epidemiology and screening of colorectal cancer

... of cancer cases and cancer fatality were estimated under a baseline scenario of no screening Data on sensitivity and Page of 16 specificity of screening [47] was used to estimate the number of ... effects of varying the frequency of screening and age at time of screening This model was based on demographic data from the WHO AmrA region (i.e Canada, Cuba and the USA) and colorectal cancer ... reported decreases in incidence of colorectal cancer of 20% and 17% for annual and biennial screening respectively Since these randomized trials reported results of guaiac FOBT as opposed to immunological...

Ngày tải lên: 13/08/2014, 11:22

... detection and screening of breast cancer The Regional Office has been proactive in the development, implementation and assessment of regional guidelines for the early detection and screening of breast ... the diagnosis and treatment of detected abnormalities 26 Guidelines for the early detection and screening of breast cancer Screening for breast cancer Breast cancer is most easily and effectively ... goal of screening should be focused on detection of breast cancer at early stages of the disease and offering opportunities for timely treatment and a change in the overall course and outcome of...

Ngày tải lên: 28/03/2014, 23:20

... Options for screening for colorectal cancer Scand J Gastroenterol 2003, 237(Suppl):13-16 Hundt S, Haug U, Brenner H: Blood markers for early detection of colorectal cancer: a systematic review Cancer ... Detection of colorectal cancer using MALDI-TOF serum protein profiling Eur J Cancer 2006, 42(8):1068-76 Zhao L, Liu L, Wang S, Zhang YF, Yu L, Ding YQ: Differential proteomic analysis of human colorectal ... HM: A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa Cancer 1991, 68:1903-1909 Page of (page number not for citation purposes) World Journal of Surgical Oncology...

Ngày tải lên: 09/08/2014, 04:21

... The role of CEA, TPA and CA 19-9 in the early detection of recurrent colorectal cancer Int J Colorectal Dis 1989; 4:230-233 20 Rodland KD Proteomics and cancer diagnosis: the potential of mass ... Genetic models of human cancer as a multistep process Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia J Exp Clin Cancer Res.2005; ... potential serum biomarkers for colorectal cancer detection A total of 264 serum samples from colorectal cancer patients and healthy volunteers was collected and analyzed A panel of differentially expressed...

Ngày tải lên: 25/10/2012, 11:18

... biologically distinct and aggressive subset of colorectal cancer Br J Cancer 2001; 84; 232–236 69 Goel A, Arnold CN, Niedzwiecki D et al Characterization of sporadic colon cancer by patterns of genomic ... L, Zong J et al Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer Cancer Res 2003; 63; 4805–4808 96 Vandrovcova J, Lagerstedt-Robinsson ... immunohistochemistry for MLH1] The glands to the left are normal and show nuclear expression of both MGMT and MLH1 The gland with features of serrated adenoma and the poorly differentiated adenocarcinoma...

Ngày tải lên: 22/03/2014, 17:20

Ngày tải lên: 01/04/2014, 13:20

... multitude of SDj of this fam- comparing repertoire restriction of tissue with blood ily CDk of a sample was defined as sum of the moduli of Per-family normalized relative concentration P'jk of a fam- ... steps of normalization: relative concentration Pj (A), Pj minus the average value of Family j of all analyzed samples (B), and deviation from average given in fold of standard deviation of the ... in design and conduct of the study UK participated in design and conduct of the study DN conceived of the study, coordinated the study and drafted the manuscript All authors have read and approved...

Ngày tải lên: 18/06/2014, 16:20

... 2-DE profile of mortalin isoforms in HCT 116 whole cell lysate 79 3.10 2-DE profile of mortalin isoforms in HCT 116 mitochondrial fraction 81 3.11 Enrichment of mortalin isoforms and presence of ... 1.1 COLORECTAL CANCER (CRC) 1.1.1 Epidemiology Colorectal cancer (CRC) forms in the tissues of the colon and rectum, and is currently the third most common cancer worldwide, ranking after lung and ... care for cancer patients where the selection, dosage and route of administration of exisiting and new therapeutic agents would be tailor-made to enhance the recovery and quality of life of the...

Ngày tải lên: 26/11/2015, 12:25

... HCC [3], and 500, 000 to 1.2 million people die of HBV infection annually [4,5] Because of the high HBV-related morbidity and mortality, the global disease burden of HB is substantial Epidemiology ... evidence of acute disease related to HBV, but the rates of chronic liver disease and liver cancer in adults are high [7] Intermediate Endemicity Hepatitis B is moderately endemic in part of Eastern and ... increased risk of HBV infection include duration of sexual activity, number of sexual partners, history of sexual transmitted disease, and positive serology for syphilis Sexual partners of injection...

Ngày tải lên: 02/11/2012, 11:12

... Lung cancer is the most common cause of cancer death for men, who account for 60% of lung cancer cases In women, lung cancer is the second most common cause of cancer death after breast cancer ... lung cancer are very poor In England, for patients diagnosed between 1993 and 1995 and followed up to 2000, 21.4% of men and 21.8% of women with lung cancer were alive year after diagnosis and ... D NICE Guideline – lung cancer 21 1.10.13 The opinions and experiences of lung cancer patients and carers should be collected and used to improve the delivery of lung cancer services Patients...

Ngày tải lên: 15/03/2014, 00:20

... S100A9 and LASP-1, respectively (B) Enlarged images of RhoGDI, S100A9 and LASP-1 in two-dimensional gels of normal colorectal mucosa, nmCRC and mCRC (C) Protein expression of RhoGDI, S100A9 and ... by celecoxib in colorectal cancer cells Cancer Epidemiol Biomarkers Prev 15, 1598–1606 Skandarajah AR, Moritz RL, Tjandra JJ & Simpson RJ (2005) Proteomic analysis of colorectal cancer: discovering ... [24,25] Differential expression of S100A8 and S100A9 has been shown to contribute to the development and progression of various types of cancer For example, S100A8 and S100A9 are over-expressed...

Ngày tải lên: 23/03/2014, 03:20

... the leading cancer death, next to lung and colorectal cancer In the present study, we demonstrate the physiological consequences of TPD52 expression in the androgen responsive prostate cancer cell ... overexpression of TPD52 and (B) cell proliferation after downregulation of TPD52 Viability of cells was measured in a colorimetric MTT assay by the detection of formazan formation The proliferation of control ... 24 h and (D) 48 h (D) Overlay of (A) and (C) TPD52 downregulation activates caspase activity and increases the loss of mitochondrial membrane potential (E, F) Showing the relative caspase-3 and...

Ngày tải lên: 30/03/2014, 02:20

... medullary and papillary cancers of the thyroid Anaplastic cancer and Hỹrthle cells occurred at older ages Of the total of thyroid cancers, 78.3% of the cases were females and 21.7% outstanding men ... EUROCARE-2 Denmark, Germany, The Netherlands, Updates in the Understanding and Management of Thyroid Cancer England, Scotland, Wales and the countries of Eastern Europe had survival below the ... thyroid cancer, (69%) were due to second malignancies (three breast cancer case, prostate cancer case, case of sigmoid colon cancer, case of liver cancer, case of glioblastoma multiform, case of pancreatic...

Ngày tải lên: 30/03/2014, 22:20

... of the Mia pcb6 cells, and Meng et al Journal of Translational Medicine 2010, 8:61 http://www.translational-medicine.com/content/8/1/61 Page of 14 Figure Stable overexpression and silencing of ... promotes invasion and metastasis of pancreatic cancer cells Journal of Translational Medicine 2010 8:61 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... mechanisms of ezrin-mediated tumor development still require further elucidation In this study, we investigated the effect of ezrin on the motility and invasion ability of the pancreatic cancer cell...

Ngày tải lên: 18/06/2014, 16:20

... spleento-liver colorectal cancer model Colorectal cancer cells (HCT116) were injected into the spleen of NMRI nude mice and intrasplenic and hepatic Lavilla-Alonso et al Journal of Translational Medicine ... Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Finland 2HUSLAB, Helsinki University Central Hospital, Finland 3Department of Obstetrics and Gynecology, Duesseldorf ... of liver metastasis of mock treated (PBS) animal (A) day before treatment and (B) on day 35 after treatment (C) Picture of liver metastasis of WT-RGD treated animal one day before treatment and...

Ngày tải lên: 18/06/2014, 16:20

... expression of IL-6 and the presence of TLR-4+ cells in the stromal and epithelial compartment (R2 = 0.16, p < 0.05, and R2 = 0.33, p < 0.05, respectively), and between the expression of IL-6 and the ... Page 10 of 16 Figure Staining in murine models of colorectal cancer Comparison of H&E, TLR-4 and IL-6 immunostaining in mice wild type and knockout for Tir8 Tir8 -/- mice had a higher grade of dysplasia ... Incidence of colorectal carcinoma in the U.S.: an update of trends by gender, race, age, subsite, and stage, 1975-1994 Cancer 1999, 85:1670-1676 Brenner H, Hoffmeister M, Haug U: Should colorectal cancer...

Ngày tải lên: 18/06/2014, 16:20

... and University of Bern, 3010 Bern, Switzerland 3Institute of Pathology, University of the Saarland, 66421 Homburg/Saar, Germany 4Institute of Medical Biometrics, Epidemiology, and Medical Informatics ... angiogenesis of CRC [20] Despite increasing knowledge about the expression of CXCL12/CXCR4 in CRC and its involvement of CXCR4 in the invasion and dissemination of CRC the precise mechanisms of CXCL12/CXCR4 ... migration of colorectal cancer cells To analyze if the chemotactic effect of CXCL12 on the migration of HT-29 and SW480 cells could be counteracted by the down-regulation of the mRNA of corresponding...

Ngày tải lên: 20/06/2014, 03:20

... conditioned media of prostate cancer [43,44], and breast cancer cell lines [45] and in the peritoneal fluid of women with uterine leiomyomas [46] The production and secretion of LRG1 by tumor ... suggesting the presence of multiple glycosylated isoforms of LRG1 Indeed, we showed that glycosidase treatment of LRG1, both purified and in extracts of ovarian cancer and NOSE cell lines, reduced ... discovery and validation of candidate prostate cancer biomarkers J Proteome Res 2008, 7:3329-3338 44 Sardana G, Marshall J, Diamandis EP: Discovery of candidate tumor markers for prostate cancer...

Ngày tải lên: 20/06/2014, 07:20

... Discussion Colorectal cancer constitutes the third most common cancer and the second leading cause of cancer deaths in UK About one in 20 men develops colorectal cancer in their lifetime (Cancer Research ... surgery and radiotherapy, chemotherapy also plays significant role in the treatment of colorectal cancer Cisplatin and oxaliplatin are two of most commonly used chemotherapeutic agents in the cancer ... chemotherapy of various cancers However the problems of recurrence of disease and metastasis are not uncommon with these platinum compounds regimens The advantages of doxycycline include long duration of...

Ngày tải lên: 09/08/2014, 04:20

... suspected cancer, the primary site of malignancy was 893 suffered from breast cancer, 428 from head and neck cancers excluding thyroid cancer, 311 from gastrointestinal cancers, 306 from lung cancer, ... localization of metastatic disease in patients with various kinds of malignancies The uptake of the FDG in the normal thyroid gland is homogenous and of low intensity; the normal thyroid gland is usually ... lesions and malignant lesions (P < 0.001) Page of (page number not for citation purposes) SUVmax World Journal of Surgical Oncology 2009, 7:63 Size of cancer (mm) Figure between SUVmax and cancer...

Ngày tải lên: 09/08/2014, 04:21