discovery and development of the hcv ns3 4a protease inhibitor danoprevir itmn 191 rg7227
Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot
Ngày tải lên :
31/03/2014, 01:20
... [8–10]) Thermal unfolding of the protein was monitored at 203 nm at a heating rate of 60 °CÆh)1 Effect of the recombinant protein on the activity of proteases The activity of the proteases on synthetic ... spectra of the second Kunitz–type protease inhibitor module of human WFIKKN The solid line indicates the spectrum of the recombinant protein, the dotted line indicates the CDPro-predicted spectrum of ... (JASCO) Fig Alignment of the sequences of the second Kunitz-modules of the human and fugu WFIKKN proteins (wfikkn_hu_2; wfikkn_fugu_2) with the second Kunitz-domains of the human and the two fugu WFIKKNRP...
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THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT pptx
Ngày tải lên :
08/03/2014, 23:20
... CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT 24 THE WHEAT BOOK THE WHEAT BOOK CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT THE STRUCTURE AND DEVELOPMENT OF THE CEREAL ... parts of a leaf are the tip of the blade and the top of the sheath Where the blade and sheath join, there are structures called the ligule and the auricles (Figure 2.3) Characteristics of the shoot ... structure of the stem and leaf of the wheat plant 27 CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT DESCRIPTION OF THE WHEAT PLANT THE WHEAT BOOK (continued) at their bases, so the oldest...
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lHistory and Development of the Sewing machines
Ngày tải lên :
30/07/2015, 10:34
... more set of threads – One set of thread is called needle thread and another set is called looper thread – The loop of one set thread is passed through the fabric and bound with another set of thread ... another side in the fabric and makes a sewn line Stitch class-200 (Hand Stitch) – Applications : Used in lapel of jacket, coat and expensive clothes Stitch type-209 is used for edge of the ... of a loop of thread through another loop formed • by the different thread INTRALOOPING • Passing of a loop of thread through another loop • formed by the same thread INTERLACING • Passing of...
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Provision, discovery and development of ubiquitous services and applications
Ngày tải lên :
10/09/2015, 08:36
... consisting these two layers for the provision, discovery, and development of ubiquitous services and applications As a proof of concept, we demonstrate the use of the framework for the development of ... this area recently, including the development of embedded system and sensors, the design of system architecture and middleware, and the implementation of software agent and application framework ... this thesis, would greatly enhance the effectiveness and flexibility of the mobile applications in the following ways: (i) services are hosted on the mobile device and the up-to-date contexts of the...
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The origins and development of the english language
Ngày tải lên :
27/08/2016, 16:46
... shaking of the finger, the lifting up of the hand in greeting and the waving of it in parting, the widening of the eyes in astonishment, the scornful lifting of the brows, the approving nod, and the ... as the pooh-pooh theory, the bow-wow theory, the ding-dong theory, and the yo-he-ho theory The nicknames indicate how seriously the theories need be taken: they are based, respectively, on the ... here” and the question language and the english language “He’s here?” is the pitch used at the end of the sentence The chief difference between the verb conduct and the noun conduct is that the...
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Báo cáo y học: "Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus" pdf
Ngày tải lên :
14/08/2014, 08:20
... TIVTSLTGRDKNEVEGEIQVVSTATQSFLATTVNGVLWTVYHGAGSKTLAGPKGPICQMYTNVDQDLVGWPAPPGARSLT R155G/I/K/L/M/S/T A156I/S/T/V HCV_ 1a HCV_ 1b HCV_ 1c HCV_ 2a HCV_ 2b HCV_ 2c HCV_ 2k HCV_ 3a HCV_ 3b HCV_ 3k HCV_ 4a HCV_ 5a HCV_ 6a HCV_ 6b HCV_ 6c HCV_ 6g HCV_ 6h HCV_ 6k : : : : : : : : : : : : : : : ... Welsch et al R16.15 T 54A/ S β3 β1 HCV_ 1a HCV_ 1b HCV_ 1c HCV_ 2a HCV_ 2b HCV_ 2c HCV_ 2k HCV_ 3a HCV_ 3b HCV_ 3k HCV_ 4a HCV_ 5a HCV_ 6a HCV_ 6b HCV_ 6c HCV_ 6g HCV_ 6h HCV_ 6k Volume 9, Issue 1, Article R16 40 60 ... study Analysis of NS3- 4A protease structures and ligand binding modes The mutated positions V36 and T54 are buried in the protease domain of NS3- 4A in the two β-strands β1 and β3 of an antiparallel...
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DEVELOPMENT OF THE OZONIZER AND OZONATION TECHNOLOGY FOR WATERWORKS IN JAPAN
Ngày tải lên :
05/09/2013, 08:40
... techniques The report then describes the recent status of each of the issues RESEARCH AND DEVELOPMENT IN INCREASING OZONE CONCENTRATION Ozone generation Method and scale of use Table summarizes the ... concentration and decomposition RESEARCH AND DEVELOPMENT IN OZONATION TECHNOLOGY Objectives of ozonation The main objectives of ozonation are to reduce trihalomethane and to remove taste and odor These ... instead of air High concentration ozonizer The original principles of ozone generation have not changed As a result of a wide spectrum of research and development, ozone concentrations of ozonizers...
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Development of the Quantitative PCR Method for Candidatus ‘Accumulibacter phosphatis’ and Its Application to Activated Sludge
Ngày tải lên :
05/09/2013, 09:38
... areas RESULTS AND DISCUSSION Development of Quantitative PCR method Specificity of the primer set was evaluated based on the melting curve and the sequencing analysis Melting peaks of the PCR product ... shown in Figure The averages of R2 value and the slope of the calibration line were 0.9998 and 3.3955, respectively (n=2) The average of amplification efficiency (E) based on the slope (Smith ... Biosystem) and the T3 Thermocycler (Biometra) Samples were preincubated at 95 °C for 10 The PCR cycle consisted of 30 sec of denaturation at 94 °C, 30 sec of annealing at 50 °C, and of extension...
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Tài liệu Report:"Language Vitality and Development among the Wakhi People of Tajikistan" pptx
Ngày tải lên :
24/01/2014, 04:20
... into the previous sections divided by age These include the use of Tajik within the community of Lyangar, the role of Khorogh in Tajik exposure, and the use of Tajik with relatives The use of Tajik ... in other parts of the Soviet Union said that the language used in the army was Russian Time in the army, then, had little impact on their proficiency in Tajik Six of the eight men with professional ... 30, though the majority (27 out of 40) was under the age of 24 Table 19 summarizes the distribution of the sample among the proficiency categories Table 19: Proficiency Levels of Men and Women:...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
Ngày tải lên :
16/02/2014, 09:20
... important in the generation of the correct class of antibodies by B-cells, and for the elimination of extracellular pathogens, such as helminths and other extracellular parasites [2] Th17 is the most ... domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3 In addition, for stat6 and foxp3, there were a few other conserved features Within the ... tissue of mouse and spleen and thymus of human and mouse [11,37] Foxp3 is also highly expressed in lymphoid organs, such as the thymus and spleen [49], and its expression within a variety of other...
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Tài liệu The Development of the Feeling for Nature in the Middle Ages and Modern Times doc
Ngày tải lên :
21/02/2014, 20:20
... and Modern Times 'Let the heavens rejoice and let the earth be glad; let the sea roar, and the fulness thereof 'Let the field be joyful, and all that is therein; then shall all the trees of the ... covers the mountains.' 'The sky is the fortress of the storm, the sun the torch of the world, the jewel of splendour.' 'Fire is eager, wild, blind, and raging; the sea is the gray sea, and the sparkling ... refreshed their eyes Their service was the song of the birds, the little brown nightingales, the throstlets and the merles and other wood birds The siskin and the ringdove vied with each other to them...
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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii Implications for the disulfide metabolism of anaerobic hyperthermophiles doc
Ngày tải lên :
07/03/2014, 17:20
... reduce the disulfides, and assayed as above Thiols were quantified by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the CoA and ... determine directly from the spectrum the fate of the reduced pyridine nucleotide During the addition of the first equivalent of NADPH, there is a blue shift in the 380 nm peak and subsequent small ... furiosus CoADR The N terminus of the CoADRs were based on the presence and proper spacing of the ribosome binding site, annotation from the genome sequence, and their good agreement with the NOX homologues...
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The Victorian Era and the Development of the Stoic-Christian Code of Honor
Ngày tải lên :
14/03/2014, 09:31
... system, and necessitate the creation of a new honor culture that transcended all classes T he Rise of the Middle Class and the Expansion of Honor At the beginning of the 19th century, the Industrial ... replicate the camaraderie and brotherhood of the past The giving and taking of oaths grew in popularity as a chance to put the Stoic-Christian ideal of making one’s word one’s bond to the test, and ... The more he excelled at the code, and the more he cultivated ambition, industry, discipline, and so on, the higher a gentleman rose in the ranks of society and the more status he gained And the...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
Ngày tải lên :
22/03/2014, 21:20
... commercial banks and of the value of focusing regulation on the nature of the activities being undertaken The Rules have clarified the prudential expectations of the BOG Better understanding of the requirements ... based on their repayment track record and the quality of the systems used to manage them The promise of repeat loans and the pressures of group or personal guarantees, and sometimes pledges of movable ... accounts as they repay the loan The group handles the collection of savings and repayments, acts as the interface with the loan officer, and bears group responsibility for recovery (though the loans...
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DESIGN AND DEVELOPMENT OF MEDICAL ELECTRONIC INSTRUMENTATION A Practical Perspective of the Design, Construction, and Test of Medical Devices docx
Ngày tải lên :
29/03/2014, 11:20
... finite period of time and then drifts back to the original baseline The time required for the return of normal operational conditions of the biopotential amplifier after the end of the saturating ... oscillation The output of the BPD op-amp is rectified by the full-wave bridge formed by D5–D8 and then amplified by the differential amplifier built using the other half of IC1 The output of this op-amp ... changes in the configuration of JP1 and JP2 cause corresponding changes in the amplitude of the output signal Set the gain to 10, and using the second channel of the oscilloscope, check that there...
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the origin and early development of the chinese writing system
Ngày tải lên :
03/04/2014, 13:25
... straightforward and comprehensible way the facts as I see them surrounding the origin and formation of the Chinese script in the second half of the second millennium B.C., and of its reformation and standardization ... representation of the verb is non-standard What such a usage of the graph (8) shows is that the link between the graph and the semantic aspect of the original word, schematically the G-S leg of the G-P-S ... describe the nature and internal structure of the Chinese script from the time of its invention in the middle of the Shang age down to the period of its sl3.ndardization in the Han, and to dispel...
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báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)" pdf
Ngày tải lên :
18/06/2014, 19:20
... assess the measurement and psychometric properties of the measure As with the development phase, the validation study methodology closely followed the guidelines laid out by the FDA for the development ... Management, and Experience of Side Effects and a theoretical model of the impact of AOM on patient functioning and well-being was developed (Figure 1) Based on this theortetical model, and relying ... dimensions of a PRO measure and the appropriateness of the total versus the domain score is dependent upon the purpose for which the measure is being used Therefore, the SAP for the TRIM-Weight was specifically...
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báo cáo hóa học: " Development of the Knee Quality of Life (KQoL-26) 26-item questionnaire: data quality, reliability, validity and responsiveness" pptx
Ngày tải lên :
18/06/2014, 19:20
... time Some of the time All of the time Knee pain present at night: None of the time Some of the time All of the time Knee pain worse on movement: None of the time Some of the time All of the time ... randomised trials and clinical practice The lack of standardisation in the choice of instruments limits the generalisability of results Furthermore, of the five instruments included in the review that ... of change The results of comparisons with other instruments and knee-related questions are evidence for the validity of the KQoL-26 The high level of correlation with the Lysholm Knee Score and...
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báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx
Ngày tải lên :
18/06/2014, 22:20
... and design of the original web-based survey FJS, SES and FP assessed the quality of the data collected and participated in the design of the validation study and the development of the statistical ... we report on the development and validity of the ITAS Methods Development of ITAS The ITAS was developed to capture type diabetes patient's current appraisal of insulin therapy The instrument ... removed, and the topic of weight gain is generally acknowledged as one of the important barriers in the current treatment of type diabetes [20] We therefore suggest to retain item in the ITAS,...
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báo cáo hóa học: " Development and validation of the WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire (WE-CARE)" potx
Ngày tải lên :
18/06/2014, 22:20
... participated; the participant was required to be the primary caregiver of the child, and had to be willing to participate throughout the course of the study and to complete the questionnaires at Weeks and ... female, usually mothers, with a mean age of 37.1 years (Table 1) The majority of the subjects were white Because only one of the adults taking part in the study was not the parent of the participating ... coordination of the study and helped to draft the manuscript RD participated in the design and coordination of the study XL contributed statistical analysis and helped to draft the manuscript RA and LA...
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