... to the American Association for Accreditation of Laboratory Animal Care guidelines The Wyeth Institutional Animal Arai et al Journal of Translational Medicine 2010, 8:51 http://www.translational-medicine.com/content/8/1/51 ... 10.1186/1479-5876-8-51 Cite this article as: Arai et al., Development and application ofa biomarker assay for determiningthe pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R ... developed a human blood biomarker assay that detects the blocking activity of Ab-01, an antibody to IL21R In parallel we have developed an adaptation of this assay and used it to demonstrate that the...
... two main categories on the basis of Attardo‟s and Oaks; classifications: lexical and syntactic ambiguity The latter was further divided into class ambiguity and a miscellaneous class of ambiguities, ... A lot of women don’t care who wear the pants in the family, as long as there is money in the pockets Have a look at another example: (15) The friendly gardener had a lot of thyme for the woman ... Pharaoh‟s Court 81 Q What‟s black and white and read all over? AA newspaper 82 A friend in need is a friend to avoid 83 A lot of women don‟t care who wear the pants in the family, as long as there...
... another main task ofthe department • Financial and Accounting department: this department deals with all financial and accounting matters Another main function is to manage the use of capital ... about a multinational join stock company’s product quality or the quality ofthe maintenance work that its staff have done, but has complained about the late reply and maintenance service ofthe ... companies including a multinational join stock company Secondly, a multinational join stock company size and market share have been small The shortage of capital is main cause ofthe company’s...
... first alternative of solving the problem, what can we suggest? We have another alternative, which is called “Simplification of access to computer classes.” We mean the organization of computer classes ... for them, instead of learning how to it themselves The third cause is lack of access to computer The fourth cause is dissatisfactory school base The fifth cause is insufficient allocation of application ... The problem of computer illiteracy as a one ofmain problems of business students Symptoms Themain symptom ofthe computer illiteracy is an inability in computer working For example,...
... Indicates that no action takes place SetDefault Indicates that the DataColumn values in the child DataTable are to be set to the value in the DefaultValue property ofthe DataColumn SetNull Indicates ... to the parent table Updating the Primary Key ofa Parent Table and Pushing the Change to the Database In this section you'll learn what happens if you attempt to update the primary key in a parent ... that the DataColumn values in the child DataTable are to be set to DBNull By default, UpdateRule is set to Cascade; therefore, when you change the DataColumn in the parent DataTable on which the...
... PsativumA SoleraceaA 197 Chlamy 200 Synechocystis 198 Synechococcus 199 R R R R R R R R R R R R R R R R R R R R AAAAAAAAAA R R R R R R R R R R AAAAAAAAAAAAAAAAAAAAA ... T T T T T G G G G G G G G G G AAAAAAAAAAAAAAAAAAAA K K K K K K K K K K AAAAAAAAAA V V V V V V V V V V S S S S AAA S AA L L L L L L L L L L V V V V V V V V V V L ... with NADH and NADPH, but the catalytic rate constant using NADPH was only half that ofthe wild type The catalytic efciency, expressed as kcat/Km, ofthe R197E mutant using NADPH was then about...
... Proceedings of Fifth Annual Meeting ofthe North American Chapter ofthe Association for Computational Linguistics Ravi Sinha and Rada Mihalcea 2007 Unsupervised graph-based word sense disambiguation ... disambiguation In the 12th Conference ofthe European Chapter ofthe ACL Satanjeev Banerjee and Ted Pedersen 2003 Extended gloss overlaps as a measure of semantic relatedness In Proceedings ofthe ... Empirical Methods in Natural Language Processing Weiwei Guo and Mona Diab 2012 Modeling sentences in the latent space In Proceedings ofthe 50th Annual Meeting ofthe Association for Computational...
... d(5¢-AACAACGCAGCTGGGCTCTG GAACCAT), ECF -A1 41Q d(5¢-TCAACCTCTAACCAG GCTACTCCGCTG) ECM-G77Q d(5¢-AACAACGCTGG CCAGCACGCTAACCAC) and ECM-Q14 6A d(5¢-TCT ACTGCTAACGCGGATTCTCCGCTG) following the manufacturer’s ... induced simultaneously after inoculation of media with cultures grown to exponential phase in the absence of paraquat and IPTG (Materials and methods [24]) The final concentration of paraquat and IPTG ... active site ofthe enzyme by reducing the occupied internal volume, allowing the introduction of an extra water molecule [29] Replacement ofthe same residue by Ala similarly maintains the same...
... functionality of such a triad is affected by the surrounding residues The results so far indicate that larger parts ofthe polar core ofthe catalytic TIM barrel of family 18 chitinases play a role ... mutant retains considerable activity, whereas the D14 2A mutant does not It has been shown by X-ray crystallography that replacement ofthe Asp142 analogue by alanine in other family 18 chitinases ... environmental factors that are taken into account in the calculations (background charges, desolvation penalty and the interaction with other titratable residues), the first factor was found to be the major...
... discusses the use of HHMMs for the text chunking task and the grammar parser The evaluation results ofthe HMM, the plain HHMM and the merged and partially flattened HHMM are presented in Section Finally, ... chunking task The results suggest that the partial flattening process is capable of improving model accuracy when the input data contains complex hierarchical structures The evaluation involves analysing ... states, whereas each state in the standard model corresponds is a production state that contains a single observation 2.1 Merging AA (a) AA (b) Figure 1: Example ofa HHMM Figure 1 (a) and Figure...
... SUMA software: subsite mapping of amylases This software calculates the apparent binding energies on the basis ofthe measured bond cleavage frequencies The calculations are based on the equation: ... Subsite map of barley a- amylase isoenzyme The binding a nities were calculated according to the data of Table Fig Subsite maps for porcine pancreatic a- amylase (PPA) The solid bars are related to ... can vary according to the calculations The primary calculated subsite energy values can be refined to the best agreement ofthe measured and recalculated BCF data by the iteration Fig shows the...
... Murakawa, M., Takahashi, S., Tsubuki, S., Kawashima, S., Sakamaki, K & Yonehara, S (1998) Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian ... hTRXL-N may account for the formation ofa monomer, instead ofa dimer in the case of TRX Furthermore, the loss of intermolecular disulfide-bonds and the disbandment ofthe hydrophobic patch may also ... 1ERT) as a search model, then refined smoothly in alternating steps of automatic adjustment with CNS and manual adjustment with the program O [34] The final model has a final R-factor of 0.222 with a...
... phosphorylation ofthea subunit Another function of AclB was found to be stabilization ofthe enzyme, as AclB prevented the degradation of AclA that was otherwise observed in the absence of AclB After ... into account the reaction mechanism of mammalian ACL [23], the nal step ofthe reaction can be assumed to be the nucleophilic attack of CoA to the phosphorylated carbonyl carbon of citryl phosphate, ... dissociation (AB) are shown in lanes and 4, the individual AclA subunits (a) are shown in lanes and 5, and AclB subunits (b) in lanes and Molecular masses (kDa) are indicated on the side of each panel The...
... bremsstrahlung irradiated in to the sample, Nm and Ng are the number of nuclei in the metastable and the ground state Figure Production and decay ofthe metastable and the ground state In gamma spectra, ... and λg are the decay constants of these states, Pm,g is the branching ratio for the decay of metastable to ground state, N0 is the number of target nuclei, φ(t) is the flux of beam per 1cm2 of bremsstrahlung ... Figure Gamma spectrum of 44 Sc measured by Gammavision Spectrometry 3.2 Calculation of typical peak area In the gamma spectrum of 44 Sc, there are two spectral peaks with energies of 271keV created...
... bremsstrahlung irradiated in to the sample, Nm and Ng are the number of nuclei in the metastable and the ground state Figure Production and decay ofthe metastable and the ground state In gamma spectra, ... and λg are the decay constants of these states, Pm,g is the branching ratio for the decay of metastable to ground state, N0 is the number of target nuclei, φ(t) is the flux of beam per 1cm2 of bremsstrahlung ... Figure Gamma spectrum of 44 Sc measured by Gammavision Spectrometry 3.2 Calculation of typical peak area In the gamma spectrum of 44 Sc, there are two spectral peaks with energies of 271keV created...
... studying the influence of laser parameters on saturated values of mode photon densities, we vary one of parameters in table and remain invariable all the rest of parameters The obtained results are ... Mathematics - Physics 23 (2007) 139-142 Discussion and conclusion In the stationary operation of two-mode random microlaser, the variation of laser parameters influences clearly on the transformation ... reveals that the increase of one mode photon density caused in the decrease ofthe other one Fig 1a Gain coefficient α1 varies Fig 1b Gain coefficient α2 varies D.V Hoang, M.H Hanh / VNU Journal...
... S1 at Lemma 4.10 There exist the following asymptotically universal bounds: n area(P0 An+2 ) n area(P0 n area(Pqn+1 An+2 ) n area(Pqn+1 area(Qn An+2 ) area(Qn An+2 ) An+2 ) An+2 ) n n area(P0 ... notion can be extended to arbitrary domains on the sphere C; it suffices to replace the Euclidean area with the spherical area in the growth condition (2.7) David proved that the analogue ofthe measurable ... neighborhood of U {x(U )}, where x(U ) is the root of U The boundary of each puzzle piece P consists ofa rectifiable arc in A( ∞) and a rectifiable arc in J(F ) The latter arc starts at an iterated preimage...
... Tzafriri, Classical Banach Spaces I Sequence Spaces, -index ofa Banach space, Israel J Springer-Verlag New York (1977) [Mc] R A McGuigan, Jr., Near isometry of Banach spaces and the Banach-Mazur ... lemma follows from Lemma and thethe classical fact that every separable Banach space 1-embeds into C[0, 1] Lemma is false for some nonseparable spaces Partington [P] and Talagrand [T] proved that ... paper is a solution to Sch¨ffer’s problem for a separable Banach spaces: Main Theorem If X is a separable infinite dimensional Banach space, then D(X) = ∞ Part ofthe work for proving theMain Theorem...
... ML, Maisetta G, Di Luca M, Gaddi LM, Esin S, Florio W, Brancatisano FL, Barra D, Campa M & Batoni G (2008) Comparative analysis ofthe bactericidal activities of amphibian peptide analogues against ... where A and B are the MICs of drug A and drug B in the combination, MICA and MICB are the MICs of drug A and drug B alone, FICA and FICB are the FICs of drug A and drug B and n is the number of ... represents the first example ofthe effects of an antimicrobial peptide from frog skin on the proteome of bacteria, and demonstrates that the bacterial membranes are the major targets of its mechanism of...