cytokines as mediators and targets for cancer cachexia

... fibrosarcomas, breast cancer, mesotheliomas and prostate cancer, transfected with HAS1, HAS2 and HAS3 genes, triggered intracellular signaling pathways that promoted anchorage-independent growth and ... CD44v6 is expressed in breast, cervical and colon cancers, and in squamous cell carcinomas Thus CD44v was chosen as a model for therapy A Phase clinical trial was performed with an immunotoxin ... cancer- associated stromal myofibroblasts [103] As hMSCs can be easily expanded in vitro and possess an extensive multipotent capacity for differentiation, they have been explored as vehicles for...

Ngày tải lên: 28/03/2014, 23:20

... SH-SY5Y (neuroblastoma) [43] and MCF-7 (breast cancer) cell lines and various cancers such as gliomas [44], cervical cancers [45], colon carcinoma [46], gastric cancers [47] and sarcomas [48] HERG ... endometrial cancer, gastric and glioblastoma [52-55] The first tissue expression of HERG channels in cancer showed that herg mRNA and HERG protein was expressed in 67 and 82% of endometrial cancer ... of shRNAs for HERG1 and the HERG-1b isoform, reduced growth rate, cell viability and inhibited colony formation of neuroblastoma cells restricting them to G0/G1 phase of cell cycle There was also...

Ngày tải lên: 09/08/2014, 03:24

... visual assessment in all patients times, separated by at least 24 hours BAL procedure and recovery of BALF BAL was performed as recommended by the American Thoracic Society according to the task-force ... ILD due to other diseases, fewer abnormalities were observed; however; some cytokines/ chemokines, such as CCL2 and CCL3, were increased in idiopathic ILD as well as in SSc-associated ILD, indicating ... early scleroderma lung disease J Rheumatol 1991, 18:1520-1528 Haslam PL, Baughman RP: Report of ERS task force: guidelines for the measurement of acellular components and standardization of BAL Eur...

Ngày tải lên: 09/08/2014, 14:22

... factors such as tumour size, tumour grade and metastasis to local lymph nodes New prognostic markers are most urgently needed for cancers such as breast and prostate cancer In breast cancer, prognostic ... markers for breast cancer are increased in patients with early disease and are thus of little value in identifying women at increased risk of developing this malignancy [55] As well as breast cancer, ... study found that the active form was more associated with breast cancer progression than the precursor form [16] As well as ADAM17 protein, high expression of ADAM17 mRNA was also found to predict...

Ngày tải lên: 13/08/2014, 13:20

... ligands (peptides, vitamins, and carbohydrates) Targeting cancer with a mAb was described by Milstein in 198123 Over the past two decades, the feasibility of antibody-based tissue targeting has ... screening for conformational-sensitive targeting agents such as affibodies, avimers and nanobodies, as well as intact antibodies and their fragments process, scFv antibodies have been identified for ... mesothelioma, ovarian and acute lymphoblastic leukaemia Adenocarcinoma of the oesophagus, 5, 91, 100, 101 metastatic breast cancer and acute lymphoblastic leukemia 73, 74 Metastatic or recurrent...

Ngày tải lên: 28/05/2014, 15:07

... evaluating standard anticoagulants for prophylaxis and treatment of VTE are as follows: American Heart Association (AHA) step and step diets AHA step and step diets recommend plenty of fruits and vegetables, ... Martínez C, Cuevas A, Panes O, Aranda E, Guasch V, Strobel P, Muñoz B, Rodríguez S, Pereira J, Leighton F: Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine ... coagulation and fibrinolysis may account for this marked increase in FPE risk associated with anticoagulant treatment [25] and prophylaxis [26] Given that at least 12 million medical and surgical...

Ngày tải lên: 13/08/2014, 16:20

... addition, increased expression of inflammatory cytokines and oxidative stress mediators has been shown to induce Aβ deposition and senile plaque formation in neuronal cells [21,22] and transform non-aggregated ... Bahety P and Ee PLR Dual inhibition of the dihydrofolate reductase and glycogen synthase kinase enzymes enhances Wnt/β-catenin signaling for improved neuronal survival 7th PharmaSci@Asia Symposium, ... development and availability of sensitive and reproducible experimental platforms for monitoring biomarkers and drug responses, for drug screening process and to evaluate the efficacy and mechanism...

Ngày tải lên: 09/09/2015, 11:27

... cancer, stomach cancer, lung cancer, breast cancer and cervical cancer, Nguyen Van Qui has carried out a study on 2400 people in Can Tho As for the types of cancers that had been well propagandized ... of the disease at an early stage when it has a high potential for cure (for example: cervical and breast cancer) The main purpose of such services is to detect cancer before it metastasizes to ... colorectal, breast and esophageal cancer [4] By gender, while men are most affected by lung cancer, stomach cancer, liver cancer, colorectal cancer and esophageal cancer, five of the most common cancer...

Ngày tải lên: 01/07/2016, 10:38

... the case of PR, and first documented sign of disease progression PFS and TTP were measured from the date of study entry until the date of disease progression or death, and survival was measured ... carcinoma Other NSCLC Site of disease Lung ± lymph nodes Lung and metastatic site Lung and ≥ metastatic sites Extra-pulmonary disease Previous surgery for neoplastic disease Yes Palliative Curative ... activity was assessed every two months according to WHO criteria A complete response (CR) was defined as the disappearance of all lesions and no appearance of new disease for at least weeks Partial...

Ngày tải lên: 18/06/2014, 15:20

... containing μM DOX was given for 24 h Cells were then lysed and the total protein content was measured using Bradford’s reagent 50 μg of total protein was loaded for SDS-PAGE Immunoblotting was carried ... used as a carrier for drug delivery To measure and compare the extent of apoptosis induced by μM of free DOX and VEVDMs on incubation for 24 h, FITC-conjugated annexin staining was done and analyzed ... major reasons behind studying δ-valerolactone based micelles for drug delivery was that the thermodynamic as well as kinetic stability of micelles is expected to increase with the increase in...

Ngày tải lên: 11/08/2014, 08:20

... RC: review IL-9 was first suggested as an asthma candidate gene by unbiased genetic mapping studies on AHR and linkage homology in both humans and mice Cell biology in vitro has shown that IL-9 ... of the allergic asthmatic response Importantly, increased lung IL-9 expression in mice and humans is tightly and specifically associated with asthma and its risk factors; decreased IL-9 is protective ... numerous genes, such as those for cytokines, growth factors, and receptors, that are potentially involved in airway inflammation and atopic asthma [10] Structural analyses of these candidate genes...

Ngày tải lên: 12/08/2014, 18:20

... To my dear uncle and my aunt Khem Kandel and Laxmi Kandel: your support and friendship has been such a help during this time Lastly, to my sweetheart Kriti Acharya, your love and support provided ... resistance to DNA damage (Lassen et al., 2006) ALDH3A1 has also been identified as a potential diagnostic marker for non–small–cell lung cancer (Kim et al., 2007) and as a candidate gene in the pathogenesis ... mustard and its mechanism of DNA cross linking Figure represents how phosphoramide mustard forms intrastrand and interstrand cross–links between guanine bases from DNA 23 B Hypothesis and approaches...

Ngày tải lên: 24/08/2014, 09:51

... block the invasion and metastasis of cancer Antisense oligonucleotides against mRNA of Bcl-2, c-myc and ras family of oncogenes has resulted in tumor growth inhibition in solid tumors and leukemia ... interfering RNA 13 1.1 Glioblastoma Malignant brain tumors such as glioblastoma multiforme (GBM) and childhood brain cancer, medulloblastoma, have remained virtually untreatable and lethal The median ... of breast cancers are estrogen receptor -and/ or progesterone-positive, and approximately one in five breast cancers is human epidermal growth factor receptor 2/erb-B2 (HER2)positive breast cancers...

Ngày tải lên: 09/09/2015, 18:56

... and ω the rotational speed Suter parameters give information for both the turbine and the pump mode for few available pumps, and the Derakhshan model predicts information for the turbine performance ... behaviour inside the runner and the dissipative effects associated such as turbulence, vorticity and leakages Commonly the only way to obtain reliable results is to measure the performance of the machine ... downstream and closure of a valve upstream Some results by Ramos et al are available for the first case and guide vane closure of a turbine, and they were obtained in lab conditions and compared...

Ngày tải lên: 05/09/2013, 14:58

... microfibrils to release glucose involves synergistic action of three enzymes: endo-glucanase, exo-glucanase and β-glucosidase Endo -and exo-glucanases are commonly referred to as “cellulases” Fungal ... milling was studied for larger screen size (12.7-50.8 mm), and optimum total specific energy consumption for wheat straw was 37.9 MJ/Mg for screen size of 25.4 mm Hammer milling was studied for smaller ... leaf, and node) of straw The stems account for 50-60% w/w and are richer in cellulose while containing less ash The leaves that account for around one third of biomass fraction contain more ash and...

Ngày tải lên: 05/09/2013, 15:28

... fragmentation and cysteine–aspartic acid protease, caspase-3, activity assays (Srivastava et al 2007) DNA fragmentation increased at anthocyanin concentrations from 50 to 150 μg·mL−1 with cv Tifblue and ... quercetin and ascorbic acid each day After an intervention period, plasma concentrations of quercetin and ascorbic acid and TEAC were significantly increased Further, a significant decrease was noted ... acids, and stilbenes such as resveratrol, pterostilbene, and piceatannol, and triterpenoids such as ursolic acid and its esters, oleanic acid, alpha-amyrin and betaamyrin, steroidal, and iridoid...

Ngày tải lên: 25/10/2013, 05:20

... ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions Suppression of ANGPTL2 as ... inflammation and systemic insulin sensitivity, they have potential side effects, such as increased body weight (adiposity and ⁄ or edema), altered bone metabolism and undesirable long-term cardiovascular ... has been shown to enhance endothelial cell migration in vitro and in avascular tissues, such as the cornea [15] Transgenic mice expressing ANGPTL2 in adipose tissue show vascular inflammation and...

Ngày tải lên: 14/02/2014, 22:20

... 30,000 new cases registered in England and Wales in 2002 This represents 12% of all new cancer cases in women and 14% of all new cancer cases in men The incidence of colorectal cancer increases with ... guide for healthcare professionals Information for people with metastatic colorectal cancer and their carers (‘Understanding NICE guidance’) Details of all the evidence that was looked at and other ... advanced disease and distant metastases (typically presenting within years of initial diagnosis) The 5-year survival rate for metastatic colorectal disease is 12% 2.4 The management of metastatic...

Ngày tải lên: 14/02/2014, 22:20

... that affect risks for certain cancers Breast cancer The risk of breast cancer in women is increased by several factors that cannot be easily changed: • Having your first period before age 12 • Not ... colon and rectum, endometrium, esophagus, kidney, and pancreas, and probably cancer of the gallbladder as well It may also be linked with increased risk of cancers of the liver, cervix, and ovary, ... safe, enjoyable, and accessible environments for physical activity in schools and workplaces, and for transportation and recreation in communities ACS Guidelines for Nutrition and Physical Activity...

Ngày tải lên: 06/03/2014, 02:21

... development and course of coronary heart disease: Current status and implications for research and practice Journal of Consulting and Clinical Psychology, 70, 548-568 Spanier, G B (1976) Measuring ... better understand gender and its relation to health At the conceptual level, it is argued that gender is a multidetermined construct and needs to be conceptualized and measured as such At the ... difference in cancer incidence is influenced by cultural and Davidson et al / Gender as a Health Determinant 733 socioeconomic factors as reflected in rates of female versus male disadvantage for cancer...

Ngày tải lên: 14/03/2014, 21:20