... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical...
Ngày tải lên: 03/11/2012, 09:57
... needed for conducting, reporting, and interpreting randomized clinical trials This knowledge cannot be inferred from an understanding of conventional experimental design in the social and behavioral ... discussions of coping with cancer and encouragement to express feelings Content included redefining life priorities and detoxifying death, building bonds, management of physical problems and side effects ... randomization, introducing bias Forty patients were each initially randomized to intervention and control conditions In the intervention group, patient was excluded owing to death, owing to incomplete...
Ngày tải lên: 15/02/2014, 05:20
The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... hospitals in Shanghai, Beijing, and other areas in China, with a total 189 patients The double-blind study used the same doses and test materials as the previous study, and examined PSP against the...
Ngày tải lên: 06/03/2014, 02:21
ADVANCES IN CANCER MANAGEMENT pptx
... phospho-inositide breakdown in human colon cancer cell line, causing translocation of protein kinase C to the membrane, and increasing [Ca2+]i by both releasing calcium stores and promoting calcium influx ... manage cancer Some of these include the evolving understanding of how Vitamin D and cancer are related, how psychological factors contribute in the development of cancer, and present newer clinical ... Preface Cancer strikes individuals and families both unexpectedly and devastatingly In the U.S., one in two men and one in three women will be diagnosed with a non-skin cancer According to a...
Ngày tải lên: 27/06/2014, 13:20
Báo cáo khoa học: " Neuropsychological testing and biomarkers in the management of brain metastases" doc
... and in evaluating agents that modify the effects of radiation Biomarkers and neuropsychological testing also may aid in making earlier diagnoses, monitoring disease progression, and determining ... of hemoglobin that works by decreasing the binding affinity of hemoglobin to oxygen thus permitting greater oxygenation of hypoxic tumor cells and enhancing the effect of radiation In addition ... also have a role in predicting a decline in neurocognitive function Ultimately, combining the outcomes of neuropsychological testing, biomarkers and imaging will help us improve the management of...
Ngày tải lên: 09/08/2014, 09:22
Báo cáo y học: " The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports" pot
... vital signs and maintaining them within tight ranges Anaesthesia from the beginning up to the end of surgery lasted 80 minutes Postoperative care, including fluid management and weaning off the ... USA for his assistance in editing this manuscript Authors’ contributions RJ was involved in conceiving, designing and writing this manuscript MT was involved in providing a description of the ... hospital’s Pediatric Intermediate Care Unit Pain was managed using Paracetamol and Piritramid intravenously as needed After the surgery, the boy complained of a relapsing upper abdominal pain Laboratory...
Ngày tải lên: 11/08/2014, 12:20
Báo cáo y học: "Combined left hepatectomy with fenestration and using a harmonic scalpel, fibrin glue and closed suction drainage to prevent bile leakage and ascites in the management of symptomatic polycystic liver disease: a case report" pps
... possible and desirable The aim of our study was to prove the suitability of the ultrasound scissors, closed suction drain and fibrin glue in surgery for PLD In our clinic, this cutting device is mainly ... become a valuable means in surgery for PLD Handling of the instrument, cutting and coagulation quality were satisfactory and safe To achieve a better and more effective coagulating effect, the portal ... was opened and the remaining cut surface carefully inspected for residual bleeding or nonoccluded bile ducts The cut surface was plain and brownish; biliary leaks or persistent bleeding were easily...
Ngày tải lên: 11/08/2014, 14:20
Báo cáo y học: "Bench-to-bedside review: Therapeutic options and issues in the management of ventilator-associated bacterial pneumonia" ppt
... Enterobacteriaceae [including extended spectrum β-lactamase-producing strains], and Enterococcus spp and S aureus, including methicillinresistant strains [46] Against P aeruginosa, tigecycline exhibits ... than those for vancomycin, linezolid and quinupristin/dalfopristin against clinically important Gram-positive and Gram-negative aerobic bacteria, including S pneumoniae, H influenzae, M catarrhalis, ... lactamase-producing, Gram-negative bacilli in many institutions and the increasing role played by Gram-positive bacteria such as MRSA, even a protocol combining ceftazidime or imipenem and amikacin would...
Ngày tải lên: 12/08/2014, 20:20
Báo cáo y học: " A heuristic approach and heretic view on the technical issues and pitfalls in the management of penetrating abdominal injuries" pdf
... isolates the injury while it maintains the blood flow in the IVC by bypassing the injury site, is challenging to perform: just consider a tense inexperienced surgeon inserting a purse string in a flimsy ... heuristic approach and heretic view on the technical issues and pitfalls in the management of penetrating abdominal injuries Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2010, ... parenchymal injury is noted, it is important to determine the integrity of the main pancreatic duct keeping in mind the intra operative criteria introduced by Heitsch et al which includes: direct...
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects"
... (GIBCO, USA) containing 10% heat-inactivated fetal bovine serum (Nuoding, China), and the HT-29 cells were grown in DMEM medium (GIBCO, USA) also containing 10% heat-inactivated fetal bovine serum All ... Biology, Chinese Academy of Sciences (Shanghai, China) The breast cancer Bcap-37 and colon cancer HT-29 cell lines were maintained in our lab A375 cells and Bcap-37 cells were grown in RPMI1640 ... then evaluated by in vitro testing in human cancer cell lines We observed that 198 RGD-M-LCL had increased anti-proliferative activity and increased the induction of apoptosis in cancer cells compared...
Ngày tải lên: 26/10/2012, 08:57
Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... leg ulcers contain localized oxidative stress (15) The recent finding revealed that insulin resistance is associated in humans with reduced intracellular antioxidant (11) Interestingly, antioxidants ... diseases and http://www.medsci.org Int J Med Sci 2010, cellular senescence (40-45) Source of reactive oxygen species in insulin secreting pancreatic β-cells and cells that are targets for insulin action ... vomiting, diarrhea and gangrene of second toe on left foot Two weeks prior to admission, the patient had sustained fall in the bathroom resulting in a left ankle fracture with vomiting and diarrhea for...
Ngày tải lên: 26/10/2012, 09:39
John Wiley and Sons - The Portable MBA in Project Management
... project management training and consulting firm based in Seattle, Washington His company trains thousands of professionals every year in the proven principles of project management including how ... knowledge management Randall L Englund, MBA, NPDP, CBM, is an author, speaker, trainer, and consultant He is a partner in a new advanced project management training venture called Madeline Learning and ... Office Office Office Office Maintain standards Organize training Mentoring and consulting support Schedule and budget analysis Enterprise project information Make project management decisions Supervise...
Ngày tải lên: 07/02/2013, 09:32
FAILURES IN LOGISTICS MANAGEMENT OF VINALINK’S LOGISTICS DEPARTMENT AND RECOMMENDATIONS
... departments within existing transport organizations Vinalink International Freight Forwarders (Vinalink) is a long-time player in this business Since its establishment in 1999, Vinalink has provided ... operations, information packages can support warehouse manager in planning, organizing and controlling goods stocking and goods circulation In freight transport management, scheduling and routing activities ... include stock holding, packaging and repackaging, incorporating value-added activities, such as postponement, as a means of reducing the number of stock keeping units (SKUs) in a system and increasing...
Ngày tải lên: 20/04/2013, 11:13
Multi criteria analysis in environmental management: Selecting the best stormwater erosion and sediment control measure in Malaysian construction sites
... required as an input, easiness to understand and use, and so forth The most essential factors for choosing the MCA technique is the easiness of understanding by the analyst, the stakeholders and use ... quality of information (input data) needed and difficulty in obtaining them, ability to handle uncrtaines and availability of user friendly software were also concerns” Ref [17] have indicated ... university academics, and private consultants and engineers There were two scenarios for assigning ordinal scores When the ordinal scales of “high” and “very low” indicates the best and worst performance...
Ngày tải lên: 05/09/2013, 16:11
Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
... the skin, non-Hodgkin lymphoma, oral (oral cavity and pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence ... Trends in Cancer Incidence and Mortality in New Jersey, 1979-2002; • Cancer Survival in New Jersey 1979-1997; • Cancer Prevalence in New Jersey on January 1, 2003; and • Childhood Cancer in New ... inactivity, and a diet high in saturated fat and/ or red meat and low in fruits and vegetables • The lower incidence for whites and blacks in the areas with low poverty may be due in part to increased...
Ngày tải lên: 14/02/2014, 21:20
Tài liệu GENETICS IN PREVENTION AND TREATMENT OF CANCER ppt
Ngày tải lên: 15/02/2014, 04:20
Tài liệu Nanotechnology in Cancer Treatment and Detection doc
... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... affinity to Cancer cells than healthy cells (EGFR binding) White light and simple, inexpensive microscope is all that’s necessary for powerful ex vivo Cancer detection The scattering is so strong...
Ngày tải lên: 15/02/2014, 05:20
Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... cultured in Dulbecco’s modified Eagle’s medium containing 10% foetal bovine serum, 100 UÆmL)1 penicillin, 1.0 mgÆmL)1 streptomycin and mM L-Glu For treating BxPC3 cells and clones with drugs affecting ... formed in metabolically radiolabelled cells The main radioactive oligosaccharides formed in BxPC3 cells (j in lower part, and A, B, and C of upper part) and T5AS clone (h in lower part, and A, B, and ... elevated in the serum of patients with various abdominal illnesses [32] including cancers of the digestive tract [33–35] Moreover, it is an E-selectin ligand [36] and may be involved in the metastatic...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Obesity guidance on the prevention, identification, assessment and management of overweight and obesity in adults and children ppt
... This includes policies relating to building layout and recreational spaces, catering (including vending machines) and the food and drink children bring into school, the taught curriculum (including ... diet and be physically active, in line with existing standards and guidance This includes policies relating to building layout and recreational spaces, catering (including vending machines) and ... weight gain, improving diet (and reducing energy intake) and increasing activity levels in children should involve parents and carers NICE clinical guideline 43 26 1.1.4.3 Nurseries and other...
Ngày tải lên: 21/02/2014, 11:20
Tài liệu Integrated Management of Childhood Illness Caring for Newborns and Children in the Community doc
... Convulsions? Swelling of both feet? Difficulty drinking or feeding? If yes, not able to drink or feed anything? Vomiting? If yes, vomits everything? Any other problem? IDENTIFY PROBLEMS: ASK AND LOOK ... MUAC strap Not able to drink or feed anything Swelling of both feet Vomits everything If NO Danger Sign Go to page Begin treatment and Assist referral To begin treatment and assist referral Go ... WHO Library Cataloguing -in- Publication Data: Integrated management of childhood illness: caring for newborns and children in the community v Contents: Manual for the community...
Ngày tải lên: 21/02/2014, 14:20