from cell cultures to man

... in human monocyte-derived dendritic cells and recombinant HEK 293 cells expressing the human A3 receptor and a chimeric Gaq-i3 protein Further, in CHO cells engineered to express the human A3 ... Analysis in Drug–Receptor Binding 35 36 P.A Borea et al a 22 hA3CHO cells Jurkat T cells A375 cells HL60 cells Human Neutrophils Human Lymphocytes Bovine Chondrocytes Bovine Synoviocytes ln KA 21 ... values) of human A3 adenosine receptors expressed in different cell lines at the six chosen temperatures, from to 30°C The substrates studied were CHO cells stably transfected with human A3 adenosine...

Ngày tải lên: 22/03/2014, 23:20

... Technology Management, Journal of Product Innovation Management, Management Science, Strategic Management Journal, R&D Management and Research Policy as well as the Harvard Business Review and Sloan Management ... why are the sources of some innovations from users and not from manufacturers? How and why some innovations from users end up replacing products offered by manufacturers? Thus, this thesis reviews ... innovators, especially manufacturers, with respect to conducting and protecting innovations from imitators User innovators can identify the unsatisfied demand and profit from the resulting innovation...

Ngày tải lên: 06/10/2015, 21:23

... considerations for a joint are degree of permanence, load type and strength Degree of permanence identifies whether a joint needs to be dismantled or not In most cases the permanence of a joining process is ... In many cases, incorrect joining processes are used due to a lack of knowledge of such factors as availability, cost and functional performance of alternatives As with primary and secondary manufacturing ... selection There is extensive evidence to suggest that many industrial products are designed with far too many parts DFA case studies indicate that in many designs large proportions of excess components...

Ngày tải lên: 20/01/2014, 00:20

... product manufacture and quality has never been greater There is extensive evidence to show that products are being designed with far too many parts and with many complex assembly and manufacturing ... its method of manufacture and, the manufacturing system, against clear customer requirements at equal levels of product and process definition Project Management – The professional management of ... in design for manufacture and assembly 1.1 Problems In today’s environment, manufacturing businesses are facing fierce competition and operating in changing markets Customer demands for higher...

Ngày tải lên: 20/01/2014, 00:20

... 1986 Central problem in the management of innovation Management Science 32, No 4, 590–607 Venkatraman N 1990 Performance implications of 154 Knowledge and Process Management strategic coalignment: ... Partners Survey of UK knowledge management practices shows that management practices that scored highest in importance by UK managers also scored the lowest in performance ratings; namely getting ... systems would help knowledge management, especially managing knowledge about customers, markets, products, services and corporate performance (Murray and Myers, 1997) Many organizations are looking...

Ngày tải lên: 24/01/2014, 00:20

... client satisfaction Chapter Quality Performance and People 118 The difference between mediocre and excellent performance; defining, valuing and leveraging excellent performers, while accepting that ... the passion required for excellence? 14 \ The Zen Approach™ to Project Management These are the questions to be answered in this exploration of project management from the Zen perspective Zen ... whether they are certified project management professionals (PMPs) or not Most people who manage projects in the world are not professional project managers Many are untrained and have little...

Ngày tải lên: 18/02/2014, 07:20

... by different managers High self-appraisal Remote manager Performance management and appraisal as a two-stage system Ongoing performance management Short cycle and long cycle performance evaluation ... resolution to your management chain Many managers the hard work of managing the disturbances, but never create any visibility of the same with higher management Your overseas managers must know ... pulls of being a manager Chapter 2, Transition: From Individual Contributor to a Manager – One of the most testing times is the transition from being an individual contributor to a manager Learn...

Ngày tải lên: 23/03/2014, 13:20

... Brassica nigra suspension cells [15], and duckweed [16] The cell wall-localized AP from –Pi B nigra suspension cells appeared to be identical to an AP secreted into the cell culture media [15], ... hydrolases for tomato seedlings and suspension cell cultures A 57-kDa AP was partially purified from the cell culture medium of 3-day-old –Pi tomato suspension cells [10], but a thorough kinetic and structural ... out at 0–4 °C Cell culture media from –Pi cells (4 L) was concentrated approximately 20-fold via tangential ultrafiltration (Millipore Mini-tan) using 10 30 kDa MWCO regenerated cellulose plates...

Ngày tải lên: 23/03/2014, 21:20

... the cells, these can be assumed proportional to the concentration differences across the junctions for each substance For example, for a pair of coupled cells the junctional fluxes from cell to cell ... oscillations in embryonic stem cell- derived primitive endodermal cells Exp Cell Res 238, 13–22 63 Bootman, M.D., Young, K.W., Young, J.M., Moreton, R.B & Berridge, M.J (1996) Extracellular calcium concentration ... multiplets, Ca2+ waves can spread from cell to cell [191–194] In contrast to isolated hepatocytes, which exhibit substantial variations of Ca2+ oscillation periods between cells when stimulated by hormone,...

Ngày tải lên: 24/03/2014, 00:21

... world, and observed the actions of men, I thought I met with many, very many, who gave too much for the whistle From Boyhood to Manhood (Life of Benjamin Franklin) 19 "When I saw one too ambitious ... becomes older, and can not command the confidence of his friends and neighbors, but is branded by them as an unreliable, dishonest man In like manner the boy who thinks it is manly to smoke and drink ... increase from month to month, and must continue to increase for some years, so far as I can see They will increase heavily if I am obliged to hire a man in John's place." From Boyhood to Manhood...

Ngày tải lên: 31/03/2014, 13:20

... product manufacture and quality has never been greater There is extensive evidence to show that products are being designed with far too many parts and with many complex assembly and manufacturing ... its method of manufacture and, the manufacturing system, against clear customer requirements at equal levels of product and process definition Project Management – The professional management of ... considerations for a joint are degree of permanence, load type and strength Degree of permanence identifies whether a joint needs to be dismantled or not In most cases the permanence of a joining process is...

Ngày tải lên: 02/04/2014, 16:25

... Figure Cell proliferation kinetics of vascular cell types obtained from human umbilical cords (UCs) Cell proliferation kinetics of vascular cell types obtained from human umbilical cords (UCs) Human ... endothelial cells from human umbilical cord Experientia 1983, 39:1144-1146 Dunzendorfer S, Bellmann R, Wiedermann C: A simple way to obtain sufficient amounts of arterial endothelial cells from human ... calculated HUAECs (Figure 4A, average of cells from 11 individuals from each group) and HUVECs (Figure 4B, average of cells from individuals from each group) from both birth weight groups showed...

Ngày tải lên: 18/06/2014, 15:20

... key-words uncovered many hundreds of 'hits': staff-mix, skill-mix, human resource management, human resource optimisation, workforce performance, human capital, skill management, human resources for ... strategic human resource management Journal of Management 1992, 18(2):295-320 171 Wright PM, Snell SA: Toward an integrative view of strategic human resource management Human Resource Management ... human and material resources Human resources management strategies: planning and staffing, education and training, working conditions, performance management Organisational outcomes Skill management...

Ngày tải lên: 18/06/2014, 17:20

... SHIELD study and helped to draft the manuscript KF performed the statistical analysis and drafted the manuscript All authors read and approved the final manuscript 16 Acknowledgements 18 The ... PhD The following individuals also contributed to the work reported in this manuscript: Richard Chapman (analysis and manuscript drafting) of ValueMedics Research; and Tina Fanning (data collection ... indicate change from reference group †p < 0.05 versus reference group EQ-5D = EuroQoL-5 Dimensions; VAS = visual analog scale; SE = standard error Discussion The EQ-5D results from the SHIELD...

Ngày tải lên: 18/06/2014, 22:20

... product manufacture and quality has never been greater There is extensive evidence to show that products are being designed with far too many parts and with many complex assembly and manufacturing ... its method of manufacture and, the manufacturing system, against clear customer requirements at equal levels of product and process definition Project Management – The professional management of ... in design for manufacture and assembly 1.1 Problems In today’s environment, manufacturing businesses are facing fierce competition and operating in changing markets Customer demands for higher...

Ngày tải lên: 03/07/2014, 12:20

... considerations for a joint are degree of permanence, load type and strength Degree of permanence identifies whether a joint needs to be dismantled or not In most cases the permanence of a joining process is ... low labor rate in the country of manufacture and therefore manual assembly becomes viable for even relatively large production volumes Although there may be many important selection drivers with ... selection There is extensive evidence to suggest that many industrial products are designed with far too many parts DFA case studies indicate that in many designs large proportions of excess components...

Ngày tải lên: 03/07/2014, 12:20

... Managing Editor: Managing Editor: Development Editor: Copy Editor: Typesetter: Cover Design: Printed at: Mehdi Khosrow-Pour Jan Travers Amanda Appicello Michele Rossi Bernard J Kieklak, Jr Amanda ... from top scholars, professionals and practitioners from various parts of the world We have received chapters from the USA, Canada, Japan, Australia, New Zealand, Korea, Singapore, India and many ... an economy Closing the Digital Divide could bring many benefits to developing countries In many ways, developing countries have the most to gain from improvements in telecommunications and information...

Ngày tải lên: 03/07/2014, 16:06

... Butterworth–Heinemann, Oxford 1.33 Miles, B and Swift, K G (1998) Design for manufacture and assembly Manufacturing Engineer, October, 221–224 1.34 Boothroyd, G and Dewhurst, P (1988) Product design for manufacture ... Edwards, L and Endean, M (1990) Manufacturing with Materials, Butterworth–Heinemann, Oxford 1.44 Bakerjian, R (Ed) (1992) Design for Manufacturability – Tool and Manufacturing Engineers Handbook ... Software Manual (1996) CSC Manufacturing, Solihull, UK Sealy, M., Berriman, P and Marti, Y.- M (1992) A practical solution for implementing sustainable improvements in product introduction performance...

Ngày tải lên: 21/07/2014, 16:21

... for the manufacture of a small lightly loaded timer gear from a domestic appliance controller in terms of production rates and economics 14 Contrast the manufacture of toothpaste tubes from aluminum ... powder metallurgy in terms of manufacturing economics and quality of conformance 25 Contrast manually operated engine lathes, automatic lathes and CNC lathes in terms of manufacturing economics and ... programmable systems, mainly due to the inherent flexibility of manual or human operations 3.3.1 Assembly costing model The total cost of manual assembly comprises the sum of the total handling and...

Ngày tải lên: 21/07/2014, 16:21