cytoprotective mechanisms in the vasculature

... genes being categorized into more than one group In the molecular function category, genes assigned to the “catalytic activity” and “binding (other binding)” groups are highly enriched In the cellular ... speculation In the future, it will be critical to determine whether the two genes are involved in the translocation of Al and/or iron in buckwheat and to examine how Al activates the expression of the ... induced by the Al treatment (Figure 6B) The MATE genes in the FRD3 subgroup have been demonstrated to be involved in the translocation of iron through the release of citrate to the xylem or in

Ngày tải lên: 26/05/2020, 23:31

... observations, in combination with the constitutive activation of SPL7 targets, when ectopically expressing the N-terminal part of SPL7 including the SBP domain, shed some light on the mechanisms governing ... metallochaperones (Figure 8) The respective interacting SPL7 domain(s) is then most likely C-terminal of the SBP-domain An overlap with the IRPGC domain, as the main conserved signature within this region, ... further confirm the SPL7-SPL7 interaction, the entire SPL7 coding sequence was amino-terminally fused to the Influenza hemagglutinin (HA) epitope tag (HA::SPL7) and co-expressed with GFP::SPL7 in

Ngày tải lên: 27/05/2020, 01:11

... [16,19,22,23,29,30], and in ancient birds [21] In C nuchalis, C86 therefore plays an important role in maintaining sensitivity in the violet range, as the replacement of C86F shifts λmax into the ancestral ... combination at the two spectral tuning sites known to be most important in specifying UVS or VS in vertebrates: C86/S90 This residue combination has been found in a few passerine SWS1 opsins in ... spectral tuning mutants of C nuchalis SWS1, finding that λmax is affected similarly by the mutations C86S, C86F and S90C as in other avian SWS1 opsins, suggesting spectral tuning in avian SWS1

Ngày tải lên: 02/11/2022, 10:43

... observed; the first is the breakdown of actin filament-containing structures including microvillar actin bundles and stress fibers, with the actin they contain being re-distributed to other ... the binding with multiple partners including cortactin Figure 3 Dynamin structural domains Fig 3 The structural domains of dynamin and the interaction of dynamin with cortactin (see ... ischemia Dynamin The SH-3 domain at the C-terminus of cortactin can bind with the proline-rich domain of multiple partners, one of which is dynamin [64] Co-localizing with cortactin and/

Ngày tải lên: 24/08/2014, 12:36

... two hypothetical cases to examine the perceptions of auditors and directors in Singapore about corporate governance practices relating to the quality of financial reporting and auditing. In the first ... addresses the scarcity of research in this environment by explor- ing governance issues relating to the quality of financial reporting and auditing in Singapore. In spite of its size, Singapore ... listed companies in Singapore participated in two experimental cases. In the first, the strength of the audit committee, the exist- ence of an internal audit function and the strength of the company’s

Ngày tải lên: 06/01/2015, 19:49

... Mabuchi, I (2006) Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast Genes ... T., Narumiya, S., and Inagaki, M (2000) Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow ... each protein involved in cytokinesis at a high spatial and temporal resolution In this thesis, I have studied the molecular mechanisms that regulate the determination of the position of the cleavage

Ngày tải lên: 14/09/2015, 14:09

... (3) depletion of circulating neutrophils reduces ischemic brain injury (Feuerstein et al., 1998) On the other hand, anti-inflammatory cytokines in the CNS maintain homeostasis and. .. that ... of brain injury, includes: (1) the capacity of pro-inflammatory cytokines to exacerbate brain damage; (2) the capacity of proinflammatory cytokine blockade to reduce ischemic brain damage; ... recombinant rat fractalkine (rrfractalkine), the ligand for CX3CR1 induce the migration of rMSCs in a heterotrimeric G protein-dependent manner in vitro Furthermore, rhSDF-1α injected

Ngày tải lên: 16/09/2015, 17:12

... incorporation into the posterior structures of the embryo This result highlights the early commitment of cell fate during the blastula period, and links the positions of cells in the gastrula to their ... to answer the question Most importantly, is it the right question to begin with I thank Chai Chou, fellow lunatic and masochist, for showing me the meaning of staying the course In the face of ... Lee-Thean Chu, another fellow traveller, for painstakingly proof-reading my manuscripts and this thesis I thank Paramjeet Singh, a dear friend and mentor in my formative years, for showing me the

Ngày tải lên: 16/09/2015, 17:12

... also named “Chinese Motherwort”, belongs to the Labiatae family in the plant kingdom (Figure 2-5). The major known ingredients in HL include stachydrine, leonuridine, leonurinin, benzenoid (Leo), phenylpropanoid, monoterpenoid, ... shown the effects of scavenging free radicals and inhibiting the formation of reactive oxygen species in vitro, indicating that pHL may play a key role in enhancing the antioxidant system during ... Secondary Injury After TBI, the damage of brain tissue can be caused by primary and secondary injury mechanisms. The primary injury refers to the direct effects of mechanical injury on the brain tissue.

Ngày tải lên: 02/10/2015, 17:15

... often defines the. .. fecal-oral route The cysts develop into vacuolar forms in the large intestines In the human intestine, vacuolar forms divide by binary fission and may develop into ... forms in the large intestines. In the human intestine, vacuolar forms divide by binary fission and may develop into amoeboid or granular forms. Encystations of vacuolar forms may occur in host intestines ... these infections is being... mammalian molecules involved in cell death signaling are missing in the protozoa and the molecular architecture of PCD in protozoan parasites therefore

Ngày tải lên: 16/10/2015, 15:35

... toxic to the cells that are the part where the inflammatory event initiates [7072] In the initial stages, the atherosclerotic plaque forms beneath the intima media - inside the arterial wall and gets ... This intricate process is mediated by selectins integrins and vascular adhesion molecule 1, starting with monocyte migration [104] through the endothelium into the sub-endothelial space in the intima- ... 105-110] THE IMMUNE SYSTEM IN ATHEROSCLEROSIS AND THE IMPORTANCE OF CYTOKINES The chronic inflammatory situation in atherosclerosis is mediated by the activation of both the adaptive and the innate

Ngày tải lên: 30/01/2019, 17:34

... shown in the bar at the top The differentially abundant proteins were grouped into clusters in Xihan No The detailed information on these proteins within each cluster is presented, including the ... shown in the bar at the top The differentially abundant proteins were grouped into clusters in Longchun 23 The detailed information on these proteins within each cluster is presented, including the ... differences increasing, as shown in the bar The expression profile of each individual protein in the cluster is depicted by gray lines, while the mean expression profile is marked in pink for each

Ngày tải lên: 22/05/2020, 04:37

... ripening percentage or 1000-grain weight These results indicate that increased sink size is not sufficient to increase rice yield in both backgrounds In addition, most QTLs were detected in either ... Takanari genome, and these are promising materials for detecting QTLs underlying high yield potential in Takanari The CSSLs in the Takanari background consisted of 39 lines covering the entire Koshihikari ... useful tool for understanding the genetic mechanisms underlying yield potential in the high-yielding rice cultivar Takanari Our results suggest that sink-size QTLs in combination with QTLs for source

Ngày tải lên: 27/05/2020, 00:19

... saline were used as negative controls (NT) This methodology mimics the layer of liquid depositing onto the air-facing lung epithelium in patients exposed to drug inhalation in the clinical settings ... LSCM images of the culture showing the F-actin (in red) and cell nuclei (in blue) organization in these cultures The Z-stack LSCM images, clearly demonstrating the 3D architecture of the models developed, ... When inhibiting the phosphorylation of mTOR by rapamycin exposure (Fig 9a-b), no increase in docetaxel cytotoxicity was detected (Fig 9c) On the other hand, in the presence of rapamycin the expression

Ngày tải lên: 17/06/2020, 17:35

... This increasing knowledge has a great potential to improve our understanding of the role of these inflammatory cells in disease mechanisms in IIMs In this review we summarize the latest findings ... immune mechanisms in IIMs Taken together, they demonstrate the complexity of involvement of the immune system in these diseases and suggest that both the innate and adaptive immune systems are involved ... perivascular/perimysial In endomysial infiltrates there was a striking dominance of CD8+ T lymphocytes, which could even be the predominating infiltrating cell type, followed by macrophages and CD4+ T lymphocytes These...

Ngày tải lên: 09/08/2014, 10:20

... by the LIM kinases 1.1.2.2.3 G1actin)binding)proteins) Actin monomer binding proteins contribute to maintaining the physiological F-/G-actin homeostasis Thymosin-β4 and profilin are two main ... participating in the assembly of perinuclear actin network This thesis has provided new findings and hypotheses on the regulation of perinuclear actin It shows that the dynamics of perinuclear actin ... 2013) In addition, the actin crosslinking protein, α-actinin, is inhibited from bundling actin filaments by calcium (Burridge and Feramisco, 1981) On the other hand, calcium-induced actin polymerization...

Ngày tải lên: 09/09/2015, 08:16

... dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic and degradative enzymes, the endocannabinoid ... significantly increased following the ischemia-like insult [42] The endocannabinoid system in cerebral ischemia The ‘dark side’ of CBs An independent line of research supports a contrasting, neurotoxic ... Concluding remarks The great deal of knowledge accumulated in the past three decades on the mechanisms underlying damage in icted to the brain tissue by cerebral ischemia has failed to translate into...

Ngày tải lên: 07/03/2014, 03:20

... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling to the immune system after environmental exposure The third group are ... keratinocytes dividing in the basal lamina and moving to the upper layer as they mature K10 is expressed in keratinocytes in the early stages following differentiation, whereas K14 is expressed in undifferentiated...

Ngày tải lên: 23/03/2014, 17:20

... are indicated in bold/underlined) from the template of a pUC19 plasmid DNA containing GH1 (Xinxiang Medical University, Xinxiang, Henan Province, China) The 677-bp GH1 DNA fragment (including the ... was gradually increased from 17% to 35% during the first week of feeding and then maintained at the same concentration for another weeks [25] Food intake was recorded daily in the control and ... higher in the GH1-treated control group than in the control group throughout the experiment (Figure 2A) The body weight in the control group was 26.47 ± 1.02 g at the end of the study but did not increase...

Ngày tải lên: 18/06/2014, 16:20

... during experimental stress Type D was also associated with a decreased activity in the amygdala in response to fearful expressions [10], suggesting inadequate emotion-processing in the brain Finally, ... endothelial progenitor cells [47] in cardiac patients These initial findings are promising, but more research is needed to examine the cardiovascular effects of stress in apparently healthy individuals ... myocardial infarction, and increased risk of mortality [4-7] Given the clinical relevance of findings on Type D research in the context of cardiovascular disorders, it is also important to assess the...

Ngày tải lên: 18/06/2014, 19:20