evaluation of cytochrome p450 activities in human hepatocytes in vitro

... member of subfamily A of family 94 (there is more about the activity of this enzyme in the accompanying minireview by Pinot & Beisson [4]) Over 11 000 P450 genes are included in this internationally ... provided strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to ... carcinogenic The 17 fumonisin biosynthetic genes are located in a gene cluster and three of them are P450 enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis...

Ngày tải lên: 22/03/2014, 16:21

... pathway is involved in the TNF-α-mediated increase in Cyp7b activity in human FLS Signaling pathways that mediate the effects of TNF-α include mitogen-activated protein kinases (MAPKs) and nuclear ... three independent experiments FLS used When SN50 was applied in combination with TNFα, conversion of DHEA into 7α-OH-DHEA was significantly inhibited in four out of five FLS cell lines R1274 To investigate ... 1d) Incubation of FLS with TNF-α strongly increased the presence of NF-κB in the nucleus This nuclear translocation of NF-κB was inhibited by SN50 (Fig 1d) PSI inhibited the TNF-α-induced increase...

Ngày tải lên: 09/08/2014, 07:20

... also in CRL tests we can observe a continuous increase of pore water pressure Unification of description of pore water pressure distribution in the course of CL tests is obtained by means of introducing ... course of the CCL–TCL curve depends only on the model of loading increase 403 (Fig 5F) One curve characterizes every CRL test independently of the rate of loading We obtain other curves while the increase ... Constantly increasing (CI) distribution In this case the CCL value increases constantly which is related to a rapid increase of the t(T = 1) value in the course of the test After changing the co-ordinate...

Ngày tải lên: 22/03/2013, 15:01

... underlying the language teaching, and language teaching methods play a major role in determining the syllabus to be adopted Theory of learning also plays an important part in determining the kind of ... natural sequence of language learning i.e Listening, Speaking, Reading, Writing It ensures the active participation of learner in teaching Learning-process It is a natural way of learning the target ... effectiveness of teaching of English at secondary level To determine the extent of availability of instructional aids in teaching of English To identity/explore the problems faced by teacher while teaching...

Ngày tải lên: 10/04/2013, 10:37

... Evaluation of ASTER data use in land use study in the Mekong Delta 29 discrimination capacity of ASTER data in land use mapping of such a dynamic area as the Mekong Delta in Vietnam ... combination is the most discriminative Due to the constraints of the spatial resolution of ASTER data in terms of parcel size in the studied area, the physical indexes such as NDVI and VSW will ... digitizing the satellite image This is not an optimal approach (Congalton and Green, 1999), but the digitizing was performed independently from training areas by a well trained person not involved in...

Ngày tải lên: 13/02/2014, 12:20

... effective tool in keeping existing and making loyal customer Generally, customer is divided into two kinds: existing and potential customer Retaining existing customers mean making them keep buying company ... Strength: Combination between fine dining and conveyor can meet various demand of customer Can utilize fine dining to diversify food menu of conveyor Weakness: Not clear in brand positioning Short ... eating out is still high in cities Chain of many restaurants in VN System of menu controlling New product adding up fast Fast speed of opening outlets External Internal Short timing on the market (10...

Ngày tải lên: 17/02/2014, 12:43

... Journal of Marketing, Journal of International Marketing, Journal of International Business Studies, Journal of Business Research, Management International Review, Journal of World Business, Journal ... identification of 43 studies, yielding a relatively large sample for review purposes These studies were published in some of the most established journals in marketing and international business, including ... 95 Industrial sector Multiple industries Multiple industries Multiple industries Multiple industries Multiple industries Multiple industries Multiple industries Multiple industries Multiple industries...

Ngày tải lên: 06/03/2014, 21:20

... of glaciofluvial deposits in northern Maine He determined soil maps are somewhat successful in showing the distribution of lacustrine silts and clays Using soil surveys as potential sources of ... faster rate of mapping than conventional geologic mapping affords Lindholm enjoyed this rate of mapping because of the availability of soil survey maps of the area In turn, cost efficiency increased ... formed in a particular parent material 13 The area surveyed in relationship to the amount of time involved in conventional mapping indicates a degree of intensity (Kite, 1982) Prescott (1973) in...

Ngày tải lên: 08/03/2014, 23:20

... streamflow in September in the Assabet River about doubled at the outlet of the Main Stem Headwaters subbasin and increased by about percent at the outlet of the Main Stem Upper subbasin These increases ... percent of total wastewater flows Applying these rates to 1997–2001 flows, and estimating infiltration for small areas of sewers in the study area in Concord and Clinton, infiltration to sewers in ... conditions, in average annual inflows to and outflows from the surficial layer of the simulated ground-water-flow system in subbasins of the A, Assabet River Main Stem; and B, tributary subbasins, in...

Ngày tải lên: 17/03/2014, 15:20

... limitations According to the data obtained in the study, most of the teachers were in favour of implementing the software at schools since they believe in the benefits of DynED courses developing English ... history of the application of DynED language learning software in Turkey is just new, there are efforts for the implementation of this software in elementary schools in Turkey DynED language learning ... information table N2 work experience of the teacher N3 sex of the teacher Results and Findings In this part of the study, the findings from the analysis of the interviews were given under three...

Ngày tải lên: 09/05/2014, 10:21

... Level of Educational Inspection Activities in terms of Professional Inspection…… 48 Level of Educational Inspection Activities in terms of Inspection Management… 49 Level of Educational Inspection ... following are the findings of the researcher: The level of educational inspection activities in terms of professional inspection shows that all the teachers in ThanhHoa Province were always using ... the inspection system prevailing in Kenya The provision of feedback regarding findings of inspection (Kamuyu 2006), especially to schools inspected, should be ongoing during the process of inspection...

Ngày tải lên: 27/05/2014, 11:38

... show the changes of these tests in working population The clinical importance of these subtle changes of liver function in working populations is not clear and further longitudinal studies are ... male office workers from the same complex Having at least years of working experience was the inclusion criteria Environmental monitoring showed a concentration of 0.7 ppm for VCM Sampling tube ... contradictory results in the increase of liver enzyme levels in workers exposed to VCM [14,17,18] Maybe the increase of sample size would lead to significant difference in the level of other liver enzymes...

Ngày tải lên: 20/06/2014, 00:20

... low-density lipoprotein (LDL) Insulin resistance (IR) was assessed using both fasting insulin levels and the homeostasis model assessment (HOMA) calculation: fasting serum insulin (micro units per millilitre) ... examination of FMD was performed in the morning after overnight fast, after 15 minutes rest in the horizontal position, by means of a Sonoline G40 ultrasound scanner (Siemens, Germany) with a linear ... E: Insulin causes endothelial dysfunction in humans Circulation 2002, 105:576-585 Singh T, Groehn H, Kazmers A: Vascular function and carotid intimalmedial thickness in children with insulin-dependent...

Ngày tải lên: 20/06/2014, 08:20

... exons of 400, 72 and 45 bp in pb-1 Although each intron that was similar in size in pb-1 was slightly larger than the corresponding intron in pb-3, each type of intron was in the same order in pb-1 ... large superfamily of heme-containing monooxygenases that are widely distributed in all kingdoms of life (Nelson 2009) CYPs are involved in the metabolism of a wide variety of endogenous and xenobiotic ... 812-8581, Japan College of Food Science and Engineering, Jilin Agriculture University, No.2888 Xincheng Street, Changchun, Jilin Province P.R.130118, China Research Institute of Biosciences, Azabu...

Ngày tải lên: 20/06/2014, 20:20

... exons of 400, 72 and 45 bp in pb-1 Although each intron that was similar in size in pb-1 was slightly larger than the corresponding intron in pb-3, each type of intron was in the same order in pb-1 ... large superfamily of heme-containing monooxygenases that are widely distributed in all kingdoms of life (Nelson 2009) CYPs are involved in the metabolism of a wide variety of endogenous and xenobiotic ... 812-8581, Japan College of Food Science and Engineering, Jilin Agriculture University, No.2888 Xincheng Street, Changchun, Jilin Province P.R.130118, China Research Institute of Biosciences, Azabu...

Ngày tải lên: 21/06/2014, 19:20

... Society of Heating, Refrigerating, and AirConditioning Engineers, Inc ASHRAE 2009 ASHRAE Handbook: Fundamentals American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc Celgard ... provides ventilation air to maintain indoor air quality o A/C maintains humidity to prevent mold growth, sick building syndrome, etc • Maintain human comfort by providing o Temperature control (heat ... and indirect evaporative cooling • Describing the DEVap A/C process • Providing a physical description of the DEVap device • Discussing the energy savings potential • Assessing the risks of introducing...

Ngày tải lên: 27/06/2014, 14:20

... comparison of 11 soft lining materials as a function of accelerated aging J Prosthetic Dentistry, 69, 114–119 Sanders, J.L, Levin, B & Reitz, P.V (1991) Comparison of the adaptation of acrylic resins ... trends to that of tensile strength, with a decrease in stiffness and increase in ductility after a period of immersion in distilled water After analyzing the results obtained in the present study, ... In this study, the curing types (heat-cure and self-cure) have a great influence in reducing the residual monomer content which is in agreement with many researches who reported similar findings.5–7...

Ngày tải lên: 07/08/2014, 14:20

... numbers of peristaltic waves in the small intestine of the sedated dogs were 0.000/min in xylazine HCl, 0.999/min, in ketamine HCl, and 1.201/min in those dogs administered xylazine HCl, ketamine ... Measurement of the peristaltic movement of small intestine in fed dogs The numbers of peristaltic waves in the small intestine after 24-hour fasting were 0.133/min hour, 0.100/min hour, 0.033/min hours, ... Relationships of motility to flow of contents in the human small intestine Gastroenterology 1982, 82(4), 701-706 16 McNeel, S V and Hsu, W H Xylazine-induced prolongation of gastrointestinal transit in...

Ngày tải lên: 07/08/2014, 14:23

... secreted proteins, such as cytokines and chemokines Conclusion In conclusion, the findings of the present study show the reliability of ST analysis using a DIA system for the evaluation of serial ... Although the reproducibility of measuring cytokine and cell adhesion molecule staining by DIA was reported to be within 10% [8], no formal studies investigating intrarater and inter-rater variability ... blinded regarding clinical data For each measurement all observers independently set their own threshold levels regarding the detection of stained antigen, nuclear staining and background staining...

Ngày tải lên: 09/08/2014, 06:23

... surrounding tissues, because these can easily be removed out of the IORT target volume [1-3] In principle, IORT can be applied using electrons of a linear accelerator situated in the operating theatre ... FA, Azinovic I, Martinez R: Intraoperative radiotherapy for the treatment of soft tissue sarcomas of central anatomical sites Radiat Oncol Invest 1995, 3:30-96 Calvo FA, Azinovic I, Martinez R, ... that they have no competing interests Authors' contributions MN was responsible for the design of the evaluation, checking the data, statistical evaluation, and writing of the manuscript JF was...

Ngày tải lên: 09/08/2014, 10:20