firm and the role of the employee in the firm

... constraints The descriptive, statistical analysis in Table indeed confirms that the lower the decline in production (or the higher its increase, in the best cases), the higher the probability of ... the left to the right-hand side of the map decreases the probability of Expected-Debt to be equal to « » (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of ... budget constraint in Berglof and Roland (1994) 22 Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm' s Qualitative Survey The main underlying question in the above-mentioned...

Ngày tải lên: 06/03/2014, 08:20

... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination ... Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis and the ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...

Ngày tải lên: 15/02/2014, 13:20

... N-linked oligosaccharide side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the ... modification may in uence many of the physicochemical and biological properties of the proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...

Ngày tải lên: 19/02/2014, 17:20

... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight into ... in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N and ... affinity of ChiB for allosamidin, which is an analogue of the proposed oxazolinium ion intermediate [32] The minor (or even positive) effects of Y214F on substrate and intermediate binding and the...

Ngày tải lên: 07/03/2014, 14:20

... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved ... important role in ‘cycling’ the pKa of catalytic Glu during catalysis [24,38] The mutation of the D1 residue to Asn (D140N) in SmChiB caused a 500-fold decrease in activity [39] On the other hand, in ... orientations of the Glu526 side-chain in the A-form were almost identical, and the maximum coordinate shift ˚ after superimposition of the two structures was 0.78 A In the B-form, in contrast, the Glu526...

Ngày tải lên: 15/03/2014, 11:20

... FEBS 2003 Role of L-chain in the elementary unit of fibroin (Eur J Biochem 271) 361 Table Determination of molar ratios of H-chain, L-chain, and fhx/P25 in the fibroin secreted into cocoons of a normal ... the action of Golgi a1,2-mannosidases to yield only the 27-kDa molecule in the secreted fibroin In order to examine a role of L-chain in the protection of a1,2-mannose residues of fhx/P25 in the ... roles in the assembly of vesicular stomatitis viral glycoprotein [28,29], in uenza virus hemagglutinin [30,31], and IgM [32] in ER, a further role of N-linked oligosacharide chains of fhx/P25 in the...

Ngày tải lên: 16/03/2014, 16:20

... using the concentration of protein in the extract as an internal standard The activity of ()119/+178) PS1CAT in the presence of the empty vector was taken as 100% The values represented in the ... all contain the highly conserved ETS domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually ... SK-N-SH and SH-SY5Y cells recognize specifically Ets motifs flanking the +1 site (A) The binding of nuclear factors is eliminated by mutations in Ets motifs The binding of nuclear factors present in...

Ngày tải lên: 16/03/2014, 18:20

... loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues The ... The third type of mutant, represented by arginines 306 and 307, are located in the C-terminus They appear to modulate the activity of the C-terminus, which encloses the DAOCS active site during ... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate of the bicyclic b-lactam nucleus, with the pro-S methyl...

Ngày tải lên: 18/03/2014, 01:20

... isosbestic point for the conversion of ferric H42A into Compound I, indicating that there are more than two absorbing species in solution and therefore consistent with the formation of an intermediate ... obtained in the absence of exogenous imidazoles Formation of Compound I again showed saturation kinetics (Fig 6), and a nonlinear least-squares fit of the data to Eqn (7) in the presence of imidazole ... determined above The maximum concentration of the intermediate under these conditions was 91% of the initial enzyme concentration Under these experimental conditions and in contrast with rAPX, there...

Ngày tải lên: 18/03/2014, 01:20

... Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease, the functional interactions between adipose tissue and the lipid and lipoprotein ... of these mice worsened the glucose tolerance and insulin sensitivity of the ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and ... establishing that the difference in the ability of human ApoE3 and murine ApoE to promote obesity in response to a high-fat diet may be the result of intrinsic differences between these two peptides Interestingly,...

Ngày tải lên: 29/03/2014, 22:21

... two residues and the edge of the substrate ring could prevent binding of 3,6-DMC and 3,5-DMC, as shown in Fig 2D,E,F Thus, the binding of 3,5-DMC and 3,6-DMC to the active site of C2,3O could ... when the side chain makes the closest contact between the residue and the substrate Lines with round ends indicate stacking between the ring of the substrate and His240 in DHBD (A), His248 in HPCD ... To investigate the in uence of the side chain of residue Thr249 of C2,3O on the cleavage of 3,5-DMC and 3,6DMC, the catalytic properties of mutants were studied Based on the results of docking...

Ngày tải lên: 30/03/2014, 10:20

... game theories New findings out of the thesis This thesis presents the following new findings (1) New findings related to theory (a) A new economic equation to relate two levels of sustainable ... to the right of OS line as long as the points are to the left of the vertical S line which represents the general sustainability line Gist of Chapter 2: ENVIRONMENTAL CONSERVATION AND TRADE The ... agreements mathematically in terms of environmental conservation The proposed thesis is, therefore, unique, original and very challenging in this aspect The followings are some of the important...

Ngày tải lên: 20/04/2014, 20:22

... dominant states play quite a signi cant role in the formation of the business cycle patterns of the formar group of states The business cycle patterns of the major oil supply states are distinctly ... (2.15) Rather than using only the previous information, it is possible to obtain the probability of the economy being in either recession or expansion Pr[St = j j using the full set of information ... level business cycle patterns In face, most of the time the state level business cycles of this group lay on the opposite side of the national business cycle.Most of the states fall into the fourth...

Ngày tải lên: 03/06/2014, 02:10

... remains to be seen how these elements, particularly reliability and discrimination, interact In closing I should directly answer the questions posed by Norman and Wyrwich in the titles of their ... points, then a discrimination is defined as any between-persons difference > = points Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the ... the results of another study [6], in which the dichotomous scoring method of the GHQ-12 was found to be less discriminating than the Likert scoring method, were 'well expected' This again suggests...

Ngày tải lên: 18/06/2014, 19:20

... or in tendinopathies at the wrist level The diagnosis of tendinopathy of the main body of the Achilles tendon is made if patients have Achilles tendon pain at rest or at exercise in the main ... either AirHeel™ wrap or eccentric training or the combination of both [57] Non-invasive topical nitroglycerin in tendinopathy The rationale for the use of topical transdermal nitroglycerin in ... Sclerosing with polidocanol was performed in the area of neovascularisation resulting in an improved knee function and reduced pain in the polidocanol group in contrast to the lidocaine/epinephrine...

Ngày tải lên: 20/06/2014, 01:20

... ylevitcepser ,puorg lortnoc a rof dna puorg noitcefni na rof dengissa erew ecim eerhT esuom detcefnifo noloc dna mucec cimerepyh dna degralne )D( dna ,esuom detcefninu na fo enitsetni lamron )C( ... ytlucaF eht yb detroppus saw krow sihT stnemgdelwonkcA snoitcefni tsniaga ytinummi evitcetorp a fo noitcudni eht rof γ-NFI fo ecnatropmi eht deilpmi stluser esehT enitsetni egral eht ni snoisel ... noswaL ,S tsirOcM ,S insaJ 761-951 ,601 ,2991 htaP pmoC J sitiretne evitarefilorp enicrop fo noitcudorper latnemirepxE JP eoloC ,R dnalroB ,RM notredlA secnerefeR 4002 ni ytisrevinU kuknoK fo dnuF...

Ngày tải lên: 07/08/2014, 18:21

... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally, ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role...

Ngày tải lên: 09/08/2014, 07:20

... (total of 98,695 introns) for TE insertions to determine the percentage of TE-containing introns (Figure 2a) The fraction of the introns that contain TEs in the non-mammalian vertebrates G gallus and ... between the fraction of introns containing TEs and median length of introns (Figure 2c), implying that TE insertions have played a role in the evolution of intron size Previous analysis of human and ... respectively The grey boxes show insertion of TEs into exons The TE family is indicated beneath the gray box, along with the length of each inserted TE Lengths of the introns and exons flanking the inserted...

Ngày tải lên: 09/08/2014, 20:22

... experience in clinical treatment of thymomas as a result of a retrospective single centre analysis done within a European university setting The role of a pseudocapsula and its clinical significance and ... [3] The reason for these is based in a couple of problems First, there is a significant interobserver variability in histological typing [2,6] Second, determination of precise cut-off points ... classified thymomas and reviewed histological and immunhistochemical staining of the specimens CS has participated as senior author in the design of the study and helped to draft the manuscript All...

Ngày tải lên: 10/08/2014, 10:20

... modulate the inflammatory profile after a viral infection by blocking the poly(I: C) induced chemokine and cytokine production while maintaining the antiviral activity [28,59] As epithelial cells ... the review, all authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... skin especially in the elderly), limited renal and hepatic function or insufficient intestinal resorption [39] In VitD deficiency, the feedback on the PTH gene promoter is lacking resulting in...

Ngày tải lên: 12/08/2014, 13:22