cytoprotective mechanisms in the vasculature
Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf
... both oral and intraperitoneal administration of simvastatin [36] Continuing studies are addressing the local cell-specific pathways subserving these in vivo observations Finally, statins have recently ... simvastatin Furthermore, it is clear that statin therapy has even short-term benefits when administered in the setting of the acute coronary syndrome in patients with normal cholesterol levels The ... lipid lowering in cardiovascular disease? The increasing body of evidence for the efficacy of statins in protecting against vascular events irrespective of cholesterol status has prompted investigation...
- 7
- 334
- 0
Báo cáo y học: " Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies" doc
... This increasing knowledge has a great potential to improve our understanding of the role of these inflammatory cells in disease mechanisms in IIMs In this review we summarize the latest findings ... immune mechanisms in IIMs Taken together, they demonstrate the complexity of involvement of the immune system in these diseases and suggest that both the innate and adaptive immune systems are involved ... perivascular/perimysial In endomysial infiltrates there was a striking dominance of CD8+ T lymphocytes, which could even be the predominating infiltrating cell type, followed by macrophages and CD4+ T lymphocytes These...
- 12
- 442
- 0
NOVEL MECHANISMS IN THE REGULATION OF PERINUCLEAR ACTIN ASSEMBLY 2
... by the LIM kinases 1.1.2.2.3 G1actin)binding)proteins) Actin monomer binding proteins contribute to maintaining the physiological F-/G-actin homeostasis Thymosin-β4 and profilin are two main ... participating in the assembly of perinuclear actin network This thesis has provided new findings and hypotheses on the regulation of perinuclear actin It shows that the dynamics of perinuclear actin ... 2013) In addition, the actin crosslinking protein, α-actinin, is inhibited from bundling actin filaments by calcium (Burridge and Feramisco, 1981) On the other hand, calcium-induced actin polymerization...
- 141
- 266
- 0
Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic and degradative enzymes, the endocannabinoid ... significantly increased following the ischemia-like insult [42] The endocannabinoid system in cerebral ischemia The ‘dark side’ of CBs An independent line of research supports a contrasting, neurotoxic ... Concluding remarks The great deal of knowledge accumulated in the past three decades on the mechanisms underlying damage in icted to the brain tissue by cerebral ischemia has failed to translate into...
- 11
- 385
- 0
Allergic Diseases – Highlights in the Clinic, Mechanisms and Treatment Edited by Celso Pereira docx
... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling to the immune system after environmental exposure The third group are ... keratinocytes dividing in the basal lamina and moving to the upper layer as they mature K10 is expressed in keratinocytes in the early stages following differentiation, whereas K14 is expressed in undifferentiated...
- 566
- 726
- 0
Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx
... intolerance Fat cells Fig Model for the role of ApoE in the development of diet-induced obesity in mice Dietary lipids are packaged into chylomicrons in the intestine and then secreted into the ... avidly by adipose tissue than the lipoproteins containing mouse ApoE There has been much discussion in the medical community concerning the role of in ammation in obesity In particular, although some ... interpretation of the results obtained by Huang et al [41] is that intrinsic defense mechanisms in adipose tissue limit adipogenesis by reducing the expression of ApoE in the fed state Certainly,...
- 9
- 655
- 0
Báo cáo hóa học: " Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice" ppt
... are indicated in bold/underlined) from the template of a pUC19 plasmid DNA containing GH1 (Xinxiang Medical University, Xinxiang, Henan Province, China) The 677-bp GH1 DNA fragment (including the ... was gradually increased from 17% to 35% during the first week of feeding and then maintained at the same concentration for another weeks [25] Food intake was recorded daily in the control and ... higher in the GH1-treated control group than in the control group throughout the experiment (Figure 2A) The body weight in the control group was 26.47 ± 1.02 g at the end of the study but did not increase...
- 15
- 392
- 0
báo cáo hóa học: " Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems" docx
... during experimental stress Type D was also associated with a decreased activity in the amygdala in response to fearful expressions [10], suggesting inadequate emotion-processing in the brain Finally, ... endothelial progenitor cells [47] in cardiac patients These initial findings are promising, but more research is needed to examine the cardiovascular effects of stress in apparently healthy individuals ... myocardial infarction, and increased risk of mortality [4-7] Given the clinical relevance of findings on Type D research in the context of cardiovascular disorders, it is also important to assess the...
- 10
- 595
- 0
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... expressing CCR1, CCR2 or CCR5 mRNA within and around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages, ... rats in the acute phase (day 13) revealed marked inflammatory lesions in the white and grey matter of the spinal cord (Fig 3D) Within the inflammatory infiltrates, numerous actively phagocytosing...
- 13
- 559
- 0
ALLERGIC DISEASES – HIGHLIGHTS IN THE CLINIC, MECHANISMS AND TREATMENT potx
... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling to the immune system after environmental exposure The third group are ... keratinocytes dividing in the basal lamina and moving to the upper layer as they mature K10 is expressed in keratinocytes in the early stages following differentiation, whereas K14 is expressed in undifferentiated...
- 566
- 1,081
- 0
Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... chemokines in RA synoviocytes, especially in the presence of TNF-α, highlighting its role in neutrophil recruitment into the joint [49] Furthermore, IL-17 induces the production of GCP-2 in a ... as the percentage of swelling (i.e 100 × the difference between the increase of thickness of the left and the right ears, divided by the thickness of the right ear) at the indicated time points ... PBS in the right ear DTH response was calculated as the percentage swelling (the difference between the increase of thickness of the left ear and the right ear, divided by the thickness of the...
- 13
- 560
- 0
Báo cáo y học: "Anti-Inflammatory mechanisms of the proteinaseactivated receptor 2-inhibiting peptide in human synovial cells" ppt
... 30 minutes and then incubated with trypsin at 30 nM for hours The addition of trypsin to the cells, pretreated with the PAR2-AP, further enhanced the COX-2 level (Figure 3B) These results indicate ... bacterial infection, or the treatment of either trypsin or PAR2-AP, and mediated inflammation in some cell types [19,20] Inhibition of COX-2 antagonized trypsin-induced PAR-2-dependent itching in an ... cells were individually resuspended in DMEM containing 10% fetal bovine serum (FBS), a 1% penicillinstreptomycin solution, a 1% amphotericin B solution, and 1% L-glutamine, and then incubated...
- 9
- 381
- 0
báo cáo khoa học: "The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation" pps
... characteristic methyl bands shielding or to the dissolution of certain groups during the process of obtaining the nanoemulsion In the case of the bands group in the range of 1150-1250 cm-1, characteristic ... stretching), an increase in the intensity of the bands is observed, which is reflected in the decrease of its transmittance from 96% to 56% This is also explained by the increasing of the quantity ... nanoemulsions induced a reduction in collagenase activity The intensity of antiinflammatory effect varies with time interval covered by the assessment of therapeutic response according to data in Table The...
- 9
- 529
- 0
Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... synthesized IκB can enter the nucleus, pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating ... switches off the induction of Bcl-2 and rather predominates Bax in controlling apoptosis within the perinatal lung This reinforces the presumption that signaling pathways mediating apoptosis in response...
- 27
- 342
- 0
Báo cáo khoa học: "A Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis" docx
... damage to the small intestine in endotoxinaemia In both of these studies, the effect of antithrombin on the leucocyte– endothelium interaction could be abolished by indomethacin, which is an inhibitor ... leucocyte adhesion to the endothelium Antithrombin inhibited the tumour necrosis factor (TNF)-α induced increase in E-selectin expression in endothelial cells by inhibiting the interaction of NF-κB ... namely the α and the β forms, which not differ from each other in their thrombin inhibiting effect, but they differ in their affinity for heparin Under normal conditions, 85–95% of circulating antithrombins...
- 9
- 393
- 0
Báo cáo y học: " Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage" ppt
... antiretroviral therapy since their binding to HIV-1 LTR in a sequence specific manner is associated with the repression of LTR activity [97,98] Interestingly, zinc-finger protein can influence the chromatin ... from the critical role CCR5 plays in maintaining HIV-1 infection, this study also raises the possibility that the main target to cure the patients from AIDS are the peripherical circulating cells ... for controlling viral expression in the human macrophages Inhibition of the NFAT5-LTR interaction by using small interfering RNA is also promising since it suppresses HIV-1 replication in primary...
- 16
- 299
- 0
Báo cáo y học: "Theoretical analysis of the mechanisms of a gender differentiation in the propensity for orthostatic intolerance after spaceflight" docx
... approach to the problem was used to integrate many of the experimental findings in to a more comprehensive theory of understanding [14] The analysis suggested that changes in the capacitance of the lower ... due to their inherent lower center of gravity and proportionately larger mass in the lower extremities Examining the theoretical consistency of the hypothesis in the context of the current considered ... blood in the capacitance veins of the lower extremities of the woman during the movement to the upright posture due to effective differences in vascular compliances as compared to the man The resultant...
- 8
- 337
- 0
Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx
... according to the stringent definition; if d ≤ 11, then two genes belong to a TAG according to the nonstringent definition We then clustered two-gene TAGs into larger TAGs by using a single linkage ... plotted in R [46] in both two-copy gene families and in the entire genome The interval of the data points in terms of Ks of the curves is 0.01 Because initially genes are singletons and the duplication ... shown in Table (a) TAGs in two-copy families The NEW gene set is plotted in bold broken lines, the linear functions of which are Hn and Mn (red) The FAM2 gene set was plotted in bold lines, the linear...
- 11
- 357
- 0
Báo cáo y học: "Origin of nascent lineages and the mechanisms used to prime second-strand DNA synthesis in the R1 and R2 retrotransposons of Drosophila" doc
... retained in the various species lineages [28] Eleven of the sequenced Drosophila species contained a single R1 family of either the R1A or R1B lineage, while D ananassae contained both lineages ... 2b) The only consistent difference in structure between the two lineages was that the two ORFs in the R1A lineage overlapped by bp with a corresponding frame shift of -2, while the ORFs in the ... evolving promoter sequences R1 elements have been suggested to contain their own promoters because in some insect lineages R1 inserts in the opposite orientation in the 28S gene, or even outside the...
- 17
- 240
- 0
THE MECHANISMS REGULATING THE TRANSCRIPTION FACTOR ATF5 AND ITS FUNCTION IN THE INTEGRATED STRESS RESPONSE
... 38) The resulting phosphorylation of eIF2α during ER stress reduces protein synthesis, lowering the influx of nascent polypeptides into the stressed ER 10 binding to the protein kinase domain ... heme-binding protein expressed predominantly in erythroid cells (51, 52) HRI contains two heme-binding sites, one in the N-terminus, and a second located in an insert region in the middle of the ... dsRNA-binding domains (dsRBDs), while the protein kinase domain is located at the C-terminus During virus invasion, binding of double-strand RNA to the dsRBDs brings two PKR molecules in close...
- 104
- 258
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008