dynamics of cell adhesion interactions during melanoma development
Báo cáo sinh học: "Letting go: modification of cell adhesion during apoptosis" pps
Ngày tải lên :
06/08/2014, 19:20
... focuses on the regulation of cell adhesion by caspases, changes in cell adhesion are also known to regulate caspases Loss of cellular attachment often leads to a form of apoptosis termed ‘anoikis’, ... Caspase-mediated cleavage of β-catenin promotes changes in cell adhesion and cell shape (a) Drosophila; (b) mammals Adherens junctions are composed of adhesion complexes of E-cadherin (gray bars), ... The fate of E- and P-cadherin during the early stages of apoptosis Cell Death Differ 1999, 6:377-386 Brancolini C, Lazarevic D, Rodriguez J, Schneider C: Dismantling cell- cell contacts during apoptosis...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
Ngày tải lên :
07/03/2014, 01:20
... differentially during panicle development in rice in this study A very high level of expression of OsARF11, a putative ortholog of MONOPTEROS, during early panicle development, representing the stages of ... expression of a significantly large number of auxin-responsive genes during various stages of reproductive development, including floral transition, floral organ development, male and female gametophyte development, ... stages of male and female gametophyte development (Table S2) Our data indicate that most of the auxin-responsive genes exhibit differential expression during more than one stage of reproductive development; ...
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Báo cáo khoa học: Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins pot
Ngày tải lên :
07/03/2014, 16:20
... cysts and during development Biochem Cell Biol 69, 96–101 Bradford, M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye ... The number of pmoles of cathepsin L were determined by titration of the active site with E-64 as described previously [29] The concentration of heterodimeric cathepsin L was 64–65% of that calculated ... Cathepsin L and cell adhesion protein in Artemia (Eur J Biochem 271) 4019 Fig Relative abundance of the catalytic and noncatalytic subunits of CLP at different stages in the life cycle of Artemia Protein...
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Paradoxical roles of the immune system during cancer development docx
Ngày tải lên :
15/03/2014, 01:20
... progression of tumours Other cells of the myeloid lineage have also been reported to contribute to tumour development 31 However, some types of innate immune cells — in particular, NK cells — can ... insoluble ECM components and cell cell and cell matrix adhesion molecules, that together alter crucial intracellular signalling pathways36 In both human and mouse models of cancer development, although ... state and cellular localization of which was under paracrine TNFα control54 Inhibition of TNFα or induction of the super-repressor mutant of IκB (inhibitor of NFκB) in transgenic animals during...
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Báo cáo y học: "Changes in the mechanical properties of the respiratory system during the development of interstitial lung edema" ppt
Ngày tải lên :
12/08/2014, 15:21
... correlating the development of lung edema with changes of lung mechanics were focused mainly either on the effects of pulmonary congestion only or on the effects of later stages of acute lung edema ... 0.01 for most of the data points As the coefficient of variation was similar for both Rrs and Xrs, Xrs is more sensitive than Rrs to the development of interstitial edema Because of the wide inter-individual ... variability of baseline values, there are very slight differences in Zrs at the end of the experiment between control and treated group Figure shows the time courses of Raw and of the estimates of the...
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Báo cáo y học: " Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift" pptx
Ngày tải lên :
13/08/2014, 16:21
... membrane of internal organelles and the plasma membrane As such, published microarray data contain a hidden wealth of information, and often specific aspects of cell regulation are of interest ... appear only as part of the model input, and their dynamics is controlled entirely by a handful of variables, which in the global picture of an entire cell constitute but one aspect of their metabolism ... importance of Ac-CoA for sphingolipid dynamics is clear from this LG profile, the specific numerical values of the LG associated with Ac-CoA should at this point be considered merely as a measure of...
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Báo cáo y học: "The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane α" ppsx
Ngày tải lên :
14/08/2014, 07:21
... domain, and also to signal extracellular ligand binding back to the inside of the cell Much of our current knowledge of the myriad of functions attributed to ligand binding of a particular αβ pair comes ... cytoskeleton, resulting in complex interactions [1] Extracellular ligation of integrins triggers a large variety of signal transduction events that modulate cell behaviors such as adhesion, proliferation, ... adhesion structures, including focal adhesions that bind cells to the extracellular matrix and podosomes (small foot-like extensions of plasma membrane) [15,19] In this manner, the affinity of...
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Modeling and simulation of cell adhesion and detachment
Ngày tải lên :
10/09/2015, 15:48
... single-molecular studies of neutrophil adhesion [35-39], examination of cell membrane’s thickness and compressibility [40], and inspection of cell- surface interactions [41] A major focus of designing and ... lamina and sarcomeres They also participate in cell- cell and cell- matrix adhesive junctions 2.2 Basics of Cell Adhesion In biological systems, cell adhesion is an integrated process involving multiple ... activities such as receptor-mediated endocytosis, cell migration, and cell- cell and cell- ECM adhesions In the case of adhesion, the lateral mobility of receptors determines the speed at which receptors...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
Ngày tải lên :
30/03/2014, 13:20
... monophosphorylation of myosin II J Cell Sci 113, 471–482 13 Parsons, J.T., Martin, K.H., Slack, J.K., Taylor, J.M & Weed, S.A (2000) Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement ... the importance of PAK1 and FAK in LPA-induced A2058 cell motility Transfection of PAK1 K299R greatly reduced LPA-induced cell motility (Fig 5) Moreover, expression of FRNK in A2058 cells blocked ... Hildebrand, J.D & Parsons, J.T (1997) Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK:...
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báo cáo hóa học:" Oocyte-granulosa-theca cell interactions during preantral follicular development" ppt
Ngày tải lên :
20/06/2014, 07:20
... pathophysiology of these conditions This review will focus on recent progress that has been made in understanding the importance of intraovarian cell- cell interactions during follicular development ... differentiation of cortical stromal cells into LH-responsive steroidogenically active theca cells by the secretion and action of a soluble factor(s) In support of this theory, an array of Page of (page ... inhibitors of apoptotic cell death in the ovary [27,67-71] These growth factors produced by theca cells might be one of the factors that decreased the incidence of apoptosis in granulosa cells during...
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Báo cáo y học: " A statistical approach to estimating the strength of cell-cell interactions under the differential adhesion hypothesis" pptx
Ngày tải lên :
13/08/2014, 16:21
... engulfment cells are of types black and white Cell sorting can be quantified by the fraction of black cells in the nearest neighborhood of single black cell and the number of isolated black cells ... through a differential expression of Cellular Adhesion Molecules (CAMs) weighted by the length of the membrane separating cells This model is inspired by cell- cell interactions driven by cadherin-catenin ... vertex dynamics cell model of space-filling polyhedra simulating cell behavior in a cell aggregate Journal of Theoretical Biology 2004, 226:439-453 Graner F, Glazier JA: Simulation of biological cell...
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Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions
Ngày tải lên :
25/11/2015, 13:27
... intracellular domain Intracellular domain of human NCAM isoform 140 Human NCAM isoform 180 Intracellular domain of human NCAM isoform 180 Extracellular domain of human NCAM Intracellular domain of ... Introduction 1.1 Cell adhesion molecules Cell adhesion is crucial for the development and maintenance of tissue structures and multicellular organs In mammals, several families of cell adhesion molecules ... functions during brain development and in adult brain Table of content I Table of content Table of content I List of figures IV List of tables V List of abbreviations...
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Báo cáo y học: "Evaluation of maternal infusion therapy during pregnancy for fetal development"
Ngày tải lên :
02/11/2012, 11:08
... distribution of infusions between controls and cases (χ28=7.55; p=0.48) and in the frequency of infusion during the second-third months of pregnancy (χ21=0.4; p=0.51) The reason of infusion for ... pregnancy and the different variables of fetal development On the one hand, there was a lower prevalence of maternal infusion in the group of total CAs, and within them, of hypospadias and multiple CAs ... infusion in the second month of gestation, i.e during the critical period of renal a/dysgenesis The type of drugs obviously has a greater impact for fetuses than the route of administration [17] Thus...
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Mechanical behaviour of PEM fuel cell catalyst layers during regular cell operation
Ngày tải lên :
05/09/2013, 14:58
... the influence of the operating parameters on fuel cell performance to investigate the in situ total displacement and degree of the deformation of the polymer membrane of PEM fuel cells ISSN 2076-2895 ... impurities in the reformate feed An important part of the fuel cell is the electrolyte, which gives every fuel cell its name At the core of a PEM fuel cell is the polymer electrolyte membrane that ... active area of the fuel cell in three-dimensions Nevertheless, except of ref [11], no models have yet been published to incorporate the effect of hygro-thermal stresses into actual fuel cell models...
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Tài liệu World Bank, Inter-American Development Bank, and Subregional Development Banks in Latin America: Dynamics of a System of Multilateral Development Banks ppt
Ngày tải lên :
16/02/2014, 06:20
... forms of publication Suggested citation: Prada, F 2012 World Bank, Inter-American Development Bank, and Subregional Development Banks in Latin America: Dynamics of a System of Multilateral Development ... importance of official flows has decreased relative to other sources of financing First, net private flows now represent more than 90% of total financial flows Despite periods of upsurge of official ... Commitments of Multilateral Development Banks, 2000–2010 (by institution, US$ billion) IBRD = International Bank of Reconstruction and Development of the World Bank Group, IDA = International Development...
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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
Ngày tải lên :
18/02/2014, 06:20
... analysis of the precise residues and interactions involved in the NTD–CTD interface [46] Most of these involve side chains from helix of the CTD which pack against the N-terminal end of helix of the ... indicate that polymerization of Gag occurs mainly through the formation of an intermediate layer of cup-shaped structures, each made of one hollow hexameric ring of CA domains placed immediately ... pseudoatomic models of capsid-like particles [30,39]; (b) analyses of the effect of CA mutations on the assembly of mature capsidlike particles (Fig 2E,F) and ⁄ or the formation of viral cores; the...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
Ngày tải lên :
19/02/2014, 13:20
... A final concentration of 180 lM peptide was added to Caco-2 or Jurkat cells for or h, which is the time of exposure of Caco-2/Jurkat cells during the adherence assay The cell viabilities were ... monomer of hCD58 was unmerged from the complex of hCD2–hCD58) [30] Ó FEBS 2004 Design of peptides for T -cell adhesion inhibition (Eur J Biochem 271) 2877 Fig Ribbon diagram of crystal structure of ... method, inhibition of adhesion between Caco-2 cells and Jurkat cells was used to evaluate the biological activity of peptides designed Caco-2 cells express CD58 while Jurkat cells express CD2...
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Tài liệu Báo cáo Y học: Phosphorylation of initiation factor-2a is required for activation of internal translation initiation during cell differentiation ppt
Ngày tải lên :
22/02/2014, 07:20
... translation of specific mRNAs during the course of differentiation During the early developmental stages of Xenopus, Caenorhabditis elegans and Drosophila, the translation of subclasses of mRNAs ... the cell- cycle of the cells was analysed by Becton Dickinson FACSort, using the Cell Quest software The Vav protein was used as a marker for differentiation To detect Vav protein level the cells ... levels of the translation products of both cistrons Overexpression of K3L, PKRD6 or eIF2a-S51A led to enhanced translation of both cistrons in nondifferentiated cells, whereas in differentiated cells...
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Báo cáo khoa học: The association of viral proteins with host cell dynein components during virus infection pdf
Ngày tải lên :
14/03/2014, 22:20
... few years, numerous studies of virus–host interactions have revealed the role of the dynein motor and the integrity of microtubules in virus infection The development of microscopy techniques has ... unequivocally proved [90] HIV enters the cells following virus binding to CD4 and co-receptors and the fusion of the viral membrane with the plasma membrane of the cell During passage through the cytosol, ... incubation of HeLa cells with recombinant adenovirus penton base protein clearly shows that a significant population of the viral protein traffics in a retrograde manner towards the cell nucleus Cell...
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Báo cáo khoa học: Dynamics of a-synuclein aggregation and inhibition of pore-like oligomer development by b-synuclein doc
Ngày tải lên :
23/03/2014, 09:21
... a-syn during molecular dynamics simulations Modeling of a-syn oligomer formation Interactions of a-syn propagating dimers predict the formation of pore-like structures The first studies of the interactions ... simulations of a- and b-syn monomers in water (A) Snapshots of molecular dynamics conformations of a-syn (B) Superimposed a-syn conformers (area of superimposition: aa 1–15) (C) Snapshots of molecular dynamics ... and b- and a-syn heterodimeric interactions Firstly, theoretical docking of various molecular dynamics conformers of a-syn to conformers of b-syn was performed All of the docked a-syn–b-syn complexes...
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