epothilones—lead structures for the discovery of improved microtubule inhibitors

... 6.6 The variations of the NMR frequency with applied A-gate voltage for the three different A-gate structures with a uniform static magnetic field of 2T along the z direction The dimensions of the ... method offers, the energy levels obtained through this scheme present close agreement with the experimental values81 However, the value of the wavefunction of the ground state at the position of the ... qubits on the performance of the main qubit for these three structures In Chapter 7, after giving a summary of all the contributions of this dissertation we propose some of the possible future...

Ngày tải lên: 30/09/2015, 06:37

... is the difference between the cost of null hypothesis and the total cost The larger the difference between the cost of the null hypothesis and total cost, the greater the likelihood that the ... %Y, the percentage of known actives in the hit list (recall); Ht, the number of hits retrieved; D, the number of compounds in the Page of 13 database; E, the enrichment of the concentration of ... data for the compounds The in vitro bioactivities of the collected inhibitors were expressed as the concentration of the test compounds that inhibited the activity of AChE by 50% (IC50) These...

Ngày tải lên: 10/08/2014, 05:21

... large inventory of normalized mathematical indexes of abnormality It is the pattern of these mathematical indexes of abnormality, obtained from analysis of multiple cardiac cycles of the resting ... Moreover, to assess the performance of the prediction of stenosis independent of the prevalence of stenosis, the positive and negative likelihood ratios (LR) were calculated [24] A value of p

Ngày tải lên: 03/11/2012, 10:58

... degrading entities [18] For example, the major role of the MMP family is the control of cellular responses critical to homeostatic regulation of the extracellular environment and the immune response ... level match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the two different conditions ... lacked the sensitivity of our house-made fluorescent dye [14] The improved detection sensitivity of Ruthenium staining helped to identify candidate substrates Further progress was achieved by the...

Ngày tải lên: 07/03/2014, 06:20

... Most of the folds are assigned to one of the five structural classes on the basis of the secondary structures of which they composed: (1) all alpha (for proteins whose structure is essentially formed ... the discovery of new structures, with folds between those of the previously known structures, will make clear their common evolutionary relationship CLASS For convenience of users, the different ... usually classified individually The protein entries in the December 1994 of the Brookhaven Protein Databank (PDB) contain 3179 domains Many of these become forms of the same protein whose differences...

Ngày tải lên: 23/03/2014, 12:20

... wetted function is 1. For other cases, value of the cell  side  wetted  function  equals  to  the ratio of the length of the wetted portion over  the total length of the cell side. After getting  all the wetted points on four sides of the cell,  ... the distances  from the boundaries towards the ends of the wave absorbing zones. Finally, at the ends of the wave  absorbing  zones,  the Summerfeld  radiation  condition  for long  waves  ... To  verify  the accuracy  of the numerical  model  on  the simulation  of the wave  transformation  on  a  natural  beach,  existing  experimental data on the wave dynamics in  the nearshore ...

Ngày tải lên: 28/03/2014, 15:20

... argument of aimer to the first argument of nager by means of a re-entrancy The set of rules given below together establish a transfer relation between (3) and (4): s Applications of the Formalism ... Completeness, on the other hand, must be verified explicitly; every part of the source FS must be subsumed by a subpart of the FS obtained by unifying the FSs induced by the left-hand side patterns of every ... obvious application for the formalism presented here lies in the domain of machine translation The transfer model of MT may be thought of as involving three distinct mappings; from the source language...

Ngày tải lên: 01/04/2014, 00:20

... Proof By definition, the vector Xm encodes the contribution to the rank polynomial of the edges of the first column L1,m of Ln,m Every time we multiply by Λm we are adding the contribution of the ... α(n)1/n n→∞ n→∞ The proof of the second equality is very similar; it relies again on the formula T (G∗ ; x, y) = T (G; y, x), and the fact that the number of forests and the number of connected ... all the edges ˆ ∼ (i, 1), for ≤ i ≤ n (see Figure 3) The reader may find it k helpful to think that for a fixed k, increasing n will make Fn grow to the right For the proofs of the following two theorems...

Ngày tải lên: 07/08/2014, 07:21

... Coherence is expressed as the amplitude ratio of the two leads squared for each frequency; the result is a measure of the correspondence of the output energy of the two leads The coherence function ... an ideal waveform (the cross-power spectrum of the two leads) This is expressed as the angle in degrees of the phase shift for each frequency: essentially, the relative angles of the harmonics ... unify these two properties, these two mathematic relations can be fused into one using the Laplace transform Mathematical transformations of ECG data The 3DMP ECG analysis employs six mathematical...

Ngày tải lên: 08/08/2014, 16:23

... [0.855-0.952] (Figure 2) The coordinates of the curve indicated that a cut-off of 4.0 provided the best combination of sensitivity and specificity for the prediction of coronary stenosis from the 3DMP test ... order to assess the performance of the prediction of stenosis independent of the prevalence of stenosis the positive and negative likelihood ratios (LR) were calculated [24] A value of P < 0.05 was ... segments of ECG data contain idiopathic extrema that deviate from the baseline by ≥ mm, • in a 25-mm section of waveform in any 5.12-second segment of the ECG data, the waveform strays from the baseline...

Ngày tải lên: 08/08/2014, 17:20

... generate the number of embryos per collection The results show that the inbreeding obtained depended on the values of the coefficient of variation and the repeatability of embryo yield By making the ... 0.00), the rate of inbreeding decreased by 4% (Models1 and 2) The effect of the coefficient of variation of embryo yield on the rate of inbreeding was notable By increasing the coefficient of variation ... on the number of calves born in the scheme By increasing the mean number of embryos per flush and per donor, the frequency of flushing or the embryo survival probability, the expected number of...

Ngày tải lên: 09/08/2014, 18:22

... ∪ σint to denote the partition of the base pairs of the first sequence, σ1, the base pairs of the second sequence, σ2, and the interacting base pairs, σint Furthermore, for the partial structure ... denotes the overlap between these two structures For the thermodynamic part, the expected accuracy EAth(σ) of σ with all structures for all sequences according to the thermodynamic ensembles is ... reliable for the prediction of consensus structures from alignments Here, however, we also have to estimate the contribution of each of the partial structures to the complete solution Because the...

Ngày tải lên: 12/08/2014, 17:20

... transferred to the precast beam if there is a bond between them The reduction of the post-tensioning force in the slab and the additional force introduced into the beam should be considered in the design ... precipitation The edges of an open parking structure may be subject to the same weather conditions as the roof, and other areas may experience runoff from the roof All floors are subject to moisture in the ... help clarify the intent of the information provided throughout the document Unless otherwise noted, the terms are as defined in ACI 116R and are repeated here for the convenience of the reader...

Ngày tải lên: 24/10/2014, 21:59

... of Mathematics Chair of the Department of Mathematics Thesis Adviser Chair of Committee John Roe Professor of Mathematics Nathanial Brown Assistant Professor of Mathematics Murat Gunaydin Professor ... many of the basic concepts which will appear in the body of the thesis Let us begin by clarifying the ideas of the previous chapter The place to start— the theory which is underpinning all of this—is ... and then one forgets first the action of C(G/B) and secondly all of the representation of G except for the representation of K Proof In a result such as this, the categorical interpretation of...

Ngày tải lên: 13/11/2014, 09:10

... In this chapter, the background and significance of the project is covered in the first section The second section presents the objectives of the project and the outline of the report 1.1 Project ... population of the whole area of the well For the FLUOstar, “matrix” 3×3 was used, whereas “matrix” 15×15 was used for the PHERAstar In 96-well plate format, “none” mode was used for FLUOstar since the ... analysis and the corresponding graphs of the deposition of collagen following the addition of the DexS to the fibroblast culture…………………………………………………… 74 Figure 4.22 The expression level of collagen...

Ngày tải lên: 09/10/2015, 11:07

Ngày tải lên: 27/04/2016, 23:10

... parallel to the two 3-in.-diameter surfaces towards the center of the disk The top ICP results are obtained by sawing across the entire top surface of the disk to a depth of about ~6 of an inch The top ... Segregation in the samples taken from the molten lead is caused by the slow cooling of lead in the mold Some elements form oxides or sulfides, or stay in the elemental form during solidification of the ... to the scatter pattern of the Pb emission inside the polychromator The bandpass at half-height for the scattered background peak is about one and a half times that of the analyte Te peak The...

Ngày tải lên: 22/07/2016, 23:06

... on the prevalence in the population, and more reflective of the test itself, lessening the impact of any unique features of the VA population Moreover, we might expect that the PPV and NPV of the ... NC) Results The characteristics of the VARA participants measured at the start of each treatment episode were evaluated Because the characteristics of VARA patients at the start of non-biologic ... contrast to other RA therapies where the drugs are typically discontinued if they are not effective Because of similarities in both the descriptive characteristics of the study populations of biologic...

Ngày tải lên: 25/10/2012, 10:45

... attempted for three SPT patients in whom the mass was located in the portion of body or tail of the pancreas For tumors of SPT located in the neck and body of the pancreas, resection of the midportion ... midportion of the pancreas and the mass with preserving the rim of the head and tail portion can be achieved However, for the patient in whom the mass was located within the head of the pancreas, ... 311 Fig The CT scan indicated the typical internal or capsular calcification in the SPT Once the diagnosis of SPT is made, surgery is the first choice of treatment, since other adjuvant therapies,...

Ngày tải lên: 25/10/2012, 11:40

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...

Ngày tải lên: 26/10/2012, 09:32