discovery of an egfr inhibitor for drug development
Development and interpretation of machine learning models for drug discovery
... points of SAR analysis and therefore widely studied [20–23] Figure 2: Exemplary 2D and 3D SAR landscapes for a set of human thrombin ligands SARs are often studied qualitatively in visual form ... in random forests for instance offer to assess the importance of each feature in terms of the number and order of splits they appear in Feature contributions of na¨ıve Bayes classification can ... prediction of compound activity, the modeling of potency values, and the profiling of ligands against a panel of related targets Aside from the development of LBVS methods, understanding the...
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báo cáo hóa học:" Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients" potx
... Assessment of Cancer Therapy-Anemia (FACTAn) Scale: A new tool for the assessment of outcomes in cancer anemia and fatigue Semin Hemtol 1997, 34(Suppl2):13-19 Vogelzang N, et al: Patient, caregiver, and ... not relevant to the aims of this project: • Similarity of items: This is inherent to the development of an item bank for CAT aiming at covering the whole continuum of fatigue • Response format: ... translated to Danish, French, German, and Spanish A total of 52 patients at five centres (in Austria, Denmark, France, Spain, and the UK) completed the 44 items and commented on them For details...
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Báo cáo y học: "Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" docx
... metrics of quality [16,17] In other words, performance in one aspect of care quality is not necessarily Page of 10 Table Advantages and disadvantages of composite indicators Advantage Disadvantage ... toolbox, their development is complex, and the editorial choices required of developers may significantly influence performance ratings [14] Therefore, development must be explicit and transparent ... quality of care in one aspect cannot be traded off another, since negative consequences of poor quality of care in any area of healthcare may have long-term consequences for a child’s health and...
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báo cáo khoa học: " Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" potx
... metrics of quality [16,17] In other words, performance in one aspect of care quality is not necessarily Page of 10 Table Advantages and disadvantages of composite indicators Advantage Disadvantage ... toolbox, their development is complex, and the editorial choices required of developers may significantly influence performance ratings [14] Therefore, development must be explicit and transparent ... quality of care in one aspect cannot be traded off another, since negative consequences of poor quality of care in any area of healthcare may have long-term consequences for a child’s health and...
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báo cáo khoa học:" Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients" doc
... Assessment of Cancer Therapy-Anemia (FACTAn) Scale: A new tool for the assessment of outcomes in cancer anemia and fatigue Semin Hemtol 1997, 34(Suppl2):13-19 Vogelzang N, et al: Patient, caregiver, and ... not relevant to the aims of this project: • Similarity of items: This is inherent to the development of an item bank for CAT aiming at covering the whole continuum of fatigue • Response format: ... translated to Danish, French, German, and Spanish A total of 52 patients at five centres (in Austria, Denmark, France, Spain, and the UK) completed the 44 items and commented on them For details...
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DEVELOPMENT OF AN INTEGRATED SYSTEM FOR HUMAN SPINE DEFORMITY MEASUREMENT
... staff and officers in the Advanced Manufacturing Laboratory, especially to Mr Tan Choon Huat, Mr Wong Chian Long, Mr Ho Yan Chee, Mr Lim Soon Cheong, Mr Simon Tan Suan Beng and Mr Lee Chiang Soon, ... methods and technologies to assess human back scoliosis are introduced and the advantages and disadvantages of these methods are compared A review of the early efforts by many researchers and doctors ... Objective and Significance of the Research The popular method of monitoring the progress of scoliosis and quantifying the degree of spinal deformity is to take measurements from full poster-anterior...
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Development of an adaptable model for distributed collaborative computer aided design
... Acknowledgements First and foremost I would like to express sincere thanks and appreciation to my supervisor, Associate Professor Wong Yoke San, for guidance, and his involvement in this research, for the technical ... Singapore Institute of Manufacturing Technologies (SIMTech), and suggestions from Dr Lu YiQiang and Dr Li Weidong, for their guidance thorough the research work, and thank to Laboratory for Concurrent ... simultaneously The hierarchical collaboration can establish an effective communication channel between upstream design and downstream manufacturing, and it can enrich principles and methodologies of...
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Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot
... is an attractive candidate for drug development in these highly aggressive tumors EphA3 (along with most of the EPH A class RTKs) is a highly promiscuous receptor for ephrins, which allows for ... substrate specificity for this biologically relevant class of receptor tyrosine kinases and provides a valuable tool for future research Results and discussion The juxtamembrane region of the cytosolic ... al Canadian Institutes for Health Research, the Canadian Foundation for Innovation, Genome Canada through the Ontario Genomics Institute, GlaxoSmithKline, Karolinska Institutet, the Knut and...
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Báo cáo khoa học: "Discovery of Topically Coherent Sentences for Extractive Summarization" doc
... synthetic experiment for model development to evaluate extracted summaries on redundancy measure In §6, we demonstrate the performance of our models on coherence and informativeness of generated summaries ... containing specific words For instance for a given sentence: ”Starbucks Coffee has attempted to expand and diversify through joint ventures, and acquisitions.”, ”starbucks” and ”coffee” are more general ... (Celikyilmaz and Hakkani-Tur, 2010) Human annotators are given two sets of summary text for each document set, generated from either one of the two approaches: best ETTM and PAM or best ETTM and HybHSum...
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PERSONAL PROFILES OF THE ACADEMIC STAFFS AS PREDICTORS OF PROFESSIONAL CHARACTERISTICS: BASIS FOR STAFF DEVELOPMENT PROGRAM
... students; Dr Tran Thanh Van, the Dean of the Graduate School of Thai Nguyen University, for his assistance and encouragement to pursue this study; Dr Dang Xuan Binh, the Director of International ... University and Humanities 24, the Criteria for performance of staff must show: An overall and accurate evaluation of lecturer's capacity which is an important factor in promoting lecturer's self -development, ... good in Basic and Specialized knowledge with mean score of 3.84; Knowledge of the policy and guidelines of the Viet nam Communist Party with mean score of 3.94; and Methods of testing and evaluating...
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báo cáo hóa học:" Benefits of an educational program for journalists on media coverage of HIV/AIDS in developing countries" docx
... data analysis and manuscript preparation CFI participated in the study design, data analysis and manuscript preparation MN and SMS participated in review and evaluation of news reports and of the ... Press Foundation for many useful discussions and for providing key sets of data that were used in our analyses We thank Beatriz E Alvarado, PhD for assisting with data analysis and survey implementation ... destigmatization of HIV, hopes and limitations of current therapy including issues of drug access in developing countries, prospects for novel therapeutic and prevention initiatives, and the successes and...
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Báo cáo hóa học: " Research Article Strong Convergence of an Iterative Method for Inverse Strongly Accretive Operators" potx
... subset of a uniformly convex Banach space E and let T be nonexpansive mapping of C into itself If {xn } is a sequence of C such that xn → x weakly and xn − T xn → 0, then x is a fixed point of T Yan ... subset of a smooth Banach space E, let D be a nonempty subset of C, and let Q be a retraction from C onto D Then Q is sunny and nonexpansive if and only if u − P u, J y − P u for all u ∈ C and y ... and 2-uniformly smooth Banach space and C a nonempty closed convex subset of E Let QC be a sunny nonexpansive retraction from E onto C, α > 0, and A an α-inverse strongly accretive operator of...
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Báo cáo hóa học: "Research Article Strong Convergence of an Iterative Method for Equilibrium Problems and Variational Inequality Problems" docx
... methods for nonexpansive mappings,” Journal of Mathematical Analysis and Applications, vol 298, no 1, pp 279–291, 2004 18 T Suzuki, “Strong convergence of Krasnoselskii and Mann’s type sequences for ... approximation methods for nonexpansive mappings and monotone mappings,” Journal of Mathematical Analysis and Applications, vol 334, no 2, pp 1450– 1461, 2007 16 X L Qin, M J Shang, and H Y Zhou, “Strong ... approximation of fixed points of compositions of nonexpansive mappings in Hilbert space,” Journal of Mathematical Analysis and Applications, vol 202, no 1, pp 150–159, 1996 G Marino and H.-K Xu,...
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Báo cáo hóa học: " Research Article Design and Performance Analysis of an Adaptive Receiver for Multicarrier DS-CDMA" doc
... designed an adaptive receiver for the multicarrier DS-CDMA system over Rayleigh fading channels and evaluated the performance of the system A closed form expression of the BER is originally derived for ... the rectangular pulse waveform with unit amplitude and duration τ, ωq and φq are the frequency and random phase of the qth subcarrier, respectively, and c(k) (t) is the spreading sequence of user ... zero mean Gaussian random variable and its variance is given by σn = Var Z (1) where p(γ) is the probability density function of γ and is given by [30] N −1 nt = (25) Assuming that any bit can be...
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Báo cáo hóa học: " WEAK CONVERGENCE OF AN ITERATIVE SEQUENCE FOR ACCRETIVE OPERATORS IN BANACH SPACES" ppt
... Problem 1.4 for an inverse strongly accretive operator in a uniformly convex and 2uniformly smooth Banach space Theorem 3.1 Let E be a uniformly convex and 2-uniformly smooth Banach space and let ... closed convex subset of a uniformly convex and 2-uniformly smooth Banach space E, D is a sunny nonexpansive retract of E and A is an inverse strongly accretive operator of D into E, then the ... Jr., Nonexpansive retracts of Banach spaces, Bulletin of the American Mathematical Society 76 (1970), 384–386 , A simple proof of the mean ergodic theorem for nonlinear contractions in Banach spaces,...
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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx
... acquisition and analysis of data HO participated in the design of the study and helped to perform the statistical analysis CS participated in analysis and interpretation of data and helped to ... study and drafted the manuscript YS indicated the design of the study and gave final approval of the version to be published NT participated in analysis and interpretation of data CIH, KO and SA ... respiratory function and tumor movement To compare the change of SpO2 levels under conditions C and D, repeated measure analysis of variance was used Survival rates and cumulative incidences of complications...
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Báo cáo y học: "Evaluation of an ambulatory system for the quantification of cough frequency in patients with chronic obstructive pulmonary disease" ppsx
... a burst of laughing Entire duration of depicted recording is 1-min and 37-sec Table provides performance summaries for the LS system to detect cough during for night vs day and for low and high ... invited to be observed for a maximum of 24 hours A total of 109 hours of simultaneous recordings of video and LS were obtained Of that time, 73.9 hours were observed during the day and 34.7 hours were ... detect cough and demonstrate a high level of agreement and accuracy when compared to video surveillance for cough over an extended period The system was well-tolerated and allowed for free movement...
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Tailoring the properties of glassy polymeric membranes for energy development
... encouragement, and guidance during my PhD study Many thanks go to Prof Jean Y.C and Dr Chen Hongmin at the University of Missouri-Kansas City for providing training and help in analyzing positron annihilation ... Comparison of gas separation performance of pure Matrimid® and hybrid nanocomposite membranes at different POSS® loadings … 85 Table 4.2 Comparison of glass transition temperatures of pure Matrimid® and ... High-Performance Thermally self-cross-linked Polymer of Intrinsic Microporosity (PIM-1) Membranes for Energy Development …….…… 192 8.1.3 UV-Rearranged PIM-1 Polymeric Membranes for Advanced Hydrogen...
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Application of recombinant antibody technology for the development of anti lipid antibodies for tuberculosis diagnosis
... APPLICATION OF RECOMBINANT ANTIBODY TECHNOLOGY FOR THE DEVELOPMENT OF ANTI-LIPID ANTIBODIES FOR TUBERCULOSIS DIAGNOSIS CONRAD CHAN EN ZUO BSc (Hons.), MRes Imperial College London A THESIS SUBMITTED FOR ... resistance to degradation and presence in a variety of clinical samples, but the lack of T cell help required for an effective B cell immune response and the insolubility of many lipid antigens ... treatment regime, compliance is important to limit the development of drug resistance; therefore patients are usually required to take their drugs in the presence of an observer, which is termed...
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Engineered hepatocellular models for drug development
... and Francis Baixue Zheng and Abhishek Ananthanarayanan.2013”Confocal Microscopy for Cellular Imaging: High-Content Screening” Imaging in cellular and Tissue engineering Taylor and Francis Ananthanarayanan ... Francis Ananthanarayanan A et al 2013 “Scalable spheroid model of human hepatocytes for HCV infection and replication” (Manuscript to be submitted) Ananthanarayanan et al 2013 “ Co-culture of rat hepatocytes ... synthetic and metabolic function of sandwich and co-culture 4.8.2 Comparing drug sensitivity and drug induction between co-culture and sandwich culture 4.8.3 TGF β1 is an important regulator of hepatocyte...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25