... group of SDS molecules Whether the C-terminus has a regulative role in metal transport remains to be investigated further It is of interest to investigate whether the peptide is inserted into the ... disappearance ofthe cross-peaks of Ala13 inthe TOCSY spectrum (Fig 6B), a significant reduction in intensities ofthe cross-peaks of Leu9 and Phe16, and a moderate reduction in intensities ofthe cross- ... observation) Interestingly, when the pH value was lowed to 4.0, almost all the resonances in NMR spectra recovered their intensities, indicating the movement ofthe C-terminus towards SDS micellar interior,...
... function of increased DP9 expression may be to retain expressing cells inthe tumor and in sites of expression inthe injured liver It would be interesting to localize the DP9-expressing cells in tumors ... DP9–GFP, in which the catalytic serine was replaced with alanine, was evaluated In addition, the RGD motif of DP9 was replaced with Arg-Ala-Glu (RAE) to investigate whether this integrin- binding motif ... adenocarcinoma and ovarian carcinoma develop [13,14] DPIV overexpression in melanoma and non-small cell lung carcinoma cell lines inhibits the processes of tumor progression, including anchorage-independent...
... the actinmyosin complex for the dissociation ofthe phosphate product The effect of nucleotides on the exibility ofthe motor domain The binding of ADP to the apo-S1 inuenced the protein dynamics ... actin binding region is maintained during the interaction of S1 with actin Inthe apo-enzyme, the exibility ofthe protein matrix along the Ser181Cys707 direction was the greatest ofthe three ... kDa upper domain and actin binding domain was suppressed, which reected the stiffening ofthe converter region between the nucleotide-binding site and the lightchain-binding domain The transition...
... analyzed the potential influences ofthe CTLA-4 genotype upon the outcome of IFN adjuvant therapy, on the basis of prior suggestions ofthe role of certain polymorphisms ofthe CTLA-4 gene and other ... further explored in other trials of IFN-a2b ofthe US and European cooperative groups Our investigation into the association of CLTA-4 polymorphisms and the results of interferon therapy in a ... [28,29] These provocative findings stimulated detailed investigation ofthe polymorphisms of CTLA-4 in larger numbers of patients treated in a subsequent study of 152 stage IV melanoma patients at the...
... functional illiterates The main implications of these findings are that in order to use PedsQL™ in our public health setting, availability of trained interviewers during questionnaire administration needs ... complete the instrument Steps to expand the use ofthe Argentinean Spanish PedsQL™ 4.0 include an alternative approach to scoring for the 2–4 year-olds, further understanding of how to increase ... provide initial evidence towards the reliability and validity ofthe Argentinean Spanish version ofthe PedsQL™ 4.0 Generic Core Scales inthe public health research setting The Argentinean Spanish...
... antiserum against the FLAG tag at the N-terminus ofthe recombinant matn-3 V5: analysis using the antiserum against the V5 tag at the C-terminus ofthe recombinant protein Reducing conditions and the ... processing site of matn-1 To further test this hypothesis, we determined whether the presence ofthe inhibitors of matrix proteases affected the proteolytic processing of matn-1 The presence of mM ... absence ofthe vWF A domain adjacent to the coiled-coil is involved in modulating oligomeric formation of matrilins The vWF A domain is one ofthe most widely distributed domains involved in cell...
... ask- Ss answer What’s the date today? Line A ask- Line B answer then It’s (May 28th 2008) change -guide Ss to say ordinals: Then Ss practice to say in pair 1st: first A: What’s the date today? 3rd: ... front of Work in pair: one asks – one the class answers -Call two Ss write on the boardOther listen and remark T remark White-write: Ss write down the no IV Other activity: book Play game: The ... practice in front ofthe class Other listen and remark Activity 4(10’) Let’s write - Guide Ss to write Let’s write Pre-write Hang some dates on the board Talk about them - Call some pairs talk in front...
... on the surface of gp120 (the internal portion and the CD4 binding region) dN/dS score visualization on the surface of gp120 (the internal portion and the CD4 binding region) Visualization ofthe ... visualization on the surface of gp120 (the 'silent' face ofthe molecule) dN/dS score visualization on the surface of gp120 (the 'silent' face ofthe molecule) Visualization ofthe dN/dS score (the posterior ... ofthe posterior mean dN/ dS value was generated using a color grade scale Both on the CD4 binding site and on the outer domain ofthe molecule the majority of sites appeared as under purifying...
... Percentage of genes interactions Figure 10 to the translation state ofofthe main ORF versus the presence of uORFs Contribution ofthe lengthmRNAs Contribution ofthe length ofthe main ORF versus the ... consequence ofthe T-DNA insertion inthe 10th exon ofthe gene This result is consistent with the low level ofthe truncated eIF3h protein detected inthe eif3h-1 allele [19] The defects inthe eif3h-1 ... after termination ofthe uORF the ribosome resumes scanning until it encounters the main AUG codon Thereby the efficiency of re-initiation can control the efficiency of initiation at the main AUG...
... inextricably linked A key finding of this study is that disruption of one function of MgtE does not always eliminate the other In interpreting the results of these experiments, there are a couple of variables ... cytotoxicity ofthe bacteria in biofilms is one ofthe adaptations that allows them to persist Previous studies indicate that deletion ofthe gene encoding the protein MgtE from P aeruginosa increases the ... disruption of magnesium transport There are a total of seven proposed magnesium binding sites inthe MgtE monomer, one inthe transmembrane domain and six inthe cytosolic domain [34], and since they...
... cysteine-rich domains with various lengths of C-terminal extensions (2, 61) Domain (D2) is involved inthe binding of GFLs (50, 62-64) while Domain (D3) provides a stabilizing effect The Nterminal ... (100, 153-155) In view of these findings, elucidating the involvement of specific cAMP downstream effectors could provide valuable insights to the mechanism underlying the physiological interactions ... isoforms In this study, we reported an unexpected finding ofthe role of cAMP signaling as an underlying mechanism contributing to the differential neuritogenic activities of GFRα2 isoforms Interestingly,...
... tyrosine kinases The binding between dynamins and these signaling proteins can be stimulated upon growth factor treatments, indicating the involvement of dynamin in cellular signaling pathway The ... correlate with their binding affinities to dynamin and synaptojanin in brain extracts Moreover, the inhibitory effects ofthe first SH3 domain (SH3A) of intersectin are on the early events of endocytosis ... study thefunctionsof endocytic proteins in this process For example, microinjection into lamprey synapse of a fragment of dynamin containing the SH3 binding site which prevents the amphiphysin-dynamin...
... to line a plastic incubation container 10 Place the slides inthe incubation container Gently place the lid on the container and incubate at 37 °C for 30 11 Remove and rinse slides in staining ... and infectious virus titers in human sera Viremia (infectious virus) in humans is influenced by the strain of virus, the day of infection the serum was collected from the patient, and the individual’s ... sensitive in detecting dengue viruses than the commonly used plaque assay, depending on the serotype or strain of virus [9] Thein uence ofthe virus strain is illustrated by the isolation rates of...
... Schiffrin 的定义,并提出了以下的定义: …a word or phrase… that is uttered with the primary function of bringing to the hearer’s attention a particular kind of linkage ofthe upcoming utterance with the immediate ... newcomer to the field, it is furthermore often very difficult to find the bits and pieces that constitute an original model ofthe meanings and functionsof discourse particles Moreover, the studies ... STUDY OFTHEFUNCTIONS AND POLITENESS OFTHE DISCOURSE MARKER “/ORH/” IN SPOKEN SINGAPORE MANDARIN 江滨 JIANG BIN (B.A Hons, NUS) 新加坡国立⼤大学中⽂文系 北京⼤大学中国语⾔言⽂文学系 双学位硕⼠士(研究)学位论⽂文 A THESIS SUBMITTED FOR THE...
... parts ofthe island At the end ofthe NE monsoon in March and April, heat islands begin to grow stronger (∼2.5◦ C) and thermal gradients are increasing Values of mean UHIraw continue to increase, ... across the estate to predict heat island intensity in a straight-line function As the H/W ratio used inthe present study focuses on the immediate proximity ofthe sensor, it may be indicative ofthe ... metadata and the accounting for various confounding factors such as weather and thermal inertia are in- line with the criteria laid out by Stewart (2011) This achieves the initial goal of having a scientifically...
... nursing handover (red, up-pointing arrows), the beginning and end ofthe daily medical shift (green, down-pointing arrows), and periods of routine nursing observations (pink, shorter, up-pointing ... activation ofthe MET service during these hours inthe years following the introduction ofthe MET system When directly compared with the study conducted by Lee and coworkers [5], 46.2% ofthe 2568 ... increase the ease of utilisation ofthe MET system at our institution Furthermore, the timing and frequency of patient observations reported inthe study would be typical of most hospitals Finally,...
... primarily due to the influence ofthe +T294C SNP The C allele frequency of 0.24 in our high risk patient group was similar as the frequency of 0.21 reported by Chen et al in their study for chd ... humans Of note both animal studies used obese models to investigate the effect of an activated PPARδ In an obese state the activities of numerous interacting genes are altered which may influence the ... effect of PPARδ on metabolism In our data and inthe study by Skogsberg et al., the effect ofthe C allele on lipid levels increased if over-weight individuals were excluded from the study Since...
... and the mean values ofthe two sites were used inthe analysis There is an apparent increase inthe degree of carotid intimal thickness inthe examined patient (0.9mm) compared with 0.6 mm inthe ... increase in tHcy inthe TT genotype individuals inthe different groups This finding supports more the lack of association between the presence ofthe T allele and the high tHcy levels in our patients ... groups Showing the frequency and the results ofthe cross tabulation ofthe T allele and the different genotypes inthe studied groups The total number of cases was 50 in each group There was...
... advertisements hiding inthe newspapers and magazines, clamoring on the radio, or dazzling on the TV On the other hand, they still need the information to guide their purchasing Therefore, to attract the consumers’ ... achieve the best results inthe study Chapter is called MAIN FINDINGS AND DISCUSSIONS, in which the author summarizes her findings inthe characteristics ofthe English language used in airlines’ ... limit ofthe range of possible interpretations, and on the other hand, a supporter ofthe intended interpretation He states as follows: The use of linguistic form identifies a range of meanings...
... This thematic report contains the main following sections: I The definition ofthe supply chaiṇ II The supply chain of marine fishing products 2.1 The chart ofthe supply chain for marine fishing ... parties involved in will conduct two functionsof buying and selling and their activities are very diverse According to the chart ofthe supply chain of marine fishing products, the involved ... inthe supply chain ofthe seafood The rate of marine fishing products, which are put inthe 14 processing factories to increase the value – added ofthe fishing products, creating more attractive...