genetic basis of celiac disease

... Magazzù G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disor- ders in Celiac Disease. Gastroenterology ... Prevalence of celiac disease in a sample of Turkish children and adoles- cents with type 1 diabetes mellitus. J Clin Gastroenterol 2006; 40: 655-7. 4. Tanure MG, Silva IN, Bahia M, et al. Prevalence of ... Development of ce- liac disease- associated antibodies in offspring of parents with type I diabetes. Diabetologia 2000; 43: 1005-11. 7. Jaeger C, Hatziagelaki E, Petzoldt R, et al. Comparative analysis of...

Ngày tải lên: 05/03/2014, 12:20

... the occurrence of an outcome of interest. This might be a study of time until disease pro- gression or overall survival. In these types of study designs, it is the person-years of follow-up that ... Health Of ce of Rare Diseases (ORD) defines a rare or orphan disease as a disorder with a prevalence of fewer than 200,000 affected individuals within the United States whereas in Europe, rare diseases ... scientist who are expert in the disease topic and underlying molecular defect, respectively. Their charge was to focus on the genetic basis and molecular patho- genesis of disease, animal models, clinical...

Ngày tải lên: 05/03/2014, 23:20

... Igs found in the serum of celiac disease patients. Keywords: autoimmunity; celiac disease; transglutaminase; epitope mapping; phage display. Celiac disease (CD) is a genetic disease strongly linked ... donors. DISCUSSION The cloning of tTG fragments on the basis of the modeled three-dimensional structure [8–10] coupled with the map- ping of the residues involved in the functionality of the molecule [5,10,19] ... Greco, L. (1999) Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology...

Ngày tải lên: 08/03/2014, 09:20

... neurobehavioral diseases mainly reflect the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of ... small amount of the trait variance. Minireview The complex genetic basis of simple behavior Anna J Jasinska and Nelson B Freimer Address: Center for Neurobehavioral Genetics, University of California, ... predictio ns of gene function. A recent study in BMC Biology using these approaches shows the complexity of the genetic contribution to aggressive behavior in Drosophila. Genetic investigation of quantitative...

Ngày tải lên: 06/08/2014, 19:21

Ngày tải lên: 12/08/2014, 03:21

... his PHD on genetics of Alzheimer disease, but because the families were still being sampled, he initially spent a lot of effort in 22 Part II / Genomic Structure 0.1% of human genetic disease, ... typical integration is then finished off by the formation of a second-strand nick and integration of the end of the cDNA (Fig. 2A). However, significant portions of the events appear to complete ... work was published in the first issue of Nature Genetics (34–37). The proof that PMP22 was the disease- causing gene for CMT1A was made after the identification of point mutations in some rare patients...

Ngày tải lên: 05/03/2014, 23:20

... trigger the generation of ‘toxic’ Ctm PrP [11]. This would link transmissible and genetic prion diseases and provide a common pathway of neurodegeneration in prion disease. Of note, another group ... molecules. Regardless, the exact mechanism of the study clearly emphasizes a critical role of the GPI anchor of PrP in the pathogenesis of prion diseases. Concluding remarks The puzzle of how infectious prions, ... species [1–5]. The formation of the disease- associated isoform of prion protein (PrP Sc ) [i.e. the misfolded and partially protein- ase K (PK)-resistant isoform of the cellular prion pro- tein...

Ngày tải lên: 30/03/2014, 09:20

... epidemiology of FMDV in Pakistan. Open Session of the Research Group of the European Commis- sion for the Control of Foot-and-Mouth Disease (EUFMD). International Control of Foot-and-Mouth Disease: ... Commission for the Control of Foot-and-Mouth Disease (EUFMD): RECOMMENDATIONS of the 73rd session of the executive committee european commission for the control of foot-and-mouth disease (EUFMD). Istanbul, ... with an insertion of two amino Alignment of the deduced amino acid sequences of the immuno-dominant residues of the VP1 surface protein, including the GH-loopFigure 5 Alignment of the deduced amino...

Ngày tải lên: 18/06/2014, 18:20

... epidemiology of FMDV in Pakistan. Open Session of the Research Group of the European Commis- sion for the Control of Foot-and-Mouth Disease (EUFMD). International Control of Foot-and-Mouth Disease: ... Commission for the Control of Foot-and-Mouth Disease (EUFMD): RECOMMENDATIONS of the 73rd session of the executive committee european commission for the control of foot-and-mouth disease (EUFMD). Istanbul, ... appearance of sublineage A/IRN/2005. The overall evolutionary development, mirrored by the phylogeny of the complete CDS of the A/IRN/2005 sub- Alignment of the deduced amino acid sequence of the...

Ngày tải lên: 20/06/2014, 01:20

Ngày tải lên: 28/06/2014, 11:20

... statistically significant genetic linkage. In a recent issue of Arthritis Research and Therapy, Nguyen et al. [1] report the fine mapping of a genetic region important for development of disease in a mouse ... factors of complex human diseases. The genetics and the environment can be carefully controlled in such models and the number of siblings is high enough to allow for the identification of statistically ... understand the genetic susceptibility in Sjögren’s syndrome, studies of disease phenotypes have been performed in the non-obese diabetic (NOD) mouse. By the identification of genetic regions...

Ngày tải lên: 09/08/2014, 01:22

... http://arthritis-research.com/sbr The Scientific Basis of Rheumatology: A Decade of Progress Genetic modifications of animals With emerging knowledge of the major genes that underlie human disease and improved animal ... tight nest of interacting genetic effects that seem to make up the genetic background of truly complex diseases such as RA will greatly benefit from a joint attack along all avenues of research. Available ... strongly linked genetic fragments controlling disease. The genetic effect may in fact be dependent on haplotypes rather than on single genetic polymorphisms. In spite of this, a number of genes -...

Ngày tải lên: 09/08/2014, 01:22

... statistically significant genetic linkage. In a recent issue of Arthritis Research and Therapy, Nguyen et al. [1] report the fine mapping of a genetic region important for development of disease in a mouse ... factors of complex human diseases. The genetics and the environment can be carefully controlled in such models and the number of siblings is high enough to allow for the identification of statistically ... understand the genetic susceptibility in Sjögren’s syndrome, studies of disease phenotypes have been performed in the non-obese diabetic (NOD) mouse. By the identification of genetic regions...

Ngày tải lên: 09/08/2014, 13:22

... fibrosis and celiac disease. Description of a clinical case and review of the literature. Pediatr Med Chir 1999, 21(5 Suppl):223-226. 16. Valletta EA, Mastella G: Incidence of celiac disease in a cystic ... initial manifestation of concomitant celiac disease and cystic fibrosis: a case report. Journal of Medical Case Reports 2011 5:116. Submit your next manuscript to BioMed Central and take full advantage of: ã ... HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol 2002, 97(3):695-699. 6. Graham DR, Bellingham AJ, Alstead E, Krasner N, Martindale J: Coeliac disease presenting as acute bleeding...

Ngày tải lên: 11/08/2014, 00:23

Ngày tải lên: 11/08/2014, 03:20

Ngày tải lên: 11/08/2014, 06:23

Ngày tải lên: 11/08/2014, 12:20