gene environment interaction and sperm chromatin
Báo cáo y học: " A model of gene-gene and gene-environment interactions and its implications for targeting environmental " doc
Ngày tải lên :
13/08/2014, 16:21
... independent (there are no gene- environment correlations), the gene- environment interaction matrix Mrelge may be written as: Additional File Gene- gene and gene- environment interaction model Contains ... cancer); (ii) the complexity of gene- gene and gene- environment interactions and/ or lack of knowledge of environmental factors (for example, schizophrenia) Targeting environmental/lifestyle interventions ... populations (i.e as ε and γ vary), provided there are no confounders This assumption restricts the model to special cases of gene- gene and gene- environment interaction Note that for a single genetic variant,...
- 24
- 603
- 0
Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... epitome of genetic determinism, can be modified by environmental factors, has focused new attention on the crucial area of gene environment interactions While understanding gene mutations and molecular ... genomics and transgenic Gene environment interactions in neurodegenerative disease technology, has focused on how individual genes contribute to brain development, function, and behaviour in standard-housed ... 2005 FEBS Gene environment interactions in neurodegenerative disease HD [51] and, more recently, in N171-82Q transgenic HD mice [52] This suggests that these findings of gene environment interactions...
- 15
- 504
- 0
Báo cáo khoa học: K182G substitution in DevR or C8G mutation in the Dev box impairs protein–DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis doc
Ngày tải lên :
22/03/2014, 16:20
... H-bonding interactions with the O6 and N7 atoms of G13 (complementary to the conserved C8 base on the sense strand) and the N7 atom of A12 (complementary to the conserved T9 base on the sense strand ... (Table 2) and 30 lg of RNA from aerobic and standing cultures (twice using two separate lots of RNA) The reactions were run alongside the sequence ladder generated using the same primer and M tuberculosis ... of protein and DNA (in a half-site of the primary binding motif), we highlight the singular importance of G13– Lys182 and partial importance of A12–Lys182 interaction for DevR binding and function...
- 9
- 351
- 0
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... (9% in controls and 14% in cases) In analyses involving CTLA-4 and PADI-4, we assessed the risk for RA in dominant, additive, and recessive models Gene- environment and gene- gene interactions We ... L, Alfredsson L: Gene- gene and gene- environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis Am J Hum Genet 2007, 80:867-875 Hernandez-Avila M, Liang ... significant additive and multiplicative gene- environment interactions between heavy cigarette smoking and the presence of the PTPN22 T allele (additive interaction: P = 0.0006; multiplicative interaction: ...
- 12
- 336
- 0
Báo cáo sinh học: "Genotype by environment interaction for adult body weights of shrimp Penaeus vannamei when grown at low and high densities" ppt
Ngày tải lên :
14/08/2014, 13:21
... their standard errors The different heritabilities across environments were caused by different additive genetic and environmental variances occurring at each environment for growth: a larger environmental ... and sire origin, and their interaction with density were not significant (P > 0.05) The covariate age (and age-squared) and the fixed effects of sex and density, as well as their interaction, were ... added to the trays three times a day and for the high density raceway every h 2.6 Statistical and genetic parameter analyses 2.6.1 Model evaluation Means and standard deviation (SD) of BWs unadjusted...
- 11
- 288
- 0
Cambridge.University.Press.Protecting.the.Polar.Marine.Environment.Law.and.Policy.for.Pollution.Prevention.Jan.2001.pdf
Ngày tải lên :
21/09/2012, 10:58
... Australia, Canada and the United States Donald R Rothwell and Christopher C Joyner Canada and the Arctic marine environment The United States and the Arctic marine environment Australia and the Antarctic ... Management and Marine Regional Building’, Ocean and Coastal Management, Vol 24, 1994, pp 17–38; and B A Boczeck, ‘Global and Regional Approaches to the Protection and Preservation of the Marine Environment , ... marine environment and the land environment This is scarcely surprising, given that the greatest impact on the marine environment comes not from the use of the sea but from the use of the land Defining...
- 300
- 786
- 3
GROWTH PERFORMANCE AND SPERM QUALITY OF STRESS NEGATIVE PIÉTRAIN BOARS AND THEIR HYBRIDS WITH DUROC
Ngày tải lên :
28/08/2013, 11:59
... tests from each genetic group The sperm quality was assessed on each ejaculate using ejaculation volume (VOL), spermatozoon motility (MO), sperm concentration (CO) and total number of spermatozoon ... Growth Performance and Sperm Quality of Stress Negative Piétrain Boars and Their Hybrids with Duroc Kawecka et al (2008), Wysokinska et al (2009), Pokrywka and Tereszkiewicz (2011) and Luc et al (2011; ... Summer, Autumn and Winter) were the only effects included in the model Table Results of the effect of genetic group (PiDu 25, 50 75, PiCC and PiCT) and season on growth performance and semen quality...
- 6
- 734
- 0
Tài liệu Báo cáo khoa học: SREBPs: protein interaction and SREBPs Ryuichiro Sato doc
Ngày tải lên :
18/02/2014, 13:20
... mitochondrial biogenesis and FEBS Journal 276 (2009) 622–627 ª 2008 The Author Journal compilation ª 2008 FEBS 623 Protein interaction and SREBPs R Sato respiration, and modulates hepatic gluconeogenesis ... interaction with importin-b [6] In the nucleus, SREBPs detach from importin-b, and their transcription factor activities are regulated through interaction with a variety of nuclear proteins Interaction ... including de novo lipogenesis and lipoprotein secretion [15] This suggests, at least in part, a mechanism through which dietary saturated fats stimulate hyperlipidemia and atherogenesis SREBPs dock...
- 6
- 589
- 1
Tài liệu Báo cáo khoa học: Globin gene family evolution and functional diversification in annelids ppt
Ngày tải lên :
19/02/2014, 02:20
... structural and functional convergence between circulating and noncirculating intracellular globin and extracellular globin genes in annelids: these genes probably evolved from a common globin-like gene ... ancestor and did not emerge independently of unrelated genes All the annelid intracellular globin gene structures reported here show the same gene structure, whereas Aph aculeata nMb gene lacks ... and Aph aculeata nMb) and extracellular globins Interestingly, we have found that, in A ornata, the DHP-encoding gene exhibits the same gene structure as extracellular globins, Ar marina Mb and...
- 12
- 594
- 0
Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
Ngày tải lên :
22/02/2014, 07:20
... different roles in the activation and repression of transcription [9] In our hands, Sp1 generated a single band and Sp3 generated two bands in EMSAs (two of three bands migrated to the same position; ... (B) Chromatin immunoprecipitation assays Chromatin immunoprecipitation assays were performed as described in the text DNA and proteins were cross-linked with formaldehyde, and DNA was sheared and ... GST fusion proteins and performed EMSAs with the P3 probe that included the GA motif Specific and different shifted bands were detected with GST–Sp1 and GST–Sp3 The shifted band due to GST–Sp3...
- 10
- 563
- 0
THE ARTS CHILD POLICY CIVIL JUSTICE EDUCATION ENERGY AND ENVIRONMENT HEALTH AND HEALTH CARE docx
Ngày tải lên :
06/03/2014, 09:21
... corresponded with government and military statements and helped generate and sustain credibility and legitimacy The conflict reached a stalemate in the late 1980s and was ultimately resolved through ... adaptation and counteradaptation between the insurgents and the COIN force; rather, these were macro-level and sea-change phases Paul, Clarke, and Grill, 2010 8 Victory Has a Thousand Fathers: ... posting of RAND documents to a non-RAND website is prohibited RAND documents are protected under copyright law For information on reprint and linking permissions, please visit the R AND permissions...
- 187
- 309
- 0
THE EUROPEAN ENVIRONMENT: STATE AND OUTLOOK 2010 pot
Ngày tải lên :
06/03/2014, 16:20
... mitigation Land use Land use Soil Nature protection and biodiversity Marine and coastal environment Waste Consumption and environment Assessment of global megatrends Material resources and waste ... urban environment European Environment Agency, Copenhagen EEA, 2010o The European environment — state and outlook 2010: land use European Environment Agency, Copenhagen EEA, 2010p The European environment ... the air has many sources and is a complex heterogeneous mixture whose size and chemical composition change in time and space, depending on emission sources and atmospheric and weather conditions...
- 46
- 448
- 0
ENVIRONMENT SCIENCE AND POLICY FOR SUSTAINABLE DEVELOPMENT: GREEN MARKETING docx
Ngày tải lên :
06/03/2014, 21:20
... Council’s “Leadership in Energy and Environmental Design” (LEED) provides a rigorous rating system and green building checklist that are rapidly becoming the standard for environmentally sensitive ... their personal needs and the environment. 56 When introducing its Renewal brand, Rayovac positioned the reusable alkaline batteries as a solution for heavy battery users and the environment with concurrent ... value and providing substantive environmental benefits Often, consumers don’t have the expertise or ability to verify green products’ environmental and consumer values, creating misperceptions and...
- 17
- 532
- 0
Báo cáo khoa học: Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells potx
Ngày tải lên :
07/03/2014, 12:20
... fractionation, and chromatography Mono Q chromatography was used to separate aspartyl aminopeptidase activity into three major peaks (Fig 1) The first and second peaks were pooled as fraction I and II, ... activity in Mono Q fractions I and II using a Superose column (s, d) Activity of fractions I and II, respectively (B, C) Results of SDS ⁄ PAGE analysis of fractions I and II Lane numbers correspond ... bacteria and eukaryotes [6] We selected 12 of these and aligned their sequences using the clustal_x program [7] (Table 3) This revealed three conserved His residues, two conserved Glu residues, and...
- 7
- 368
- 0
Báo cáo khoa học: A unique vertebrate histone H1-related protamine-like protein results in an unusual sperm chromatin organization pot
Ngày tải lên :
08/03/2014, 08:20
... histones and protamines, and was originally described and characterized in bivalve molluscs [17,18] It consists of a highly heterogeneous group of SNBPs that are rich in both arginine and lysine and ... chromatin from rabbits and fowl [37] They are also very similar to the DNase I digestion patterns obtained with human sperm chromatin [38] and those observed in invertebrate sperm chromatin consisting ... Protamine-like proteins and chromatin A B C Fig The sperm chromatin of M surmuletus consists of bundles of parallel DNA molecules (A) Electron microscopy of spread sperm chromatin rotary shadowed...
- 14
- 484
- 0
Human Pharmaceuticals in the Environment: Current and Future Perspectives pot
Ngày tải lên :
16/03/2014, 22:20
... on Human Pharmaceuticals in the Environment Bryan W Brooks, Jason P Berninger, Alejandro J Ramirez, and Duane B Huggett Background Human interaction with the environment remains one of the most ... global trade and digital communications, energy security, natural resource scarcities, climatic changes and environmental quality, emerging diseases and public health, biodiversity and habitat ... et al [15], Ternes [16], and Daughton and Ternes [17] Citation information from Web of Knowledge Pharmaceuticals and Personal Care Products (PPCP) in the environment and by doing so coined the...
- 302
- 1.6K
- 2
Gene Therapy - Tools and Potential Applications by Francisco Martin Molina Contributors ppt
Ngày tải lên :
17/03/2014, 21:20
... genes in the desired cell population In this chapter we explain the concept and aim of gene therapy, the different gene delivery systems and therapeutic strategies, how genes are deliv ered and ... Pilar Zaragoza and Rosario Osta Chapter 11 Transposons for Non-Viral Gene Transfer 269 Sunandan Saha and Matthew H Wilson Chapter 12 Lentiviral Gene Therapy Vectors: Challenges and Future Directions ... the Human Ge nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi fied...
- 754
- 589
- 0
Policing Football Social Interaction and Negotiated Disorder pot
Ngày tải lên :
17/03/2014, 21:21
... consider two main aspects of interaction between the police officers and supporters: the informal guidelines and rules that can structure interaction during a match day and how these rules are enacted ... assistance and advice during the course of this research project and book preparation: the individual police officers and staff from the main police force I studied, without whose generous co-operation ... these and many other activities before, during and after football matches, and feel that their role is far from insignificant, both operationally as well as socially This project focuses on the interaction...
- 231
- 444
- 1
THE ARTS CHILD POLICY CIVIL JUSTICE EDUCATION ENERGY AND ENVIRONMENT HEALTH AND HEALTH CARE doc
Ngày tải lên :
22/03/2014, 21:20
... Relationships and Implications for the United States Air Force. RAND Project AIR FORCE RAND Project AIR FORCE (PAF), a division of the RAND Corporation, is the U.S Air Forces federally funded research and ... RAND Corporation is a nonprofit research organization providing objective analysis and effective solutions that address the challenges facing the public and private sectors around the world RANDs ... long as it is unaltered and complete Copies may not be duplicated for commercial purposes Unauthorized posting of RAND documents to a non-RAND Web site is prohibited RAND documents are protected...
- 164
- 257
- 0
Threats to the Marine Environment: Pollution and Physical Damage pptx
Ngày tải lên :
23/03/2014, 04:20
... cause it to sink) and its high pour point and viscosity lowers its tendency to spread out and disperse.189 Damage to Habitats and Animals Even without causing pollution of the marine environment, ... dragging and swinging of large anchor cables and chains As the chain and anchor of a large ship can weigh up to tonnes, these activities may destroy living coral heads and create gouges and scars ... to humans and the environment very much depend on the activity, the biodistribution and the half-life of the radioisotope.150 Chronic exposure to elevated levels of radioactivity is generally...
- 15
- 527
- 0