cytofluorimetry of human skeletal myoblasts fo

... mutation-induced loss of p53 function which occurs 38 in more than half of human cancers implicates the importance of p53 in apoptosis within cancer cells (Hofseth et al., 2004) Due to the importance of apoptosis ... suppression of CAMs expression which alleviates the inflammatory response is one of the mechanisms of anti-inflammatory activity of parthenolide iNOS and NO production Nitric oxide (•NO) is one of the ... synthesis and release of the •NO are mediated by an inducible isoform of nitric oxide synthase (iNOS) Parthenolide has been demonstrated to suppress the gene expression of iNOS in several cell...

Ngày tải lên: 16/09/2015, 17:14

... on the short arm of chromosome 5p (Bryce et al., 2000) While several differentially spliced forms of hTERT have been identified, the protein forms of these alternative spliced forms have not been ... class of 2005, Sinong, Chewy, Zhi Xiong, Greg, Lakshmi, Ai Kia, Swamy and Grace for having shared my happiness, frustrations, successes and failures and for being a huge source of support for me ... one of the biggest pillars of strength in my life, thank you for shielding me, grooming me, inspiring me and for the confidence you placed in me Watching you, I have learnt the true meaning of...

Ngày tải lên: 14/09/2015, 08:38

... the mean ± SD of four independent experiments the uptake of this rhodamine analogue As expected for the active efflux mechanism of rhodamine dyes, agents allowing the enhanced uptake of rhodamine ... the presence of ATP [25]; thus, the increased uptake of rhodamine dyes observed in the presence of NBD-Cl does not appear to be due to the inhibition of Pgp A half maximal effect of NBD-Cl was ... mechanism responsible for the exclusion of rhodamine dyes from cells, we surveyed a variety of agents known to interfere with the transport of anticancer drugs and dyes in and out of cells (Table 2)...

Ngày tải lên: 18/02/2014, 13:20

... example of this approach 26 ingly careful measures of inputs—for example, by adjusting labor inputs for the impact of education and training on the quality of labor and by introducing a measure of ... Frameworks in Need of Reform The deteriorating performance of the global economy has raised concerns about the choice of macroeconomic policy frameworks and the appropriateness of policies affecting ... previous three months Survey of changes to credit standards for loans or lines of credit to enterprises for the euro area; average of surveys on changes in credit standards for commercial/industrial...

Ngày tải lên: 18/02/2014, 16:20

... different osmosensors, amplifies this information, and turns on ⁄ off a large number of appropriate effector mechanisms (i.e mechanisms of physiological acclimation) Some of these euryhaline fish (e.g tilapia) ... studies to date have focused on the role of aquaporins as effector proteins of osmosensory signal transduction pathways and the potential role of these proteins in osmosensing of fish cells has yet ... conservation of orthologs of the putative osmosensors TRPV4 and aquaporin and the osmosensory signal transcription proteins TonEBP and TSC22D2 in vertebrates The human sequences of TRPV4 (871...

Ngày tải lên: 18/02/2014, 16:20

... MA, USA) For differentiation experiments, cells (1 · 106 mL)1) were seeded and cultured in the presence of lM ATRA for days or in the presence of 0.13 lM TPA for days After incubation for and ... incubated for days in the presence of lM ATRA The results from one representative experiment out of three performed are shown (A) Cystatin F showed an 18-fold downregulation in cell extract and a 9-fold ... aware of two recent publications that contain results of relevance for the present work In a study aiming at characterization of the proteome of lysosomes in U937 cells, cystatin F was found...

Ngày tải lên: 21/02/2014, 01:21

... mechanisms of defense more maturely deemed stressful for one individual may not be for another, than young adults However, the effectiveness of coping or the magnitude of the impact of a given ... the form of chronic Elderly subjects may worse(6) In a certain way, coping modifies the stress or in the presence of prolonged expo- perceive their ego is stress evolution through strategies of ... The Chi-square test was performed to compare coping styles among elderly who elected emotion and problem-focused coping(13) Student’s t was performed to compare means of stress symptoms among individuals...

Ngày tải lên: 14/03/2014, 20:20

... absorption spectrum of the stable Fe(II)–O2 complex of the L99F mutant A similar result was also obtained for the R220I mutant of BjFixL [19] The rates of auto-oxidation for the Ec DosH mutant ... electronic states of Leu mutants of Ec DOS A B C D Fig (A) Changes in the optical spectra of the Fe(II)–O2 complex formation of the wild-type protein after mixing solutions of protein (8 lM per ... slow phase of the L99F mutant was independent of the O2 concentration b Measurement of the rate of O2 binding was not feasible because of low heme binding affinity and instability of the protein...

Ngày tải lên: 16/03/2014, 13:20

... signaling pathways for both of these stresses are often mediated by Ca2+, the effect of exogenous Ca2+ was analyzed on the protein level of PsCCaMK As shown in Fig 3, the level of the kinase was ... International Center for Genetic Engineering and Biotechnology and funds from Department of Science and Technology, Government of India We thank Prof S Assmann for critical reading of the manuscript ... antiZmCCaMK Ig Fig Purification of PsCCaMK from immuno-affinity columns Roots of 5-day-old plants treated with calcium (100 mM) for 24 h were used for the purification of kinase using the immuno-affinity...

Ngày tải lên: 18/03/2014, 01:20

... neurons Food intake Relaxin-3 was first reported to stimulate food intake when administered into the third ventricle or PVN of male Wistar rats Administration of human relaxin-3, but not human relaxin-2, ... suggesting that this effect of relaxin-3 is not a result of increased locomotor or arousal activity [34] Chronic intra-PVN administration of human relaxin-3 (180 pmol twice a day for days) also increased ... Wistar rats (A) Effect of human relaxin-3 (H3) (18– 180 pmol) on 1-h food intake *P < 0.05 versus vehicle in the early light phase (B) Effect of H3 (18–180 pmol) on cumulative food intake over h...

Ngày tải lên: 29/03/2014, 21:20

... with 0.1 M HCl for the termination of the oxidation The formed peroxide is extracted with a twofold volume of chloroform/methanol (1/1) The extract is evaporated, dissolved in chloroform, and then ... other Humana titles, contact Humana at the above address or at any of the following numbers: Tel: 973-256-1699; Fax: 973-256-8341; E-mail: humana@humanapr.com, or visit our Website at www.humanapress.com ... • Division of General Surgery, Department of Surgery, St Louis University, St Louis, MO YOJI KATO • School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology,...

Ngày tải lên: 11/04/2014, 10:00

... attacks on staff Assessments of professional quality of life were made with the Professional Quality of Life Scale (ProQOL) [16], which is a validated development of the Compassion Fatigue Test ... have had more symptoms and therefore being reluctant to answer because of avoidance issues related to PTSD But, if these findings of low prevalence of PTSD symptoms found in our study could be replicated ... relatively high frequency of violence During the year of the study (2006), staff experienced 221 incidents of threat and violence corresponding to 13.8 incidents/bed/year of which 7.4 incidents/bed/year...

Ngày tải lên: 18/06/2014, 18:20

... consequent loss of the ability to perform normal everyday activities and, therefore, loss of self-sufficiency of the subject Intense research is currently aimed at defining the cause of the disease: ... indicate that the quality of life of the informal caregivers is closely correlated with the severity of the behavioural disorders and to the duration of the disease Most of the subjects interviewed ... 2004 Folstein MF, Folstein SE, McHugh PR: "Mini-Mental State" A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 1975, 12(3):189-198 Katz S, Ford...

Ngày tải lên: 18/06/2014, 19:20

... instrument was found for the audience of our study, because these models are developed to evaluate psychosocial stress in general irrespective of the mode of work or the profession The focus of our study ... basis of the threshold values of the German Society for nutrition, the thresholds for high-risk alcohol consumption were taken as > 20 g pure alcohol per day for men and > 10 g pure alcohol for ... difficult customers.“ Measures Demographic information was collected including data on gender, age, type of work, weekly working hours and the number of years of professional work • „Over the past few...

Ngày tải lên: 20/06/2014, 00:20

... educational structure of sub-samples (Table 1) The analysis of the dimensions of quality of life survey in the four investigated groups indicated the presence of strong differences in the four distinctive ... determinants of quality of life in these patients The use of more advanced statistical analytic methods indicated the existence of several cluster of quality of life, suggesting a presence of several ... all four dimensions of quality of life estimation, thus suggesting the fine interplay and sometimes unclear boundary between these two groups of patients This type of synergistic action of different...

Ngày tải lên: 20/06/2014, 15:20

... ¥l a

Ngày tải lên: 29/06/2014, 09:20

... the names of these two forms to problem-focused and emotionfocused, respectively Problem-focused coping strategies are similar to problem-solving tactics These strategies encompass efforts to ... inward to alter some aspect of self Many of the efforts directed 10 PART I. INTRODUCTION at self fall into the category of reappraisals— for example, changing the meaning of the situation or event, ... Emotion-focused coping is the more common form of coping used when events are not changeable (Lazarus & Folkman, 1984) Lazarus (1966) and Lazarus and Folkman (1984) summarize a large body of empirical...

Ngày tải lên: 09/07/2014, 08:25

... giving the number of units of domestic currency necesiary to acquire one unit of foreign currency r * is the number of units of foreign =- r currency necessary to acquire a unit of domestic currency ... domestic currency and, therefore, for the supply of foreign eschanqe I t is clear, therefore, that an analysis taking into account only the elasticities of demand for f o r e i ~ n exchange as ... one-tenth of total imports While the postwar predominance of balanceof-payments problems requires watching of the balance expressed in foreign exchange and, secondarily, of the ratio of exports...

Ngày tải lên: 23/07/2014, 16:28

... †The genome size of S glossinidius is comparable to that of free-living Enterobacteriaceae, but it is in an early state of degeneration, as exemplified by the massive presence of pseudogenes and ... novel aspect of the symbiotic relationship of stinkbugs with extracellular γ-proteobacteria [4], a continuation of their previous work on stinkbug endosymbionts [3] A major conclusion of their investigations ... symbionts of the novel genus Candidatus Rosenkranzia are located in specialized midgut crypts that are sealed off from the rest of the midgut, thereby leading to complete isolation of the bacteria...

Ngày tải lên: 06/08/2014, 19:20

... members of the superfamily (NCBI conserved domain Pfam00153, mito_carr superfamily) The elucidation of the three-dimensional structure of the ANT has confirmed this structural arrangement [4] Therefore, ... that ensures the highly dynamic traffic required for the full integration of the mitochondrion into cellular metabolism For two decades the function of UCP1 from brown adipose tissue was considered ... dissipation of the proton gradient when non-shivering thermogenesis was Figure Three-dimensional structure of the adenine nucleotide translocator (a) Ribbon representation of the structure of the...

Ngày tải lên: 06/08/2014, 19:20