gene symbol pdha1 pyruvate dehydrogenase e1 component subunit alpha somatic form mitochondrial
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
Ngày tải lên :
12/09/2015, 11:08
... diabetes, which troglitazone was used to treat can arise from genetic mitochondrial dysfunctions in the OXPHOS or mitochondrial biogenesis (Mantena, et al., 2008, Mootha et al., 2003, Patti et ... Figure taken from Chem Res Toxicol (2007) 20: 344-369 28 Genetic mitochondrial abnormalities in the partial Sod2 knockout mouse generate a mitochondrial environment of cumulative endogenous ROS/RNS ... critical proteins including ATP synthase β -subunit, aconitase-2 (ACO2), and mitochondrial dicarboxylate carrier (DIC) exhibited decreased abundance In addition, mitochondrial protein carbonyls and nitrotyrosine...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
Ngày tải lên :
23/03/2014, 06:20
... Dihydrolipoyl dehydrogenase (E3) Dihydrolipoyl succinyl transferase (E2o) Component X Pyruvate dehydrogenase kinase, isoenzyme Pyruvate dehydrogenase kinase subunit variant p45 Pyruvate dehydrogenase alpha ... preparation as follows: E1o (band 1), E2p (band 2), E3 (band 3), E2o and the E3-binding component of the pyruvate dehydrogenase complex (protein X; band 4), E1pa (band 6), E1pb (band 8) This was ... dehydrogenase kinase subunit variant p45 Pyruvate dehydrogenase alpha subunit (E1pa) Pyruvate dehydrogenase beta subunit (E1pb) 40786469 55742725 28201978 mus 21704122 mus 8895958 117 419 57 645...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
Ngày tải lên :
19/02/2014, 16:20
... pGL3Basic to generate )975 and )404 subfragments did not significantly affect luciferase 1037 Thromboxane A2 receptor gene expression A T Coyle and B T Kinsella B A Prm1 E1 -5895 -8500 Prm2 E1b Prm3 ... -404 Prm2 E1b -3308 -1394 +1 Luc -975 E1 -5895 -8500 +1 Luc -154 +1 Luc -106 +1 Luc -50 pGL3Basic +1 Luc +1 Luc +1 Luc pGL3Enhancer +1 Luc Luciferase Activity (RLU) C D Prm1 -8500 Prm2 E1b E1 -5895 ... receptor (TP) alpha and beta isoforms Biochim Biophys Acta 1425, 543–559 25 Coyle AT, Miggin SM & Kinsella BT (2002) Characterization of the 5¢ untranslated region of alpha and beta isoforms of the...
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Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc
Ngày tải lên :
21/02/2014, 01:21
... Data Bank of Japan The gene encoding 4-amino-3-hydroxybenzoate 2,3-dioxygenase is currently being cloned; the analysis of the entire amino acid sequence will reveal more information on the strict ... purified from Pseudomonas pseudoalcaligenes JS45 J Bacteriol 178, 6227–6232 Takenaka, S., Murakami, S., Shinke, R., Hatakeyama, K., Yukawa, H & Aoki, K (1997) Novel genes encoding 2-aminophenol 1,6-dioxygenase ... 33 34 35 high-performance liquid chromatography Int J Syst Bacteriol 39, 159–167 Moss, C.W & Guerrant, G.O (1983) Separation of bacterial ubiquinones by reverse-phase high-performance liquid chromatography...
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Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt
Ngày tải lên :
07/03/2014, 21:20
... receptor (TP) alpha and beta isoforms Biochim Biophys Acta 1425, 543–559 40 Coyle AT, Miggin SM & Kinsella BT (2002) Characterization of the 5¢ untranslated region of alpha and beta isoforms of the ... thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq FEBS Journal 272 (2005) 4754–4773 ª 2005 FEBS Effect of 15d-PGJ2 action on TP gene expression 67 68 69 ... The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization J Biol Chem 275, 20412–20423 38 Reid HM & Kinsella BT (2003) The alpha, ...
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Báo cáo khoa học: NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery – synthesis,in vitro transfection activity, and physicochemical characterization docx
Ngày tải lên :
23/03/2014, 07:20
... intent of enhancing the transport of exogenous genetic material into cells in vitro, and their design eliminates the need for additional components in the gene- delivery system (i.e DOPE and cholesterol), ... of chloroform and loaded onto a silica gel column (26 ã 2.8 cm) The column was eluted sequentially with 100 mL chloroform, and 1, 3, 5, 7, 8, 9, 10, 12 (300 mL) and 15% methanol chloroform The ... lipid)-mediated in vivo gene delivery to mouse liver Gene Ther 10, 180187 20 Narang AS, Thoma L, Miller DD & Mahato RI (2005) Cationic lipids with increased DNA binding afnity for nonviral gene transfer...
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A Prince of Sinners E. Phillips Oppenheim BOOK 3 CHAPTER 2 pot
Ngày tải lên :
06/07/2014, 05:20
... his shoulders "I not fear it," he answered, calmly "As a matter of fact, however, I am going to form a council to take the management of the financial organization It is getting too large a thing ... on my heels You are a woman, Catherine, and you don't know the suffering of the most intolerable form of ennui loneliness." "And you?" she asked, looking at him with softening eyes "Always It rode ... emotion which had ever filled your life were dead, as though you were indeed but the shadow of your former self Even to know that you feel pain is better than to believe you void of any feeling whatever."...
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Dictionary of Engineering Episode 3 Part 2 ppt
Ngày tải lên :
21/07/2014, 15:20
... including the six components of strain, of the deformation within a homogeneously deformed volume { stat əv stran } ¯ ¯ state of stress [MECH] A complete description, including the six components of ... ədиər } stamper [ENG ACOUS] A negative, generally made of metal by electroforming, used for molding phonograph records { stamиpər } stamping [ELECTR] A transformer lamination that has been cut out ... minimum amount of distortion { skwer ¦wav amиplə fıи ¯ ¯ ər } square-wave generator [ELECTR] A signal generator that generates a square-wave output voltage { skwer ¦wav jenиə radиər } ¯ ¯ square-wave...
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Handbook of Mechanical Engineering Calculations ar Episode 3 Part 2 pps
Ngày tải lên :
05/08/2014, 09:20
... and total heat generated (d) The work of friction, w ϭ W / LD, where the symbols are as defined earlier Substituting, w ϭ 2356 / 15.19 ϭ 155.1 ft-lb / (3.5 W) (e) The total heat generated ϭ Q ϭ ... cm) Compute the rate of bearing heat generation The rate of heat generation in a plain sleeve bearing is given by h ϭ ƒLdR / 3000, where h ϭ rate of heat generation in the bearing, Btu / min; ... area, (b) pressure on bearing, (c) total work, (d) work of friction, (e) total heat generated, and (f) heat generated per minute per unit area Calculation Procedure: Determine the bearing dimensions...
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Handbook of Mechanical Engineering Calculations ar Episode 3 Part 2 ppsx
Ngày tải lên :
05/08/2014, 09:20
... and total heat generated (d) The work of friction, w ϭ W / LD, where the symbols are as defined earlier Substituting, w ϭ 2356 / 15.19 ϭ 155.1 ft-lb / (3.5 W) (e) The total heat generated ϭ Q ϭ ... cm) Compute the rate of bearing heat generation The rate of heat generation in a plain sleeve bearing is given by h ϭ ƒLdR / 3000, where h ϭ rate of heat generation in the bearing, Btu / min; ... area, (b) pressure on bearing, (c) total work, (d) work of friction, (e) total heat generated, and (f) heat generated per minute per unit area Calculation Procedure: Determine the bearing dimensions...
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Handbook Of Shaft Alignment Episode 3 Part 2 pot
Ngày tải lên :
05/08/2014, 11:20
... Figure 18.25 A recording sheet shown in Figure 18.26 can be used to record all the required information to generate an alignment model of the misalignment condition 18.12 MODELING V-BELT ALIGNMENT ... condition on belt and sheave drive equipment You will have to generate two different views of your drive system One view will be generated from above (i.e., the top view), which will show any ... of the cylinder, study and perform the tasks shown in Figure 19.17 through Figure 19.20 Install and center a target at the far end of the near cylinder Again, perform the tasks shown in Figure...
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The Cambridge History of the English Language Volume 3 part 2 ppsx
Ngày tải lên :
05/08/2014, 14:20
... and were handicapped by the English alphabets having no symbol for / / She presents a number of points in rebuttal: (a) (b) Robinson (1619) invented a new alphabet, deliberately unrelated to ... Orthographia was the rst of the four components of traditional grammars, and so named from at least the Middle Ages (Michael 1970: 356); it dealt with letters of the alphabet, syllables and spelling ... Caxtons death, see Salmon (1989) Alston (1974) gives detailed bibliographical information about the works printed in reformed spelling in the 1570s 2.4 Mulcasters Elementarie is essential reading...
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Design and Optimization of Thermal Systems Episode 3 Part 2 pdf
Ngày tải lên :
06/08/2014, 15:21
... number of materials and components available for design Finite numbers of components, such as pumps, blowers, fans, compressors, heat exchangers, heaters, and valves, are generally available from ... guessed values are based on information available on the physical system However, values of the multipliers are not easy to estimate Earlier analysis of the system, information on sensitivity, or ... objective function to changes in the constraints This is important additional information obtained by this method and forms a valuable input in deriving the final design of the system Finally, the...
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Báo cáo khoa học: "Teratological effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): induction of cleft palate in the ddY and C57BL/6 mouse" pptx
Ngày tải lên :
07/08/2014, 14:23
... 1973, 5, 6779 Poland A and Glover E Genetic expression of aryl hydrocarbon hydroxygenase by 2,3,7,8-tetrachlorodibenzop-dioxin: Evidence for a receptor mutation in genetically non-responsive mice ... K A., Yamashita K., Ohmori H and Yasuda M Pathogenesis of cleft palate in mouse embryo exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Tertogenesis Carcinog Mutagen 2000, 20, 73-86 ... Tetatology 1981, 24, 149-162 Greene R M., and Pratt R M Developmental aspects of secondary palate formation J Embryol Exp Morphol 1976, 36, 225-245 Hassoun E A., Wilt S C., Devito M J., Van Birgelen...
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Material Science_ Vol 1 of 2 - US DOE (1993) WW Part 3 docx
Ngày tải lên :
11/08/2014, 14:20
... DEFINE the term alloy 1.11 DESCRIBE an alloy as to the three possible microstructures and the two general characteristics as compared to pure metals 1.12 IDENTIFY the two desirable properties of ... solids are bound tightly together When the attractions are weaker, the substance may be in a liquid form and free to flow Gases exhibit virtually no attractive forces between atoms or molecules, and ... together by the force of attraction due to the opposite polarity of the charge Covalent bond - A bond formed by shared electrons Electrons are shared when an atom needs electrons to complete its outer...
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Material Science_ Vol 2 of 2 - US DOE (1993) WW part 3 docx
Ngày tải lên :
11/08/2014, 14:20
... failure of the materials Thermal shock is caused by nonuniform heating or cooling of a uniform material, or uniform heating of nonuniform materials Suppose a body is heated and constrained so ... Compressive stress Causes of thermal shock include: Nonuniform heating (or cooling) of a uniform material Uniform heating (or cooling) of a nonuniform material Thermal shock (stress) on a material, ... system components Operating procedures are designed to reduce both the magnitude and the frequency of these stresses Operational limitations include heatup and cooldown rate limits for components,...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
Ngày tải lên :
12/08/2014, 04:20
... [LIVM]-xx-Y- [IFL]-x- [WY]- [RS] in alpha- helix 1, G-x-x- [FY]x-x- [LF]-x-x- [FYL]- [KD]-x-x-A in alpha- helix 2, and [IV]-G- [LF]-x- [ASG] in alpha- helix (alpha- helices numbered according to ... binding site Alpha- helix forms part of the dimerization surface in N1, B15 and A52 proteins [11,12,14] In the N1 homodimer residues Arg7 and Asp14 of alpha- helix of different monomers form a potential ... indicates the kind of variation in the gene content since the preceding node: green for nodes with a net gene gain, red for nodes with a net gene loss, and grey if the gene content remained unchanged...
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