drug discovery by the pharmaceutical industry
Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... whether the binding of nucleotide to ABCG2R482G was the power stroke required to switch the configuration of the drug binding site(s) This hypothesis was examined using a direct measure of drug ... other multidrug transporters, contains more than one drug binding site In addition, the binding sites are linked by both negative and positive heterotropic allostery In a departure from the drug ... ABC protein [23] The translocation of drugs across the plasma membrane requires that the drug binding event(s) in TMD is intrinsically coupled to the catalytic cycle within NBDs The best evidence...
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Marching to Different Drummers: Health Advocacy Groups in Canada and Funding from the Pharmaceutical Industry pptx
... Health Canada by the Consumer Advocare Network, another national advocacy umbrella supported by the pharmaceutical industry, argues that the Canadian ban on DTCA denies patients their “fundamental ... don’t add drugs for their condition to formularies.k 40 By contrast, groups that remain independent of the industry focus on whether exaggerated claims have been made for the new drug, whether it ... challenge pharmaceutical industry influence while at the same time accepting funds from the industry Project Inform reasons that the pharmaceutical industry has a debt to AIDS patients “[A]s the one...
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Manufacturing location decisions in the pharmaceutical industry an exploratory study from a network perspective
... Figure 2-4 illustrates the theory of transaction cost analysis The further the transaction is from the centre of the three axes base the higher is the transaction cost The utility of this classification ... in pharmaceutical industry Outsourcing has to be studied more specifically for the pharmaceutical sector as the specificity of the pharmaceutical manufacturing activities and the situation of the ... out the usefulness of the weighted score model in location decisions compared with the other models: 14 MANUFACTURING LOCATION DECISIONS IN THE PHARMACEUTICAL INDUSTRY MATHIEU PELLERIN 2003 “The...
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Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration pptx
... dietary supplements, foods, or drugs under the Act, depending on the product's intended use Other factors may also affect the classification of the product, e.g., whether the product contains a "dietary ... under the Act or the PHs Act; and a To show that neither the Act nor the PHs Act contains any exemption for CAM products In other words, if a product meets the statutory definition of drug, device, ... 321(p)) defines the term "new drug" to mean: (1) Any drug (except a new animal drug or an animal feed bearing or containing a new animal drug) the composition of which is such that the drug is not...
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The challenges for implementation of good manufacturing practices by local pharmaceutical manufactures in vietnam
... as the quality of drugs depends significantly on the way they are distributed For example, quality of pharmaceutical products can be badly affected on the way they are transported due to the ... quality control These two parts together represent the "core" of the GMP guidelines published by WHO • U.S GMP GMP regulations in the United States of America were developed by the FDA in 1975 ... approach to the documentation in the organization, and the corner stone of the standards is that procedures and records are generated where they are required by the standards, and where they are...
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A WEB APPLICANTION FOR THE TOURISM INDUSTRY IN HANOI by Dinh Huu Son
... another possibility While there were other limited ways to interconnect different networks, they required that one be used as a component of the other, rather than acting as a peer of the other ... lies at the center of the triangular basin of the Red River The tourist site of Tam Dao lies 50 km from Hanoi to the north Ba Vi is the same distance to the south-west In the Hanoi region, the chain ... vouchers These mechanisms have various characteristics, such as the extent to which the parties are identified, the traceability of the transaction, and the taxability of the transaction The reason...
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Tài liệu IAB Internet Advertising Revenue Report: An Industry Survey Conducted by PwC and Sponsored by the Interactive Advertising Bureau (IAB) doc
... advertising The report is conducted independently by PwC on behalf of the IAB PwC does not audit the information and provides no opinion or other form of assurance with respect to the information ... billion The second half of the year is seeing an increasingly larger part of the revenue, as 53% of revenue in 2010 was spent in the second half, compared to 52% in 2009, continuing the trend ... the results of the rest of this report Mobile advertising information is gathered from publicly available information, industry research, and a small percentage of direct submissions within the...
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ORGANIC CHEMICAL INDUSTRY PVC PRODUCTION BY THE SUSPENSION PROCESS pot
... in the new version of the RAINS model [8] for the modelling work carried out in the scope of the CAFÉ programme and the revision of the Gothenburg protocol Costs are not yet available on the ... introduced by the Western Europe s-PVC industry since 1974 Synopsis-sheet-PVC suspension-30-09-05 Organic chemical industry: PVC production by the suspension process For simplification in the presentation ... which mix the batch with other batches to insure product uniformity The mixed batches are then fed to a continuous centrifuging operation that separates the polymer from the water in the slurry...
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Regulation of the Pharmaceutical - Biotechnology Industry
... In these circumstances, if an individual patient is not cured by the drug or suffers an adverse effect, determining whether their condition is inappropriately caused by the drug or is simply the ... biosimilars accumulates Since the 1990s the regulatory authorities and the industry in the three major pharmaceutical markets – the US, the EU and Japan – have worked through the International Commission ... Following the ODA, the number of orphan drug approvals has increased significantly Between 1979 and 1983, orphan drug approvals increased at approximately the same rate as other drugs By 1998, there...
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The Competitive Status of the U.S. Pharmaceutical Industry docx
... pharmaceuticals would appear to be based on two rather unique features of the industry In the first place, the time lapse between strategic decisions by ethical drug firms and the impact of these ... first chapter provides a primer on competition within the ethical drug industry EMERGENCE OF THE MODERN PHARMACEUTICAL INDUSTRY The drug industry before 1930 was profoundly different from that ... Engineering in the conduct of their services to the government, the public, and the scientific and engineering communities It is administered jointly by both Academies and the Institute of Medicine The...
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THE PART BORNE BY THE DUTCH IN THE DISCOVERY OF AUSTRALIA 1606-1765 pdf
... again struck by the fact that the part borne by the Netherlanders in the discovery of the continent of Australia is very insufficiently known to the Dutch themselves, and altogether misunderstood ... borne by the Netherlanders in the discovery of the fifth part of the world I have not been actuated by any desire to belittle the achievements of other nations in this field of human activity The ... between the Managers on one hand, and able Governors-General on the other, touching the line of conduct to be followed by the Netherlanders in the East The Managers were in the first place the directors...
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Báo cáo khoa học: Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane potx
... concentrations, the anesthetics further enhanced the rate of passive drug permeation and interfered with the active export of the drug by Pgp Effect of modulators on the efflux of the rhodamine ... diethyl ether reversed the resistance by acceleration of the passive transport of the drug or dye across the plasma membrane At these concentrations, the anesthetics did not inhibit the Pgp-mediated ... reduces the amount of drug incorporated in the plasma membranes [31], it seems that the anesthetics accelerate the permeation by enhancing the drug flip-flop rate across the lipid core of the membrane...
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Designation: C 51 – 00a - Lime and Limestone (as used by the Industry)1 pptx
... either primarily or as a by- product of materials other than limestone, for example, Ca(OH)2 formed by acetylene generation from calcium carbide (CaC2), water treatment sludges, etc DISCUSSION The ... considered to be the volatile fraction pH the negative logarithm of the hydrogen ion concentration, which can be greatly affected by temperature, particularly under alkaline conditions It is therefore ... either primarily or as a by- product of materials other than limestone, for example, Ca(OH)2 formed by acetylene generation from calcium carbide (CaC2), water treatment sludges, etc DISCUSSION—The...
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báo cáo khoa học: " Changes in time-use and drug use by young adults in poor neighbourhoods of Greater Buenos Aires, Argentina, after the political transitions of 2001-2002: Results of a survey" potx
... either did not work or who decreased their work time increased the time they spent using drugs, whereas only 4% of those who either maintained their work time at the same level, or increased the ... drug use; work; looking for work; and hanging out in the neighbourhood In the case of the variable change in time using drugs, we excluded those cases reporting no drug use in either period The ... validated by the Bureau of Labour Statistics in relation to their Current Population Survey [27] The reliability of retrospective data collection among drug users can be increased by linking the time...
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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc
... these old 'safe' drugs, which supports an increasingly shared notion in drug development that the most fruitful basis for the discovery of a new drug is to start with an old drug [83-85] Another ... clear that the more folds the ligands cover, the higher the average RotBonds are for the ligands interactions tions between protein-binding ability and the four kinds of parameters The protein-binding ... pathogenetic factors, the more-investment-less-outcome predicament is attributed in part to the limitations of the current one -drug- one-target paradigm in drug discovery [79,86] Therefore, more and...
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Báo cáo y học: "Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices" pptx
... CCR5, a receptor used by the human immunodeficiency virus (HIV) to enter cells Making the right clinical decisions There remains the challenge of matching the “right drug to the right patient” Good ... individualized medical care The prospects for both drug- discovery and drug- development scientists and their patients look better and better Precisely how the pharmaceutical industry is going to position ... Brown’s prescription to “use the right technology to find the right drug modulating the right target in the right patient” It was made clear that genomic approaches to the problem are likely to...
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Drug discovery metformin and the control of diabetes
... render the compounds less toxic, whilst maintaining the hypoglycaemic effect of the guanidine groups However, they weren’t nontoxic enough Their debilitating effects on the liver led to them being ... became increasingly resistant to it The supply of the drug – it was imported from Java – was also inconsistent during periods of global unrest By the 1930s, the search was on to find alternatives ... diabetes-related amputations each week in results from the auto-immune destruction of the cells the UK Many of these problems can be prevented by in the pancreas which produce insulin It occurs most...
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Implementation of a drug discovery tool for the evaluation of anti fibrotic compounds application in fibrovascular disorders
... as drugs (Shappell, 2003) Therefore, metabolic-based cell viability assay may not be suitable for the drug discovery tool since the drug tested may cause alteration in the metabolic state of the ... Collagen biosynthesis The biosynthesis of collagen begins with the transcription of the individual collagen genes and concludes in the maturation of the collagen fibrils in the ECM This biosynthesis ... In this chapter, the background and significance of the project is covered in the first section The second section presents the objectives of the project and the outline of the report 1.1 Project...
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Potential Challenges Faced by the U.S. Chemicals Industry under a Carbon Policy
... On the other hand, more research is needed to determine the actual mix of feedstock energy sources used by the industry and the past and expected in the future, and make new assessment of the ... petrochemical industry, yet large and potentially troubling impacts on the chlor-alkali industry, on the other Under the assumptions regarding the nature of the energy mix and prices used in the II-CPM ... the BAU case It also shows the additional energy costs that the industry would have to bear if the Mid-CO2 Price Policy were enacted As with the other industries, materials costs constitute the...
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