... the androgen receptor to control cellular processes such as proliferation, apoptosis and other metabolic events in prostate cancer [14] Taken together, a combination of gene amplification and androgen ... 24 h and (D) 48 h (D) Overlay of (A) and (C) TPD52 downregulation activates caspase activity and increases the loss of mitochondrial membrane potential (E, F) Showing the relative caspase-3 and ... as TPD52 and its locus has been mapped on chromosome 8q21 [4,5] Its encoding gene is also referred to as PrLZ and is a member of the tumor protein D52 (TPD52) gene ⁄ protein family and is designated...
Ngày tải lên: 30/03/2014, 02:20
Ngày tải lên: 01/04/2014, 13:20
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
... psychologists and psychiatrists who treat patients with tinnitus and other hyperactive auditory disorders The book provides the basis for a broad understanding of the anatomy and function of the ear and ... flange (helix, antihelix, and lobule), concha (cymba and cavum), and ear canal (reprinted from Shaw, E A C 1974 The external ear In: Keidel, W D and Neff, W D (eds) Handbook of sensory physiology ... describes cochlear and brainstem implants and hearing conservation programs are discussed in an appendix The four chapters of Section I cover anatomy and physiology of the middle ear and the cochlea,...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
... the middle ear intact and the sound conducted to the tympanic membrane (solid lines), and after removal of the middle ear and the sound conducted to the oval window (dashes) and round window (dots) ... adult deafness and understanding of the processes that underlies this transformation opens new prospects for understanding of some forms of genetically related hearing impairment and for providing ... between 2.5 and kHz the amplification of sounds by the head and the pinna varies from to 21 dB depending on the angle to the sound source in the horizontal plane (azimuth) The shadow and baffle...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
... muscles and neck muscles Sound can also activate reflexes such as the acoustic middle-ear reflex and the startle reflex, and it can affect wakefulness and sounds can influence the autonomic system and ... the classical and the non-classical routes and the lateral nucleus of the amygdala (AL), showing the “high route” and the “low route” Connections between the basolateral (ABL) and the central ... representation of simple sounds such as tones and clicks and subsequent sections will discuss neural coding of complex sounds such as tones and broad band sounds the frequency or amplitude of which...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
... cochlea and the cochlear nucleus and potentials that originate in the cochlea and the cochlear nucleus are conducted to the recording site by passive conduction in the eighth cranial nerve and the ... (peak I and II of the ABR) and the third (peak III) (reprinted from Scherg and von Cramon, 1985, with permission from Elsevier) same distance from the midline as the cochlear nucleus The fifth and ... evoked potentials have contributed to understanding of the function of the ear and the auditory nervous system In this chapter, I will discuss the near-field and far-field potentials from the auditory...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
... hand graph: stimulation with 0.5 kHz; right hand graph: stimulation with 1.45 kHz Open circles are the ipsilateral response and closed circles the contralateral response (reprinted from Borg and ... L, and Syka J The responses of neurons in subdivisions of the inferior colliculus of cats to tonal, noise and vocal stimuli Exp Brain Res 98: 53–64, 1994 Andersen P, Eccles JC, Schmidt RF, and ... physiological and anatomical study Brain Res 49: 101–123, 1973 15 Borg E, Counter SA, and Roesler G Theories of middle ear muscle function Orlando, FL: Academic Press, 1984 16 Borg E and Møller...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
... methylation, histone acetylation, and RNA interference, and their effects in gene activation and inactivation, are important factors in phenotype transmission and development [107] is probably ... was 0.46 with a standard deviation of 0.15 The SP was significantly larger in Ménière’s patients at and kHz but not at and kHz Campbell et al [41] used kHz tones as stimuli and that may be the ... balance between inhibition and excitation, and degeneration of nerve fibers and nerve cells Decrease in inhibition or increase in excitation may cause hypersensitivity and hyperactivity Opening...
Ngày tải lên: 11/08/2014, 06:21
ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
... area, the hypothalamus, and a part of the mesencephalic tegmentum The limbic system also influences endocrine and autonomic motor systems and it affects motivational and mood states (see p 19) ... control (AGC), and then filtered into four contiguous frequency bands, with center frequencies at 0.5, 1, 2, and 3.4 kHz The filtered waveforms go through adjustable gain controls and then are ... 11.3) uses a combination of temporal and spectral coding (F0/F1/F2 strategy) The fundamental (voice) frequency (F0) and the first and second formant (F1 and F2) are extracted from the speech...
Ngày tải lên: 11/08/2014, 06:21
báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx
... (4°C) and centrifuged, and the supernatant was assayed by HPLC The stability was also determined by radio-TLC directly from plasma and blood samples without further handling; free 64Cu and purified ... pathways, such as protein and peptide interactions with cellular targets [30] Our laboratory has reported the synthesis and the characterization of DOTA and NOTA-BBN derivatives and showed that the ... the in vivo stability and the biodistribution of radiolabeled NOTA-BBN monomer and NOTA-BBN homodimers and which differed by the spacer length between the two peptide ligands (Figure 1) Our design...
Ngày tải lên: 21/06/2014, 17:20
báo cáo khoa học: "Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report" pps
... cytosine-phosphate-guanosine Tisman and Garcia Journal of Medical Case Reports 2011, 5:413 http://www.jmedicalcasereports.com/content/5/1/413 (CpG) islands and cancer initiation, promotion, and progression is ... groups), support methyl group generation and folate metabolism SAM delivers the methyl groups responsible for promoter CpG islands and global DNA cytosine Tisman and Garcia Journal of Medical Case ... natural folate, and avoided those foods high in folate When I found out the government had mandated the addition of folic acid to basically all products containing flour and grains since 1998...
Ngày tải lên: 10/08/2014, 23:20
EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
... dimer α helices are numbered and drawn as coils, β strands are lettered and drawn as arrows, and other elements are drawn as tubes ball -and- stick representation of ADP and PCho molecules are shown ... include recently identified (and cloned) choline transporter hOCT1 (Burckhardt and Wolff, 2000) and hOCT3 (Burckhardt and Wolff, 2000) in kidney and liver Saturation kinetics and substrate specificity ... 1977; Infante and Kinsella, 1978) and regulatory in some circumstances for instance in phosphatidylcholine synthesis in mitogen stimulated NIH3T3 cells (Warden and Friedkin, 1985) and ras oncogene...
Ngày tải lên: 24/08/2014, 10:38
Tài liệu Transmission and Pathogenesis of Tuberculosis docx
... Chapter 2: Transmission and Pathogenesis of Tuberculosis 42 References American Thoracic Society and CDC Diagnostic standards and classification of tuberculosis in adults and children Am J Respir ... Factor TB infection and no risk factors TB infection and diabetes TB infection and HIV infection Risk of Developing TB Description For people with TB infection, no risk factors, and no treatment, ... and surround the tubercle bacilli The cells form a barrier shell, called a granuloma, that keeps the bacilli contained and under control (LTBI) Shell breaks down and tubercle bacilli escape and...
Ngày tải lên: 15/02/2014, 12:20
Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... elevated, and consequently, the levels of nuclear SREBP-1c protein and lipogenesis are enhanced in the liver and adipose tissues Intake of energy molecules such as sugars, carbohydrates and saturated ... p21, p27, and p16, and causes cell cycle arrest Feedback Glucose G6PD Glc6P Fig Regulation of glucose and lipid metabolism by SREBPs Acetyl-CoA is produced from glycolysis of glucose, and passed ... SREBP-1c by saturated fatty acids and PUFAs Saturated fatty acids activate, and PUFAs suppress, SREBP1c, leading to and protecting from hepatic insulin resistance and pancreatic b-cell insulin secretion,...
Ngày tải lên: 18/02/2014, 13:20
ANATOMY, PHYSIOLOGY, AND PATHOPHYSIOLOGY FOR ALLIED HEALTH pot
... Pituitary Gland 133 The Thyroid Gland and Parathyroid Glands 134 The Adrenal Glands 134 The Pancreas 135 Other Hormone-Producing Organs 135 The Stress Response 135 Pathophysiology/Common Diseases and ... loss, and produces vitamin D precursors Consists of skin, hair, nails, and sweat glands Provides protection and support, allows body movements, produces blood cells, and stores minerals and fat ... tissues in skin and primarily occurs on the face and legs ɀ Causes This skin disease is caused by staphylococcal and streptococcal bacteria ɀ Signs and symptoms Skin appears red and tight and is often...
Ngày tải lên: 06/03/2014, 07:20
THE BIOLOGY, PHYSIOLOGY AND SOCIOLOGY OF REPRODUCTION ALSO SEXUAL HYGIENE WITH SPECIAL REFERENCE TO THE MALE docx
... muscle and glands and the consumption of the cell substances of these tissues results in the development of the nerve, muscle [34 ]and gland cells into a condition larger, better equipped and more ... stallion are, first, the great breadth and depth of chest, great mass of shoulder and hip muscles, and the high arched neck, fiery eye and luxuriant mane and tail Second, the functional features ... in the limbs and back, nausea, sleeplessness and nervous irritability and fever, followed by the appearance of a rash upon the face and body, falling out of the hair, sore throat and mouth These...
Ngày tải lên: 06/03/2014, 13:20
Lung cancer - The diagnosis and treatment of lung cancer pdf
... England, for patients diagnosed between 1993 and 1995 and followed up to 2000, 21.4% of men and 21.8% of women with lung cancer were alive year after diagnosis and only 5.5% of both men and women ... Palliative interventions and supportive and palliative care This section focuses on palliative interventions and supportive and palliative care for patients with lung cancer and therefore only evidence ... information, both verbal and written, on all aspects of their diagnosis, treatment and care This information should be tailored to the individual requirements of the patient, and audio and videotaped formats...
Ngày tải lên: 15/03/2014, 00:20
A TREATISE ON ANATOMY, PHYSIOLOGY, AND HYGIENE DESIGNED FOR COLLEGES, ACADEMIES, AND FAMILIES potx
... solids and fluids;—of solids, differing in character and properties, arranged into organs, and these endowed with functional powers, and so associated as to form of the whole a single system;— and ... organs to gain nourishment from the soil and atmosphere, and the power to give strength and increase to all their parts And animals need not only a digesting and circulating apparatus, but organs ... together organs and parts of organs, and to envelop, fix, and protect the vessels and nerves of organs Fig Fig Arrangement of fibres of the cellular tissue magnified one hundred and thirty diameters...
Ngày tải lên: 15/03/2014, 13:20
Guidelines for the early detection and screening of breast cancer ppt
... hand (first supporting from below and then pressing down from the top) and examine it with the other hand, again first from above and then from below 30 Guidelines for the early detection and ... standing positions: arms relaxed at the sides; hands pressed firmly on the waist and leaning forward; and arms over the head During this process, the examiner identifies subtle asymmetries and ... meeting their targeted goals and objectives, that any areas forimprovement are identified and managed in a timely and effective manner, and to be able to define interventions and continuation of the...
Ngày tải lên: 28/03/2014, 23:20