... [10] The result is cytotoxic hypoxia caused by the inhibition of CCO by the high affinity of CN to heme a of the enzyme The effect is a structural change and a reduced activity of the enzyme and ... CCO and CN binds to either the reduced CCO heme (Fe 2+ ) or oxidized heme (Cu B 2+ ) [20-22] The primary effect of CN is a blocking of the mitochondrial respiration chain and the formation of ... (CCO), the terminal enzyme complex of the respiratory chain in complex IV [10] The active (O2-binding) site of CCO is binuclear, consisting of heme a and Cu B [19] CO binds to the reduced form of...
Ngày tải lên: 13/08/2014, 23:20
... development of technology for the simultaneous measurement of most of the mRNAs encoded by the mouse and human genomes has led to efforts to establish the transcriptomes of tissues and cells under ... males and females (c) Gene cluster analysis comparison of the effects of CR on hippocampal transcriptomes of male and female mice of different ages Note the similarities in responses of young and ... the transcriptomes of cells in the striatum and cerebellum were insensitive to CR, while cells in the other three brain regions were significantly more responsive to CR The transcriptome of the...
Ngày tải lên: 14/08/2014, 08:20
Tài liệu Future Flight: A Review of the Small Aircraft Transportation System Concept pdf
... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their ... uses in transportation, the system of airports and airways they operate in, and the qualifications and characteristics of the pilots that fly them is provided Much of the discussion is background, ... scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare On the authority of the charter granted to it by the Congress...
Ngày tải lên: 17/02/2014, 06:20
Tài liệu Báo cáo Y học: The glucose-specific carrier of the Escherichia coli phosphotransferase system Synthesis of selective inhibitors and inactivation studies pptx
... to the theoretical model and in the subsequent simulations [22] the corresponding ratios were KI2/KS2 ¼ and KI1/ KS1 ¼ 0.7 These values and the transition of the Eadie– Hofstee plot from the ... lM KS1 and KS2 are the dissociation constants of E1 and E2 for Glc, KI1 and KI2 the dissociation constants for the inhibitor, and k1 and k2 are the turnover numbers DYNAFIT was used to fit the experimental ... curved shape of the plot and the KI/KS ratios indicate that the C-6 epoxide 1d, like the C-6 aldehydes of Glc and aMGlc [15], preferentially inhibits the low-affinity site of EIIGlc For the phosphorylatable...
Ngày tải lên: 21/02/2014, 01:21
History of the FIGO cancer staging system pptx
... the Radium Centre for Carcinoma of the Uterus, London, UK; the Institute of Radium at the University of Paris, France; and the Radiumhemmet, Sweden), the number of contributing institutions and ... reports would be expanded to include material relating to cases of carcinoma of the corpus uteri and of the vagina [14] The main objective of the Annual Report was to provide the greatest possible ... Organization of the League of Nations It recommended that the new classification should be called The International Classification of the Stages of Carcinoma of the Uterine Cervix” and that all...
Ngày tải lên: 14/03/2014, 14:20
Lung cancer - The diagnosis and treatment of lung cancer pdf
... Preoperative chemotherapy and surgery Surgery followed by chemotherapy Surgery then chemo- and radiotherapy Radical radiotherapy Chemotherapy and radical radiotherapy b a Chemotherapy Symptomatic treatment, ... should be offered information, both verbal and written, on all aspects of their diagnosis, treatment and care This information should be tailored to the individual requirements of the patient, and ... control and quality of life 4.5.2 The impact of the time between first symptom (or first detection if asymptomatic) and the treatment of lung cancer on patients’ survival and quality of life...
Ngày tải lên: 15/03/2014, 00:20
Improving the diagnosis and treatment of smear-negative pulmonary and extrapulmonary tuberculosis among adults and adolescents pdf
... Improving the diagnosis and treatment of smearnegative tuberculosis Part i Improving the diagnosis and treatment of smear-negative tuberculosis Background management of smear-negative pulmonary and ... aspirate is obtained, move the needle in and out of the centre of the node while pulling back on the syringe piston Gently compress the node with the nondominant hand and revolve the needle in both directions ... taken and examined for AFB One of the specimens should be early-morning Part i Improving the diagnosis and treatment of smear-negative tuberculosis Figure Algorithm for the diagnosis of tuberculosis...
Ngày tải lên: 15/03/2014, 03:20
Báo cáo " Implementation of the digital phase-sensitive system for low signal measurement " docx
... represent the signal and the reference X is called the synchronous in-phase component and Y is the quadrature When θ = 0, X reaches maximum and Y = Taking the square of both X and Y then sum up them, ... VNU Journal of Science, Mathematics - Physics 24 (2008) 239-244 243 The development of the amplitude and the phase shift according to the noise level Noise (V) Fig The dependence of the output ... Fig.8 The Fig shows the constancy of the output dc-voltage (Vs = 0.495 V) when the amplitude of noise reaches 5V Similarly, we record the dependence of the phase shift on the amplitude of noise...
Ngày tải lên: 22/03/2014, 11:20
Báo cáo khoa học: The molecular identity of the mitochondrial Ca2+ sequestration system potx
... that is also located in the IM The process of Ca2+ uptake is driven by the membrane potential; the process of Ca2+ release is driven by the pH gradient, in the case of the Ca2+ ⁄ 2H+ exchanger ... accumulation of Ca2+, the storage capacity of this ‘nucleation factor’ is exceeded, and the Ca2+ concentration in the matrix and the intermembrane space rises above the threshold for PTP assembly, thereby ... the presence of Ca2+ The binding to the membrane could further be modulated by pyridine nucleotides, which also bind to calvectin; bound NAD+ decreased the association of calvectin with the membrane...
Ngày tải lên: 23/03/2014, 03:20
UPDATES IN THE DIAGNOSIS AND TREATMENT OF VASCULITIS pot
... because of the widespread involvement of vessels and the fact that it affects the entire thickness of the vessel wall [1] A disorder of necrotizing vasculitis, granulomatous lesions of the entire ... expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility is accepted for the accuracy of information contained in the ... allowing them to understand and manage cases that did not fit the strict criteria of Goodman and Churg [15] In the early 1970s, Fauci and Wolff introduced treatment with cyclophosphamide and corticosteroids...
Ngày tải lên: 30/03/2014, 00:20
Updates in the Diagnosis and Treatment of Vasculitis Edited by Lazaros I. Sakkas and Christina Katsiari pptx
... because of the widespread involvement of vessels and the fact that it affects the entire thickness of the vessel wall [1] A disorder of necrotizing vasculitis, granulomatous lesions of the entire ... expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility is accepted for the accuracy of information contained in the ... allowing them to understand and manage cases that did not fit the strict criteria of Goodman and Churg [15] In the early 1970s, Fauci and Wolff introduced treatment with cyclophosphamide and corticosteroids...
Ngày tải lên: 30/03/2014, 18:20
Dự án nông nghiệp " Improving capability of provincial extensionists for assessing soil constraints to sustainable production through the use of the SCAMP decision support system " MS5 pptx
... concerning their topography The demonstration field experiment was also visited, and observations made on crop growth responses to the farmer’s practice and the SCAMP treatments On the last day of the ... reducing the impact of soil compaction (improving soil aeration and water infiltration rate), and addition of a high-activity clay to increase the nutrient holding capacity of the soil These treatments ... texture, pH, and EC of soils and to observe and record properties such as position in the landscape, drainage, permeability, colour, structure and compaction The implications of these properties...
Ngày tải lên: 21/06/2014, 04:20
Báo cáo khoa học nông nghiệp " Improving capability of provincial extensionists for assessing soil constraints to sustainable production through the use of the SCAMP decision support system ( Attachment 2 )" pdf
... Conclusion The pre- and post-course questionnaires identified some major changes in the perceptions of extensionists as a result of the course In particular, a better understanding of the effects of ... recognised the importance of applying organic amendments and retaining crop residues as a means of improving productivity Post-course survey According to the post-course survey, the awareness of the ... management based on the inherent constraints identified for the soil It was clearly the desire of the extensionists to pass on their knowledge to farmers through training courses The role of a mobile...
Ngày tải lên: 21/06/2014, 04:20
DIAGNOSIS AND TREATMENT OF ABDOMINAL AND THORACIC AORTIC ANEURYSMS INCLUDING THE ASCENDING AORTA AND THE AORTIC ARCH pptx
... experience of the use of self-fixating synthetic prosthesis for remote endoprosthesis of the thoracic and abdominal aorta and iliac arteries through the femoral artery and as intraoperative endoprosthesis ... advantage in the visualization of the surgical field and all the advantages that this leads well as its main disadvantage is the pain of the wound For the approach of the distal aortic arch and descending ... that the ligature could decrease or stop the movement Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch of blood within the aneurysmal...
Ngày tải lên: 27/06/2014, 19:20
AUTISM SPECTRUM DISORDERS: THE ROLE OF GENETICS IN DIAGNOSIS AND TREATMENT pot
... Fragile X syndrome and the FMR1 gene Schematic representation of the location of the FMR1 gene on the long arm of the X chromosome (a) The FMR1 gene comprises a polymorph repetition of the base pairs ... syndrome and the MECP2 Gene Schematic representation of the location of the MECP2 gene on the long arm of the X chromosome (a) The MECP2 gene is constituted by coding exons .The majority of mutations ... groups of patients, on the one hand, and groups of healthy individuals, on the other hand (Vorstman et al., 2006a) The research findings make it clear, however, that the pathophysiology of autism...
Ngày tải lên: 28/06/2014, 05:20
báo cáo khoa học: "Evaluation of the new AJCC staging system for resectable hepatocellular carcinoma" pptx
... for these factors and the most important drawback of the TNM-7 staging system is the lack of incorporation of host and surgical factors Staging systems are designed to predict prognosis and to ... invasion, and satellite lesions The new 7th edition (TNM-7) of the AJCC/UICC TNM system [10], which was introduced in 2009, is a modified version of the 6th edition (TNM-6) of this system The major ... as the period from the date of hepatectomy to the date of recurrence as detected by imaging studies Overall survival (OS) was defined as the period from the date of hepatectomy to the date of...
Ngày tải lên: 09/08/2014, 02:21
Báo cáo khoa học: "Highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis" ppsx
... diagnosed Four of the seven cases of synovial sarcoma, two of the three cases of alveolar soft part sarcoma, two cases of myxofibrosarcoma, and one case each of high-grade leiomyosarcoma and clear ... drafted the manuscript, ChaHK and ChuHK participated in the design of the study, IJC and JiHP conceived of the study, and participated in its design and coordination All authors read and approved the ... study, one of the three cases of alveolar soft part sarcoma occurred in adolescence, and the other two occurred in young adults In two of these three cases, the chief complaint was of a painless...
Ngày tải lên: 09/08/2014, 03:22
Báo cáo y học: "The changing landscape of the clinical value of the PM/Scl autoantibody system" pdf
... Arthritis Research & Therapy Vol 11 No Mahler and Fritzler Comments on the report of Hanke and colleagues Hanke and colleagues are the first to report the use of a novel LIA for the simultaneous ... incremental clinical value to the diagnosis and management of SSc patients Comparison with other methods: quality of PM/Scl-100 For reasons described above and in the closing below, the authors’ conclusion ... interest and putative clinical relevance, but at the same time they are in contrast to previous observations An understanding of the comparative performance characteristics of the new LIA and multicentre...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: "The feasibility of axial and coronal combined imaging using multi-detector row computed tomography for the diagnosis and treatment of a primary spontaneous pneumothora" pps
... improved with the advent of the multidetector row technique and the introduction of the spiral CT The MDCT permits reconstruction of coronal images There has been a growing trend and interest ... ELCs from the apex to the hilar regions of the lung However, less than one-third of the images are necessary using the coronal view, and the image quality is better [19] The addition of coronal ... gross inspection are Page of Figure The ideal resection margin of bleb and bullae The dotted line shows the ideal resection margin of ELC in the treatment of pneumothroax The visible lesions which...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: "Complicated sternal dehiscence treated with the strasbourg thoracic osteosyntheses system (STRATOS) and the transposition of greater omentum: a case report" pot
... with the greater omentum The use of the greater omentum in the treatment of the mediastinitis and deep sternal wound infection has been described in the literature and its immunological and angiogenetic ... prevent the further extension of local infection and facilitate the primary closure of the superficial tissues, leading to the healing of the sternal wound [4] In conclusion, we purpose the use of ... completely destroyed This system is effectiveness in the stabilization of the chest wall, reducing the pain, improving the ventilation and facilitating the quick healing of the wound Authors Contributions...
Ngày tải lên: 10/08/2014, 09:22