format and content of the human pharmacokinetics and bioavailability section of an application guidance 1997
báo cáo khoa học: "Prediction of genetic merit from data on binary and quantitative variates with an application to calving difficulty, birth weight and pelvic opening" pot
Ngày tải lên :
09/08/2014, 22:23
... Station, France Each calving record included information on the following: region of origin and sire of the heifer, pelvic opening and season of calving, sex and birth weight of the calf, and calving ... &dquo; n and Sm is the effect of the i sire of the heifer; b, and b are partial « regression coefficients of the underlying variate on birth weight of the calf and pelvic opening of the heifer, ... is the effect of the i‘&dquo; department of origin of the heifer (i= 1,2), T’ is the effect of the j‘&dquo; season of calving (j=1,2), Sk is the effect of the k sire of heifer ’ t (k= 1, , 6) and...
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Open business models and platform mediated networks: an application in the mobile industry
Ngày tải lên :
28/06/2015, 18:25
... The economic globalization and the application of information and communication technologies offer firms the opportunity to develop new knowledge and increase the possibilities of accessing and ... detailed analysis of a relevant player in the mobile industry contrasted with personal interviews with experts and managers of the firm The insights provided by this research broadens the extant theory ... as an organizational form and heterogeneity of users demands [30] Arguably in a context in which demand is non homogeneous economies of scale not exist, or at least are difficult to achieve, and...
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summary content of subject application of siemens s7 in automation manufacture
Ngày tải lên :
26/09/2014, 23:46
... two companies This is HaiVan cement company and Larger beer company Hai Van cement company have a real difficult, this is : * Company want to raise automation standard of Rotopacker group from ... subject consist of chapter and make a study of matters : * Introduce general about two company where I practice * Organization, civil of company * Character manufacture, product of company * Introduce ... about company, reason of be born, achiement * Organization diagram of company * Introduce obout organization of company, consist of: diretor, deputy director of businiss, deputy diretor of technical,...
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Contrastive analysis on english and vietnames proverbs referring to parts of the human body
Ngày tải lên :
12/12/2013, 00:03
... referring to parts of the human body and their Vietnamese equivalents Meaning In the language there are two basic kinds of meaning and they are direct meaning and indirect meaning Direct meaning directly ... discusses types of meaning, the change and the development of meaning, the grouping of words and so on 2.3 Etymology: It refers to the history and the origin of words Etymologists divide the English ... parts of the human body Meanings of English and Vietnamese proverbs referring to parts of the human body IV Methods of the study Statistic method Contrastive and comparative method Analysis and...
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The transference of meaning through class of words denoting parts of the human body in english and vietnames
Ngày tải lên :
18/12/2013, 21:45
... - The bowel of the earth The hand of a child - The hand of a lock The heart of a man - The heart of a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of ... One's hands - The hands of a farm 13 The heel of a person - The heel of the hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom of the ... linguistics and culture England and Vietnam have their own culture, human race, geography and history We can also see that, the class of words denoting parts of the human body is very familiar to us and...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
Ngày tải lên :
15/02/2014, 01:20
... II The hood domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The ... compared to the spectrophotometric methods Because the enzymatic activity of PRTFDC1 towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 ... kinetics, ligand binding, and crystallography Biochemistry 45, 6615–6627 24 Raman J, Sumathy K, Anand RP & Balaram H (2004) A non-active site mutation in human hypoxanthine Studies of the human PRTFDC1...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
Ngày tải lên :
19/02/2014, 06:20
... Fig The strand-exchange activities of the Rad51 mutants (A) A schematic diagram of the strand-exchange assay (B) The Rad51 concentrations were lM (lanes 2, 5, 8, 11, 14, 17, 20, and 23), lM (lanes ... in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of their ... dichroism analysis and ATPase activities of the Rad51 mutants (A–C) CD spectra of HsRad51 (6.7 lM) and the Rad51 mutant (6.7 lM) were recorded at 25 °C HsRad51 (A); Y232A mutant (B); and F279A mutant...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
Ngày tải lên :
19/02/2014, 07:20
... compares the studied network with randomized versions of it with the same size and degree distribution The so-called Z-score quantifies the difference between the studied network and an ensemble of randomized ... Thanks to Dr J Aldana-Montes and members of Kha´ os group research of the University of Malaga for their help in data acquisition Thanks to P Fernandez and S Valverde from the ICREA-Complex Systems ... TAFII and NC2 and NF-Y factors that have histone fold motifs [52] Group G is a small subset that contains all the SMAD proteins of the HTFN and APC and b-catenin-related factors Groups C and D...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
Ngày tải lên :
19/02/2014, 16:20
... consumption and to examine the possible role played by cells and molecules of the immunological system in hepatic injury and repair Understanding the interdependence between the metabolism of iron and ... Vale, F Pisarra and M.T Silva for help and comments on TEM, and M Santos and R Hultcrantz for critical reading of the manuscript We also thank M de Sousa for mentoring this work M.C and C.F.P were ... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21] After their synthesis in the endoplasmic...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
Ngày tải lên :
19/02/2014, 16:20
... (60 lgÆ lane)1) prepared from HEL (C and D; lane 1) and HEK293 (C and D; lane 2) cells The positions of the molecular size markers (kDa) are indicated to the left and right of the (C) and (D), ... complexity of TXA2 signaling and provides an additional critical mechanism whereby the effects of TXA2 can be modulated in an isoform and ⁄ or cell ⁄ tissue specific manner The overall aim of the current ... Characterization of the 5¢ untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP) Differential promoter utilization by the TP isoforms Eur J Biochem 269, 4058–4073 26 Quandt...
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Báo cáo khoa học: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals doc
Ngày tải lên :
07/03/2014, 11:20
... 82.2% identical to that of Gao Although the similarity of the aA–aE region and the region upstream of a4 was relatively low, the N-terminal region (aN a1), the aF–aG region and the C-terminal region ... GOA-1 and Gao [31,32] The five regions of the Ga-subunit involved in receptor recognition are the a2 helix, the b6 ⁄ a5 loop, the a5 helix and the N- and C- extreme termini [31] In addition, the ... expressed over the detection sensitivity in the western blot analysis and well transferred in the membrane fraction Binding properties of muscarinic ligands with M2::GOA-1 fusion protein The binding...
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Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
Ngày tải lên :
07/03/2014, 12:20
... to anticancer drugs Therefore, we used cisplatin, etoposide and paclitaxel to investigate the effects of these anticancer drugs on LXF-289 cells in the presence of ATP These anticancer substances ... specific for the human isoforms There was evidence for the expression of mRNA for the P2Y receptor subtypes P2Y2, P2Y6, P2Y11 and P2Y13 and for the P2X4 receptor, whereas expression of the P2Y1, ... growth, the role of nucleotides as effectors of neoplastic transformation and the ubiquitous expression of the purinergic receptors led to the investigation of the therapeutic potential of nucleotides...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx
Ngày tải lên :
07/03/2014, 16:20
... HR (1997) Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast EMBO J 16, 1832–1841 Munro S (1995) A comparison of the transmembrane domains of Golgi and ... membrane expression [6] In the absence of positive transport signals, the localization of a protein in the ER may result from the properties of the TMD and its interaction with the membranes ... BamHI site and UGT1A6 nucleotides 1467– 1482 and an antisense primer 5¢-CTCGAGTCAATGG GTACTGGAACTGTGGGCTTTCTT-3¢ introducing the mutations and encoding for the last six residues of human UGT1A6...
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Báo cáo khoa học: Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B docx
Ngày tải lên :
07/03/2014, 17:20
... orientations that differ between hHR23B and hHR23A are shown Also, b-N and b-C are the N- and C-termini of XPCB–hHR23B; a-N and a-C are the N- and C-termini of hHR23A FEBS Journal 272 (2005) 2467–2476 ... further our knowledge with respect to the mechanisms of action of these proteins, it is crucial that we define the precise boundaries of the STI1-homologous domain and compare the structures of these ... inducible) and TPR (tetratrico peptide repeat) domains (B) Multiple sequence alignments of the XPCB domains of hHR23B and hHR23A with other STI1-homologous domains from yeast STI1 and DSK2, and from human...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc
Ngày tải lên :
08/03/2014, 08:20
... 17aOHpreg and DHEA – and analyzed androstadienol formation from each substrate As observed in Fig 3, the biosynthesis of androstadienol in humans (A) and pigs (B) does not require prior formation of ... demonstrates the specific implication of P450c17 in the formation of this metabolite Formation of androstadienol by human and porcine P450c17, with and without cyt b5 Using porcine and human P450c17 ... precursors, but also in the production of androstadienol which is considered to be an intermediate in the 16-androstene pathway leading to the biosynthesis of androstenol and of 5a(16)androsten-3-one,...
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NEW JERSEY DEPARTMENT OF ENVIRONMENTAL PROTECTION INSTRUCTIONS AND GUIDE TO WASTEWATER MANAGEMENT PLAN FORMAT AND CONTENT pptx
Ngày tải lên :
08/03/2014, 14:20
... Point and then north to Trenton It encompasses the waters and waterfronts of the Hudson River and related water bodies south of the Raritan Bay, the Atlantic Ocean and some inland areas from Sandy ... May, the Delaware Bay and some inland areas, and the waterfront of the Delaware and related tributaries The coastal zone encompasses areas in which the State has the authority to regulate land and ... results and strategies to address the findings of the environmental assessments/analyses should appear in the wastewater management plan text The quantity of hard copies to be submitted and the software...
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Hampering the Human Hacker and the Threat of Social Engineering pptx
Ngày tải lên :
08/03/2014, 15:20
... and application environment Education, audits, and automation, they combine to build the new “social engineering firewall” – a firewall that hampers the human hacker, and protects companies and ... together they provide rigorous multi-factor authentication, and form a robust and difficult to penetrate bastion against elicitation and pretext attacks And, once access is granted, employees and ... engineers out of your company and your systems, we recommend a three-step plan: Education – Teach employees the importance of protecting company and personal information Make both employees and customers...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
Ngày tải lên :
14/03/2014, 23:20
... oxidation and ketose reduction; KiNADH and KiNAD are dissociation constants for NADH and NAD+; and KmRO and KmROH are Michaelis constants for ketose and polyol Note: in the random bisubstrate mechanism, ... Are oxidoreductases other than AfM1PDH and AfM2DH involved in the metabolism of mannitol by A fumigatus? We searched the genome of the organism, and identied an ORF whose translated product is ... of the rst product, Man-ol1P or NAD+ In random bireactant systems, kcat Km stands for reaction of the variable reactant with the corresponding binary enzyme substrate complex Inspection of the...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
Ngày tải lên :
15/03/2014, 10:20
... further understand the human phenotype Recent investigations have further refined our understanding of this phenotype, and bear reviewing in this manuscript In human CCM disease, the lesions exhibit ... understand the basic processes that have been disrupted, resulting in the vascular malformation Between observational and genetic studies in humans and biochemical and cellular studies at the bench ... increase in both the intracerebral hemorrhage phenotype of rap1b and the cardiac developmental phenotype of san The zebrafish experiments demonstrate the role of the CCM genes in cardiac and vascular...
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