... reports have indicated that MVP is tyrosine phosphorylated in vivo in CHO and PC12 cells and phosphorylated by PKC and casein kinase II in vitro using specific kinase agonist and inhibitors [31,32]. ... kinase activity. Domains within Src kinases target the enzyme to specific subcellular locations where they bind to regulatory and ⁄ or substrate proteins and are integrated into cell signalling pathways and cell ... UD, Src homology 3 and Src homology 2 (SH2) domains in Src are key binding sites for proteins that regulate Src activity and integ- rate Src into important signalling pathways and cell cycle events....
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation pptx
... function in pre-mRNA splic- ing. Indeed, an EV HPV E2 protein interacts with cellular splicing factors, including prototypical SR pro- teins and RS domain-containing small nuclear ribonu- cleoprotein ... (pre)-mRNA splicing [1–3]. RS domain variants, such as serine and arginine-rich motifs or arginine–aspartate or arginine– glutamate dipeptide-rich domains, are also found in many nuclear proteins. In addition ... Therefore, SR proteins, together with other RNA-binding proteins, coordinate the coupling of splicing and polyadenylation. SR proteins participate in viral protein translation SR proteins are primarily...
Ngày tải lên: 23/03/2014, 06:20
INCENTIVES AND TEST-BASED ACCOUNTABILITY IN EDUCATION doc
... reserved. Incentives and Test -Based Accountability in Education 10 INCENTIVES AND TEST -BASED ACCOUNTABILITY IN EDUCATION ronment where there is substantial interest in test -based incentives ... reserved. Incentives and Test -Based Accountability in Education 34 INCENTIVES AND TEST -BASED ACCOUNTABILITY IN EDUCATION proven to be important in many settings: how incentives are framed and communicated. Framing ... of “increasing effort”—one involving greater focus on the full curriculum and the other involving extra time in test preparation. A model of teacher and student reactions to test- based incentives—in...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... contains a sole NrpR consisting of one single NrpR domain with a N-terminal HTH domain [26], it is of specific interest to elucidate whether the single NrpR domain of M. kandleri is also binding ... using 300 lL of pro- tein-binding buffer (see above). Potentially DNA-bound proteins were subsequently eluted step-by-step using 200 lL of binding buffer containing increasing amounts of NaCl (100, ... via the DNA-binding domain. In a recent genetic approach, Leigh and Lie showed that changing amino acid 390 located in the second NrpR domain of M. maripaludis NrpR (S390A) resulted in a complete loss...
Ngày tải lên: 29/03/2014, 21:20
báo cáo sinh học:" Agreement between physicians and non-physician clinicians in starting antiretroviral therapy in rural Uganda" docx
... two-week training of the clinical team. Sites in Masaka district in southwest Uganda, for example, were the first to be trained, in June 2004, whereas other sites in northern Uganda received training in ... by the Ministry of Health to standardize nursing training and to reduce the wide variation in education and training between nurses working at government health units, particularly those in rural ... conditions. In outpatient HIV/AIDS care, NPCs in industrialized nations play a cen- tral role in ensuring patient follow-up, providing adher- ence support and counselling, and managing and triaging therapy...
Ngày tải lên: 18/06/2014, 17:20
báo cáo hóa học: " Can we derive an ''''exchange rate'''' between descriptive and preference-based outcome measures for stroke? Results from the transfer to utility (TTU) technique" doc
... Ware J: Using generic measures of functional health and well- being to increase understanding of disease burden. Spine 2000, 25:1467. 17. Ware J, Kosinski M and Keller S: SF-36 physical and mental hea ... improvements in predictive validity that we were able to obtain by deriving separate transformations for clinically distinct subgroups of patients. Finally, our findings suggest that validity in predicting ... separately scored, using item weighting and additive scaling, to yield a 0–100 point scale. These eight dimensions can be combined into two summary measures – physical function (PCS index) and mental h...
Ngày tải lên: 18/06/2014, 18:20
báo cáo hóa học:" Poor Efficacy and Tolerability of Stavudine, Didanosine, and Efavirenz-based Regimen in Treatment-Naive Patients in Senegal" potx
... sepsis. In a comparison of patients treated in industrialized and poor countries, a large difference in mortality was noted during the 12 months following the initiation of HAART. This was linked ... bilirubin, and creatinine) were performed at baseline, weeks 2 and 4, and every 3 months thereafter for 18 months. Blood triglycerides, total cholesterol, and glu- cose were measured at baseline and ... programs in the southern hemisphere, first-line treatments in industrialized countries have tended to become simpler and better tolerated, thereby improving their convenience and reducing the incidence...
Ngày tải lên: 20/06/2014, 08:20
báo cáo hóa học:" Do diabetes and depressed mood affect associations between obesity and quality of life in postmenopause? Results of the KORA-F3 Augsburg population study" pdf
... personal interview (CAPI), a self- administered questionnaire, physical examination by trained personal (including assessments of body weight and height) and blood sampling. The sampl e of the original ... risk in obese women aged 45 to 74 years. Considering these finding s and the pathophysiological cluster including visc eral fat, de pressive and meta bolic disorders [15], the present study investigates ... linearly associated with pain and gastrointestinal symptoms. However, due to sum- scoring no assertions could be drawn as to which dis- eases produced the differences. In their review, Jones and...
Ngày tải lên: 20/06/2014, 15:20
Báo cáo hóa học: " Evaluating interaction forces between BSA and rabbit anti-BSA in sulphathiazole sodium, tylosin and levofloxacin solution by AFM" potx
... that AFM could be helpful in the design and screening of drugs-modulating protein-protein interaction processes. 1. Introduction A molecular level understanding of protein-protein inter- actions is fundamentall ... affect the interaction force between BSA and rabbit anti-BSA. These findings may enhance our understanding of antigen/antibody binding processes in the presence of drug molecules, and hence indicate ... salt concentration increased, henc e diminishing the strong repulsive protein-protein interactions. In addition, increas- ing the solution IS may disrupt the hydration shell coating on protein surfaces and...
Ngày tải lên: 20/06/2014, 22:20
Báo cáo hóa học: " Research Article Performance Optimization for Delay-Tolerant and Contention-Based Application in IEEE 802.16 Networks" pptx
Ngày tải lên: 21/06/2014, 23:20
Báo cáo y học: "The relationship between inflammation and new bone formation in patients with ankylosing spondylitis" docx
Ngày tải lên: 09/08/2014, 13:21
Báo cáo sinh học: "Genetic interaction between sire and population of mates in Drosophila melanogaster" pps
Ngày tải lên: 14/08/2014, 19:22
Social Media and Internet-Based Data in Global Systems for Public Health Surveillance A Systematic Review
Ngày tải lên: 08/04/2015, 17:20
Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... encoding reg- ulators of immune and in ammatory responses and also genes involved in apoptosis and cell proliferation [36]. In this paper, we report the results of cell -based, in vitro and in silico ... pre- warmed in a water bath at 37 °C) was dispensed into each well and incubated for 15 min (prewarming fixative is critical to maintaining cell integrity). After 15 min, the plates were inverted ... grown overnight in 10 mL LB medium containing 100 lgặmL )1 ampicillin. A colony of E. coli .in LB agar plates was inoculated into 50 mL of LB liquid med- ium and incubated on shaking platform with...
Ngày tải lên: 16/03/2014, 11:20