disease and disorder of both the eye and ear

... Properties of the iron-binding site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycan moiety and of the non-covalent interactions between the N- and C-terminal ... the gp120–gp41 complex, to attach cells and induce the fusion of virus and cell membranes. The receptor complex for HIV entry consists of the CD4 molecule and at least one of the members of the ... proteogly- cans [19]. Therefore, the mechanism implicated in the internalization of Lf should be different from that of midkine, although both of these ligands require the presence of accessible surface...

Ngày tải lên: 07/03/2014, 15:20

... used Sc-RNase H2* and Tk-RNase HII as model proteins to analyze the effect of a disease- causing mutation on the activity, stability, and structure of human RNase H2 and the role of the glycine residue ... comparable to the sum of the molecular masses of three subunits in a His-tagged form (89 336), and 53 kDa for the second peak, which is comparable to the sum of the molecular masses of Sc-Rnh2Bp* and Sc-Rnh2Cp* ... 0.01 a The k cat values of the mutant proteins relative to that of the parent protein. b The specific activities were determined at the substrate concentration of 1 l M. c The specific activities of the...

Ngày tải lên: 17/03/2014, 17:20

... the rate of [ 35 S]sulfate appear- ing in the medium was suppressed by the inclusion of the sulfated polysaccharides. At the end of the culture period, both CaPPS and heparin reduced the appear- ance ... inclusion of these sulfated agents there was significant inhibition (40%) of rate of loss of 35 S-labeled large proteogly- cans from the matrix by the end of the culture period. Similarly, by day 10 of ... macromolecules that appeared in the medium on each day of culture and that remaining in the matrix at the end of the culture period [41]. From these data, the per- centage of 35 S-labeled proteoglycans...

Ngày tải lên: 23/03/2014, 10:21

Ngày tải lên: 12/06/2014, 11:29

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 21/02/2014, 05:20

... for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste  1  INTRODUCTION AND SUMMARY The Strategy for the Management and Disposal of Used Nuclear Fuel and ... and high-level radioactive waste. 2 The BRC report and the Strategy build on the body of physical and social science work completed during the prior decades and benefit from the lessons learned ... between independence of the new organization and the need for oversight by Congress and the Executive branch. Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive...

Ngày tải lên: 21/02/2014, 21:20

... that the professional involvement of the researchers in the refugee project. One of the researchers is the project manager and the other researcher has worked at the project as an advice worker ... result, there were concerns that the uneven power relationship between the researcher and the researched’ would be exacerbated by the fact that the interviewees may also be clients of the interviewers. ... briefed on the aims of the study and were instructed to take care when they translated concepts and terms from one language to another and to make sure that they did not imbue the responses of interviewees...

Ngày tải lên: 24/02/2014, 18:20

... Introduction: “Where Was the Ethics Officer”? 1 With the wreckage of the first generation of Enron-type corporate scandals in the rear view mirror, and the chaos of Madoff and the subprime meltdown ... compliance and ethics activities. Notwithstanding these and other changes in law and regulation affecting corporate directors, in the years since SOX there has been a series of further scandals and ... INDEPENDENCE AND VOICE One of the resounding themes of the conference was that many of the concrete elements of corporate compliance and ethics programs, such as codes of conduct, hotlines, and formal...

Ngày tải lên: 06/03/2014, 22:20

... brief in what follows. The key elements of the Hollywood productionthe one tier and partially in the other, and others move erratically in and out of the sphere of operation of the complex today can ... majors and their cohorts of allied firms on the one hand; and (2) the mass of independent production companies on the other. Fourth, I reaffirm the continuing tremendous agglomerative attraction of ... Valley). The distribution of films made by independent producers isof scripts, actors, directors and other assets that they then present to the studios in the hope of securing a handled for the most...

Ngày tải lên: 07/03/2014, 15:20

... ably contain the same kind of errors in the same kind of situations. This may cause the training procedure to learn the errors -especially if they are systematic- and thus the resulting tagger ... tend to make the same errors that appear in the test set. On the contrary, if the train- ing and test sets come from different sources -sharing only the tag set- the behaviour of the resulting ... the error commited by the tagger is other than the er- ror in the test corpus, but wrongly evaluated as right (false positive) if the error is the same. Table 1 shows the computation of the...

Ngày tải lên: 08/03/2014, 05:21

... assess the effectiveness and feasibility of the guidelines and thus inform changes in policy and practice. Objectives of the evaluation The primary intent of the evaluation is to meas- ure the ... No further investigations are needed if the aspi- rate is clear and straw-coloured and there are no other features suggestive of a diagnosis other than tuberculosis. ã Failure of the aspirate ... authorities, research groups and interested par- ties are needed to assess the likely benefits and responsiveness of the recommendations for the dual tuberculosis and HIV epidemics. The findings of these...

Ngày tải lên: 15/03/2014, 03:20

... of Identity Politics in the UK and the Unaddressed Question of a Union Identity . . . . . . . . . 424 3. The Devolution Programme: A New Role for the Judicial Committee and Implications for the ... Legal Systems . . . 427 4. Securing a Role The Scope of “Devolution Issue” . . . . . . 428 C. The “Devolution Theme”—Securing the Constitutional Status of the Devolution Acts . . . . . . . . . . ... The Court’s Diverging Approaches to the Defence of National and Regional Interests. . . . . . . . . . . . . . . . . 398 (i) The Neglected Virtues of “Formalism” . . . . . . . . . . 398 (ii) The...

Ngày tải lên: 15/03/2014, 10:20

... isolating the cDNA of PO-CHH and identifying the native CHH neuropeptide in the ES, after the recent report of CHH cDNA from the ES [28]. Also, we examined the physiological responses of the release and ... full- length cDNA of PO-CHH and identified the presence of the neuropeptide forms in the ES and PO. For the first time in crustaceans, the expression profiles of these two CHHs in response to oxygen and tempera- ture ... On the other hand, as a neurohormone, PO-CHH may be released from the surface of the PO and into branchiocardiac veins through the direct open- ings of anterior and posterior bars [35]. Furthermore, considering...

Ngày tải lên: 16/03/2014, 06:20

... the farther we go; for instance, the sum of the first six terms of the geometrical progression is 126, whereas the sum of the first six terms of the arithmetical progression is only 42, the ... between the geometry of volumes and the geometry of surfaces, the difference between the two chemistries involves a difference of dimensionality. The higher energies of the chemistries of the higher ... life and in work—collectively and individually—because the conditions of the earning of a livelihood influence and shape all our mental processes and activities, the quality and the form of human...

Ngày tải lên: 22/03/2014, 23:20

... research is needed to substitute for TEFs.’ Now the TEFs are getting locked in, and the research wasn’t done. People get used to using the old numbers, and they take on a life of their own. There’s ... health concern, the greater the extent and cost of the cleanup). Given the enormous volume of material involved, excavation and disposal could cost liable parties hundreds of millions of dollars for ... pp. 5-20. Gilman and EPA. 1994. Memorandum of Understanding between Gilman Paper Company and the U.S. Environmental Protection Agency Regarding the Land Application of Pulp and Paper Mill Materials. Hanmer,...

Ngày tải lên: 24/03/2014, 05:20

... leafhoppers, but the tens of thousands of young spiders on each square yard of land simply vanish, and the swarms of fireflies that fly up from the stands of grass disappear at once. The second application ... his shoulder, they immediately open the sack and thrust their hands in. They think that to understand the interior of the sack, they must know its contents. Supposing they found the sack to be ... They should have investigated the causes underlying the disruption in the harmony of nature and the outbreak of pests, and on the basis of these findings decided whether pesticides are really...

Ngày tải lên: 24/04/2014, 14:00

Ngày tải lên: 12/06/2014, 11:19