gene regulation and information flow

... Evgenia V Kriventseva, and Nicola Mulder vii 17 19 Information Fusion and Metabolic Network Control ¨ Andreas Freier, Ralf Hofestadt, Matthias Lange, and Uwe Scholz 49 II Gene Regulation: From Sequence ... questions of gene regulation and metabolism without explicit mention of the connection between networks and the phenotype One of the challenges, computationally, in understanding gene regulation ... approaches to metabolism and gene regulation This is an area of computational biology that welcomes new methods, ideas, and approaches with the goal of generating a better understanding of the complex...

Ngày tải lên: 08/04/2014, 12:45

... Evgenia V Kriventseva, and Nicola Mulder vii 17 19 Information Fusion and Metabolic Network Control ¨ Andreas Freier, Ralf Hofestadt, Matthias Lange, and Uwe Scholz 49 II Gene Regulation: From Sequence ... questions of gene regulation and metabolism without explicit mention of the connection between networks and the phenotype One of the challenges, computationally, in understanding gene regulation ... approaches to metabolism and gene regulation This is an area of computational biology that welcomes new methods, ideas, and approaches with the goal of generating a better understanding of the complex...

Ngày tải lên: 11/04/2014, 00:45

... Brief Program P.2 C ĐĂNG KÝ Để đăng ký dự thi, thành viên phải tải mẫu đăng ký từ website: www.sunflowermedia.com.vn gửi yêu cầu đăng ký tới ntmnguyet@hoamattroi.com Một mẫu đăng ký hoàn chỉnh với...

Ngày tải lên: 10/07/2014, 19:52

... epigenetic gene regulatory mechanisms Nutrition is important in providing methyl donors for DNA, and some genes are especially sensitive to nutritional changes during embryogenesis Rob Waterland ... sequences and epigenetics, are involved in controlling meiotic recombination in humans Nutritional influences during prenatal and early postnatal development may affect gene expression, and subsequently ... enhancers in c-Myc and N-Myc, genes that play a role in growth control and tumorigenesis From the same group, Mikael Björklund presented a genome-wide RNA interference (RNAi) analysis of genes that are...

Ngày tải lên: 14/08/2014, 17:22

... of gene regulation by cohesin is vertebrate specific Epigenetic regulation of inflammatory gene expression Two talks addressed the role of epigenetic mechanisms in regulation of inflammatory gene ... signal transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate follow-up ... dynamic regulation of gene expression A plethora of studies in the past few years, and several talks at this meeting, mapped histone modifications genome-wide Keji Zhao (National Heart, Lung, and...

Ngày tải lên: 14/08/2014, 20:22

... retinoblastoma gene family and added to the complexity of cell cycle regulation This chapter will elaborate on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression ... Retinoblastoma Gene Family 4.1 Rb Gene Family Members The retinoblastoma gene family comprises, besides Rb, the structurally and functionally related Rb-like genes p107 (RBL1) and p130 (RBL2) ... hypothesis The Retinoblastoma Gene Family in Differentiation and Tumorigenesis Regulation of the E2F transcription factors is a key role of the retinoblastoma gene family and disruption of that function...

Ngày tải lên: 25/10/2013, 21:20

... anisomycin and FBS on actin stress fibers in SMCs and their modulation by toxin B and latrunculin B Cells were first stimulated with either S1P, anisomycin or FBS for 30 and then fixed, permeabilized and ... RhoA GTPase and p38 in transcriptional and post-transcriptional regulation of the CTGF/CCN2 gene In order to determine whether CTGF/CCN2 expression occurs via increased transcription and/ or by ... transcripts and the role of RhoA GTPase and p38 signaling in such a regulation, nuclear run-on assays and message stability analyses were carried out The transcription rate of the CTGF/CCN2 gene was...

Ngày tải lên: 19/02/2014, 16:20

... two-hybrid EcR gene switch with high ligand sensitivity and low background expression levels when compared to the earlier versions of EcR gene switches [14] The chemical-inducible gene regulation ... LmRXR and HsRXR LBDs as a partner of CfEcR, we were able to combine these two important aspects of the gene switch together and develop a tight EcR gene regulation system with improved ligand sensitivity ... VCH9, and GCfEVY + VCH9) and VGCfEQ454E, and monopartite (VGCfEH436E, VGCfEVY) switch formats and compared to the data obtained from the gene switches containing wild-type CfEcR (GCfEWt + VCH9 and...

Ngày tải lên: 16/03/2014, 06:20

... Discussion From its identification as a Drosophila gene responsible for resistance to morphogenetic and toxic effects of JH and JHAs, the Met gene product has been implicated to have an involvement ... activator of gene regulation [45] Contrary to this, MET exists in the nucleus even in the absence of ligand Upon ligand binding, it becomes a transcriptional activator This resembles the ligand-dependent ... purified, digested and subcloned into EcoRI and XbaI sites FEBS Journal 272 (2005) 1169–1178 ª 2005 FEBS Characterization of Drosophila Met gene product of pBluescript II (Stratagene), and the identity...

Ngày tải lên: 16/03/2014, 18:20

... sensitive, and that the pA1lacO-1 promoter and the lacI q1 gene are surrounded by a DNA fragment originating from upstream the gyrA gene and a fragment containing the N-terminal part of the gyrA gene ... digested with the enzymes DraI and EcoRV and a 842-bp fragment containing the DNA region upstream of topA and the topA promoter was isolated and inserted into pUC19 (New England Biolabs) digested with ... were obtained from and used as recommended by New England Biolabs and Boehringer Mannheim Plasmid and ATP, ADP extraction Aliquots (0.8 mL) were removed from cell cultures and placed into an...

Ngày tải lên: 18/03/2014, 01:20

... cycle, including positive-strand and minus-strand DNA synthesis, pre-genomic RNA packaging, and virion formation and release [17,18] This core protein is a phosphoprotein, and its function may be ... proteins, and thereby may influence host or viral gene expression at the post-transcriptional level In this review, we describe these viral SR proteins and also discuss the interplay between host and ... protein–protein and protein–RNA interactions of SR proteins [1–5] Reversible phosphorylation of SR proteins is important for assembly and function of the spliceosome and for proper regulation of...

Ngày tải lên: 23/03/2014, 06:20

... mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies Biotechnol Prog 17, 1–51 48 Lewandoski, M (2001) Conditional control of gene expression ... Varmus, H.E (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes Genes Dev 15, 3249–3262 Moody, ... for cancer and neurological disorders Here, the use of tTA and rtTA to control expression of an oncogene revealed for solid tumors [146,147] and for leukemias [148,149] that the oncogene is not...

Ngày tải lên: 23/03/2014, 21:20

... Extensive and divergent circadian gene expression in liver and heart Nature 417, 78–83 16 Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB & Fitzgerald GA (2004) BMAL1 and CLOCK, ... that gene expression follows the metabolic rhythm [21,40] Almost all genes are cyclically transcribed and can be clustered in three groups: 650 are expressed in the oxidative phase, and 2429 and ... sulfur metabolism and RNA metabolism occur in the oxidative phase; cell division and mitochondrial biogenesis occur in the first Metabolic cycles reductive phase and glycolysis and fatty acid oxidation...

Ngày tải lên: 30/03/2014, 04:20

Ngày tải lên: 06/08/2014, 19:21

... paralogous genes tdcE and pflB are both regulated by CRP and IHF Because tdcE and pflB are in operons, and because the first genes of those operons are not homologous (tdcA and focA), the regulation ... known regulation, gene regulation could be more conserved than would be implied by the recent origins of the typical TF However, HGT genes have more complex regulation than native genes, and most ... Species tree Given a gene tree and a species tree, we identified horizontal transfer events using a combination of the gene phylogeny and the pattern of gene presence and gene absence If a strongly...

Ngày tải lên: 14/08/2014, 08:20

... co-expressed gene sets as well Examples are GATA factors, NFATs and HAND1 in heart development; HNF-1 and HNF-4 in liver-specific gene expression; PU.1 in lymphocyte specific gene expression; and myogenin, ... to the quality of the input genes The ratio of true positive genes (containing the smooth muscle cisregulatory module [CRM]) to negative genes (approximated by random genes) was varied Each time, ... constant at ten, and the number of negative genes was varied Red: the total number of genes was kept constant at ten, and the ratio negative genes/positive genes was varied Sensitivity to noise To...

Ngày tải lên: 14/08/2014, 08:21

... (Figures and 3) Because cooperative and competitive interactions are common in gene regulation, the explicit consideration of concentration is likely to be necessary for a complete understanding of gene ... experimicroarraySum1aofORFs)genesaregulatedprobabilitydata from chrogenes) published and( intersectionvitro [7] derived matrix both publishedbyNdt80pand Fkh1p binding [5] sets, andgeneschromatin ments ... distinguish regulated genes from other genes that have a comparable number of binding sites [24-26] GOMER, on the other hand, can distinguish genes with clustered binding sites from genes whose sites...

Ngày tải lên: 14/08/2014, 14:22

... period costs eliminates U and I and any variation in U and I over time and across firms It leaves ∆A (1 + ∆R) for the period after regulation and ∆A for the period before regulation The difference ... should equal the rate of information flow because prices change in response to information If the regulation serves to concentrate information flow on earnings announcements and other public disclosures, ... more pronounced for smaller and less liquid stocks Return volatility around mandatory announcements is also lower but overall information flow is unchanged when mandatory and voluntary announcements...

Ngày tải lên: 31/10/2014, 12:03

... PPARs 1.1.5 Ligands and physiological functions of PPARα and PPARδ 1.1.6 Ligands of PPARγ 1.1.7 PPARγ and adipogenesis 10 1.1.8 PPARγ and insulin sensitization ... (Boitier et al., 2003) Prostaglandins are metabolites of arachidonic acid generated via the cyclooxygenase pathway (Scher and Pillinger, 2005) Prostaglandin J2 and prostaglandin A2 are produced from ... Overall, the cross talk between PPARγ and TNFα plays an important role in the regulation of lipid and glucose metabolism and its associated pathogenesis 1.1.9 PPARs and cancer As described previously,...

Ngày tải lên: 09/09/2015, 10:19

... similarity between MPO and NHE1 PPRE predicts possibility of PPARγ binding to DR2 in NHE1 promoter, and subsequent regulation of NHE1 gene expressions in a similar manner as MPO gene Besides high ... ligands on NHE1 protein is not drug specific, but is conserved in both the endogenous and synthetic PPARγ ligands.The difference in extent of NHE1 repression by 15d-PGJ2 and synthetic PPARγ ligands ... absence of exogenous ligands Our previous results demonstrated that both synthetic and endogenous ligands of PPARγ were capable of inducing down -regulation of PPARγ NHE1 and mRNA Among them, the...

Ngày tải lên: 09/09/2015, 10:19