the oligomers, we isolated several fractions 541 Degradation of chitosans with ChiB A Sứrbotten et al obtained at a ẳ 0.11 and a ẳ 0.37, and analyzed...
- 12
- 474
- 0
Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx
Ngày tải lên :
16/03/2014, 14:20
... subsites )1 and )2, the substrate conformations and interactions with the enzyme are very similar between D356N ⁄ P2 and D356N ⁄ E396Q ⁄ G6 In both structures, the O2 and O3 atoms of Glc–2 and Glc–1 ... collection, and structure determination The substrates of P2 and P5 were synthesized and purified as reported [21] D356N and D356N ⁄ E396Q were purified in the same way as wild-type TVAI [22], and confirmed ... mimic of the enzyme ⁄ product complex Because a-(1,4) and a-(1,6) glycosidic link- ages are found between Glc–1 and Glc–2, and between Glc–2 and Glc–3, respectively, the mode of binding found in...
- 9
- 342
- 0
Báo cáo khóa học: Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide doc
Ngày tải lên :
16/03/2014, 16:20
... times of and were 11.5 and 12.7 min, respectively, and those of the corresponding nitration products, 3-(4-hydroxy-3-nitrophenyl)-propionic acid and 4-hydroxy-3-nitrobenzonitrile, were 13.9 and 15.7 ... latter reaction competes with phenol nitration and gives rise to the dimeric and oligomeric phenol coupling products shown Materials and methods Materials and instrumentation Bovine lactoperoxidase ... 6.8) in 20 min, from 25 35% in 60 and from 35100% of buffer B in 20 min, and monitored at 280 and 412 nm The lactoperoxidase containing peak was manually collected and the homogeneity of the protein...
- 12
- 414
- 0
Báo cáo khoa học: Hodgkin Reed–Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo Novel insight into the inflammatory features of classical Hodgkin lymphoma ppt
Ngày tải lên :
30/03/2014, 04:20
... LTD4 and LTE4 and these mediators are potent proinflammatory mediators and bronchoconstrictors [7] There are two forms of 15-LO, named type and [6,8] It has been shown that patients with asthma and ... and 72 °C for b2-microglobulin was run for 24 cycles and 15-LO-1 and 15-LO-2 for 34 cycles Translocation assay and western blot L1236 cells were washed twice in NaCl ⁄ Pi without Ca2+ ⁄ Mg2 +and ... temperature was 375 °C and sheath and auxiliary gas was optimal at 60 and arbitrary units, respectively Skimmer offset was at 10 V and tube lens was 99 V MS ⁄ MS product ions of 626, 497 and 440 m ⁄ z,...
- 13
- 350
- 0
Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues Edited by Laura Sterian Ward pdf
Ngày tải lên :
30/03/2014, 23:20
... monoiodothyronine, and diiodothyronine Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues 4th stage is the coupling and T3 and T4 are synthesized from MIT and DIT (Figure ... The thyroid gland anatomy Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues gland is wrapped up by a fibrosis capsule named thyroid The thyroid gland is nourished ... Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues, Edited by Laura Sterian Ward p cm ISBN 978-953-51-0221-2 Contents Preface IX Part Evaluating the Thyroid Gland and...
- 330
- 345
- 0
PERIPHERAL NEUROPATHY - A NEW INSIGHT INTO THE MECHANISM, EVALUATION AND MANAGEMENT OF A COMPLEX DISORDER doc
Ngày tải lên :
30/03/2014, 23:20
... perception of vibration and light touch Both low and high threshold afferents are pseudounipolar neurons of the Peripheral Neuropathy - A New Insight into the Mechanism, Evaluation and Management of ... review see [21] 17 18 Peripheral Neuropathy - A New Insight into the Mechanism, Evaluation and Management of a Complex Disorder 17 Genetic and environmental determinants of pain susceptibility ... galactosemic lens and nerves often manifest functional and structural lesions resulting from acute and exaggerated galactitol intoxication that differ from those of diabetic cataract and neuropathy...
- 172
- 396
- 0
Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
Ngày tải lên :
31/03/2014, 07:20
... convergence ensured throughout Ligand structures were divided into fragments and reconstructed stepwise within the active site using FLEXX As alternative placements of the ligand fragments are possible, ... Modeled ligand–protein complexes of PAH and TH (Eur J Biochem 270) 1067 energies The total electric charge was +6 for 5pah and )16 for 2toh, as 2toh comprises the catalytic core domain and the tetramerization ... substrates and the active site iron, the maximal distance dTyr-Fe or dPhe-Fe between the center of the ring and ˚ the iron atom was defined as 6.5 A (Fig 2) As previous Fig Ligands docked into the...
- 11
- 335
- 0
human genome epidemiology 2nd edition building the evidence for using genetic information to improve health and prevent disease jan 2010
Ngày tải lên :
11/06/2014, 10:43
... disorders—Epidemiology Medical genetics—Methodology Genomics I Khoury, Muin J [DNLM: Genetics, Medical—methods Genetic Diseases, Inborn—epidemiology Genetic Predisposition to Disease epidemiology Genetic Screening ... the Evolving Knowledge of Human Genetic Variation in Health and Disease Marta Gwinn and Wei Yu 63 PART II Methods and Approaches for Data Collection, Analysis, and Integration The Global Emergence ... Outcomes Research and Policy Program, and Institute for Public Health Genetics University of Washington Seattle, WA Mukesh Verma, PhD Methods and Technologies Branch Epidemiology and Genetics Research...
- 701
- 498
- 0
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
Ngày tải lên :
19/06/2014, 22:20
... reduces clinical disease Taken together, the results of the present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39,40,42] and EAE [22,44,46], ... Kipnis J: Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases J Neurol Sci 2005, 233:163-6 Luster AD, Alon R, von Andrian UH: Immune cell ... pathogenetic mechanisms leading to demyelination and tissue injury are not fully understood, activated macrophages and microglia seem to play a central role in the destructive process both in MS and...
- 13
- 559
- 0
THYROID AND PARATHYROID DISEASES – NEW INSIGHTS INTO SOME OLD AND SOME NEW ISSUES ppt
Ngày tải lên :
27/06/2014, 10:20
... monoiodothyronine, and diiodothyronine Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues 4th stage is the coupling and T3 and T4 are synthesized from MIT and DIT (Figure ... The thyroid gland anatomy Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues gland is wrapped up by a fibrosis capsule named thyroid The thyroid gland is nourished ... Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues, Edited by Laura Sterian Ward p cm ISBN 978-953-51-0221-2 Contents Preface IX Part Evaluating the Thyroid Gland and...
- 330
- 409
- 0