... Properties ofthe iron-binding site ofthe N-terminal lobe of human and bovine lactotransferrins. Importance ofthe glycanmoiety andofthe non-covalent interactions between the N- and C-terminal ... the gp120–gp41 complex, to attach cells and induce the fusion of virus and cell membranes. The receptorcomplex for HIV entry consists ofthe CD4 molecule and atleast one ofthe members ofthe ... proteogly-cans [19]. Therefore, the mechanism implicated in the internalization of Lf should be different from that of midkine, although bothof these ligands require the presence of accessible surface...
... used Sc-RNase H2* and Tk-RNase HII as model proteins to analyze the effect of a disease- causing mutation on the activity, stability, and structure of human RNase H2 andthe role of the glycine residue ... comparable to the sum ofthe molecular masses of three subunits in a His-tagged form (89 336), and 53 kDa for the second peak, which is comparable to the sum ofthe molecular masses of Sc-Rnh2Bp* and Sc-Rnh2Cp* ... 0.01a The kcatvalues ofthe mutant proteins relative to that ofthe parent protein.b The specific activities were determined at the substrateconcentration of 1 lM.c The specific activities of the...
... the rate of [35S]sulfate appear-ing in the medium was suppressed by the inclusion of the sulfated polysaccharides. At the end ofthe cultureperiod, both CaPPS and heparin reduced the appear-ance ... inclusion of these sulfated agents there was significant inhibition(40%) of rate of loss of 35S-labeled large proteogly-cans from the matrix by the end ofthe culture period.Similarly, by day 10 of ... macromolecules that appeared in the mediumon each day of culture and that remaining in the matrix at the end ofthe culture period [41]. From these data, the per-centage of 35S-labeled proteoglycans...
... for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste 1 INTRODUCTION AND SUMMARY The Strategy for the Management and Disposal of Used Nuclear Fuel and ... and high-level radioactive waste.2 The BRC report andthe Strategy build on the body of physical and social science work completed during the prior decades and benefit from the lessons learned ... between independence ofthe new organization and the need for oversight by Congress andthe Executive branch. Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive...
... that the professional involvement ofthe researchers in the refugee project. One ofthe researchers is the project manager andthe other researcher has worked at the project as an advice worker ... result, there were concerns that the uneven power relationship between the researcher andthe researched’ would be exacerbated by the fact that the interviewees may also be clients of the interviewers. ... briefed on the aims ofthe study and were instructed to take care when they translated concepts and terms from one language to another and to make sure that they did not imbue the responses of interviewees...
... Introduction: “Where Was the Ethics Officer”?1 With the wreckage ofthe first generation of Enron-type corporate scandals in the rear view mirror, andthe chaos of Madoff andthe subprime meltdown ... compliance and ethics activities. Notwithstanding these and other changes in law and regulation affecting corporate directors, in the years since SOX there has been a series of further scandals and ... INDEPENDENCE AND VOICE One ofthe resounding themes ofthe conference was that many ofthe concrete elements of corporate compliance and ethics programs, such as codes of conduct, hotlines, and formal...
... brief in what follows. The key elements ofthe Hollywood productionthe one tier and partially in the other, and others moveerratically in and out ofthe sphere of operation ofthe complex today can ... majors and their cohorts of allied firms on the one hand; and (2) the mass of independent production companies on the other. Fourth, I reaffirm the continuing tremendousagglomerative attraction of ... Valley). The distribution of films made by independent producers isof scripts, actors, directors and other assets that theythen present to the studios in the hope of securing a handled for the most...
... ably contain the same kind of errors in the same kind of situations. This may cause the training procedure to learn the errors -especially if they are systematic- and thus the resulting tagger ... tend to make the same errors that appear in the test set. On the contrary, if the train- ing and test sets come from different sources -sharing only the tag set- the behaviour ofthe resulting ... the error commited by the tagger is other than the er- ror in the test corpus, but wrongly evaluated as right (false positive) if the error is the same. Table 1 shows the computation of the...
... assess the effectiveness and feasibility ofthe guidelines and thus inform changes in policy and practice. Objectives ofthe evaluation The primary intent ofthe evaluation is to meas-ure the ... No further investigations are needed if the aspi-rate is clear and straw-coloured and there are no other features suggestive of a diagnosis other than tuberculosis. ã Failure ofthe aspirate ... authorities, research groups and interested par-ties are needed to assess the likely benefits and responsiveness ofthe recommendations for the dual tuberculosis and HIV epidemics. The findings of these...
... of Identity Politics in the UK and the Unaddressed Question of a Union Identity . . . . . . . . . 4243. The Devolution Programme: A New Role for the JudicialCommittee and Implications for the ... Legal Systems . . . 4274. Securing a Role The Scope of “Devolution Issue” . . . . . . 428C. The “Devolution Theme”—Securing the Constitutional Status of the Devolution Acts . . . . . . . . . . ... The Court’s Diverging Approaches to the Defence of National and Regional Interests. . . . . . . . . . . . . . . . . 398(i) The Neglected Virtues of “Formalism” . . . . . . . . . . 398(ii) The...
... isolating the cDNA of PO-CHH and identifying the native CHH neuropeptide in the ES,after the recent report of CHH cDNA from the ES[28]. Also, we examined the physiological responses of the release and ... full-length cDNA of PO-CHH and identified the presence of the neuropeptide forms in the ES and PO. For the first time in crustaceans, the expression profiles of these two CHHs in response to oxygen and tempera-ture ... On the other hand, as a neurohormone,PO-CHH may be released from the surface ofthe PO and into branchiocardiac veins through the direct open-ings of anterior and posterior bars [35]. Furthermore,considering...
... the farther we go; for instance, the sum ofthe first six terms ofthe geometrical progression is 126, whereas the sum ofthe first six terms ofthe arithmetical progression is only 42, the ... between the geometry of volumes andthe geometry of surfaces, the difference between the two chemistries involves a difference of dimensionality. The higher energies ofthe chemistries ofthe higher ... life and in work—collectively and individually—because the conditions ofthe earning of a livelihood influence and shape all our mental processes and activities, the quality andthe form of human...
... research is needed tosubstitute for TEFs.’ Now the TEFs are getting locked in, andthe research wasn’t done. People get usedto using the old numbers, and they take on a life of their own. There’s ... healthconcern, the greater the extent and cost ofthe cleanup). Given the enormous volume of material involved, excavation and disposal could cost liable parties hundreds of millions of dollars for ... pp. 5-20.Gilman and EPA. 1994. Memorandum of Understanding between Gilman Paper Company andthe U.S.Environmental Protection Agency Regarding the Land Application of Pulp and Paper Mill Materials.Hanmer,...
... leafhoppers, but the tens of thousands of young spiders on each square yard of land simply vanish, andthe swarms of fireflies that fly up from the stands of grass disappear at once. The second application ... his shoulder, they immediately open the sack and thrust their hands in. They think that to understand the interior ofthe sack, they must know its contents. Supposing they found the sack to be ... They should have investigated the causes underlying the disruption in the harmony of nature and the outbreak of pests, and on the basis of these findings decided whether pesticides are really...