efficacy of vitamin e in human health and disease

... where As is the absorbance in the presence of the sample and H2 O2 , A0 is the absorbance of the control in the absence of the sample and H2 O2 , and A is the absorbance only in the presence of ... superoxide anion generation system and B is the change speed of absorbance of the test sample Vc was used as a positive control in the study 2.10 Cell lines and culture PC12 cells (ATCC, American Type ... tetramethylsilane as internal standard All data were presented as means ± standard deviation (SD) of three replications Statistical analyses were performed using Stu- X Ding et al / International Journal of...

Ngày tải lên: 28/06/2014, 11:20

... to explore better the chemistry and antioxidant properties of 5H-dibenz[b,f]azepine and its derivatives Six molecules (a–f) were synthesised, and their structures were established by chemical and ... grade and obtained from Merck, Mumbai, India Melting points of the compounds were determined by the open capillary method and are uncorrected The IR spectra were recorded on a FT-IR 021 model (Perkin ... for the synthesis of the registered anticonvulsant drug oxcarbazepine,13 the structure of which has recently been reported.14 Dibenz[b,f]azepine and its derivatives have been variously reported...

Ngày tải lên: 07/08/2014, 14:20

... implicated in the pathophysiology of a number of neurodegenerative diseases [17] we also investigated the antioxidant potential of TPBIA, since there are some reports concerning the role of free radicals ... change with increase in molecular weight, any gain in size by the molecule increases its time of residence on the receptor [16] c) Some clinical studies [6,25] have shown that vitamin E (a well established ... pharmacokinetic profile of drugs Among these properties are the intestinal absorption and the blood-brain barrier penetration PSA has been found to be useful in modeling intestinal absorption together...

Ngày tải lên: 08/08/2014, 20:23

... regulates Figure Effect of different concentrations of Tuberosin on LPS induced iNOS expression in attached rat peritoneal macrophages The macrophages were pretreated with quercetin and tuberosin ... = EC50 of tuberosin- 49.22 mM, EC50 for quercetin- 0.60 μmuM@ Level of significance: p* < 0.1 and p** < 0.001 @Reference 18 Table Effect of tuberosin in the deoxyribose assay in the presence of ... behave as foreign proteins and affect the immune system They may activate the inflammatory cascade, resulting in initiation of various degenerative diseases and autoimmune disorders [15] Therefore,...

Ngày tải lên: 11/08/2014, 03:20

... example, the clove, coriander and fennel essential oils were composed of only five, eight and seven compounds, respectively On the other side, some oils were very complex The everlast, nutmeg and, ... Ionization of sample components was performed in the EI mode (70 eV) A volume of mL was injected The linear retention indices for all compounds were determined by co-injection of the sample with ... fractionation of essential oils Except for laurel (93.0 %), more than 95 percent of constituents were identified in all other essential oil samples The results of these analyses are presented in Table I...

Ngày tải lên: 16/08/2014, 22:31

... regions of Asia and the Mediterranean However, the elucidation of the pathogenesis of diabetes occurred mainly in the 20th century The role of the pancreas in the disease pathogenesis of diabetes ... endocrine role of the pancreas in metabolism and the existence of insulin were not fully clarified until 1921 Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and ... Increase the number insulin receptor sites Decrease the leaking-out of glycogen Enhancement of the use of glucose in tissues and organs 41 Based on the mechanisms stated above, the oral anti-diabetic...

Ngày tải lên: 12/09/2015, 10:58

... as free radical scavengers by preventing and repairing damage caused by ROS and, therefore, can enhance the immune defense and lower the risk of cancer and degenerative diseases [6,12] The human ... components [18] These natural plant antioxidants can therefore serve as a type of preventive medicine Recent reports indicate that there is an inverse relationship between the dietary intake of ... oleuropein, demethyl-oleuropein, ligstroside, and oleoside (8) represent the predominant phenolic oleosides [47], whereas verbascoside [78] is the main hydroxycinnamic derivative of the olive...

Ngày tải lên: 12/01/2016, 18:24

... is believable to protect against the development of many diseases In this study we have investigated the protective effect of pravastatin against primaquine induced oxidative stress in human erythrocytes ... buffered gluteraldehyde Aldehyde was drained and rinsed times each of in phosphate buffer and post-fixed in osmium tetroxide for h After this, the samples were rinsed in distilled water and then dehydrated ... lysine, arginine, proline, and threonine in the polypeptide http://www.medsci.org Int J Med Sci 2010, chains [27] PCO level was assessed to evaluate primaquine-mediated protein oxidative damage...

Ngày tải lên: 25/10/2012, 11:40

... [fullerene]/[b-carotene] gave a good regression line with intercept = for each of the antioxidants, C60, C60O, and a commercially available mixture of fullerene oxide C60On.1 The dotted line indicates ... indicates the value in the absence The C60On, instead of C60O2 due to the difficulty in availability, was used to investigate the effect of the number of pin-up oxygen on C60 as well as the scope for ... scavenging rate constants krrs (= kf/kc) of fullerenes versus b-carotene, as given in Eq [18], where R0 is the bleaching rate in the absence of antioxidants ([fullerene] = in Eq 1) R0 kobs of control...

Ngày tải lên: 22/06/2014, 01:20

Ngày tải lên: 28/06/2014, 11:20

... the least sensation at the far left and the most at the far right Scores were determined by measuring the distance in mm from the left end of the line and the change in numerical values between ... inhaled viral and bacterial pathogens where they can be eliminated or held in check by immune defenses, thereby reducing the risk and/ or severity of lower airway infections [16-19] Evidence indicates ... confluence on 12-well inserts were treated as indicated for 15 and incubated for 12 hr at 37°C Rinsed cells were fully lysed and luciferase luminescence was generated using the E4 030 Luciferase Assay...

Ngày tải lên: 12/08/2014, 13:22

... (1-8) Methods 2.1 Sample preparation ‒ Fresh fruits was collect and separated into part, one were used in moisture experiment and the other part were used in the rest experiment ‒ Fruits were treat ... carried out for the aim of verifying the effect of solvent and temperature on the same object when extracted anthocyanins from fruits There were two factors in this experiment, solvent and temperature; ... only stems and leaves for sale, the left over fruits after harvest are kept as breeding purpose in few amount, the rest are useless The flesh contain red or purple – red color, these pigments can...

Ngày tải lên: 06/10/2015, 15:58

... tyrosine kinase activity, and residues 924-973 are located in an essential motif for dimerization of receptor tyrosine kinases [30] Since EphR is often overexpressed in cancer and involved in metastasis ... screened in the Origene TissueScan Cancer Survey Panel 96-I and normalized to the internal control, β-actin in the different patients The fold-difference in mRNA expression at each disease stage ... dimerization of receptor tyrosine kinases, residues 924-973 (C) Identical and homologous residues are shown in red and blue, respectively The sequence identity and homology between RIZ1 and EphR were 34.2%...

Ngày tải lên: 25/10/2012, 11:15

... microsensors A potential difference b/w the working electrode and the reference Reference electrode (Ag/AgCl) Working electrode (Pt wire) 50 m pH, NO2- and NO3microsensors Charge separation of ions ... 62% of the total domestic wastewater biofilm clones sequenced were closely related to members of Nitrosomonas ureae with more than 97% sequence similarity These clones were closely related to each ... performed Fixation and Cryosectioning of Biofilm Samples Biofilm samples were taken at regular time intervals during the periods of the biofilm development The biofilm samples were fixed with freshly...

Ngày tải lên: 05/09/2013, 08:40

... the photocatalyst and were able to penetrate the outer layer of bacteria These reactive species oxidized the membrane and broke the main permeability barrier of bacteria The slow leakage of intracellular ... be retarded as Ag+ which acts as an electron acceptor Therefore, the time for •OH generation can be extended and the effectiveness in killing bacteria increased However, in the present study, ... step for maximizing the reaction efficiency but minimizing the shading effect Effect of stirring speed In addition to the effect of photocatalyst concentrations, the effect of stirring speed in...

Ngày tải lên: 05/09/2013, 09:08

... Table Effect of MA on different representative proteases All tests were performed at a fixed concentration of enzyme and selected according to the detection limit The MA concentration range was ... falciparum infected erythrocytes may be mediated by the inhibition of one or more proteases, probably corresponding to metalloproteases, serine and ⁄ or cysteine proteases, which are required to reach ... readily be achieved by chelating agents that bind to metal cations required in the active site of the enzyme The observed inhibition of MA on thermolysin and PfSUB1, a calcium-dependent serine...

Ngày tải lên: 14/02/2014, 14:20

... generated in sedfit and then optimised using the meniscus and f ⁄ f0 as floating parameters The relative concentration and weight-average sedimentation coefficient were determined for each species ... two molecules of the bleomycin antibiotic within two crevices formed at the interface of the domain swapped dimer [46] Equally intriguing is the T7 endonuclease I, representing one of the most ... (‘G-proteins’) all possess a conserved guanine nucleotide-binding domain, with the five polypeptide loops that comprise the guanine nucleotide-binding site being the most highly conserved elements...

Ngày tải lên: 16/02/2014, 09:20

... Likewise, a close examination of Itch expression during development and in different cell types is needed Recently, the Itch gene has been reported to be amplified in anaplastic thyroid carcinoma ... reducing the basal level of Itch reduces cell survival and increases caspase activity, consistent with increased tBid levels in these cells Interestingly, Itch interacts specifically with tBid, and not ... due to uneven transfection levels, as very consistent expression levels were obtained in untreated cells Intriguingly, it is directly correlated with the disappearance of tBid–GFP, which can be...

Ngày tải lên: 16/02/2014, 09:20

... mm leupeptin (inhibitor of trypsin-type serine proteases and cysteine proteases) or mm E- 64 (cysteine protease inhibitor) (Fig 8B) Obvious effects of other protease inhibitors were not observed ... not been reported Thus, the N-terminal regions of calpain might have evolved to acquire different strategies for involvement in the ESCRT system, and the tandem MIT domains may govern interacting ... mGFP–calpain 7C290S–Strep itself made the substrate more resistant to the protease Moreover, the efficiency of generation of 30 K in the intermolecular reaction experiment seems less than that observed...

Ngày tải lên: 18/02/2014, 04:20