effects and how likely are they to happen

... in secretory granules by PC enzymes such as PC1 ⁄ 3, PC2 or PC5 ⁄ 6A Understanding how these enzymes and their substrates are targeted to secretory granules is thus critical in understanding this ... A sepharose, separated by SDS ⁄ PAGE, and detected by fluorography (C) Autoradiograms similar to those shown in (B) were exposed to storage phosphor screen and quantified The ratios (mean ± SEM) ... secretory granule-sorting domain is predicted to form an a-helix The secretory granule-sorting domains of PC1 ⁄ and PC2 correspond to regions predicted to form a-helices [3,6] In order to determine...

Ngày tải lên: 18/02/2014, 16:20

... answers will help us understand what changes need to be made at the storage-manager and query executor levels to rowstores if row-stores are to successfully simulate column-stores All of our experiments ... component attributes, and execute normal row-store operators on these rows to process (e.g., select, aggregate, and join) data Although likely to still outperform the row-stores on data warehouse workloads, ... applied and the way a (late materialization) hash join is executed The advantage How the different attempts to emulate a column store in a row-store compare to the baseline performance of C-Store?...

Ngày tải lên: 30/03/2014, 13:20

... DNA-binding protein thought to have a role in the regulation of TNFA expression and which is related to a hereditary motor and sensory neuropathy (LITAF), and a DNA base-excision and repair gene (LIG3) ... variants may in fact be rare (that is,

Ngày tải lên: 11/08/2014, 12:20

... I/It, It and I are total and unphosphorylated inhibitor concentration, (PP2)t is total phosphatase 2A, k1 and k2 are rate constants for phosphorylation and dephosphorylation of inhibitor-1 respectively ... glucose-6-phosphate; PP1 Inhibitor-1, Inhibitor of PP1; Km1 to Km8 are Michaelis-Menten constants, k1 to k8 are rate constants, K11, K22, Kd are dissociation constants as shown in the figure Positive and negative ... multi-step and zero-order effects and inhibitor sensitivity in response to cAMP and glucose The regulatory system for glycogen synthesis and breakdown mainly consists of phosphorylation and dephosphorylation...

Ngày tải lên: 13/08/2014, 22:22

... penetrating trauma in the US is known to be higher than in Australia, hence US trauma datasets are likely to include more injuries to deeper torso, neck and brain structures This will affect ... and commented on the manuscript, and we thank them for their valuable advice Many thanks to Sue McLellan, Andrew Hannaford and Peter Cameron from the Victorian State Trauma Outcome Registry and ... used to compare calculated ISS across the whole population using AIS98 and mapped AIS08 codes Where categorical data was evaluated, chi-square tests were performed where possible, and standardised...

Ngày tải lên: 13/08/2014, 23:20

... commuter cars to taxis Rather than fighting to protect its existing customer base, GM plans to ensure that it has the products to sell to the new type of customer they will have to restructure ... from branding to marketing Nike, for example, has transformed itself from a sportswear maker to a fitness and lifestyle brand, using social media to foster communities and driving customer engagement ... production and product development as they start to get to grips with analysing the wealth of data they can now generate They are also keeping a keen eye on developments from tech competitors such...

Ngày tải lên: 02/12/2015, 14:15

... fitted in-store—posed problems when it wished to move into online sales It turned to UEA to develop a tool enabling parents to find out their children’s shoe size from home by uploading photographs ... their customers want and so improve their products and come up with new ones In 2007, for example, Dell launched IdeaStorm, a blog and website that allows customers to post their ideas and suggestions ... to be advantageous to both sides However, it is a relationship that needs to be carefully managed, and requires each side to have a good understanding of the other’s viewpoint and needs—with slightly...

Ngày tải lên: 04/12/2015, 00:04

... counterparty risk, and push trading edge However, they are unsure whether the greater of more products onto exchange and into central transparency required by regulation will have a clearing They put in ... number say they have a strategy in place to jurisdiction’s regulatory constraints New systems and communicate the impact of regulatory changes to processes are being put in place to meet demanding ... in the UK, however, as the industry waits for many financial institutions Banks are already exiting some elements of the Dodd-Frank Act to be translated into businesses and are likely to shrink...

Ngày tải lên: 04/12/2015, 00:22

... strategy can yield significant competitive advantage To understand how companies are being affected by supply-chain risk, and how they are responding to it, the Economist Intelligence Unit surveyed ... Recovery, however, is likely to take several years So what steps are companies taking to boost supply-chain resilience to help them ride out the storm? To begin with, the recession does not appear to ... strategy, and 35% nominate underestimation of supply-chain risk Such factors can exact a high cost, both in terms of lost sales and market share, and in longterm damage to a brand In some sectors—such...

Ngày tải lên: 06/12/2015, 23:07

... that they are making the right decisions about how and when to change Companies also admit that they are much better at gathering information than they are at acting on it Similarly, executives are ... decisions about how and when a response to change is required 38% 31% No change 24% Making the right decisions about how and when to respond to change 39% 20% Implementing changes to systems and processes ... need to build awareness of the possibility of change in their management team and ensure that they are comfortable with multiple paths Employees who are affected by change are much more likely to...

Ngày tải lên: 06/12/2015, 23:07

... Application Protocol (WAP) and WAP2 – Provide a standard way to transmit, format, and display Internet data • For devices such as cell phones • WAP was developed in 1997 – Enables devices to send and receive ... devices • Messages are limited to about 160 characters – Applications • • • • • Person -to- person Agent -to- person Information broadcast services Software configuration Advertising How Cellular Telephony ... Objectives • Describe wireless wide area networks (WWANs) and how they are used • Describe the applications that can be used on a digital cellular telephone • Explain how cellular telephony functions...

Ngày tải lên: 13/09/2012, 10:52

... Changes to immigration policy that fail to factor in the aspirations and needs of doctors who have already migrated to the UK are likely to disrupt the career paths of many non-European doctors, ... overseas doctors comprise up to 50% of all junior doctors [2] General Medical Council (GMC), the United Kingdom's regulatory and licensing body for doctors, had a total of 239 661 doctors registered ... doctors Respondents were requested to recommend the survey to other non-EU doctors using a pre-programmed input area on our webpage to ensure maximum reach among our target sample Programming tools...

Ngày tải lên: 18/06/2014, 17:20

... practice Science and technology are expected to offer new tools to design clinical interventions and, vice versa, clinical problems are anticipated to foster basic research in neuroscience and the development ... clinicians to monitor vital signs, but also track motor activities and provide a means to analyze motor patterns associated with recovery Furthermore, robotic devices will be used to enhance ... Access to outstanding and visionary scientific reports appears to be a tremendous tool to increase the speed at which clinical practice changes as a result of advances in neuroscience and biomedical...

Ngày tải lên: 19/06/2014, 10:20

... prominent and there is conspicuous brand identity (Chandler et al 2004) 85% of ‘Chuppies’ are aware of the top European designers, and unlike America and Europe most of those purchasing luxury goods are ... Wal-Mart, Metro, and 7-Eleven have become popular places to purchase food, as they provide ‘Chuppies’ with air conditioning no need to haggle, and the ability to buy in bulk and store at home, which ... want to purchase American shoes, and 64% say want to purchase blue jeans (which are still in their infancy in China) Cosmetics and Toiletries International brands have gained a large market share...

Ngày tải lên: 27/06/2014, 23:20

... is luck They were lucky to be born into certain families, and to be born in certain countries They were lucky to have some unique gifts They were lucky to be able to attend good schools and get ... successful people I have met are highly intelligent They are also hard workers They believe in preparation They relate very well to others But if you ask me to point to the most important reason ... which combine to make a successful outcome that much more elusive Chapters 4, 5, and address the whens, whats, and wheres: when to look, what to look for, and where you’re likely to find what you’re...

Ngày tải lên: 28/06/2014, 21:20

... is luck They were lucky to be born into certain families, and to be born in certain countries They were lucky to have some unique gifts They were lucky to be able to attend good schools and get ... successful people I have met are highly intelligent They are also hard workers They believe in preparation They relate very well to others But if you ask me to point to the most important reason ... which combine to make a successful outcome that much more elusive Chapters 4, 5, and address the whens, whats, and wheres: when to look, what to look for, and where you’re likely to find what you’re...

Ngày tải lên: 10/08/2014, 07:21

... from that experience And to top it all off, we think we’re far better at people choices than we really are From Success to Happiness Up to this point, I have tried to appeal to your calculations ... Collins went back to the GSB and began his research and teaching career, and soon received the Distinguished Teaching Award After seven years in Palo Alto, he returned to his home town of Boulder, ... companies like IBM and Merck, to name just two Today, companies know that they have to gain access to the ideas of outsiders At the same time, they know that their own knowledge workers are increasingly...

Ngày tải lên: 10/08/2014, 07:21

... businesses; today, you have to contend with greatly increased customer and investor power in all businesses In the past, Fortune pointed out, you had to know how to negotiate with unions; today, it’s ... our very human tendency to procrastinate, how we build in a bias toward action—toward rooting out problems and acting on them? I believe the first step is to be aware of, and on the lookout for, ... priority is to figure out where you stand Later chapters in this book will analyze in much more detail what to look for when making people decisions, where to look for candidates, and how to appraise...

Ngày tải lên: 10/08/2014, 07:21

... intelligence”) are well aware that soft competencies are key to success at the top As a result, many organizations now have a clearly articulated inventory of competencies, and attempt to hire and promote ... incidents: The new manager was certain to face sudden and unexpected price cuts by competitors, and would have to know how to react swiftly He or she would have to reposition for one product, despite ... or experience, but a lack of transparency and self-control What better way to restore faith in business and its leaders than to build emotional intelligence into our organizations? Finally, an...

Ngày tải lên: 10/08/2014, 07:21

... on-line HR tool that they developed to monitor and track competencies on all employees worldwide One of their objectives, they told us candidly, was to reduce the amount of outside searching they needed ... know the stockbroker If the recipients knew the stockbroker, they could send it to him directly If they didn’t, they were asked to forward it to someone they did know who might be closer to the ... know the best candidates People waste too much time calling too many irrelevant candidates It makes much more sense to drum up people who are likely to know of several high-quality candidates right...

Ngày tải lên: 10/08/2014, 07:21