energy and nitrogen metabolism in cancer

... Working together, GS, CPS III and OTC form citrulline in the matrix, which then exits the mitochondria Citrulline is converted to arginine via argininosuccinate synthetase and argininosuccinate ... body during hibernation It minimizes body protein loss and conserves mobility, providing greater flexibility during winter and facilitating rapid resumption of foraging and growth in spring (Barboza ... a decrease in protein synthesis and an increase in protein degradation, resulting in muscle atrophy (Childs, 2003) However, a drastic increase in proteolysis, as in the case of fasting alone,...

Ngày tải lên: 14/09/2015, 14:10

... Engineering from North Carolina State University, Master of Engineering in Mechanical Engineering and Master of Business Administration from the University of Hartford, and her doctorate in Engineering ... Improvement in energy and environmental efficiency strengthens the communities’ sustainability plan In addition, using the energy efficiently and following ISO norms can minimize infrastructure ... beginning point for the integrated process map Table Goals of energy versus environmental management systems Goals of Energy Management System Optimize energy efficiency Minimize energy waste Increase...

Ngày tải lên: 05/09/2013, 15:28

... arginase I and ODC direct ornithine towards polyamine synthesis and the mitochondrial enzymes arginase II and ornithine aminotransferase favor the channeling of ornithine to proline ⁄ glutamine ... estimation of proline and ornithine J Biol Chem 199, 91–95 45 Van Pilsum JF, Martin RP, Kito E & Hess J (1956) Determination of creatine, creatinine, arginine, guanidinoacetic acid, guanidine, and methyl-guanidine ... GAMT in EAC and S180 cells and in sarcoma tissue indicates that the upregulated proteins are entirely tumor-cell specific On the other hand, the in ux and efflux rate of creatine in both EAC and...

Ngày tải lên: 07/03/2014, 04:20

... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in ... neoplastic tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocellular carcinoma, lung cancer, colon cancer and endocrine pancreatic tumors...

Ngày tải lên: 16/03/2014, 01:20

... was incorporated into arginine as a nitrogen storage compound The GLU1 mutant showed a 5.8-fold increase in arginine relative to the wild-type plants in air, whereas in high CO2, arginine remained ... Ornithine, citrulline and arginine contents in leaves of Arabidopsis plants cultured with mM ammonium in air (G) Ornithine, citrulline and arginine contents under high-CO2 conditions (H) Ornithine, ... determined Despite a tight linkage of CPSase to arginine synthesis, the carB mutant showed negligible effects on overall arginine levels The levels of ornithine, citrulline and arginine remained...

Ngày tải lên: 30/03/2014, 01:20

... involvement of TK2 in the in situ phosphorylation of thymidine, Ca and Pa lines were also incubated in the presence of lM BVDU added 15 before [3H]thymidine, and the incubation was continued for (dotted ... confirming the involvement of TK2 in the phosphorylation of thymidine in both cell lines inferred above (Table 1) 1108 from the inhibition of thymidine phosphorylation in vitro caused by KIN109 ... c.p.m.Æpmol)1 in Ca and Pb cells, and about 5000 in Cb and Pa cells (Fig 2B), indicating that one-third of the dTTP of Ca and Pb cells and between one-quarter and one-fifth of the dTTP of Cb and Pa cells...

Ngày tải lên: 30/03/2014, 02:20

... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... colorectal cancer, which will be discussed in details below a Chromosomal instability (CIN) Chromosomal instability lead to increase rate of losing or gaining chromosomes during cell division and accounts ... targets in cancer are also included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer present comprehensive and expert...

Ngày tải lên: 30/03/2014, 09:20

... K Rathinasamy and D Panda [10] The binding site of benomyl in tubulin is yet to be determined However, it has been suggested that benomyl binds to tubulin at a site that is distinct from ... the motor proteins and spindle checkpoint proteins [19] This reduction of checkpoint proteins is required for inactivating the spindle checkpoint signal and progression in the cell cycle [20] The ... beneficial in chemotherapy Similar to taxol and vinblastine, benomyl also induces apoptosis in HeLa cells, indicating that benomyl may be useful in combination with other potent anticancer drugs...

Ngày tải lên: 30/03/2014, 10:20

... propagates inflammatory responses and is a significant RAGE ligand in the setting of sepsis and acute inflammation HMGB1 is an apparent autocrine/paracrine regulator of monocyte invasion, involving ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult...

Ngày tải lên: 18/06/2014, 15:20

Ngày tải lên: 18/06/2014, 19:20

... European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85(5):365-376 de Haes ... close to in previous studies: 6–7 in hepatobiliary carcinoma [13], and 5–6 in breast cancer [10] Final results were summarized as a range of MID esti- http://www.hqlo.com/content/5/1/70 mates and ... Drs Pickard and Cella have received consulting fees from GlaxoSmithKline, which financed this manuscript including the articleprocessing charge They not have any stocks or shares in an organization...

Ngày tải lên: 18/06/2014, 22:20

... (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post-Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg protein) A Page of 16 ... described above and killed at or days after injury (n = per group per timepoint) Brains were perfusion fixed using 4% paraformaldehyde and embedded in paraffin wax Brain tissue blocks were cut into 10 ... rats being 2.43 ± 0.54% in TAI and 2.04 ± 0.45% in TAI+Hx animals The production of cytokines is enhanced following TAI +Hx The neuroinflammatory response was determined by measuring changes in cytokine...

Ngày tải lên: 19/06/2014, 22:20

... between nitrogen mineralization and grazing intensities in an Inner Mongolian typical steppe Plant and Soil, 300: 289–300 Yang X., Xu M (2003): Biodiversity conservation in Changbai Mountain Biosphere ... temperature is maintained at 20°C For the given vegetation type of Changbai Mountain, soil C and N mineralization rate, potential mineralizable C (C0) and potential rate of initial C mineralization ... Ecosystem, 2: 196–206 (in Chinese) Cole L., Buckland S.M., Bardgett R.D (2008): Influence of disturbance and nitrogen addition on plant and soil animal diversity in grassland Soil Biology & Biochemistry,...

Ngày tải lên: 07/08/2014, 10:21

... IR index was found at the beginning of autumn and the lowest in spring Accordingly, the periods showing the highest percentages of N may be intimately correlated with those in which leaf shedding ... contrasted with that obtained for the same date from leaves that fell during shedding: 0.68%, the contents in the leaves decreasing in favour of an increase in nitrogen in branches and bark for the same ... concentration of nitrogen in the leaves was determined in the spring and sum- The procedure most commonly used to estimate the biomass in forest ecosystems involves destructive techniques in combination...

Ngày tải lên: 08/08/2014, 14:21

... differences in growth He suggested that dry matter increment be determined at multiple intervals of time during the growth period and that increments be plotted against the mean initial dry weight ... Samples were incubated in -1 the dark at 25 °C, aerated daily, and weighed at 3- or 4day intervals Water was added as needed to maintain the original mass Twelve samples - three randomly selected ... seedlings and their individual tissue components (1-year-old foliage, total foliage, stem and branches, roots) were analyzed In addition, relative dry-matter increment (RDMI) and relative N increment...

Ngày tải lên: 08/08/2014, 14:21

... decrease, indicating that Q macrocarpa could not utilize rain water in the upper soil layers and Knapp, 1986) The ability to increase root growth into and to increase root proliferation within enriched ... conflicting problem of maintaining some degree of photosynthesis while minimizing water loss Stomatal control in response to varying moisture stress is the first and perhaps the most important step in ... seedlings or of decreases in carbon fixation or shifts in carbon pools, starch hydrolysis and efficiency of sucrose loading into the phloem may increase to maintain transport are young developing...

Ngày tải lên: 08/08/2014, 18:21

... the remaining in secondary metabolism (respectively, groupsI and II) (Bergmann, 1991) Allelic frequencies were estimated within each population; observed and expected heterozygosities within populations ... studied Enzymes involved in secondary metabolism exhibited higher withinpopulation variation than enzymes involved in primary metabolism These discrepancies were due to differences in allelic frequency ... diversity in plant species In: Plant Population Genetics, Breeding and Genetic Resources (Brown AH, Clegg MT, Kahler AL, Weir BS, eds) Sinauer Associates, Sunderland, MA, 23-42 Kleinschmit J (1993) Intraspecific...

Ngày tải lên: 08/08/2014, 19:21

... the hands, wrists, and distal part of the feet were obtained at baseline and after 12 and 24 months Forty joints in the hands and feet were scored (in the hands, proximal interphalangeal joints ... HRT, in line with our previous findings of an increase in insulin-like growth factor in the HRT group [41] PICP correlated significantly with CTX-I and COMP and inversely with bone mass in the ... and intra-articular and intramuscular glucocorticosteroid injections were allowed during the study period The patients were not receiving and had not used in the preceding years drugs affecting...

Ngày tải lên: 09/08/2014, 01:24

... proteins These proteins are rich in arginine and other basic amino acids (Kang and Titus, 1980), accumulate in the fall, disappear in the spring and are glycoproteins similar to those found in ... continues late into the fall in the main stem and roots as soluble nitrogen moves from twigs to main stem, and newly absorbed inorganic nitrogen is converted into organic nitrogen and stored in ... leaf and shoot growth slows in early summer The initiation of storage is often indicated by an increase in arginine as new concentration in small branches and bark tissue Both soluble and protein...

Ngày tải lên: 09/08/2014, 04:20

... greening soybean and lupin tissues Plant Sci 56, 1-7 Marzluf G.A (1981) Regulation of nitrogen metabolism and gene expression in fungi Microbiol Rev 45, 437-461 Oaks A & Hirel B (1985) Nitrogen metabolism ... to be classical in both mycorrhizal fungus, where GDH predominates (Marzluf, 198 1and roots, where GS is the major route of ammonium assimilation (Oaks and Hirel, 1985) Our findings also show that ... be operative in mycorrhizal tissues The further transfer to an amino group or to other carbon skeletons might occur through aminotransferases, since both AAT and GPT were detected in the mycorrhizal...

Ngày tải lên: 09/08/2014, 04:20