diagnostic and prognostic cancer biomarkers from traditional to systems approaches

... procalcitonin test probability may turn into high post-test probability of bacterial infection and therefore more suitable care Biological markers must be considered diagnostic and prognostic tools ... assay (Kryptor PCT, Brahms, Hennigsdorf, Germany) This assay is based on a polyclonal antibody against calcitonin and a monoclonal antibody against katacalcin, which bind to the calcitonin and katacalcin ... procalcitonin and white count Acad Emerg Med 2004, 11:393-396 van Langevelde P, Joop K, van Loon J, Frolich M, Groeneveld PH, Westendorp RG, van Dissel JT: Endotoxin, cytokines, and procalcitonin...

Ngày tải lên: 13/08/2014, 03:21

... Wharton School of Business “Here is anything and everything you need to know about where marketing stands today and where it’s going tomorrow You can plunge into this tour de force at any point from ... bring it to the customer’s attention and easy access, and how to keep the customer wanting to buy more from you Furthermore, marketing strategy and actions are not only played out in customer markets ... your company also has to raise money from investors As a result you need to know how to market to investors You also want to attract talent to your company So you need to develop a value proposition...

Ngày tải lên: 21/09/2012, 17:33

... owners rarely switch to another brand Nor Apple Macintosh users want to switch to Microsoft A well-known brand fetches extra pennies The aim of branding, according to one cynic, “is to get more money ... How are brands built? It’s a mistake to think that advertising builds the brand Advertising only calls attention to the brand; it might even create brand interest and brand talk Brands are built ... genius, faith and perseverance to create a brand.” The sign of a great brand is how much loyalty or preference it Brands commands Harley Davidson is a great brand because Harley Davidson motorcycle...

Ngày tải lên: 24/10/2013, 08:20

... Insights from A to Z • From mass marketing to customized marketing The mass market is splintering into mini-markets and your company now has the capability of marketing to one customer at a time • From ... customer at a time • From owning assets to owning brands Many companies are beginning to prefer owning brands to owning factories By owning fewer physical assets and outsourcing production, these companies ... training, exchanging, and communicating • From single-channel marketing to multichannel marketing Companies no longer rely on one channel to reach and serve all their customers Their customers have different...

Ngày tải lên: 24/10/2013, 08:20

... great value to customers The customers would spend more and cost the firm less to serve Everyone would benefit, and special rewards would go to employees who rendered outstanding customer service ... structure, systems, and technology to empower the workforce to take any steps necessary to satisfy its target customers Today’s CEOs must show employees, in financial terms, how much more affluent they and ... is to watch your competitors, it is more important to obsess on your customers Customers, not competitors, determine who wins the war Most markets are plagued by too many fishermen going after too...

Ngày tải lên: 24/10/2013, 08:20

... iron, and lead customers The better customers should be given more benefits, both to retain them longer and to give other customers an incentive to migrate upward 40 Marketing Insights from A to ... opportunity to so.” Products come and go A company’s challenge is to hold on to its customers longer than it holds on to its products It needs to watch the market life cycle and the customer life ... competitors Some customers are profitable but tough They can be a blessing If you can figure out how to satisfy your toughest customers, it will be easy to satisfy the rest Pay attention to customer...

Ngày tải lên: 24/10/2013, 08:20

... choice to customers, (2) the employer of choice to employees, (3) the partner of choice to distributors, and (4) the company of choice to investors Its reputational capital will contribute to its ... opportunity to experience the cowboy West, fairyland castles, pirate 62 Marketing Insights from A to Z ships, and the like The aim of the experiential marketer is to add drama and entertainment to what ... with dignity and worth.” At a board meeting, coffee was accidentally spilled on the carpet and a janitor was called in Bill took the cleaning solvent from the janitor and knelt down to clean the...

Ngày tải lên: 24/10/2013, 08:20

... a day in response to orders from individual store managers of what they expect to sell in the next few hours 7-Eleven not only trains its store operators to capture customer and sales information ... to sell their ideas to their investors, peers, and staff Leaders need to be teachers and teach others to be leaders Bad managers, in contrast, rely on command and control to get their ideas carried ... foreign distributors carefully They need to define distributor performance very clearly and be aware of host country laws regarding distributor treatment The distributors need to be given adequate...

Ngày tải lên: 24/10/2013, 08:20

... loyal customers Too often, however, companies give a better deal to new customers than to their old customers Thus a telecom company may offer brand-new handsets and a reduced-price call plan to attract ... clerks handle difficult questions from customers, how well telephone operators answer phone calls, how easy it is to locate merchandise in a store, and many other uses Mystery shopping is used to evaluate ... company prices too high, saying that more money should go to the sales force (and less to advertising) to raise their compensation or to hire more salespeople When marketing and sales get into conflict,...

Ngày tải lên: 24/10/2013, 08:20

... Goals and Performance Measures • Percentage of new customers to average number of customers • Percentage of lost customers to average number of customers • Percentage of win-back customers to average ... product • Staying in touch with customers after the sale to ensure that they are satisfied • Gathering customer ideas for product and service improvements and conveying them to the appropriate departments ... respect to customers? At least the following: • Detecting and evaluating new opportunities • Mapping customer perceptions, preferences, and requirements • Communicating customer wants and expectations...

Ngày tải lên: 24/10/2013, 08:20

... retailers to carry two or three store brands pitched at different quality and price levels The main requirement was to create trust in the retailer and to give good value to the customer Fourth, ... more customers are attracted by its lower price) This works when the low-price firm gives good quality and service to its customers Profits come from finding ways to deliver more value to customers ... the factory Don’t fix them there Send them to the dealer and let the dealer fix them There was no thought about the cost to the customer who had to drive back to the dealer, give up the car, and pray...

Ngày tải lên: 24/10/2013, 08:20

... high attention to the brand, add to its credibility, and offer reassurance Not surprisingly, 169 170 Marketing Insights from A to Z singers, actors, and sports figures stand ready to sell their ... day, and Lands End can answer 90 percent of the calls within 10 seconds Overflow calls are routed to stand-by operators working at home And customers 180 Marketing Insights from A to Z who use Lands ... Boeing “the toughest customer we have” and they’re grateful for it By meeting the standards of a demanding customer, the company finds it much easier to satisfy their less demanding customers arget...

Ngày tải lên: 24/10/2013, 08:20

... exclusively to the never -to- be-superseded topics of love, war, and wine The people of our day have little heart or appreciation for song, except in Scotland and Ireland England and America are too prosaic ... Queen's." With face and fashion to be known, With eyes all white, and many a groan, With neck awry and snivelling tone, And handkerchief from nose new-blown, And loving cant to sister Joan; 'Tis ... He is declared to be, And that his lands, as well as goods, Sequester'd ought to be As if our prisons were too good, He is to Yarmouth sent, By virtue of a warrant from The King and Parliament...

Ngày tải lên: 06/03/2014, 13:20

Ngày tải lên: 23/03/2014, 13:20

... look into data in your web applications You’ll see how to download, configure, and manage a SQL Server Express instance, and how to access the data and functionality in it from code, from UI tools, ... Applications CHAPTER Introduction to Web Development T o understand web development, you have to understand the Web, and to understand the Web, you have to understand the Internet that the Web is ... scenario of a store wanting to provide links to potential customers of their current products Their inventory changes rapidly, and static documents require people who understand the inventory and can...

Ngày tải lên: 27/03/2014, 13:34

... emerging hallmark of cancer cells and plays important roles in cancer progression and metastasis (Hanahan and Weinberg, 2011) With regard to cancer therapy, blockade of CTLA-4 (cytotoxic T lymphocyte-associated ... CANCER PREVENTION – FROM MECHANISMS TO TRANSLATIONAL BENEFITS Edited by Alexandros G Georgakilas Cancer Prevention – From Mechanisms to Translational Benefits Edited by Alexandros G ... factors, cytokines, chemokines and ECM proteases to stimulate angiogenesis and cancer cell proliferation and invasion For example, CAFs secrete elevated levels of stromal cell-derived factor...

Ngày tải lên: 28/03/2014, 10:20

... chickens, and has been expanded to include recommendations for the care and handling of turkeys Each section pertaining to a particular type of poultry (eggs, broilers and roasters, and turkeys) is to ... should be designed and located to permit transport vehicles to turn around, to reach them without having to back out of a public road, and to leave them without having to back into a public road ... Facilities for and handling of caged poultry 5.1.1 Owners and operators of poultry operations have a responsibility to provide facilities and equipment that make bird handling, loading, and unloading...

Ngày tải lên: 31/03/2014, 08:20

... seems to be very bright and promising) to the understanding of human reasoning and cognition They are also developing novel methods for dealing with systems and processes that are too complex to ... neurosensory systems (such as neurovision systems) and neurocontrol systems will be the key to the development of truly intelligent control systems and, in general, intelligent systems We also ... to the mid-1960s, were devoted to the use of "precise" mathematical tools in systems theory and decision processes No doubt, this work made a great contribution to the field of controls and systems, ...

Ngày tải lên: 03/06/2014, 02:13

... immunobiology and role in immunomodulation and tissue regeneration Cytotherapy 2009, 11:377-391 doi:10.1186/1479-5876-8-31 Cite this article as: Stroncek and Puri: Cell and gene therapies: moving from ... hypothesis We welcome contributions from all those participating in this field; clinicians, scientists, and engineers from academia, industry and the regulatory community Author details Department ... Cell and Gene Therapy Section is to advance this field by reporting the results of translational medicine studies and by being a forum for the exchange and discussion of new information, ideas and...

Ngày tải lên: 18/06/2014, 16:20

... Immunotherapy of Cancer (SITC) The purpose of this Summit is to bring clinical and laboratory investigators and those involved with producing, assessing and regulating cellular therapies, together to present ... protocols have also begun to use NK cells Clinical investigators interested in treating both cancer and hematologic malignancies and leukemia have been using both allogeneic and autologous natural killer ... cancer involves arming autologous T cells with T cell receptors (TCR) that have a high affinity to cancer antigens, expanding these genetically modified T cells in vitro and infusing them into...

Ngày tải lên: 18/06/2014, 22:20