gene delivery technology adeno associated virus

... PE: Evaluation of adeno- associated virus- mediated gene transfer into the rat retina by clinical fluorescence photography Hum Gene Ther 1999, 10:641-648 Redmond TM, Hamel CP: Genetic analysis of ... improve adenovirus vector performance in vitro and in vivo Gene Ther 2000, 7:1624-1630 Malik AK, Monahan PE, Allen DL, Chen BG, Samulski RJ, Kurachi K: Kinetics of recombinant adeno- associated virus- mediated ... RPE65 dog model was generated by using recombinant adenoassociated virus (rAAV) to deliver and express normal, non-mutated RPE65 cDNA [16,22,23] The use of rAAV-mediated gene therapy has attracted...

Ngày tải lên: 14/08/2014, 19:22

... (2005) Adeno- associated virus vectors in clinical trials Hum Gene Ther 16, 541–550 Promoter and SUMF1 effect on Morquio gene transfer 34 Wu Z, Asokan A & Samulski R (2006) Adeno- associated virus ... Pandey K, Xu H, Feuss S, Storm TA et al (2008) The host response to adenovirus, helper-dependent adenovirus, and adeno- associated virus in mouse liver Mol Ther 16, 931–941 62 Chung S, Ma X, Liu Y, ... recombinant adeno- associated virus Gene Ther 5, 1642–1649 51 Toniatti C, Bujard H, Cortese R & Ciliberto C (2004) Gene therapy progress and prospects: transcription regulatory systems Gene Ther...

Ngày tải lên: 29/03/2014, 21:20

... vectors have been gaining an important place in gene therapy approaches, especially adenovirus and adeno- associated virus Since the adeno- associated virus was first isolated and its biological properties ... required for adeno- associated virus DNA replication in the absence of adenovirus coinfection J Virol 1998, 72:2777-2787 Linden RM, Berns KI: Molecular biology of adeno- associated viruses Contrib ... vectors for gene delivery Curr Gene Ther 2005, 5:299-310 Muzyczka N, Warrington KH Jr: Custom adeno- associated virus capsids: the next generation of recombinant vectors with novel tropism Hum Gene Ther...

Ngày tải lên: 18/06/2014, 18:20

... vectors have been gaining an important place in gene therapy approaches, especially adenovirus and adeno- associated virus Since the adeno- associated virus was first isolated and its biological properties ... required for adeno- associated virus DNA replication in the absence of adenovirus coinfection J Virol 1998, 72:2777-2787 Linden RM, Berns KI: Molecular biology of adeno- associated viruses Contrib ... vectors for gene delivery Curr Gene Ther 2005, 5:299-310 Muzyczka N, Warrington KH Jr: Custom adeno- associated virus capsids: the next generation of recombinant vectors with novel tropism Hum Gene Ther...

Ngày tải lên: 20/06/2014, 01:20

... by adenovirus-mediated gene transfer Hum Gene Ther 1999, 10:1667-1682 12 Jung SC, Han IP, Limaye A, Xu R, Gelderman MP, Zerfas P, Tirumalai K, Murray GJ, During MJ, Brady RO, Qasba P: Adeno- associated ... mouse model Among them, a recent gene therapy study using pseudotyped recombinant adeno- associated virus (rAAV) vector showed very promising results [13] Although the gene therapy studies should have ... regarding a comparison study of gene therapy and ERT In the present study, we investigated pseudotyped rAAV2/8-mediated gene delivery of α-Gal A and compared the efficacy of gene therapy with that of...

Ngày tải lên: 10/08/2014, 05:21

... it is essential to explore other gene delivery vectors for prolonged gene expression We sought to use adeno- associated viruses (AAV) for the longevity of transgene expression [4] Furthermore, ... recombinant adenoassociated virus vectors Hum Gene Ther 1998, 9:2745-2760 Conway JE, Rhys CM, Zolotukhin I, Zolotukhin S, Muzyczka N, Hayward GS, Byrne BJ: High-titer recombinant adeno- associated virus ... recombinant adeno- associated virus vectors J Virol 1996, 70:3227-3234 McCarty DM, Fu H, Monahan PE, Toulson CE, Naik P, Samulski RJ: Adeno- associated virus terminal repeat (TR) mutant generates...

Ngày tải lên: 14/08/2014, 19:22

... cells poorly, and adenoviruses produce an acute inflammatory response and an immune response to viral vector-encoded antigens [7,8] We therefore developed an adeno- associated virus (AAV) system ... dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis J Virol 2001, 75:3501-3508 Ponnazhagan S, Mahendra G, Curiel DT, Shaw DR: Adeno- associated virus ... 1997, 176:322-330 Bueler H: Adeno- associated viral vectors for gene transfer and gene therapy Biol Chem 1999, 380:613-622 Kay MA, Glorioso JC, Naldini L: Viral vectors for gene therapy: the art of...

Ngày tải lên: 14/08/2014, 19:22

... Carter BJ: Adeno- associated virus vectors for gene therapy Gene Ther 1995; 2: 357-362 [23] Liu J, Saghizadeh M, Tuli SS et al: Different tropism of adenoviruses and adenoassociated viruses to ... Generation of recombinant adeno- associated virus vectors by a complete adenovirus-mediated approach Mol Ther 2001; 3: 787-792 [40] Matsushita T, Elliger S, Elliger C et al: Adeno- associated virus ... naturally occurring serotypes of adeno- associated virus (AAV) as novel vectors for human gene therapy Curr Gene Ther 2003; 3: 281-304 [21] Carter BJ: Adeno- associated virus vectors Curr Opin Biotechnol...

Ngày tải lên: 05/09/2015, 11:13

... recombinant adeno- associated virus type infection J Virol 1999, 73:10371-10376 Bartlett JS, Wilcher R, Samulski RJ: Infectious entry pathway of adeno- associated virus and adeno- associated virus vectors ... Mutagenesis of an AUG codon in the adeno- associated virus rep gene: effects on viral DNA replication Virology 1989, 173:120-128 Berns KI, Adler S: Separation of two types of adeno- associated virus ... required for adeno- associated virus DNA replication in the absence of adenovirus coinfection J Virol 1998, 72:2777-2787 Pereira DJ, McCarty DM, Muzyczka N: The adeno- associated virus (AAV) Rep...

Ngày tải lên: 19/06/2014, 08:20

... recombinant adeno- associated virus type infection J Virol 1999, 73:10371-10376 Bartlett JS, Wilcher R, Samulski RJ: Infectious entry pathway of adeno- associated virus and adeno- associated virus vectors ... Mutagenesis of an AUG codon in the adeno- associated virus rep gene: effects on viral DNA replication Virology 1989, 173:120-128 Berns KI, Adler S: Separation of two types of adeno- associated virus ... required for adeno- associated virus DNA replication in the absence of adenovirus coinfection J Virol 1998, 72:2777-2787 Pereira DJ, McCarty DM, Muzyczka N: The adeno- associated virus (AAV) Rep...

Ngày tải lên: 20/06/2014, 04:20

... preparation of virus supernatants To produce virus, HEK293 cells (Stratagene) which contain the adenovirus E1 gene were co-transfected with the E1 deleted adenovirus helper plasmid pHelper (Stratagene) ... 19q for integration of adeno- associated virus DNA by non-homologous recombination Embo J 1992, 11:5071-5078 Smith RH: Adeno- associated virus integration: virus versus vector Gene Ther 2008, 15:817-822 ... Falck-Pedersen E: Adeno- associated virus site-specific integration and AAVS1 disruption J Virol 2004, 78:7874-7882 Owens RA: Second generation adeno- associated virus type 2-based gene therapy systems...

Ngày tải lên: 12/08/2014, 01:21

... recombinant adeno- associated virus vectors J Virol 1996, 70:3227-3234 Xiao W, Warrington KH Jr, Hearing P, Hughes J, Muzyczka N: Adenovirus-facilitated nuclear translocation of adeno- associated virus ... the gene delivery system Adenoviral vectors provide only transient gene expression, and there are safety questions with retroviral and lentiviral vectors Vectors based on adeno- associated viruses ... naturally defective human parvovirus with a 4.7 kb genome [10] To replicate, AAV2 usually requires a helper virus, such as an adenovirus or herpesvirus [11] AAV2 has not been associated with a human...

Ngày tải lên: 12/08/2014, 04:21

... References Muzyczka N: Adeno- associated virus (AAV) vectors: will they work? J Clin Invest 1994, 94:1351 Flotte TR, Carter BJ: Adeno- associated virus vectors for gene therapy Gene Ther 1995, 2:357–362 ... expand the utility of adeno- associated virus vectors for gene therapy Proc Natl Acad Sci USA 2000, 97:6716–6721 12 Flotte TR, Afione SA, Zeitlin PL: Adeno- associated virus vector gene expression occurs ... novel adeno- associated virus promoter J Biol Chem 1993, 268:3781–3790 10 Duan D, Yue Y, Yan Z, Engelhardt JF: A new dual-vector approach to enhance recombinant adeno- associated virus- mediated gene...

Ngày tải lên: 12/08/2014, 18:20

... Myocardial gene transfer and long-term expression following intracoronary delivery of adeno- associated virus J Gene Med 2005, 7:316-324 Bennett J: Immune response following intraocular delivery ... Srivastava A: Adeno- associated virus type 2-mediated gene transfer: correlation of tyrosine phosphorylation of the cellular single-stranded D sequencebinding protein with transgene expression ... KA, Chen L, Yoder MC, Srivastava A: Adeno- associated virus type 2-mediated gene transfer: role of cellular T-cell protein tyrosine 17 phosphatase in transgene expression in established cell lines...

Ngày tải lên: 14/08/2014, 19:22

... Lai YK, Rakoczy PE: Adenovirus and adeno- associated virus vectors DNA Cell Biol 2002, 21:895-913 22 McCarty DM, Young SM Jr, Samulski RJ: Integration of adeno- associated virus (AAV) and recombinant ... long-term gene transfer into muscle tissue of immunocompetent mice by adeno- associated virus vector J Virol 1996, 70:8098-8108 26 Mueller C, Flotte TR: Clinical gene therapy using recombinant adenoassociated ... adenoassociated virus vectors Gene Ther 2008, 15:858-863 27 Xiao X, Li J, Samulski RJ: Production of high-titer recombinant adenoassociated virus vectors in the absence of helper adenovirus J Virol...

Ngày tải lên: 14/08/2014, 19:22

... Kháng bệnh đơn gene (monogenetic resistance) Tính kháng bệnh đơn gene thƣờng gene có tính trội điều khiển vài gene điều khiển nhƣng gene định vị rất gần liên kết với rất chặt chẽ Các gene kháng ... đƣợc giống 2.3.3.2 Kháng bệnh đa gene (polygenetic resistance) Tính kháng bệnh nhóm đƣợc biểu nhiều gene Các gene kháng có gene trội lẫn gene lặn Do có nhiều gene kháng nên giống nhóm kháng với ... đỏ đầu virus Virus liên quan đến bệnh héo dứa (PMWaV) thực chất phức hợp loại virus PMWaV - PMWaV - Dựa vào đặc điểm di truyền, hai loại virus đƣợc xếp vào họ Closterovirus, loài Ampelovirus,...

Ngày tải lên: 03/09/2013, 09:59

... Grapevine leafroll associated virus Virus Genes 2008, 37:110-118 Peremyslov VV, Hagiwara Y, Dolja VV: Genes required for replication of the 15.5-kilobase RNA genome of a plant closterovirus J Virol ... cherries [21] and plums [22] Grapevine leafroll -associated virus (GLRaV-3), the type member of the genus Ampelovirus, represents the second largest virus in the family Closteroviridae with a monopartite ... nt 5′NTRs The genome organization of GLRaV-3 is shown in Fig Unlike other viruses in the genera Closterovirus and Ampelovirus, GLRaV-3 contains two small ORFs (p7 and p4) nearest to the 3′-terminus...

Ngày tải lên: 12/08/2014, 04:20

... chromosomes by adeno- associated virus vectors Nat Biotechnol 2002; 20(7):735-738 119 Porteus MH, Cathomen T, Weitzman MD, Baltimore D Efficient gene targeting mediated by adenoassociated virus and ... that might serve to achieve human germline gene therapy If human gene transfer technology is limited to adding-in gene functions via non-targeted transgene integration, and if the process needs ... Wieringa [117], in which the creatine kinase M gene (CKM) in ESCs was targeted More recently, adeno- associated virus (AAV) vectors have been used to gene target somatic cells at high frequencies...

Ngày tải lên: 03/11/2012, 10:01

... pháp tạo virus 2.8.1 Sơ lƣợc hình thái, cấu tạo di chuyển virus thực vật [2] Hình thái Virus thực vật có hình thái kích thước đa dạng Virus có dạng hình gậy (virus khảm thuốc - TMV, virus khảm ... (virus khảm dưa chuột, virus khảm súp lơ), hình khối đa diện, hình sợi (virus X khoai tây, Closterovirus…)… Cấu tạo Thông thường virus cấu tạo từ protein acid nucleic Trường hợp đặc biệt số virus ... dứa (PMWaV) thực chất phức hợp loại virus PMWaV-1 PMWaV-2 Dựa vào đặc điểm di truyền, hai loại virus xếp vào họ Closterovirus, loài Ampelovirus, giống Vinivirus [14] Các phân tích phát sinh loài...

Ngày tải lên: 19/03/2013, 09:41

... Syndrome Virus - WSSV), vi-rút gây hội chứng Taura (Taura Syndrome Virus - TSV), vi-rút gây bệnh đầu vàng (Yellow Head Virus - YHV) Đặc biệt vi-rút gây bệnh liên kết mang (Gillassociated Virus - ... nuôi tôm toàn giới White Spot Syndrome Virus (WSSV), Yellow Head Virus (YHV), Taura Syndrome Virus (TSV), Infectious hypodermal and hematopoietic necrosis virus (IHHNV) Bảng 2.1 Diện tích, sản ... 2003) Do đề tài “Ứng dụng kỹ thuật PCR RT-PCR chẩn đoán WSSV (White Spot Syndrome Virus) GAV (Gill associated virus) tôm sú (Penaeus monodon) đồng sông Cửu Long” thực Mục tiêu đề tài Xác định...

Ngày tải lên: 22/02/2014, 12:42