... applicants, a random sample of 15,703 credit applicants was selected for the study. The study then asked the CRAs to review the credit files of the individuals in the sample and determine whether the credit ... assessment ofthe degree of difficulty, andthe types of difficulties, with which each ofthe above tasks was performed. The results ofthe pilot study, andthe next steps taken by the Commission in ... both test the feasibility of a national survey and allow the FTC to estimate the potential costs of such a survey. Depending on the outcome ofthe pilot study, the FTC may conduct further pilot...
... construct the SIB1 FKBP22 variants containingeither one of these domains and compare their activities and stabilities with those ofthe intact protein.In this report, the N- and C-domains of SIB1FKBP22 ... proteolysis of L. pneumophila MIP allows the separation of their N- and C-domains such that the C-domain contains the C-terminal half ofthe a3helix [23,24]. In addition, the C-domain of E. coliFkpA ... com-posed of N- and C-domains, which are spanned by a 40amino acid long a3 helix. The N-domain consists of a1 and a2 helices and an N-terminal region of a3 helix. The C-domain consists of six b-strands...
... the formyl group ofthe c ofactor andthe aminogroup of a protein residue. In contrast, the absence of absorption maximum at 420 nm ofthe mutant enzymespectrum directly demonstrates that the ... expression vector under the control ofthe T7promoter, and coexpression of oraE and oraS genes wascarried out in E. co li. Meanwhile, the extent of the involvement of AdoCbl or PLP in the in vivo foldingprocess ... determined by measuring the apparent Kmvalue of D-ornithine at 25 , 50, 100, 200 and 400 lM of the inhibitor.For the measurement ofthe activity ofthe substrateanalogues, an HPLC and NMR-based method...
... common in people of northern European descent. Their diagnosis is obvious when they are visible as glittering particles upon the surface ofthe optic disc. However, in many patients they are hidden ... fulminant papilledema. Optic Disc Drusen These are refractile deposits within the substance ofthe optic nerve head (Fig. 29-13). They are unrelated to drusen ofthe retina, which occur in age-related ... cerebrospinal fluid, points by exclusion to the diagnosis of pseudotumor cerebri (idiopathic intracranial hypertension). The majority of patients are young, female, and obese. Treatment with a carbonic...
... Chapter 029. DisordersoftheEye (Part 14) Stroke This occurs when interruption of blood supply from the posterior cerebral artery to the visual cortex is prolonged. The only finding ... variety of genetic diseases, such as myotonic dystrophy, neurofibromatosis type 2, and galactosemia. Radiation therapy and glucocorticoid treatment can induce cataract as a side effect. The cataracts ... viewing light reflected from the fundus with an ophthalmoscope or by examining the dilated eye using the slit lamp. The only treatment for cataract is surgical extraction ofthe opacified lens. Over...
... detachment ofthe retinal pigment epithelium andthe neurosensory retina. These detachments produce acute or chronic symptoms of metamorphopsia and blurred vision when the macula is involved. They ... by administration of panretinal laser photocoagulation at the appropriate point in the evolution ofthe disease. For further discussion ofthe manifestations and management of diabetic retinopathy, ... Chapter 029. DisordersoftheEye (Part 16) Central Serous Chorioretinopathy This primarily affects males between the ages of 20 and 50. Leakage of serous fluid from the choroid causes...
... 029. DisordersoftheEye (Part 17) Melanoma and Other Tumors Melanoma is the most common primary tumor oftheeye (Fig. 29-18). It causes photopsia, an enlarging scotoma, and loss of vision. ... atrophy of retrobulbar fat, or fracture ofthe orbital floor. The position ofthe eyes within the orbits is measured using a Hertel exophthalmometer, a hand-held instrument that records the position ... to a therapeutic trial of systemic glucocorticoids indirectly provides the best confirmation ofthe diagnosis. When the globes appear asymmetric, the clinician must first decide which eye...
... stretching and redundancy of eyelid skin and subcutaneous fat (dermatochalasis). The extra weight of these sagging tissues causes the lid to droop. Enlargement or deformation ofthe eyelid from infection, ... drooping ofthe eyelid. Unilateral or bilateral ptosis can be congenital, from dysgenesis ofthe levator palpebrae superioris, or from abnormal insertion of its aponeurosis into the eyelid. ... weakness), or a family history of ptosis should be sought. Fluctuating ptosis that worsens late in the day is typical of myasthenia gravis. Chapter 029. DisordersoftheEye (Part 18) Orbital...
... "lazy" eye) in the deviated eye. Chapter 029. DisordersoftheEye (Part 19) Myogenic Ptosis The causes of myogenic ptosis include myasthenia gravis (Chap. 381) and a number of rare myopathies ... primary gaze, and then with the head turned and tilted in each direction. In the above example, a cover test with the head turned to the right will maximize the fixation shift evoked by the cover ... If theeye movements are full and the ocular misalignment is equal in all directions of gaze (concomitant deviation), the diagnosis is strabismus. In this condition, which affects about 1% of...
... when the oculomotor nerve is injured by trauma or compression (tumor, aneurysm). Miswiring of sprouting fibers to the levator muscle andthe rectus muscles results in elevation ofthe eyelid ... from microvascular infarction ofthe nerve, somewhere along its course from the brainstem to the orbit. Usually the patient complains of pain. Diabetes, hypertension, and vascular disease are major ... the subarachnoid space the oculomotor nerve is vulnerable to aneurysm, meningitis, tumor, infarction, and compression. In cerebral herniation the nerve becomes trapped between the edge of the...
... generally have the opposite effect: the eyes deviate conjugately away from the irritative focus. Parietal lesions disrupt smooth pursuit of targets moving toward the side ofthe lesion. Bilateral ... impaired eye- hand coordination (optic ataxia), difficulty initiating voluntary eye movements (ocular apraxia), and visuospatial disorientation (simultanagnosia). Chapter 029. DisordersoftheEye ... sclerosis are the most common etiologies of brainstem abducens palsy. After leaving the ventral pons, the abducens nerve runs forward along the clivus to pierce the dura at the petrous apex,...