discovery of antifungal agents from natural sources virulence factor targets
Tài liệu Báo cáo khoa học: Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori docx
... for binding substrate and NADP cofactor The detailed structural information might expedite the discovery of novel SDH inhibitors and further of antimicrobial agents, though few SDH inhibitors ... s)1, Km of 0.148 ± 0.028 mm and kcat ⁄ Km of 5.2 · 104 m)1Æs)1 toward shikimate, and a kcat of 7.1 ± 0.7 s)1, Km of 0.182 ± 0.027 mm and kcat ⁄ Km of 3.9 · 104 m)1Æs)1 toward NADP Different from ... of shikimate, suggesting that NADP is the preferred cofactor of HpSDH We also tested whether HpSDH could utilize quinate as substrate Even in the presence of quinate at a high concentration of...
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báo cáo khoa học: "Numerical techniques for the analysis of polygenes sampled from natural populations" ppsx
... pool Each isofemale line derived from this pool carries a sample of alleles, ranging from one extreme to the other (from p = 1.0 toq = 1.0) The relative frequency of each type of isofemale line, ... the polygenic loci of interest, the genetic makeup of isofemale strains will differ as a function of the gene frequencies in the population and the probabilities of each type of mating a In this ... nested (i.e., one isofemale line might be a member of one cluster at one level of dissimilarity and of another cluster at a slightly different level) The results from this type of clustering can...
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Báo cáo y học: "Discovery of biological networks from diverse functional genomic data" ppt
... Another factor in the performance of our method is its robustness to the quality and size of the query set For each of the 31 The query-driven nature of the search algorithm is a key factor in ... multiple sources of evidence receive higher weights Proteins are then added in order of weight for network recovery Neither of these simpler approaches achieves accuracy similar to that of our ... applications of probabilistic data integration to the related but simpler problem of predicting protein function from diverse genomic data have demonstrated that integrated analysis of heterogeneous sources...
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Protecting New Health Facilities from Natural Disasters: Guidelines for the Promotion of Disaster Mitigation potx
... force the evacuation of some parts of the facility, resulting in a loss of operational capacity Protecting New Health Facilities from Natural Disasters Secondary effects of the damage to nonstructural ... supervisors of health facility construction projects: • • • • The Ministry of Health The Ministry of Public Works Social Security Government offices or independent agencies in charge of enforcing ... Facilities from Natural Disasters Source: Proceedings, International Conference on Disaster Mitigation of Health Facilities, Mexico, 1996 (a) Only health facilities of the Ministry of Health have...
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Báo cáo khoa học: Discovery of a eugenol oxidase from Rhodococcus sp. strain RHA1 ppt
... hydroxylases is the mode of binding of the FAD cofactor In VAO, FAD is covalently bound to a histidine, whereas the bacterial counterparts contain a tyrosyl-linked FAD cofactor [3,19] It has been ... indicating that the FAD cofactor is in a similar microenvironment and histidyl-linked The presence of a histidyl-linked FAD cofactor agrees with the model that could be prepared of EUGO The structural ... PAGE analysis of FAD-incubated EUGO resulted in an increase in flavin fluorescence (Fig 2, lane 3) This shows that the cofactor incorporation leads to covalent attachment of the FAD cofactor The successful...
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Báo cáo khoa học: "Acquisition of Conceptual Data Models from Natural Language Descriptions" doc
... derived from the structures of natural language, on the justification that a database comprises a set of sentences and the purpose of the conceptual darn model is to specify a grammar of the sentences ... the processing of natural language text for the purpose of knowledge acquisistiort, a problem that is much wider than the specific case of information systems design The role of natural language ... instances of complete natural language interfaces which comprise beth syntactic and semantic components As such they are potential models for the development of interfaces to new types of software...
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Citizen Investigation of Toxic Air Pollution from Natural Gas Development pdf
... Citizen Investigation of Toxic Air Pollution from Natural Gas Development Table of Contents Executive Summary pg Oil and Natural Gas Development and Air Pollution pg a) Life Cycle of Natural Gas Development ... increased risk of cancer from long-term exposure Communication from Miriam Rotkin-Ellman, Natural Resources Defense Council June 2011 The USEPA Reference Concentration (RfC) is an estimate of a continuous ... comprised of water-based concoctions riddled with assortments of chemicals and proppants like sand The chemical makeup of the fluid varies from company to company and site to site The process of fracking...
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Báo cáo khoa học: "Unsupervised Discovery of Domain-Specific Knowledge from Text" pptx
... modifier of “Steve Young” Similar information can be gained from appositions (e.g., “Steve Young, the quarterback of his team, said ”), and copula verbs (“Steve Young is the quarterback of the ... number of classes per entity is 6.87 The total number of distinct classes for entities is 63, 942 This is a huge number to model in our state space.1 Instead of manually choosing a subset of the ... task of finding the best set to the model We note, however, that the distribution of classes for each entity is highly skewed Due to the unsupervised nature of the extraction process, many of the...
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Báo cáo khoa học: Functional aspects of the solution structure and dynamics of PAF – a highly-stable antifungal protein from Penicillium chrysogenum pdf
... antifungal proteins from filamentous fungi have become the subject of investigation within the last decade [1] Apart from the antifungal protein (AFP) from Aspergillus giganteus, Penicillium antifungal ... antifungal protein (PAF) from Penicillium chrysogenum is one of the most studied antifungal peptides of fungal origin Both belong to a distinct group of cysteine-rich antifungal proteins, effectively ... reduction of the protein activity (Fig 1B) accompanied by degradation of the protein (data not shown) Structure and dynamics of an antifungal protein Exposition of 104 conidiaÆmL)1 to lgÆmL)1 of PAF...
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interactions of yeasts, moulds, and antifungal agents how to detect resistance
... considered or use of the liposomal formulation of amphotericin Some of the side effects of amphotericin can be reduced with use of the lipid formulations of amphotericin The lipid formulations of amphotericin ... of >1 m g/ml is often considered as indicative of yeast resistance [12, 38] 1.1.1.12 Comments Because of the often severe kidney toxicity of this agent, amphotericin is not always the first antifungal ... A Pfaller, M.D Division of Clinical Microbiology, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA University of Iowa College of Public Health, Iowa City,...
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Báo cáo hóa học: " Respiratory function and bronchial responsiveness among industrial workers exposed to different classes of occupational agents: a study from Algeria" potx
... part of the PhD-project of FOK at the University of Oran, for which BN served as promoter The research was supported by the administration of education and sciences of Algeria TN is a fellow of ... The spirometric values of exsmokers did not differ from those of nonsmokers Independently of smoking status, FEV1 tended to increase by 0.15% (SD: 0.08; P = 0.07) per year of employment Bronchial ... differs from that in a control population of unexposed workers Methods Study design The survey took place between January and October 1996 Factories situated within a radius of 40 km of Oran,...
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báo cáo hóa học:" New views on the hypothesis of respiratory cancer risk from soluble nickel exposure; and reconsideration of this risk''''s historical sources in nickel refineries" potx
... transform of the probability of disease from exposure (P), expressed as a linear function of regression variables (x) whose values correspond to the levels of exposure to the risk factors (total ... Nikkelraffineringsverk, Norway Dec 23, 1977 Available from Xstrata Nickel], and a translation (from Norwegian) of a publication of KNR's history [25] We reviewed a published study of historical environmental exposures ... Figure Plan view of the three floors of KNR's Purification section Plan view of the three floors of KNR's Purification section Shows stacking and abutment where typical composition of arsenic in...
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Báo cáo hóa học: " Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus" pot
... thankful to Professor Les Copeland (Faculty of Agriculture, Food and Natural Resources - The University of Sydney, New South Wales, Australia) and Professor Kaeko Kamei (Department of Biomolecular ... modifications of the enzyme Application of the fibrinolytic enzymes has also been of great interest in Vietnam, focusing especially on the use of local enzyme sources The preliminary experiments of this ... http://www.amb-express.com/content/1/1/26 Page of 11 Figure Effect of temperature on the activity of P excavatus proteases: (A) Temperature optimum and (B) thermostability of all isolated fractions The highest activity of each fraction...
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Application of Bacillus spp. Isolated from the Intestine of Black Tiger Shrimp (Penaeus monodon Fabricius) from Natural Habitat for Control Pathogenic Bacteria in Aquaculture ppt
... 72, 96 and 120 hours for enumeration of the number of bacteria RESULTS Isolation and identification of Bacillus spp From 120 samples of P monodon, 114 strains of genus Bacillus were isolated for ... MATERIALS AND METHODS Isolation and identification of Bacillus spp Bacillus spp were isolated from the intestine of Penaeus monodon collected from the Gulf of Thailand at Chonburi province Every month, ... development of antibiotic resistance has become a matter of growing concern One of the alternatives to antimicrobials in disease control could be the use of probiotic bacteria as microbial control agents...
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Discovery of botanical flavonoids as dual peroxisome proliforator, activated receptor (PPAR) ligands and functional characterization of a natural PPAR polymorphism that enhances interaction with nuclear compressor
... Physiological Aspects of PPAR 11 1.3 Ligands of PPAR 21 1.4 Molecular mechanisms of PPAR activity 27 1.5 Molecular mechanisms of PPAR activity- Coregulators 34 1.6 Natural polymorphisms of the PPARα gene ... Effects of isoflavones on endogenous PPARγ function in adipocytes 115 Figure 3.2.7 Effects of isoflavones differentiation preadipocyte 117 Figure 3.2.8 Screening of different groups of flavonoids ... not well understood in terms of cofactor recruitment by each partner of the heterodimers (Feige et al 2006) Indeed, mutation of the PPARγ AF2 abolishes the ability of RXR/PPARγ heterodimers to...
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Efficient discovery of binding motif pairs from protein protein interactions
... derived from 10 sets of equal size of random starting motif pairs 85 4.11 The percentage of stable and significant motif pairs derived from our starting motif pairs and those derived from 10 sets of ... sequences of a protein group by standard motif discovery algorithms, a motif pair can be easily formed from an interacting protein group pair We demonstrate the effectiveness of both of these methods from ... discovering binding motif pairs from different types of protein interaction data These are the discovery of binding motif pairs in the form of regular expressions from protein interaction sequence...
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Discovery of safe anti dengue virus drugs from libraries of FDA approved drugs and plants through screening against viral RNA dependent RNA polymerase activity
... NS2B cofactor (Zhou et al., 2007) In earlier studies, the minimal requirement of NS2B protein as a NS3 protease cofactor was found to be a 40-residue central hydrophilic region spanning from amino ... sufficient for basal cofactor activity, as the optimal NS2B cofactor function was highly dependent on the hydrophobic flanking regions of the protein, presumably acting as an anchor of the protease ... resistance of HIV (Zdanowicz, 2006) As this occurs due to the high rate of viral replication coupled to the lack of proof-reading ability of reverse transcriptase which result in high mutation rates of...
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antimicrobial susceptibility testing of bacterial agents isolated from asian seabass (lates calcarifer)
... also low, ranging from 0.125 to 4µm/ml ii TABLES OF CONTENTS ACKNOWLEDGEMENT i ABSTRACT ii TABLES OF CONTENTS iii LIST OF FIGURES v LIST OF TABLES vi CHAPTER 1 1.1 Background of study 1.2 Research ... diseases caused by bacteria of genus Vibrio (Woo and Bruno, 1998) This type of disease is commonly considered stress mediated with the predisposing factors of handling, moving from fresh to salt water ... than 10-15mm from the edge of the petri dish A maximum of six disks may be placed in a 9-cm petri dish and 12 disks on a 150mm plate The zones of inhibition are observed after 24 hours of incubation...
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