... undergoes conformational changes also affecting the drug binding site [17]. Conformational changes of Pgp upon its catalytic cycle can be detected by measuring the binding of certain monoclonal antibodies ... question, we compared the effects of P i analogues (V i ,BeF x ,AlF 4 ), trapping nucleotides at the catalytic site of Pgp, and of ATP depletion, on UIC2- shift and UIC2/MM12.10 competition. Accurate ... data) 1 interactwithPgpinsuchamannerthat preincubation of the cells with UIC2 completely suppresses the subsequent binding of MM12.10. In contrast, UIC2 mAb added at saturating concentration decreased the extent of MM12.10 labeling only mildly...
Ngày tải lên: 08/03/2014, 23:20
Ngày tải lên: 05/09/2013, 08:40
Tài liệu The Effects of Childhood Stress on Health Across the Lifespan pptx
... Lifespan 11 The Effects of Childhood Stress on Health Across the Lifespan is a publication of the National Center for Injury Prevention and Control of the Centers for Disease Control and Prevention. Centers ... 12.5% 8 The Effects of Childhood Stress on Health Across the Lifespan U.S. Department of Health and Human Services Centers for Disease Control and Prevention National Center for Injury Prevention and Control ... initiation of smoking, sexual activity, and illicit drug use. 3 As the number of A CE increases, the number of co-occurring 3 health conditions increases. 6 The Effects of Childhood Stress on...
Ngày tải lên: 12/02/2014, 19:20
Tài liệu The Effects of Equipment Age on Spare Part Costs - A Study of M1 Tanks pptx
... Contract No. DASW01-01-C-0003. ISBN: 0-8330-3869-9 iv The Effects of Equipment Age on Spare Part Costs: A Study of M1 Tanks For more information on RAND Arroyo Center, contact the Director of Operations ... be filled in order to conduct thorough analyses on the effects of age on costs. This research, which addresses the effects of equipment age on financial costs, is a companion piece to Peltz et ... Negative Actual Expenditures 41 D. Additional Statistical Information on Regression Analyses 45 Bibliography 61 Analysis of the Effects of Equipment Age on Spare Part Costs 25 Figure 4.2 Average...
Ngày tải lên: 17/02/2014, 22:20
Tài liệu The Effects of Equipment Age On Mission Critical Failure Rates pptx
... Comparison of Battalion Failure Distributions and Poisson Distribution in 2nd Infantry Division 80 B.6. Comparison of Battalion Failure Distributions and Poisson Distribution in 3rd Infantry Division ... complete RECAP of current aged fleets has been found unaffordable. Thus, the Office of the Deputy Chief of Staff, G-8 (Programs), the Office of the Deputy Chief of Staff, G-3 (Operations and Plans), the Office ... 2.2—Distribution of Tank Age by Location 6 The Effects of Equipment Age on Mission-Critical Failure Rates brigades, which have the oldest tanks in the active Army, are the only two brigades that consistently...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu A PRELIMINARY ANALYSIS OF THE EFFECTS OF HR 2454 ON U.S. AGRICULTURE doc
... and up to 488 million tons through afforestation (147 million tons from cropland and 342 million tons from grassland). Figure 4 shows the regional breakout of the potential carbon dioxide equivalent ... afforestation on cropland and pastureland and through soil management at a carbon price of $34 per CO2e. Figure 4—Carbon Sequestration Potential by Region (based on carbon price of $34/MT CO2e) 0 ... more pronounced effects on energy costs over time, the effects on agriculture are more pronounced in the medium and long term analyses. In addition to higher energy costs, the emissions allowances...
Ngày tải lên: 21/02/2014, 01:20
Tài liệu Báo cáo Y học: The effects of low pH on the properties of protochlorophyllide oxidoreductase and the organization of prolamellar bodies of maize (Zea mays) pot
... these conditions, hence the lack of reformation of POR-PChlide 650 . Addition of low concentrations of NADPH to PLB aged at pH 7.5 which show only limited structural reorganization, in contrast, results ... contribution of the pH-driven conformational changes from the other effects, a parallel study was carried out on the low-pH induced blue shift in the PChlide absorption maximum of nonphotoconverted ... dependence of the photo- conversion of PLB at pH 6.5. Plots of the extent of photoconversion in response to a single saturating flash, and to a series of such flashes separated by a dark time of 30...
Ngày tải lên: 22/02/2014, 04:20
The effects of oxidative stress on female reproduction: a review ppt
... contribute to the culmination of these effects in spontaneous abortion [321]. The generation of ROS [322-324] is often associated with DNA strand breaks induced by THC [315]. Epoxi- dation of ... complications will be discussed below. 10.2. Spontaneous aborti on Spontaneous abortion refers to the unintentional termin- ation of a pregnancy before fetal viability at 20 weeks of gestation or ... and around endometriotic lesions [115]. Future studies in- vestigating the use of iron chelators may prove beneficial in the prevention of lesion formation and the reduction of lesion size. Many genes...
Ngày tải lên: 05/03/2014, 16:20
Báo cáo " Effects of biosolids application on soil chemical properties in peri-urban agricultural systems " doc
... Inubushi, Measurement of concentrations of trace metals in arable soils with animal manure application using instrumental neutron activation analysis and the concentrated acid digestion method, Soil ... content of trace metals increases above a certain critical concentration due to their accumulation in soil, it can have negative environmental effects, which can include negative effects on ... objective of this paper was to quantify the effects of reuse of biosolids (in the form of animal manure) as nutrient sources by: (i) investigating the effects of biosolids application on soil...
Ngày tải lên: 05/03/2014, 16:20
Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... a two-state t ransition with t he observation of a r ange of mid- point denaturant concentrations, [D] 50% values, indicating significant context-dependent effects of the mutations on protein stability ... buffered solution of native protein was unfolded by a 1 : 10 dilution to yield final concentrations of GdmCl near or above the midpoint of the equilibrium unfolding transition (concentrations of GdmCl ... of the polypeptide chain by restricting r otation around the N-Ca bond to a relatively small region of conformational space. This factor, coupled with the lack of an amide NH hydrogen bond donor...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) potx
... than control pcDNA–HEK293 cells. Nontoxic concentra- tions of each polyphenol were used in combination with increasing concentrations of etoposide to deter- mine the effects of the polyphenols on ... polyphenol concentrations. Furthermore, recent studies show a correlation between the in vitro effects of flavonoids in the low micromolar range and in vivo work using oral solutions of flavonoids [13,14]. Many ... presence and absence of BeFx. The reaction was initiated by addition of 5 m M ATP and terminated with SDS (2.5% final concentration) after 20 min incubation at 37 °C. The amount of P i released was...
Ngày tải lên: 07/03/2014, 21:20
Review of the Need for a Large- scale Test Facility for Research on the Effects of Extreme Winds on Structures pptx
... Committee con- sisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The National Academy of Sciences is a private, nonprofit, ... Research on the Effects of Extreme Winds on Structures Board on Infrastructure and the Constructed Environment Commission on Engineering and Technical Systems National Research Council NATIONAL ACADEMY ... Committees on Wind Effects, Dynamic Effects, and the Reliability of Offshore Structures and recipient of the Federal Engineer of the Year Award from the National Society of Professional Engineers...
Ngày tải lên: 08/03/2014, 19:20
The Effects of Workplace Hazards on Female Reproductive Health pot
... functions of these tissues are largely controlled by hormones 6 How Does the Female Reproductive System Work? 20 Notes 19 Notes The Effects of Workplace Hazards on Female Reproductive Health National ... Additional Information is Available from NIOSH? current practice of minimizing the use of X-rays on pregnant women, the use of newer equipment that re- duces the risk of exposure, and the use of ... egg every month. These sex hormones also contribute to the basic health of the heart, bones, liver, and many other tis- sues. Finally, during pregnancy the placenta produces a hormone (human chorionic...
Ngày tải lên: 14/03/2014, 16:20
The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California pdf
... ftp://ftp.abag.ca.gov/pub/mtc/census2000/TIGER/BayArea_waterclipped/. 40 In terms of language, about 5% of consumer and provider respondents used the Spanish version of the survey, while 7.4% of Contra Costa IHSS consumers consider Spanish to be their ... (MTC) data i The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California ... of consumers and providers, and the extent of care consumers received. The six interrelated hypotheses predicted that, given the income constraints of both populations and the disability constraints...
Ngày tải lên: 14/03/2014, 17:20
Research " THE EFFECTS OF CUSTOMER LOYALITY ON PROFITABILLITY " ppt
Ngày tải lên: 16/03/2014, 03:20
THE EFFECTS OF REPLACEMENT SCHEMES ON CAR SALES: THE SPANISH CASE doc
... assumptions may underlie the referred overestimation of the transitory eect of the Prever scheme: the absence of a second hand market and the assumption of a constant physical depreciation rate. Figure ... possible by both the inclu- sion of the term e w into the individual valuation of nondurable goods, and the consideration of a stationary stochastic process –a Poisson process– for the underlying ... preferences h w f (w)+v (w d (w)) defined on nondurable consump- tion f and durable goods services v. For simplicity, consumers own one and only one car. Services of a car bought at time w d are defined as...
Ngày tải lên: 16/03/2014, 12:20
Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx
Ngày tải lên: 16/03/2014, 18:20
Báo cáo "Effects of Zn content on the magnetic and magnetocaloric properties of Ni-Zn ferrites " pdf
Ngày tải lên: 22/03/2014, 11:20
Bạn có muốn tìm thêm với từ khóa: