functional models for the discriminative effects of drug mixtures

... engendered by the financial friction This is because of the rate of growth of the price of tradable goods, which enters in the definition of the gross interest rate which governs the size of the wedge ... market We calculate the cost of credit for the median firm as the ratio of the real value of interest payments to the real value of the stock of bank debt As observed in the figure, this real implict ... depreciation The sudden stop episodes studied include the Latin American debt crises of the 1980s, the Mexican crisis of the first half of the 1990s and the East Asian and Russian crises of the late...

Ngày tải lên: 15/03/2014, 22:20

... is the number of cells strictly left of c in the diagram of λ (3) The leg of c, denoted l(c), is the number of cells strictly below c in the diagram of λ (4) The coleg of c, denoted l (c), is the ... invalid in the other.) This lemma, together with the discussion preceding it, completes the proof of formula (18) We leave to the reader the task of showing that this formula reduces to formula ... journal of combinatorics 11 (2004), #R68 c Figure 1: Diagram of a partition (1) The arm of c, denoted a(c), is the number of cells strictly right of c in the diagram of λ (2) The coarm of c, denoted...

Ngày tải lên: 07/08/2014, 08:20

... accuracy of prognostic models for the early care of trauma patients Conclusions This systematic review located and appraised the quality of five prognostic models for the early care of trauma ... care of trauma patients The majority of models were developed in cohorts of trauma patients from the 80’s All except one of the models were developed in populations from high-income countries The ... the clinical credibility of the model remained unevaluated, and none of the models were tested in a randomised clinical trial Discussion This systematic review located prognostic models for the...

Ngày tải lên: 13/08/2014, 23:20

... densities or products thereof may be specified for the prior density p(ϕ) on ϕ, depending, again, on the number of sets of random effects and whether there are any covariances thereof [21] Finally, ... al The generation of individual elements θj , j = 1, 2, , p + q or blocks thereof of θ from their respective FCD is straightforward using the strategy presented by Wang et al [48] The FCD of ... hierarchical models The DIC is based on the posterior distribution of the deviance statistic, which is −2 times the sampling distribution of the data as specified in the first stage of a hierarchical...

Ngày tải lên: 14/08/2014, 13:22

... Assemblage of the clones yield the full-length cDNA sequences of at least two distinct LDH-A isoforms, which differ substantially in the coding sequence and length of the 3¢-UTR Therefore, isoform-specific ... All the observed dynamic changes in enzyme properties under acclimation should be considered in the context of the relevance for the performance of metabolic networks, because the theory of metabolic ... in their 3¢-UTR sequence binding sites for specific proteins that increase ⁄ decrease the rate of poly(A) shortening, i.e affect the lifetime of the mRNA [32], therefore it is likely that the...

Ngày tải lên: 19/02/2014, 02:20

... and Zn2+ (results not shown) These effects suggest the involvement of sulfhydryl group(s) in the catalytic activity of the mycobacterial enzyme, as observed for the plant l-galactono-1,4-lactone ... l-gulono-1,4-lactone dehydrogenase of M tuberculosis is a specific enzyme for the biosynthesis of L-AA As far as we know, this is the first report of a specific biosynthetic enzyme for vitamin C in bacteria ... mutants of the gene could be obtained [40] The gene is well conserved within the M tuberculosis complex, except for the M bovis BCG Pasteur (1173P2) strain, which lost the gene due to the deletion of...

Ngày tải lên: 07/03/2014, 12:20

... clarify the binding properties of each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos ... and XI of the receptor serine ⁄ threonine kinase domain [22] Another striking point is the phase conservation of the intron– exon boundaries that lie either side of the exon encoding the extracellular ... end and C2 defines the domain closest to the cell membrane A comparison of the inferred amino acid sequence of the C1 and C2 domains reveals that only the approximate spacing of the 10 cysteine...

Ngày tải lên: 07/03/2014, 21:20

... collect information about wider effects of oral health on daily living The main advantage of generic measures is that they allow comparison of various domains of quality of life for the condition ... needs Therefore, the objective of this study was to assess the discriminative ability of one generic and one condition-specific OHRQoL measure, namely, respectively, the short form of the Oral ... treatment For that, the prevalence of oral impacts was calculated as the percentage of adolescents reporting one or more items 'fairly often' or 'very often' for OHIP-14 [23] and as the percentage of...

Ngày tải lên: 18/06/2014, 19:20

... page) the drug sensitive virus (solid lines in black), the drug resistant one (dashed lines) and the sum of Prevalence of infection with the drug sensitive virus (solid lines in black), the drug resistant ... in dependence of a given time delay between the importation of the drug sensitive and the drug resistant infection (0–30 days) Current mathematical models focus more on de novo drug resistance ... ure 1b) If the time point for the importation of the resistant strain is shifted towards the initial phase of the epidemic, the resistant strain increasingly replaces the sensitive strain (Figure...

Ngày tải lên: 20/06/2014, 01:20

... Proceedings of the National Academy of Sciences of the United States of America, vol 27, no 4, pp 222–224, 1941 T Aoki, “On the stability of the linear transformation in Banach spaces,” Journal of the ... well as on the equation Df x, y We refer the reader to the expository papers 11, 12 or to the books 13–15 see also the recent articles of Forti 16, 17 , for supplementary details On the other hand, ... application of our result for 1.8 , the stability for the following generalized functional equation of the square root spiral f p−1 p x k f x hx 1.9 is obtained Thereafter, we present the generalized Ulam-Hyers...

Ngày tải lên: 22/06/2014, 06:20

... (i.e the inverse of hydraulic resistance) is defined as the ratio that measures water movement through the roots relative to an external driving force controlling the water flow The adequacy of the ... topology For the morphological characterisation of shoots and roots and the topological characterisation of roots, 22 seedlings were taken randomly per type of container at the end of the vegetative ... information according to their partially overlapping position in the biplot, with overall higher values for all these variables characterising the shorter (ST) tube type On the other hand, the...

Ngày tải lên: 08/08/2014, 00:22

... the simulation The analytical models of Verrier et al [14] and Chevalet [3] will then be described, each corresponding to a different choice of hypotheses for the algebraic formalization of the ... the ’semi-finite’ model or SFM The joint distribution of the gene effects is then assumed to be multivariate normal Derivations of the variances of gene effects and covariances between gene effects ... predictions provided by the three models for the joint effects of population intensity on the evolution of genetic variance were compared illustrates the case of intermediate value of selection intensity...

Ngày tải lên: 09/08/2014, 18:22

... development over the past 30 years The bottom half of the timeline denotes the emergence of key humanized mouse models The top half of the timeline denotes the application of the models to HIV-1 ... model Here, we focus on the development of each of these models for the study of human retroviral infection, i.e., with HIV-1 and HTLV-1 The comparison of all of these models in historical context, ... Comparison of animal models for the study of retroviral infection The identification of HIV-1 as the causative agent of AIDS was followed only a year later by the recruitment of chimpanzees for the...

Ngày tải lên: 12/08/2014, 23:22

... represent a single pathological entity and therefore there is no single strategy for their prevention Conflict of interest The author has declared that no conflict of interest exists References Czeizel ... corrected by drugs immediately after birth In Hungary 25.2% of congenital abnormalities were prevented by these methods Previously the selective abortion, i.e termination of pregnancy after the prenatal ... diagnosis of severe fetal defects was also named as secondary prevention Recently the WHO and other international bodies have excluded this approach from the term “prevention” In Hungary about 20% of...

Ngày tải lên: 02/11/2012, 11:12

... the scope of the study, the aims of the study, the methods of the study and finally the design of the study *Part II includes three chapters: + Chapter one is the literature review in which the ... in the previous chapter 3.1 The content area of the test The following topic checklist of the course book will help to point out the content area of the reading test The Topic checklist of the ... The mean is the sum of all the values in a distribution divided by the total number of values (50) The formula for the mean is: M = ∑f N x M= mean where: ∑= sum of (or add up) N= the number of...

Ngày tải lên: 07/11/2012, 14:12

... reward For the first hypothesis, we could not make predictions based on the name of the pay form; however, when considering the effects associate with the type of reward, the name of the pay form ... controlling for prior performance to examine the effects of payfor-performance plans on future performance Second, the study considered the different effects of the characteristics of multiple pay -for- performance ... performance levels THREE FORMS OF PAY -FOR- PERFORMANCE PLANS There are many forms of pay -for- performance (Milkovich & Newman, 2005), and while there has been research performed on many of these...

Ngày tải lên: 11/09/2013, 11:44

... I wish for you 365 days of Happiness 12 months of Fun 52 weeks of Success 8760 hours of Good Health 525600 minutes of Good Luck 3153600 seconds of Blessings ...

Ngày tải lên: 13/09/2013, 21:10

... Interpretation of the Convention D Interpretation of the contract; usages E Form of the contract Part Two Formation of the contract Part Three Sale of goods A Obligations of the seller B Obligations of the ... paragraph for any lack of conformity of the goods if at the time of the conclusion of the contract the buyer knew or could not have been unaware of such lack of conformity Article 36 (1) The seller ... delivered at the address of the offeror on the last day of the period because that day falls on an official holiday or a non-business day at the place of business of the offeror, the period is...

Ngày tải lên: 22/10/2013, 10:15

... records The information may be all of the information about the record, or it may be selected information The way in which the information is extracted will depend on its input into the cable ... Standard for the Telecom Infra of Com Bldgs Other Information Other Linkages Equipment Records PC120 the equipment the cable terminates at (desk top) Other Linked Records Linkages • are the connections ... contain the linkages to other elements of the telecommunications system The record will be contained in a database which may be searched and sorted according to the requirements of the users There...

Ngày tải lên: 10/12/2013, 02:15

... Preparing the Western Cape for the Knowledge Economy of the 21st Century 3.1 The economy of the Western Cape is woven tightly into the global economy Almost two-thirds of the output of the private ... Cape, is therefore how to channel the forces of globalisation for the elimination of poverty and the empowerment of people to lead fulfilling lives A related challenge is posed by the rise of the ... prepare the people of the province for the knowledge economy of the 21st century; To contain the spread of HIV/AIDS and TB; To empower the poor people of our province through the provision of basic...

Ngày tải lên: 27/01/2014, 12:20