... or
unfavorable, depending on the disease. As a case in
point, formation of huntingtin-containing inclusion
bodies in Huntington’s disease encourages cell survival,
whereas monomers and small inclusion bodies ... deficient in
desmin, again demonstrating inclusion body construc-
tion independent of intermediate fialments [62]. Inter-
estingly, inclusion body formation is slowed by
aB-crystallin, Hsp27 and HspB8, ... aA-
crystallin requires this domain [66]. Attachment of
R116C aA-crystallin to Hsp27 and aB-crystallin
increases in comparison to wild type, while binding to
cC-crystallin and bB2-crystallin decreases....
...
expected in this setting. Recommended types of exercise include interval training at moderate
intensity, e.g., ball games and running games, or moderate stamina training. Their afterload
reducing ...
surgery/interventions (including ablations)
Group 1 Patients after cardiac surgery/interventions
(including ablations)
1.1 Without remaining findings (complete correction)
1.2 With minimal findings
1.3 ... requiring surgery 0 No sports
A No (remaining) cardiac defects 1.1 Unlimited
B Mild (remaining) findings
1.2; 2.1; 2.2; 2.3; 2.4; 4.2 Unlimited
C Clinically significant (remaining findings) 1.3;...
... gastro-intestinal diseases, injuries and poisoning, and infectious and
parasitic diseases in the last three decades, in Portugal [10]. Since some of these causes of
death are more common in the ... in 2004,
surpassed by infectious and parasitic diseases, perinatal conditions and unintentional injuries.
Age-standardized mortality rates from CVD have been declining for several decades in ...
significant change in the log-linear slope of the trend (joinpoints) [14]. The analysis starts
with the minimum number of joinpoints (no joinpoints corresponds to a straight line), and
tests whether...
... recognized sponsoring specialties and who are certified
in Sleep Medicine. Faculty should be available to participate in consultation and
teaching in disciplines related to Sleep Medicine including cardiology, ... disorders, movement
disorders, multiple sclerosis, neurodegenerative disorders, headaches, and trau-
matic brain injury. They should also possess in- depth knowledge of intrinsic
brain sleep disorders ... Their stud y included both institutionalized and community-dwelling
individuals. Espie et al. found decreased REM sleep, an increased REM sleep
latency (172.5 minutes), and “indiscriminate” nonREM...
... Chapters 3 and 4) have not been applied widely in clinical assessments
of older adult balanceandgait disorders. Instead, a set of functional gait
andbalance tasks (which includes gait- related ... book is to provide clinicians, thera-
pists and others treating gaitdisorders with an understanding of the mechan-
isms underlying gaitdisordersand how to best manage these disorders. To a
large ... Classifications of Gait Patterns Using Gait
Analysis in CP . . . . 251
III. Gait Analysis in PD and HD . . . . 254
IV. Huntington’s Disease . . . . 257
xii Contents
III. Static Balanceand PN . . ....
... recognition in the normal splicing
process [55]. First, U1snRNP binding to an intronic
splicing processing element has been found to inhibit
pathological pseudoexon inclusion in intron 20 of ... 847
MINIREVIEW
Alternative splicing: role of pseudoexons in human disease
and potential therapeutic strategies
Ashish Dhir and Emanuele Buratti
International Centre for Genetic Engineering and ... splice-
supporting intronic mutation in the last bp position of
a cryptic exon within intron 6 of the CYBB gene
induces its incorporation into the mRNA causing
chronic granulomatous disease (CGD)....
... Fibrosis and Bony Ankylosis
283 Tumors in the Temporomandibular Joint Region
284 Joint Disorders Articular Surfaces
286 Joint Disorders Articular Disk
287 Joint Disorders Bilaminar Zone and Joint ... of the dentist in diagnosing and treating pain in the
head and neck region increasingly obscure rather than more
clear. In the academic debate concerning the etiology—pre-
dominantly psychological ... receptors
through inflammation or rupture,
resultina in Dain.
8 Primary Dental Evaluation
Findings in the Teeth and Mucous Membrane
The intraoral evaluation includes in particular:
• careful...
... that interfacial
protein–protein interactions between the hinge region of ISP
and the extramembranous cd2 helix of cytochrome b are
important for maintaining the structure of the hinge region
and, ... substrate
and the inherent partioning of quinol into the Q
o
site. The
Fig. 3. Steady-state level of the iron–sulfur protein (ISP) in G167E.
Immunoblots of denaturing gels, loaded with 40 lg of protein ... glutamate (in yeast or humans) may affect the
structure of the hinge region, resulting in a hindered move-
ment and enzyme instability. As suggested previously for a
yeast mutant with a +1 alanine insertion...
... including
investigations in human tissues, and that this has
implications for how to interpret the role of the stud-
ied enzymes in health and disease.
Results
The distribution and relative intensity ... toxic
isoquinolines such as salsolinol [23]. In line with the
suggested role of ADHs and ALDHs in protection
against toxic insults, mRNAs encoding these enzymes
have previously been identified in tissues ... corresponding rat tis-
sues show expression only in duodenum, colon and rectum. In both mouse and rat, Adh4 is found in the epithelial lining of upper GI tract
including the tongue, esophagus and stomach,...
... gene containing a trinucleotide repeat
that is expanded and unstable on Huntington’s disease
chromosomes. Cell 72, 971–983.
6 Young AB (2003) Huntingtin in health and disease.
J Clin Invest 111, ... neurodegeneration in Huntington’s disease: a
comparative study of cannabinoid, dopamine, adeno-
sine and GABA (A) receptor alterations in the human
basal ganglia in Huntington’s disease. Neuroscience ... made
in identifying genetic factors contributing to PD in
recent years [135]. Low concordance for clinical disease
in monozygotic twins indicates environmental in uen-
ces on PD [136], and the...